ABSTRACT
Objectives To evaluate whether age at menarche and time to menstrual regularity were related to cardio-metabolic risk factors in Mexican women. Methods The study population comprised 54,921 women from the 2008-2010 wave of the Mexican Teacher's Cohort. A modified Poisson approach was used; exposures were age at menarche and time to menstrual regularity (< 1 year vs. ≥1 year), and outcomes were prevalent obesity, type 2 diabetes, high blood pressure, and high cholesterol. Results Mean (SD) age of women was 42.1 (7.6) years, and mean (SD) menarcheal age was 12.5 (1.5) years. Compared to women with menarche age 13 years, those with menarche < 9 years had a 65% (95% CI 43-90%); 27% (95% CI 4-55%); and 23% (95% CI 1-49%) higher prevalence of obesity, high blood pressure, and high cholesterol, respectively. For diabetes, there was a U-shaped association; compared to menarche age 13 years, those with menarche < 9 years had an 89% higher prevalence of diabetes (95% CI 39-156%), and those with menarche ≥ 17 years had a 65% higher prevalence (95% CI 16-134%). Among women with regular cycles (n = 43,113), a longer time to menstrual regularity was associated with diabetes (PR = 1.11 with 95% CI 1.02-1.22), high blood pressure (PR = 1.11 with 95% CI 1.06-1.17), and high cholesterol (PR = 1.09 with 95% CI 1.04-1.14). Conclusions for practice Mexican women with earlier and later ages at menarche and/or longer time to menstrual regularity may have higher risk of cardio-metabolic disease in adulthood.
Subject(s)
Heart Diseases/complications , Menarche/physiology , Metabolic Diseases/complications , Adult , Age Factors , Female , Heart Diseases/metabolism , Humans , Menarche/metabolism , Metabolic Diseases/metabolism , Mexico , Middle Aged , Odds Ratio , Poisson Distribution , Prospective Studies , Risk Factors , Surveys and QuestionnairesSubject(s)
Humans , Female , Adolescent , Adult , Menstruation Disturbances/epidemiology , Menstruation Disturbances/etiology , Menarche/metabolism , Age of Onset , ArgentinaSubject(s)
Humans , Female , Adolescent , Adult , Age of Onset , Menarche/metabolism , Menstruation Disturbances/epidemiology , Menstruation Disturbances/etiology , ArgentinaABSTRACT
Tendo como objetivo definir os índices de maior utlidade na propedêutica de osteoporose pós-menopausa, foram estudadas prospectivamente, clínica, radiológica e laboratorialmente 102 mulheres menopausadas. Atendidas no Ambulatório de Reumatologia da FCM-UNICAMP no período de 1987 a 1989. Observou-se que: o índice vertebral apresenta uma distribuiçäo homogênia em todos os grupos etários. Os índices de Nordin e Singh apresentam correlaçäo com o índice vertebral e uma maior positividade com a idade. A avaliaçäo clínica e fatores de risco para o desenvolvimento da osteoporose näo foram suficientes para caracterizaçäo das pacientes quanto a presença ou gravidade da osteoporose. A presença de cifose está relacionada com o grau de comprometimento vertebral e näo com o processo de envelhecimento. Näo houve relaçäo de exclusividade entre artrose e osteoporose. A menarca após os 12 anos de idade pode ser um fator determinante para o aparecimento da osteoporose pós-menopausa. Com a metodologia empregada näo houve diferença dos valores séricos laboratoriais entre as pacientes estudadas. O índice hidroxiprolina/creatinina näo apresentou correlaçäo com a idade e mostrou ter valor preditivo positivo
Subject(s)
Humans , Female , Menopause/metabolism , Osteoporosis/etiology , Radiology , Aging/physiology , Brazil , Menarche/metabolism , Menopause/physiologyABSTRACT
La menarquía es el inicio de la menstruación causado por un incremento gradual en la secreción de hormona gonadotrófica, se conoce la incidencia de factores étnico-geográficos, nutricionales y hábitos de vida como determinantes de la aparición de la menarquía. En este estudio se analizó la edad de presentación de menarquía en un grupo de adolescentes de 10 a 18 años (n=87) en el que se obtuvo positividad en 22 personas de acuerdo a la edad en que fue encuestado. La media fue de 13 años con un rango entre los 11 a los 15 años. El mayor porcentaje se encontró a los 14 años (45.45 por ciento) y en orden de frecuencia 13, 12, 11 y 15. También se corroboran los datos de peso y talla encontrándose que los casos que presentan menarquía siempre se encuentran por encima de la media de estos datos obtenidos en la muestra total por edades (peso X=37.5g; talla x=137 cm).