Cervical mesonephric adenocarcinoma: A case report of a rare gynecological tumor from embryological remains of the female genital tract / Adenocarcinoma mesonéfrico cervical: Relato de caso de um tumor ginecológico raro de restos embriológicos do trato genital feminino

Abstract Introduction Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. Case report A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. Conclusion We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.

Cervical Mesonephric Adenocarcinoma: A Case Report of a Rare Gynecological Tumor from Embryological Remains of the Female Genital Tract.

INTRODUCTION: Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. CASE REPORT: A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. CONCLUSION: We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.

Mesonephric adenocarcinoma of the cervix: a case report with a three-year follow-up, lung metastases, and next-generation sequencing analysis.

BACKGROUND: Mesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract, which originates from mesonephric duct remnants. Its diagnosis is pathologically challenging, because MNAC may exhibit a mixture of morphological patterns that complicates the differential diagnosis. CASE PRESENTATION: The patient in this case was a 48-year-old woman with a polypoid mass protruding into the endocervical canal. The patient underwent a total hysterectomy outside the institution. During biopsy, the mass showed a cerebroid aspect. Histological study revealed a tumor with a predominantly tubular and ductal growth pattern. The immunoprofile showed negative staining for calretinin, carcinoembryonic antigen (CEAm), estrogen receptors (ER), and progesterone receptors (PR), and positive staining for CD10, p16, and PAX2. The Ki-67 score was 46%. Using a next-generation sequencing assay, we documented genomic alterations in KRAS and CTNNB1, low tumor mutation burden (TMB), and an absence of microsatellite instability. In addition, gain of the long arm of chromosome 1 (1q) was also documented using chomogenic in situ hybridization (CISH). Three years later, the patient presented pulmonary nodules in the lingula and left basal lobe that were resected by thoracotomy. The histopathologic study of the pulmonary nodules confirmed the presence of metastases. CONCLUSION: Carcinomas of mesonephric origin are among the rarest subtypes of cervical tumors. We report the first case of mesonephric adenocarcinoma of the cervix with lung metastases showing a CTNNB1 gene mutation.

Tumor del seno endodérmico de la nasofaringe en niños con teratoma maduro previo / Endodermal sinus tumor of the nasopharynx in children with previous mature teratoma

Se presentan dos ejemplos de tumor del seno endodérmico desarrollados en la rinofaringe meses a años después de haberse detectado una masa teratomatosa en esa región. El primer caso sucedió en un recién nacido con dificultad respiratoria debida a un teratoma nasofaríngeo que fue extirpado. Los síntomas reaparecieron 2 años después, a causa de un tumor del seno endodérmico en la misma ubicación. En el segundo la masa tumoral inicial fue detectada a los 7 meses de edad y el tumor del seno endodérmico cinco meses mas tarde. En ambos casos el teratoma inicial estaba compuesto predominantemente por tejido nervioso. Este fenómeno reproduce el mas conocido de aparición de un tumor del seno endodérmico en el teratoma sacrococcígeo. Dado que el diagnóstico diferencial de las lesiones rinofaríngeas conteniendo tejido nervioso depende de una cuidadosa correlación anatómica, clínica y radiológica no siempre fácil de lograr, se sugiere el seguimiento de las mismas mediante el dosaje de alfa-fetoproteína sérica como marcador del TSE

Peritoneal cytology of uncommon ovarian tumors.

Peritoneal cytology has been well established as a diagnostic and staging tool in the management of the common epithelial tumors of ovary. Germ cell, mesenchymal, and sex-cord stromal tumors are much less frequently encountered in peritoneal specimens, often with cytologic features that may pose problems in differential diagnosis. This report presents the cytomorphology of the ascitic fluid in cases of endodermal sinus tumor, dysgerminoma, and Sertoli-Leydig-cell tumor, and peritoneal washings in a case of ovarian malignant mixed mullerian tumor. The cytologic features of Sertoli-Leydig-cell tumors have not been well described. Careful correlation of peritoneal cytologic findings, cell-block preparations, and immunocytochemistry with the cytohistologic features of these tumors is crucial for correct tumor classification.

Imunohistoquimica no diagnostico do disgerminoma e tumor do seio endodermico do ovario: expressao de citoceratina, alfa-fetoproteina e alfa-antitripsina / Immunohistochemistry in the diagnosis of dysgerminoma and endodermal sinus tumor of ovary: cytokeratin, alpha-fetoprotein and alpha-antitrypsin antibodies expression

Os autores estudaram sete casos de disgerminoma e tres de tumor do seio endodermico do ovario, no intuito de avaliar a utilidade da imunohistoquimica, empregando anticorpos anti-citoceratina, alfa-fetoproteina e alfa-1-antitripsina no diagnostico destes tumores. Os 10 tumores expressaram alfa-1-antitripsina. Nenhum disgerminoma expressou citoceratina enquanto todos os tumores do seio endodermico mostraram reacoes positivas. Os tres tumores do seio endodermico e um disgerminoma expressaram alfa-fetoproteina. Apos investigacao detalhada, este caso foi classificado como um tumor misto de celulas germinativas, tambem por corresponder a um mau prognostico e curta sobrevida, nao muito caracteristico de disgerminomas puros. Este estudo indica que a imunohistoquimica pode ser util no diagnostico destes tipos de tumor, principalmente quando ha areas suspeitas que podem levar a um diagnostico de um tumor misto de celulas germinativas.

Tumor do seio endodermico do ovario / Endodermal sinus tumor of the ovary

Neste artigo, e feita uma revisao da literatura sobre o tumor do seio endodermico do ovario. Suas caracteristicas clinicas e anatomopatologicas sao comentadas e sua terapeutica e discutida.

A propósito de un caso de tumor del seno endodermal del mediastino y breve revisión de la literatura / A case of endodermal sinue tumor at the mediastinum literature revision

El tumor del Seno Endodermal (TSE) es una neoplasia de las células germinales, de baja presentación en la población general y extraordinariamente rara en el compartimiento mediastinal. En el presente informe se hace referencia de un paciente de 20 años de edad que presentó TSE del mediastino anterior de grandes dimensiones, localmente avanzado y con comportamiento muy agresivo. El diagnóstico se estableció mediante biopsia intratorácica percutánea por aspiración y el paciente recibió quimioterapia combinada con plantino y eptopósido, falleciendo antes de completar el primer curso de tratamiento

Endodermal sinus(yolk sac) tumour of the mediastinum.

An endodermal sinus tumour of the anterior mediastinum is described in a 19-year-old man. This very rare condition is reported for the first time in the Caribbean literature.

Endodermal sinus (yolk sac) tumour of the mediastinum

An endodermal sinus tumour of the anterior mediastinum is described in a 19-year-old man. This very rare condition is reported for the Caribbean literature (AU)

Endodermal sinus (Yolk Sac) tumour of the mediastinum

An endodermal sinus tumour of the anterior mediatinum is described in a19-year-old man. This very rare condition is reported for the first time in the Caribbean literature

Tumor estromal esclerosante de ovário: a propósito de um caso / Sclerosing stromal tumor of the ovary: a case report

A case of sclerosinhg stomal tumor of the ovary in a 23 years old case is reported. She presented metrorrhagia and abdominal mass in the lower quadrants, measuring 12.5 x 16.7 x 9.0 cm (USG). clinically, there was anaovulation with result infertility, which was resistent to therapy with clomiphene citrate. The tumor was removed from the patient's left ovary. The cut surface showed a solid and edematous pattern. Histological examination revealed a mixture of fibromatous and lipoid cells separated by edematous or sclerosing stroma into pseudonodules. The tumor was benign and considered to arise from gonadal stroma of the ovary. Both menstrual disorders and problems of infertility were corrected by tumor's excision. Ultrastructural and immunohistochemistry studies, as well as clinical patterns have indicated in many cases, that the tumor is functionally active and from ovarian stromal origin. This specific tumor is worthwhile to present due to its rarity, its association with sterility and a difficulty in finding a definitive nomenclature. Two months after the surgery the patient was pregnant for the first time

Valor diagnóstico da estrutura de Schiller-Duval no tumor do seio endodérmico / Diagnostic value of the Schiller-Duval structure in endodermal sinus tumor

Tecem-se consideraçöes histológicas sobre o tumor do seio endodérmico baseado em dois casos desta neoplasia com localizaçäo ovariana e em um caso originado primariamente no testículo de um recém-nascido. O tumor apresenta um quadro histológico bastante complexo o que torna muitas vezes difícil sua caracterizaçäo. Chama-se a atençäo para as estruturas de Schiller-Duval, bem como para os glóbulos hialinos de localizaçäo intra e extracelular, que representam elementos de extrema importância diagnóstica na caracterizaçäo deste tumor

Tumor del seno endodérmico en un paciente portador de una disgenesia gonadal / Endodemal sinus tumors in a patient with gonadal dysgenesia

Se presenta un caso de tumor del seno endodermal en un paciente de 14 años de edad, portador de un cuadro de disgenesia gonadal

Tumor do seio endodérmico: apresentaçäo de um caso / Endodermal sinus tumor: report of a case

Apresenta-se um caso de tumor raro ovariano de linhagem germinativa que é o tumor de seio endodérmico, em uma paciente com 11 anos de idade. Sua queixa era aumento do volume abdominal com evoluçäo rápida. Optou-se pela laparotomia exploradora onde se encontrou tumor sólido-cístico com áreas de hemorragia, medindo aproximadamente 18 x 18 cm, sendo realizada anexectomia unilateral. O exame histopatológico revelou tumor de seio endodérmico. Em vista disto foi realizada uma segunda laparotomia (histerectomia total + anexectomia) contralateral e omentectomia. O tratamento foi complementado com poliquimioterapia (vimblastina - bleomicina - cisplatinum). Porém na terceira série a paciente recusou-se a continuar o tratamento. Um ano após a cirurgia a paciente encontra-se assintomática e sem sinais clínicos e laboratoriais de recidivas ou metástases

Tumor del seno endodérmico / Endodermal sinus tumor

Paciente de 12 años de edad, con dolor y tumor abdominal, sin antecedentes patológicos de importancia, a quien se practicó laparotomía exploradora, encontrándose tumor ovárico izquierdo de 15 x 10 x 8 centímetros, con peso de 390 gramos y cuyo estudio histo-patológico reveló Tumor del Seno Endodérmico. Se encontró también un tumor más pequeño, de 8 centímetros de diámetro en el ovario derecho y cuyo estudio reveló que se trataba de un Teratoma Quístico

Adenocarcinoma de células claras (tipo mesonefroma) de colo uterino / Clear-cell adenocarcinoma (type mesonephroma) of the cervix uteri

Apresenta-se breve história do adenocarcinoma de células claras do colo uterino, descreve-se sua evoluçäo clínica, tratamento e relata-se um caso

Tumor do seio endodérmico do ovário: relato de um caso / Endodermal sinus tumor of the ovary: a case report

Apresenta-se um caso de tumor do seio endodérmico do ovário, observado na Clínica Ginecológica do Hospital da Lagoa, entre junho de 1963 a outubro de 1984. Tecem-se, ao mesmo tempo, consideraçöes sobre a raridade, diagnóstico, tratamento, agressividade e prognóstico da neoplasia, à luz dos recursos mais atualizados