Subject(s)
Crohn Disease/complications , Dermatologic Agents/therapeutic use , Erythema Nodosum/drug therapy , Erythema Nodosum/etiology , Lung Diseases/drug therapy , Lung Diseases/etiology , Necrobiotic Disorders/drug therapy , Necrobiotic Disorders/etiology , Ustekinumab/therapeutic use , Adult , Female , Humans , Lung Diseases/diagnostic imaging , Necrobiotic Disorders/diagnostic imagingSubject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , Crohn Disease/drug therapy , Lung Diseases/etiology , Multiple Pulmonary Nodules/etiology , Necrobiotic Disorders/etiology , Adult , Antibodies, Monoclonal, Humanized/adverse effects , Crohn Disease/complications , Crohn Disease/pathology , Diagnosis, Differential , Humans , Lung/diagnostic imaging , Lung/pathology , Lung Diseases/diagnosis , Lung Diseases/diagnostic imaging , Lung Diseases/pathology , Male , Multiple Pulmonary Nodules/diagnosis , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/pathology , Necrobiotic Disorders/diagnosis , Necrobiotic Disorders/diagnostic imaging , Necrobiotic Disorders/pathology , Tomography, X-Ray ComputedSubject(s)
Crohn Disease/complications , Multiple Pulmonary Nodules/etiology , Necrobiotic Disorders/etiology , Adult , Crohn Disease/diagnosis , Crohn Disease/diagnostic imaging , Female , Humans , Multiple Pulmonary Nodules/diagnostic imaging , Necrobiotic Disorders/diagnostic imaging , Symptom Assessment , Tomography, X-Ray ComputedSubject(s)
Chest Pain/etiology , Crohn Disease/complications , Granuloma/complications , Multiple Pulmonary Nodules/complications , Necrobiotic Disorders/complications , Adult , Anti-Inflammatory Agents/therapeutic use , Chest Pain/drug therapy , Granuloma/diagnostic imaging , Granuloma/drug therapy , Humans , Male , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/drug therapy , Necrobiotic Disorders/diagnostic imaging , Necrobiotic Disorders/drug therapy , Pleura , Prednisone/therapeutic use , Tomography, X-Ray Computed , Young AdultABSTRACT
The present article reports the case of a 22-yr-old female with new onset Crohn's colitis, anterior uveitis and multiple pulmonary nodules which, on histological examination, were necrobiotic nodules. This is a rare but recognised pulmonary extraintestinal manifestation of Crohn's disease and only the fourth reported case. The present case report is followed by a brief review of the relevant literature.
Subject(s)
Crohn Disease/complications , Multiple Pulmonary Nodules/etiology , Necrobiotic Disorders/etiology , Female , Humans , Multiple Pulmonary Nodules/diagnostic imaging , Multiple Pulmonary Nodules/pathology , Necrobiotic Disorders/diagnostic imaging , Necrobiotic Disorders/pathology , Tomography, X-Ray Computed , Young AdultSubject(s)
Crohn Disease/complications , Lung Diseases/etiology , Necrobiotic Disorders/etiology , Crohn Disease/diagnostic imaging , Crohn Disease/pathology , Humans , Lung Diseases/diagnostic imaging , Lung Diseases/pathology , Male , Middle Aged , Necrobiotic Disorders/diagnostic imaging , Necrobiotic Disorders/pathology , Tomography, X-Ray ComputedABSTRACT
A 43-year-old woman was referred for examination because of an abnormal shadow on a chest X-ray film. She had a 12-year history of seropositive rheumatoid arthritis. Chest X-ray films and CT scans showed a pleurabased solitary nodule without a cavity. Cytological examination of a transbronchial biopsy specimen did not lead to a diagnosis, so thoracoscopic enucleation was performed. Histologically, the nodule consisted of lymphocytes and fibroblasts surrounding a central necrotic area, which indicated that it was a rheumatoid nodule. This solitary necrobiotic nodule was radiographically indistinguishable from lung adenocarcinoma, so histologic confirmation was necessary.