Paediatric jaw tumours: experiences and findings from a resource limited tertiary health care center.

INTRODUCTION: primary maxillofacial tumors are uncommon in pediatric patients. When they do occur, the tissue damage caused directly alters facial growth, development as well as psycho-social evolution. This study was carried out to determine the pattern, sociodemographic characteristics and histologic peculiarities of paediatric jaw tumors in our environment. METHODS: a retrospective hospital-based study where the case notes of children below the age of 14 years who presented with jaw tumors and tumor-like lesions from January 2014 to December 2018 were studied. RESULTS: eighty-two patients were studied; patients aged 10-14 years had the highest representation. Mean time of presentation was 8 months with jaw swelling being the commonest presentation (84.1%). Majority of the fathers were in their 4th decade of life while most of the mothers were in their third decade of life and both parents possessed primary school certificate as their highest level of educational attainment. Fathers were mostly traders, while mothers were mostly full-time housewives. The maxilla and mandible were most commonly affected with the left side showing higher preponderance. Burkitt lymphoma (19 (23.2%)) and adenomatoid odontogenic tumor (14 (17.1%)) were the commonest lesions. When the tumor involved both the maxilla and the mandible, the tumor was most likely malignant. CONCLUSION: in our center, paediatric jaw tumors are commonest in male children with the 10-14 years´ age group most commonly affected. Burkitt lymphoma and adenomatoid odontogenic tumors were the commonest tumors. Early presentation must be encouraged since these tumors if presented early can be successfully treated.

Oral and maxillofacial cancer in pediatric patients: 30 years experience from a Brazilian reference center.

OBJECTIVE: The aim of this study is to determine the relative frequency, demographic distribution and clinicopathological features of pediatric oral and maxillofacial cancer (POMC). METHODS: Medical records were retrospectively reviewed for all cancer cases diagnosed from 1986 to 2016 affecting patients aged 19 years and younger. Demographic variables, anatomical site, and histopathological diagnoses were collected and analyzed by descriptive statistics. RESULTS: Fifty-five (0.77%) POMCs were found among 7181 pediatric malignancies. Mean age at diagnosis was 8 years and patients aged 5-9 years presented the higher prevalence of malignant tumors (40%). White male patients were more frequently affected (78.18% and 65.45%, respectively). The most common cancer type was lymphomas (52.73%) followed by sarcomas (27.27%) and carcinomas (20%). Burkitt lymphoma (32.73%), rhabdomyosarcoma (14.55%), diffuse large B-cell lymphoma (9.09%), and mucoepidermoid carcinoma (9.09%) were the most common histopathological diagnoses. The main affected anatomical site was the oropharynx (38.18%), followed by salivary glands (30.91%), maxillofacial bone (20%), and oral cavity (10.91%). CONCLUSION: POMC has a low incidence; however, highly aggressive tumors, such as lymphomas and sarcomas, are common in this scenario. A better knowledge about the clinicopathological distribution of POMC may contribute to early diagnosis and improve survival rates.

Clinical and Histopathological Analysis of Odontogenic Tumors in Institution-A 10 Years Retrospective Study.

AIM: The present study was conducted to analyze the clinical and histopathological cases of odontogenic tumors (OTs). MATERIALS AND METHODS: The present 10-year retrospective study comprised of 104 OTs. Parameters such as name, age, gender, clinical features, location, extension, etc were noted. H and E stained slides were carefully assessed by an oral pathologist and were classified according to the latest WHO classification of head and neck tumors. RESULTS: Out of 104 OTs, the most common was ameloblastoma constituting 45 cases, KCOT (28), odontoma (17), odontogenic myxoma (4), Calcifying epithelial odontogenic tumor (CEOT) (5), cementoblastoma (3) and calcifying cystic odontogenic tumor (2). The p value found to be 0.01 (significant). Common OTs was ameloblastoma (25 males and 20 males), KCOT (12 males and 16 females), odontoma (10 males and 7 females), odontogenic myxoma (3 males and 1 female), CEOT (3 males and 2 females), cementoblastoma (2 males and 1 female) and calcifying cystic odontogenic tumor (1 male and 1 female). Ameloblastoma, KCOT, and odontoma were predominantly seen in the age group 21-30 years, CEOT and cementoblastoma in age group 31-40 years. The difference was significant (P < 0.05). Common clinical features in OTs were facial disfigurement (65), swelling (78) and pain (55). The difference was non significant (P > 0.05). The average size of ameloblastoma was 6.8cm, KCOT was 4.2 cm, odontoma was 3.9 cm, odontogenic myxoma was 2.7 cm, CEOT was 5.5 cm, cementoblastoma was 3.8 cm and Calcifying cystic odontogenic tumour (COC) was 3.6 cm. The difference was non-significant (p > 0.05). CONCLUSION: Mandible exhibited more OTs as compared to the maxilla. The most common lesion was ameloblastoma, KCOT, and odontomas. We observed male predominance. CLINICAL SIGNIFICANCE: The study helps in assessing the occurrence of the odontogenic tumor. This is useful for identification and clinical management.

Histopathological pattern of primary bone tumours and tumour-like lesions in Ile-Ife, Nigeria.

INTRODUCTION: Bone tumours are relatively rare in comparison with neoplasms in other parts of the body. Previous studies have noted higher frequencies of these tumours in young adults with potentially devastating consequences. METHODS: This study aimed to demonstrate the histopathological pattern of primary bone tumours and tumour-like lesions in Ile-Ife, Nigeria with emphasis on relative frequencies and distribution according to age, sex and anatomical location. A 13 year (1991-2003) retrospective study was carried out on 100 cases of primary bone tumours and tumour-like lesions. Records were retrieved from the surgical registers of the Histopathology Department, Qbafemi Awolowo University Teaching Hospitals Complex, Ile-Ife. Original histopathological slides were retrieved for examination and when they were unavailable, the paraffin blocks were searched out and new slides were made. RESULTS: A total of 100 cases met the inclusion criteria for this study accounting for 1.55% of the 6,464 cases of all neoplasms seen within this period. Of the 100 cases, 50 were malignant (50%), 28 were benign (28%) and 22 had tumour-like lesions (22%). The male to female ratio was 1.3:1 and the most common benign and malignant tumours were osteochondroma and osteosarcoma respectively. The femur was the most frequently involved bone in primary malignant lesions (24%) followed by the pelvis and the maxilla (14% each). CONCLUSION: The age, sex and morphological distribution of benign and malignant bone tumours is similar to earlier reports in other African and international journals. Tumour-like lesions occur more frequently in females than in males. The femur is the most favourable site for malignant primary bone tumours and the jaw bones for tumour-like lesions.

[A retrospective clinical study of 3 382 cases of malignant oral maxillofacial tumors].

To investigate the incidence of malignant tumors in oral and maxillofacial region and the pathological features of various tumors, a total of 3 382 cases of malignant tumors in oral and maxillofacial region admitted to Jilin University from Januarary 2000 to December 2017. The characteristics of age, sex, location and pathological types of all kinds of tumors were analyzed. The median onset age is 57 years old, 51 to 70 years old is a high-risk age group, the ratio of male to female was 1.9∶1. The primary tumor location is tongue, gingiva and floor of mouth. Epithelial, lymphatic hematopoietic system, bone and soft tissue were the three major sources of tumor tissue, and squamous cell carcinoma was the most common pathological type (65.1%), followed by mucoepidermoid carcinoma and adenoid cystic carcinoma. In summary, oral and maxillofacial malignancies have a high incidence in elderly men, and tongue is the most common site of disease. Epithelial-origin and squamous cell carcinomas are the first of their origins and pathological types, respectively.

Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review.

BACKGROUND: The aim of this study was to integrate the available data published on calcifying odontogenic cyst (COC), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinomas (GCOCs) into a comprehensive analysis of their clinicoradiological features, treatment, and recurrence. MATERIALS AND METHODS: An electronic search with no publication date restriction was undertaken in October 2017 in the following databases: PubMed, Medline Ovid, Web of Science, and Scopus. Eligibility criteria included publications containing enough clinical, radiological, and histopathological information to confirm a definite diagnosis of these lesions. Data were evaluated descriptively. RESULTS: The literature review indicated a total of 234 publications reporting 367 COCs, 55 DGCTs and 44 GCOCs. These lesions have a predilection for Asian males. COCs mainly affect the mandible and patients in the second decade of life, DGCTs mostly affect the mandible and patients in the fourth decade of life, and GCOCs mostly affect the maxilla and patients in the fifth decade of life. CONCLUSION: Conservative surgery was the most common therapy for COCs and DGCTs, while radical surgery was most common for GCOCs. This study provides important and interesting data that could help clinicians and surgeons as well as oral and maxillofacial pathologists with the diagnosis and management of these lesions.

Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: A French multicenter study.

OBJECTIVES: Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck is a rare entity with uncertain clinical behavior. Radical surgical resection is the current recommended treatment, however this can cause severe aesthetic and functional sequelae. The aim of this study was to clinically characterize MNTIs and to stratify risk factors that may influence locoregional recurrence. METHODS: A retrospective multicenter study, including 11 patients from eight centers with a confirmed diagnosis of MNTI, was conducted. Epidemiological, clinical, radiological, pathological, and immunohistochemical examinations were reviewed. A statistical analysis using a t-test was conducted to calculate parameters correlating with tumor recurrence. RESULTS: MNTIs mainly occurred in the maxilla, with a mean age at diagnosis of 3.18 months (range: 0-6 months). Primary surgery was performed on 10 patients, with a clear margin resection on two patients. Overall recurrence rate was 27% with a survival of 100% at time of follow-up. No statistical correlation between recurrence rate, age at diagnosis, localization, resection margins, and pathological and immunohistochemical characteristics could be established. CONCLUSION: In our study, locoregional tumor recurrence did not seem to correlate with resection margins, so a conservative surgical approach may need to be considered to avoid functional and aesthetic sequelae.

Odontogenic myxoma: A 63-year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature.

BACKGROUND: Odontogenic myxoma (OM) is an uncommon neoplasm of the jaws. Considering the importance of defining the relative incidence and demographic profile of these lesions in South America, the aim of this study was to analyze the clinical and imagiological features of OM from three South American oral pathology services and to discuss these findings in light of the literature. METHODS: Data regarding age, gender, anatomic site, and imagiological features from 85 cases of OM were collected. Additionally, we did a review of OM studies published in three electronic databases. RESULTS: Among 63 450 oral biopsies, 1178 (1.85%) were odontogenic tumors (World Health Organization - 2017), of which 85 (7.21%) met the criteria of OM. The mean age was 30.7 years (range: 10-61 years; SD: 12.22). Forty-five (52.9%) cases occurred in females and 40 (47.1%) in males (ratio: 1:1.12). Maxilla was affected in 44 cases (53%) and mandible in 39 (47%). Of the 41 informed cases (48.2%), all of them were radiolucent lesions. The literature review indicated a majority of mean ages in third decade and a predilection for females, mandible, and multilocular radiolucent lesions. CONCLUSIONS: The features of OM samples have strong similarity to that reported in studies from other continents. It is possible to infer that geographic variation does not help to explain some differences observed in the clinical features of OM.

A multicenter study of malignant oral and maxillofacial lesions in children and adolescents.

OBJECTIVES: To investigate the frequency of malignant oral and maxillofacial lesions among children and adolescents from representative geographic regions of Brazil. MATERIALS AND METHODS: A retrospective study was conducted on biopsies obtained from 1990 to 2016 at six Brazilian oral and maxillofacial pathology referral centers. A total of 85,105 biopsy specimens from children and adolescents were analyzed. Gender, age, anatomical location, symptomatology and histopathological diagnosis were evaluated. Data were analyzed using descriptive statistical methods. RESULTS: Fifty-eight (0.06%) malignant oral and maxillofacial lesions were diagnosed in children (19%) and adolescents (81%). The lesions were more frequent among females (60.3%) and adolescents. The most prevalent lesions were mucoepidermoid carcinomas (22.4%), osteosarcomas (13.8%), squamous cell carcinomas (12.1%), and Burkitt's lymphomas (12.1%). The most commonly affected sites were the palate (19%), mandible (13.8%), and maxilla (13.8%). Almost half the patients were asymptomatic. CONCLUSION: Pediatric oral and maxillofacial malignant lesions were infrequent and showed wide diversity, with a prevalence of mucoepidermoid carcinomas. Analysis of malignant lesions in children and adolescents helps pediatric dentists and oncologists to obtain a better understanding of such lesions and to reduce the time for diagnosis, with a consequent improvement of prognosis.

Cáncer Bucomaxilofacial en Niños III: Tumores Malignos del Tejido Blando / Oral and Maxillofacial Cancer in Children III: Malignant Soft Tissue Tumors

RESUMEN: El grupo de neoplasias malignas de tejido blando de la región de cabeza y cuello en pacientes pediátricos está representado por carcinomas, sarcomas, melanomas y tumores de diferenciación incierta. La neoplasia más prevalente en la población pediátrica es el Rabdomiosarcoma, seguido por el carcinoma de células escamosas. Los rangos de presentación son muy amplios, siendo los grupos entre 2-6 años y 15-19 años los que presentan mayor incidencia. Se ha planteado que la etiología de estas neoplasias es incierta. El tratamiento de estas neoplasias es comúnmente de enfoque multimodal, combinando un procedimiento quirúrgico con quimioterapia y radioterapia. El pronóstico y sobrevida del paciente dependerán principalmente del momento en que se realice el diagnóstico de la lesión. Un diagnóstico y tratamiento temprano favorecen las posibilidades de sobrevida y el pronóstico del paciente. Este estudio corresponde a la 3ra parte de "Cáncer bucomaxilofacial en niños". Se hará referencia a los distintos tumores malignos del tejido blando en la población pediátrica en el territorio de cabeza y cuello, abarcando sus generalidades, etiología, epidemiología, tratamiento y pronóstico.

ABSTRACT: Head and neck malignant tumors in pediatric patients comprise carcinoma, sarcoma, melanoma and tumours of uncertain differentiation. Within the pediatric population, the most prevalent neoplasm is rhabdomyosarcoma, followed by squamous cell carcinoma. There is a wide range in the presentation, and it varies significantly with age groups of 2-6 and 15-19 year-olds who present the higher incidence rates. For this reason, it has been suggested that the etiology of head and neck neoplasms remains unclear. Treating these pathologies usually involves a multimodal approach that combines surgery, radiation and chemotherapy. Prognosis and survival rates depend mainly of the stage at the time of diagnosis. Early diagnosis and treatment can improve prognosis and survival rates. In this 3rd part of "Maxillofacial Cancer in Pediatric Patients", we studied a variety of malignant tumors in head and neck soft tissue from a paediatric sample. Specifically, we aim to analyze their etiology, epidemiology, treatment and prognosis.

Risk factors associated with oral and maxillofacial benign tumors: A case-control study.

This study aimed to investigate the risk factors for oral and maxillofacial benign tumors (OMFBTs). A total of 138 patients diagnosed with OMFBTs between September 2010 and September 2015 were retrospectively analyzed. Clinical data including demographic characteristics, smoking and drinking status, dietary habit, oral hygiene and tumor related family history were collected and compared with 134 cases of healthy people who visited the hospital for physical examination during the same time. Logistic regression analysis was performed for multivariable regression analysis. OMFBTs was associated with smoking more than 20 cigarettes per day, accumulated cigarette consumption more than 30, accumulated cigarette package consumption more than 1000, present smoking and drinking, passive smoking before 18 years old, initial smoking age more than 20 years old and alcohol consumption more than 50 g/d (P < 0.05). Consumption of meat, fish, seafood, fruits and vitamin tablets were associated with lower risk of OMFBTs. Non-conditional logistic regression analyses indicated that the independent risk factors of OMFBTs included accumulated cigarette consumption, passive smoking before the age of 18, meat-free, fish-free, fruit-free, vitamin tablets-free, frequency of tooth brushing lower than once a day, not routinely attending oral examination, wearing denture and drinking alcohol (P < 0.05). Smoking and drinking should be discouraged in dental patients. Keeping a good dietary habit and routinely attending oral examination are highly encouraged.

Tumor odontogénico adenomatoide. Reporte de un caso y revisión de la literatura / Adenomatoid odontogenic tumor. Case report and literature review

El tumor odontogénico adenomatoide (TOA) es una neoplasia benigna de posible origen odontogénico con múltiples presentaciones en su aspecto histopatológico, por lo que ha generado controversia acerca de su etiología y diagnóstico. El objetivo del presente artículo es mostrar un caso clínico con su diagnóstico clínico e histopatológico y plan de tratamiento; adicionalmente se hace una revisión de literatura (AU)

The adenomatoid odontogenic tumor (TOA) is a benign neoplasm of possible odontogenic origin with multiple presentations in its histopathological aspect, reason why it has generated controversy about its aetiology and diagnosis. The aim of this article is to show a clinical case with its clinical and histopathological diagnosis and treatment plan; additionally a literature review is done (AU)

Maxillary ameloblastoma: Factors associated with risk of recurrence.

BACKGROUND: Maxillary ameloblastomas are rare and associated with an aggressive course because of the anatomic composition of the maxilla and adjacent structures. The risk factors associated with recurrence were analyzed in this retrospective study. METHODS: Cases of maxillary ameloblastoma reported in a tertiary hospital from 2005 to 2015 were analyzed to identify clinicopathological and radiological factors associated with recurrence using univariate and multivariate Cox regression analyses. RESULTS: A total of 890 patients with ameloblastomas were treated in this study, of whom only 51 (5.7%) had maxillary ameloblastomas. The median follow-up period was 56 ± 28.65 months. Of the maxillary ameloblastomas, 29 (56.8%) were primary and 22 (43.1%) were recurrent. Soft tissue or maxillary sinus invasion and primary or recurrent tumor status were risk factors significantly associated with recurrence in the univariate analyses (p = .006 vs p = .025, respectively), whereas the association between recurrence and surgical methods was borderline significant (p = .08). The multivariate Cox regression analysis showed that soft tissue or maxillary sinus involvement was significantly associated with recurrence (p = .023). CONCLUSION: Recurrent tumors and tumors with soft tissue or maxillary sinus involvement were risk factors for recurrence among patients with maxillary ameloblastoma. © 2017 Wiley Periodicals, Inc. Head Neck 39: 996-1000, 2017.

A multi-centre evaluation of oral cancer in Southern and Western Nigeria: an African oral pathology research consortium initiative.

INTRODUCTION: Oral cancer is a leading cause of cancer deaths among African populations. Lack of standard cancer registries and under-reporting has inaccurately depicted its magnitude in Nigeria. Development of multi-centre collaborative oral pathology networks such as the African Oral Pathology Research Consortium (AOPRC) facilitates skill and expertise exchange and fosters a robust and systematic investigation of oral diseases across Africa. METHODS: In this descriptive cross-sectional study, we have leveraged the auspices of the AOPRC to examine the burden of oral cancer in Nigeria, using a multi-centre approach. Data from 4 major tertiary health institutions in Western and Southern Nigeria was generated using a standardized data extraction format and analysed using the SPSS data analysis software (version 20.0; SPSS Inc. Chicago, IL). RESULTS: Of the 162 cases examined across the 4 centres, we observed that oral squamous cell carcinomas (OSCC) occurred mostly in the 6th and 7th decades of life and maxillary were more frequent than mandibular OSCC lesions. Regional variations were observed both for location, age group and gender distribution. Significant regional differences was found between poorly, moderately and well differentiated OSCC (p value = 0.0071). CONCLUSION: A multi-centre collaborative oral pathology research approach is an effective way to achieve better insight into the patterns and distribution of various oral diseases in men of African descent. The wider outlook for AOPRC is to employ similar approaches to drive intensive oral pathology research targeted at addressing the current morbidity and mortality of various oral diseases across Africa.

Clinicopathological and cell proliferation evaluation of ameloblastomas and keratocystic odontogenic tumors: a 10 year retrospective study.

Odontogenic tumors (OTs) are important lesions of the gnathic bones due to their clinicopathological heterogeneity and variable biological behavior; therefore, epidemiological studies are needed to outline the incidence and behavior of these tumors. To evaluate the incidence and epidemiological profile of ameloblastoma (AMB) and keratocystic odontogenic tumor (KCOT) from an oral pathology service, and correlate morphological findings of these tumors with the immunoexpression of a cellular proliferation marker (Ki-67), a retrospective study (2002-2012) was conducted to characterize demographic, clinical, radiological, and morphological data of AMBs and KCOTs. Then, a representative sample composed of 49 cases of each tumor was selected to perform immunohistochemical (IHC) analysis of Ki-67 through the streptavidin biotin peroxidase technique. For statistical analysis, we used Fisher's exact test (p < 0.05). A total of 279 OTs were found in the service, in which 91 (32.6%) were AMB and 98 (35 %) were KCOT. Most cases occurred in white women, and the average age of patients with AMB and KCOT was 32 and 33 years, respectively. The maxilla-mandible ratio was 1:6 and 1:3.6 for AMB and KCOT, respectively. Regarding IHC analysis, AMB and KCOT had similar levels of cellular proliferation. However, KCOTs with intense inflammation showed higher Ki-67 expression (p < 0.001). Recurrent cases had similar Ki-67 immunoexpression. The demographic profile of the studied tumors corroborates with data reported in the literature, and the levels of cellular proliferation were similar in both tumors, although the inflammation seems to induce a differential proliferative behavior in KCOT.

A retrospective review of 61 cases of adenomatoid odontogenic tumour seen in five tertiary health facilities in Nigeria.

INTRODUCTION: Adenomatoid odontogenic tumor (AOT) is a benign lesion originating from the dental lamina or its remnants. It is a relatively uncommon neoplasm representing about 3% of all odontogenic tumors. The aim of this study was to examine the clinical and radiological characteristics of AOTs in five major tertiary centres in Nigeria. METHODS: Archival hospital-based data stores of five tertiary health facilities in Nigeria were accessed. Case files and biopsy records were retrieved to obtain relevant information. Data was collected according to a proforma for standardization and entered into and analysed using SPSS for Windows (version 20.0; SPSS Inc. Chicago, IL). RESULTS: 61 (4.5%) cases of AOT were documented. The age range was 8-46 years with a mean age of 20.4±9.9 years. Male: Female ratio was 1:1.3. The anterior maxilla had 34 (55.8%) cases and the anterior mandible had 20 (32.8%) cases. 40 (65.6%) follicular cases, 20 (32.8%) extra-follicular cases and 1(1.6%) extra-osseous case were found. 31 cases (61.1%) were associated with impacted teeth and the upper canine was involved in 19 (57.6%) cases. CONCLUSION: This study showed AOT to be more common in the maxilla, more in females, most often associated with impacted canines, however, the suggestion of AOT being a "Two third tumour" was not observed in this study.

Odontogenic myxoma: a clinicopathological study in a South African population.

BACKGROUND: Odontogenic myxoma is a benign, locally aggressive neoplasm of the jaws. Prevalence rates range between 0.5% and 17.7% of odontogenic tumours. There are few reports in the literature on this lesion in African populations, and therefore, this study aimed to report on odontogenic myxoma in a South African population over a 40-year period. METHODS: The clinical records and orthopantomograms of 29 histopathologically diagnosed odontogenic myxoma were retrospectively analysed. Details of age, gender, ethnic origin and clinical, histological as well as radiological features were recorded. RESULTS: The ages of patients ranged from 7 to 44 years with a mean of 21.3 years. The male-to-female ratio was 1:2.6 with the majority of patients being of mixed race and Africans. Clinically, 31% complained of pain while 58.6% had a history of swelling. The majority of odongenic myxomas (62.1%) were located in the mandible with the posterior region being most commonly affected. Multilocular lesions (69.2%) were more common and were significantly larger than unilocular lesions (P < 0.05). The outline of these tumours was mostly well-defined (84.6%) with different degrees of cortication. Only one tumour caused tooth resorption, while 20 cases (76.9%) caused tooth displacement. Six tumours expanded into the maxillary sinus, and 14 tumours caused expansion of the mandible. CONCLUSIONS: Odontogenic myxomas have variable clinical, radiological and histological features. Most of these features in this population were similar to other populations. It is mandatory to use conventional radiographs along with histopathological examination to aid in arriving at an accurate diagnosis.

[Primitive oto-rhino-laryngology and cervico-maxillofacial tumors: epidemiological and histological aspects]. / Cancers primitifs oto-rhino-laryngologiques et cervico-maxillo-faciaux: aspects épidémiologiques et histopathologiques.

INTRODUCTION: Establish the panorama of primitive oto-rhino-laryngology and cervico-maxillofacial tumors diagnosed at a reference center in Togo. METHODS: We conducted a retrospective, descriptive study of cancers diagnosed at the ORL and cervico-maxillofacial surgery department of the CHU Sylvanus Olympio of Lomé. It was conducted over a period of 10 years (1 January 2005 - 31 December 2014). RESULTS: ORL and cervico-maxillofacial tumors account for 0.48% of consultations and 15.3% of all ORL tumors. The average age of patients was 47 years, ranging from 3 months to 86 years. We noted a male predominance; the sex ratio was 1.45. Drinking alcohol and smoking tobacco prevailed in the cancer of the larynx. Upper aerodigestive tract (UAT) tumors accounted for 64,8%, with a prevalence of cancers of the oral cavity (36,2% of UAT), followed by cancers of the oropharynx (18,5% of UAT) and finally by cancers of the larynx (18,1% of UAT). Primary malignant cervical adenopathies accounted for 18%. The rarest lesions were cancers of the ear and of maxillomandibular bone tissue (2.24% each). Histology was dominated by squamous cell carcinoma (61.4%) followed by non-Hodgkin lymphoma (23.2%). CONCLUSION: ORL and cervico-maxillofacial tumors are frequent in Togo and can be diagnosed at any age. The predominant tumor types reported are those of the oral cavity, pharynx and primary malignant cervical adenopathies.

Epidemiologia das lesões fibro-ósseas benignas dos maxilares / Epidemiological study of the benign fibro-osseous lesions (BFOLs) of the jaws

As lesões fibro-ósseas benignas (LFOBs) são condições raras caracterizadas pelo desenvolvimento de doenças neoplásicas, reativas ou displásicas, nas quais o osso normal é substituído por tecido conjuntivo composto por colágeno, fibroblastos e diferentes materiais mineralizados semelhantes ao osso ou cemento. Os principais tipos são: displasia fibrosa (DF): monostótica (DFM) ou poliostótica (DFP); displasia óssea (DO): periapical (DOP), focal (DOFoc) ou florida (DOFlor); e o fibroma ossificante (FO): convencional (FOC) ou juvenil (FOJ). O objetivo deste estudo foi descrever o perfil epidemiológico das LFOBs dos maxilares diagnosticados no serviço de referência em Patologia, Estomatologia e Radiologia da Faculdade de Odontologia da Universidade Federal de Minas Gerais e comparar com os resultados encontrados em outros estudos. Os dados foram obtidos dos arquivos dos serviços clínico e laboratorial, no período de 26 anos (1990-2015). Informações de gênero, idade, raça dos pacientes e principais características clínicas e radiográficas da lesão foram coletadas. Foi realizada a análise estatística descritiva das variáveis e teste de associação entre os grupos de lesões e o gênero, faixa etária, aumento de volume e osteomielite. Entre todos os diagnósticos do período avaliado (27998 prontuários), as LFOBs representaram 1,36% (n=383). As DOs (n=187, 48,8%) foram as mais frequentes, seguidas pela DF (n=103, 26,9%) e FO (n=93, 24,3%). Quanto aos subtipos de LFOBs, as mais frequentes foram a DOFlor e a DFM, ambas com 101 casos (26,4%). As mulheres foram a maioria no estudo, com frequência de 82,0% (n=314), assim como os pacientes não negros (59,0%, n=226). Entre todas as LFOBs a média de idade foi de 38,52 ± 17,54, acometendo mais a 4ª e 5ª décadas. As características radiográficas mais comuns foram imagens mistas: radiopaca e radiolúcida (51,7%). A mandíbula foi a região mais acometida (n=247, 64,5%), exceto para DF que envolveu mais a maxila (n=68, 66,0%). A DF foi observada mais entre os homens que em mulheres, assim como entre os pacientes mais jovens. DOs foram mais comuns em mulheres e em pacientes mais velhos. Enquanto que no FO não foi observada diferença significativa entre o gênero. A associação entre a presença de osteomielite e DO foi estatisticamente significante (p=0,0001). O aumento de volume foi significante na DF e FO (p=0,0001). A frequência de LFOB é semelhante à previamente reportada na literatura no mesmo país, mas difere dos dados observados em outras populações. É importante considerar a correlação de dados clínicos, radiográficos e histopatológico para o diagnóstico definitivo de LFOBs. Estudos epidemiólogicos podem orientar o clínico sobre a perfil do paciente acometido por uma doença. Nossos resultados são importantes para auxiliar no diagnóstico e manejo clínico das lesões fibro-ósseas benignas

Benign fibro-osseous lesions (BFOLs) are rare conditions characterized by the development of neoplastic, reactive or dysplastic disease, in which is observed replacement of the normal bone by collagen, fibroblasts and different mineralized materials like bone and cementum. The main types are: fibrous dysplasia (FD): monostotic (MFD) or polyostotic (PFD); osseous dysplasia (OD): periapical (POD), focal (FocOD) or florid (FlorOD); and ossifying fibroma (OF): conventional (COF) or juvenile (JOF). The aim of this study was to describe the epidemiological profile of BFOLs of the jaws diagnosed in the reference service in oral pathology at the Universidade Federal of Minas Gerais and compare it with the results found in other studies. Data were obtained from the archives of clinical and laboratory services in the period of 26 years (1990-2015). Gender, age, race and main clinical and radiographic characteristics of the lesion were collected. Descriptive statistical analysis of each variable and associations test between groups of lesions and gender, age, swelling and osteomyelitis were made. Among all diagnoses in the period (n=27998 records), the BFOLs represented 1.36% (n=383). The ODs (n=187, 48.8%) were the most frequently diagnosed, followed by FD (n=103, 26.9%) and OF (n= 93, 24.3%). Regarding the subtypes, the most common were FlorOD and MFD, both with 101 cases. Women were the majority in the study, with frequency of 82.0% (n=314), as well as non-black patients with (n=226, 59.0%). Among all LFOBs the average age was 38.52 ± 17.54, affecting more the 4th and 5th decades. The most common radiographic features were mixed images: radiopaque and radiolucent (51.7%). The mandible was the most affected region (n=247, 64.5%), except for DF involving more maxilla (n=68, 66.0%). The DF was observed more in men than in women, as well as among younger patients. DOs were more common in women and older patients. The FO was no significant difference between genders. The association between the presence of osteomyelitis and OD was statistically significant (p=0.0001). The swelling was significant in FD and FO (p=0.0001). The frequency of LFOB is similar to that previously reported in the literature in the same country, but differs from data observed in other populations. It is important to consider the correlation of clinical, radiographic and histopathologic for definitive diagnosis of LFOBs. Epidemiological studies can guide the clinician on the patient's profile affected by a disease. Our results are important to assist in the diagnosis and clinical management of benign fibro-osseous lesions

Odontogenic tumors: analysis of 188 cases from Saudi Arabia.

BACKGROUND AND OBJECTIVES: Odontogenic tumors (OTs) represent an uncommon group of lesions that arise from the tooth-forming apparatus. They pose a significant diagnostic and management challenge. There is a lack of data among the Saudi population. The aim of the study was to establish the relative frequency of the various histological types of OTs. DESIGN AND SETTINGS: A retrospective study of 188 cases of OTs using the histopathology archives of the College of Dentistry, King Saud University. METHODS: The histopathology archives of the College of Dentistry, King Saud University were reviewed from January 1984 to December 2010 for OTs. The age and gender of the patients, tumor site, and histopathologic typing were analyzed. RESULTS: A total of 188 (4.3%) patients met the criteria for being classified as an OT. Odontogenic keratocystic tumor (36.7%) was the most commonly diagnosed, followed by ameloblastoma (25.0%), odontoma (14.9%), and odontogenic myxoma (6.4%). Two cases of malignant OTs (1.1%) are found. The male-to-female ratio was 1.4:1. The most frequently affected area was the posterior mandible (48.9%), followed by the anterior maxilla (22.9%). CONCLUSION: This is a relatively large series of OTs revealing aspects of similarities and differences with those of previous studies of populations in Africa, Asia, and the Americas. The findings of the present study may be useful as a guide for clinicians who need to make clinical judgments prior to biopsy about the most probable diagnosis.