1.
Appl Radiat Isot
; 140: 294-299, 2018 Oct.
Article
in English
| MEDLINE
| ID: mdl-30098587
ABSTRACT
In the process of developing [18F]FBEM coupled target peptide, we have instituted a robust automated synthesis of [18F]FBEM, a sulfhydryl (-SH) site specific agent for radiolabeling of peptides and proteins. The radiosynthesis generated 1.67-3.89 GBq (45.1-105.1â¯mCi, 7.5-18.8% non-decay corrected yield) of [18F]FBEM from 22.2 GBq (600â¯mCi) of starting [18F]fluoride with molar activity of 31.8⯱â¯5.3 GBq/µmol (0.86⯱â¯0.14â¯mCi/nmol) (nâ¯=â¯3) at the end of synthesis. Radiochemical purity was greater than 98%, and total synthesis time was ~90â¯min.