Lymphomatoid papulosis type C of the eyelid in a young girl: a case report and review of literature.

PURPOSE: To report an unusual presentation of a case of Lymphomatoid papulosis(LyP) in a young girl. MATERIAL AND METHODS: A 14-year-old female presented with a history of swelling of the left upper eyelid of two weeks duration. There was a history of trivial trauma prior to the swelling. The patient was diagnosed as having pre-septal cellulitis elsewhere and was put on oral antibiotics. The lesion was non-responsive to oral antibiotics. The patient was then referred to our hospital. Ocular examination revealed an elevated lesion measuring 15 mm × 10 mm on the left upper eyelid, associated with pre-septal swelling and induration. Ocular movements were normal. The anterior and posterior segment examination was normal. Incision biopsy was done from the eyelid lesion. Multiple cutaneous lesions were also biopsied. RESULTS: The histopathology examination confirmed the diagnosis of lymphomatoid papulosis type C. Dermatological and systemic evaluation ruled out the other aggressive forms of CD30(+) lymphoid proliferation. CONCLUSION: We report an unusual presentation of lymphomatoid papulosis(LyP) type C in a young girl. Complete systemic work up and histopathological evaluation is mandatory in cases of suspicious lesions, not responding to conservative treatment.

Aplicación de la tecnología láser en las lesiones de genitales / Application of laser technology to genital lesions

El empleo del láser en urología ha presentado un avance significativo y en la actualidad es empleado en una gran variedad de patologías. El desarrollo de los diferentes tipos de láser, el empleo de diferentes tipos de longitudes de onda, los sistemas de fibra óptica, la precisión y la reducción del coste han hecho mejorar la tecnología del láser, y extender y potenciar sus indicaciones. Los diversos tipos de láser de los que disponemos en la actualidad, suponen una excelente alternativa terapéutica en el tratamiento de diversas patologías benignas, pre-malignas y malignas localizadas en los genitales, con excelentes resultados estéticos y funcionales, y con una reducida morbilidad. El objetivo de esta trabajo es proporcionar las indicaciones clínicas más importantes y aplicaciones con el láser más novedosas en las lesiones genitales (AU)

The use of laser applications in urology has undergone significant advances and is now used in a wide variety of procedures. Improvements in types of lasers, the wavelength of energy used, optical fiber delivery systems, precision of laser applications and cost reduction have served to further improve laser technology and extend the potential applications. The different types of lasers available at the present time appear to be an alternative treatment modality with excellent cosmetic and functional results and low morbidity in the treatment of benign, pre-malignant and malignant lesions in the genital area. The objective of this article is to provide an update on the most important clinical and experimental advancements therapeutic applications of lasers in genital lesions (AU)

Tuberculum sellae meningioma associated with lymphomatoid papulosis.

BACKGROUND: Meningiomas involving the tuberculum sellae and planum sphenoidale typically cause visual loss by affecting the optic nerve and anterior chiasm. We present a case of a tuberculum sellae meningioma concurrent with lymphomatoid papulosis, a T-cell lymphomatoid skin disorder. CASE REPORT: A 50-year-old black woman came to the eye clinic with a symptom of decreased vision in the right eye for one week, especially when reading. Best-corrected vision was counting fingers at two feet O.D. and 20/40 O.S. She was seen seven months earlier, with 20/25 O.D. and O.S. Dilated fundus examination revealed bilateral optic atrophy, O.D. greater than O.S. MRI revealed a meningioma arising from the tuberculum sellae and planum sphenoidale region. The meningioma was partially resected nine days later Visual field performed 18 days postoperatively demonstrated an overall depression in the right eye and no defect in the left eye. Best-corrected vision improved to 20/150 O.D. and 20/30 O.S. CONCLUSION: Meningiomas are generally benign tumors that can cause symptoms if vital structures are compromised. Altered visual function and optic atrophy may be the only presentation of intracranial and orbital tumors. Intracranial meningiomas may be associated with systemic conditions that can infiltrate the optic nerve, including lymphocytic disorders. Lymphomatoid papulosis (LyP) is a rare cutaneous disorder involving infiltrating clonal T-cells that has been associated with disseminated lymphomatic skin tumors. It is unclear if there is a direct association between LyP and meningiomas.

[Lymphomatoid papulosis type C or transition to CD30+-T-cell lymphoma? A difficult differential diagnosis]. / Lymphomatoide PapuloseTyp C oder Ubergang in CD30+-T-Zell-Lymphom? Eine schwierige Differenzialdiagnose.

Lymphomatoid papulosis (LyP) is a recurrent papulonodular eruption, characterized by self-healing skin lesions. While this disorder usually has a benign course, about 10% of the patients develop lymphoproliferative disorders such as CD30+ T cell lymphoma. We report 2 patients with LyP type C. In one case progress to a cutaneous CD30+ large T cell lymphoma could not be excluded. Histologic differentiation between LyP and malignant lymphoma causes considerable problems. In this regard, the evaluation of the clinical course is essential. A long-term follow-up including diagnostic imaging studies is required.

[Lymphomatoid papulosis in a child]. / Papulose lymphomatoïde chez un enfant.

BACKGROUND: Lymphomatoid papulosis (LyP), uncommon in children, has a benign clinical course in contrast with a malignant histology. CASE REPORT: A 9-year old boy developed nodular skin lesions for 6 months on the scalp and penis and a papule skin on his trunk. Surgical excision of scalp nodules was performed to prevent necrosis and ulceration of the ear. The biopsy showed a dense mixed cellular infiltrate including histiocytes, lymphocytes and numerous atypical large cells of which a minority expressed the CD30 antigen. PCR showed an oligoclonal rearrangement of the TCR gamma chain gene. Physical examination, bone marrow aspirate and thoracoabdominal CT scans were normal. Three years after surgery, no other lesions occurred. DISCUSSION: Differential diagnosis of LyP is difficult with non Hodgkin's lymphoma, especially CD30+ lymphoma. Prognosis remains the major problem in LyP. Ten to 20% of cases are associated with lymphomas in adults.