Inflammatory myofibroblastic tumor in the urinary bladder in a dog.

An 8-year-old castrated male Maltese dog was presented with a urinary bladder mass, urolithiasis, and hematuria. A solitary, pedunculated, intraluminal mass on the caudodorsal wall was identified with extensive irregular bladder wall thickening, and the mass was surgically removed. Postoperative histopathology demonstrated a submucosal lesion comprising spindle cells with marked inflammatory cell infiltration, without malignant changes. Immunohistochemical staining revealed vimentin and desmin positivity in the mass. An inflammatory myofibroblastic tumor (IMT) was definitively diagnosed. No recurrence was observed during a 43-month follow-up period. Although IMTs are rare in dogs, they should be considered a differential diagnosis for mass-like urinary bladder lesions accompanying a chronic inflammatory disease process. Key clinical message: Canine IMT should be included in the differential diagnoses of bladder masses, especially when dogs exhibit chronic irritation and inflammation.

Tumeur myofibroblastique inflammatoire de la vessie chez un chienUn chien maltais mâle castré de 8 ans a été présenté avec une masse à la vessie, une lithiase urinaire et une hématurie. Une masse intraluminale pédonculée solitaire sur la paroi caudodorsale a été identifiée avec un épaississement important et irrégulier de la paroi vésicale, et la masse a été retirée chirurgicalement. L'histopathologie postopératoire a mis en évidence une lésion à la sous-muqueuse comprenant des cellules fusiformes avec une infiltration cellulaire inflammatoire marquée, sans modification maligne. La coloration immunohistochimique a révélé une positivité à la vimentine et à la desmine dans la masse. Une tumeur myofibroblastique inflammatoire (IMT) a été définitivement diagnostiquée. Aucune récidive n'a été observée au cours d'une période de suivi de 43 mois. Bien que les IMT soient rares chez le chien, ils doivent être considérés comme un diagnostic différentiel des lésions de la vessie de type masse accompagnant un processus de maladie inflammatoire chronique.Message clinique clé:L'IMT canine doit être incluse dans les diagnostics différentiels des masses vésicales, en particulier lorsque les chiens présentent une irritation et une inflammation chroniques.(Traduit par Dr Serge Messier).

Inflammatory myofibroblastic tumours of the liver - a systematic review.

BACKGROUND: Hepatic inflammatory myofibroblastic tumours (HIMTs) are rare and poorly described in the literature. Most publications are single patient case reports and lack detailed reporting on characteristics, management, and outcomes. This systematic review aimed to assess the demography, clinical presentation, typical imaging features, histopathology, treatment, and outcomes of patients presenting with HIMTs. METHODS: A systematic literature search was performed in MEDLINE (PubMed), EMBASE (Scopus), JSTOR, Cochrane CENTRAL (Cochrane Library), and the databases included in the Web of Science for studies published between 1940 and 2023 on HIMTs, including its reported synonyms. Case series or cohort studies that reported on the management and outcomes of at least four patients with histologically confirmed HIMTs were included in the analysis. RESULTS: After screening 4553 publications, 22 articles including a total of 440 patients with confirmed HIMTs were eligible for inclusion. The average age was 53.4 years (range 42.0-65.0) with a male to female ratio of 1.7:1. Abdominal pain, discomfort, fever, and loss of weight were the most common presenting symptoms. Surgical resection is the standard of care for HIMTs and is associated with low mortality of 3.4% and low disease recurrence. CONCLUSION: HIMT is a disease more often affecting middle-aged males. The lesions are typically solitary with low recurrence after treatment. The relative roles of surgical versus medical treatment remain unclear. Differences in clinical presentation, histopathology, and treatment of HIMTs compared to inflammatory myofibroblastic tumour (IMT) at extrahepatic sites could challenge the current view of IMT as a single pathological entity.

Inflammatory myofibroblastoma mimicking cavernous hemangioma in the liver.

A 37-year-old female patient was admitted to the hospital with a large liver mass, diagnosed as hepatic inflammatory myofibroblastic tumour (HIMT), characterized by unique radiographic features and predominantly occurring in adults. HIMT consists of myofibroblast spindle cells infiltrated by plasma cells and/or lymphocytes, with an unclear aetiology linked to factors like infection and immune response. Treatment typically involves surgical resection, with chemotherapy or targeted therapy options for cases of incomplete resection or metastasis, emphasizing the need for precise diagnosis and tailored treatment strategies.

Unresectable infantile myofibroma discovered in utero.

The authors present a case of a proliferative nodule located beneath an infant's lower lip that was initially discovered on prenatal ultrasound and fetal magnetic resonance imaging (MRI). Biopsy revealed a smooth muscle actin-positive spindled cell proliferation with hemangiopericytoma-like vessels consistent with infantile myofibromatosis (IM). Since the location prevented surgical management, the clinicians opted to observe the lesion. Ultimately, the lesion fully regressed on its own confirming conservative management is an option for isolated IM.

A case of Crohn's disease combined with inflammatory myofibroblastoma of abdominal wall / 中南大学学报(医学版)

Inflammatory myofibroblastoma (IMT) is a rare solid tumor, and its etiology and pathogenesis are unclear. Crohn's disease is a non-specific intestinal inflammatory disease. The clinical manifestations, laboratory examinations, and imaging examinations of IMT are not specific, making diagnosis difficult. A case of Crohn's disease combined with IMT of abdominal wall was admitted to the Department of Gastroenterology at the Third Xiangya Hospital, Central South University, on Nov. 21, 2017. This patient was admitted to our hospital because of repeated right lower abdominal pain for 4 years. A 6 cm×5 cm mass was palpated in the right lower abdomen. After completing the transanal double-balloon enteroscopy and computed tomographic enterography for the small intestinal, the cause was still unidentified. The patient underwent surgery due to an abdominal wall mass with intestinal fistula on Sept. 12, 2018 and recovered well currently. According to histopathology and immunohistochemistry, he was diagnosed with Crohn's disease combined with IMT. Up to July 2020, the patients still took azathioprine regularly, without abdominal pain, abdominal distension, and other discomfort, and the quality of his life was good.

Rare Bronchial Tumour and an Emergent Surgery Due to Uncontrollable Haemorrhage / Tumor bronquial infrecuente y cirugía de emergencia por hemorragia incontrolable

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Tumor miofibroblástico inflamatorio de la mama: presentación de caso y revisión de la literatura / Inflammatory miofibroblastic tumour of the breast: presentation of a case and review of the literature

El tumor miofibroblástico inflamatorio (TMI), forma parte del grupo de seudotumores inflamatorios compuesto de células fusiformes mezcladas con células plasmáticas maduras y células inflamatorias. Frecuentemente descritos en la región abdominal, pélvica, pulmonar y retroperitoneal, en pacientes pediátricos y adolescentes. La presentación en la glándula mamaria es extremadamente rara (27 casos descritos en la literatura), motivo por el cual su historia natural, recurrencia y potencial metastásico permanecen en estudio. Se trae a presentación un caso de una paciente posmenopáusica la cual fue tratada con cirugía de conservación, así como la revisión de la literatura de esta entidad

Inflammatory myofibroblastic tumour (IMT) belongs to the group of pseudo inflammatory tumours, composed of fusiform cells mixed with mature plasma cells and inflammatory cells. It is frequently described in the abdomen, pelvis, lung and retroperitoneum in paediatric and adolescent patients. Presentation in the mammary gland is extremely rare (27 cases described in the literature), which is why its natural history, recurrence and metastatic potential remain under study. We present the case of a postmenopausal patient, who was treated with conservation surgery, as well as a review of the literature of this entity

Masa abdominal de crecimiento rápido; tumor miofibroblástico inflamatorio / Abdominal mass with rapid growth; inflammatory myofibroblastic tumour

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Miofibroblastoma de mama en el varón: un desafío diagnóstico. A propósito de 2 casos / Myofibroblastoma of the breast in men: a diagnostic challenge. Apropos of two cases

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Tumor miofibroblástico de laringe: reporte de caso clínico y revisión de literatura / Miofibroflástico larynx tumor: case report and literature review

El tumor miofibroblástico inflamatorio de laringe es una patología rara dentro de los tumores de cabeza, cuello y de vía aérea, con una baja prevalencia, existiendo escasa literatura al respecto. Corresponde a un tumor benigno que generalmente se presenta como hallazgo incidental en relación a cuerdas vocales con mayor frecuencia, que puede ser de carácter asintomático o presentarse con clínica de obstrucción de vía aérea como estridor y disnea progresiva, además de disfonía. Puede afectar a pacientes de cualquier edad, siendo más frecuentes en adultos en edad media. El diagnóstico se hace a través de radiología y visualización directa mediante laringoscopía con la consiguiente obtención de muestra y estudio histopatológico. El tratamiento consta en la resección quirúrgica completa de la lesión, asociado o no a terapia esteroidal, sin embargo la curación completa no se logra en todos los casos producto de la naturaleza recidivante de la lesión.

The inflammatory myofibroblastic umor of the larynx is a rare condition in tumors of head, neck and airway, with a low prevalence, and scarce existing literature. It corresponds to a benign tumor that usually occurs as an incidental finding in relation to vocal cords more frequently, which can be asymptomatic or present with clinical character of airway obstruction, as progressive stridor and dyspnea, plus dysphonia. It can affect patients of any age are more common in adults in middle age. The diagnosis is made by radiology and direct laryngoscopy with visualization by obtaining sample and histology. Treatment consists of surgical removal of the entire lesion with or without steroid therapy, however complete healing is not achieved in all the cases product of the recurrent nature of the patology.

The Juscelino Kubitschek government and the Brazilian Malaria Control and Eradication Working Group: collaboration and conflicts in Brazilian and international health agenda, 1958-1961 / O governo JK e o Grupo de Trabalho de Controle e Erradicação da Malária no Brasil: encontros e desencontros nas agendas brasileira e internacional de saúde, 1958-1961

Malaria, a disease which was under control in the beginning of Juscelino Kubitschek government, became the most important endemic disease in 1958, when Brazil made a commitment with the World Health Organization to convert its control programs into eradication programs. For this purpose a Malaria Control and Eradication Group was set up under the leadership of the malaria specialist Mário Pinotti. Malaria would become an important bargaining chip in the context of the development policies of Kubitschek. This article focuses on path of the Malaria Control and Eradication Working Group in Brazil, in its varying relationships with the arguments and guidelines established at international level.

A malária, doença que estava controlada no início do governo de Juscelino Kubitschek, torna-se a mais importante endemia em 1958, quando o Brasil assumiu o compromisso com a Organização Mundial da Saúde de converter seus programas de controle em programas de erradicação. Para isso foi instalado um Grupo de Controle e Erradicação da Malária sob a direção do malariologista Mário Pinotti. A malária seria uma importante moeda de negociação no contexto da política de desenvolvimento de Kubitschek. Este artigo tem como foco a trajetória do Grupo de Trabalho de Controle e Erradicação da Malária no Brasil, em suas diferentes relações com as discussões e normativas travadas e estabelecidas em âmbito internacional.

Miofibroblastoma intraganglionar: a propósito de un caso / Intranodal myofibroblastoma: A case report

Introducción. Los miofiobroblastomas pertenecen a un grupo heterogéneo de tumores fusocelulares que fueron descritos por primera vez en 1989. Pueden tener un comportamiento más agresivo o tratarse de tumores benignos. Clínicamente se presentan como masas en los tejidos blandos, con crecimiento progresivo y no doloroso. Descripción del caso. Adolescente de 12 años, de sexo femenino, acudió a nuestro hospital con una masa inguinal no dolorosa de 1 año de evolución y crecimiento progresivo. Se hizo la escisión quirúrgica del nódulo, cuya histología reveló una proliferación densa de células fusiformes, con haces entrecruzados o en paralelo y con núcleos en empalizada, que ocupaban los ganglios linfáticos. El estudio inmunohistoquímico evidenció una expresión intensa y difusa de vimentina, focalmente positiva para CD34 y actina de músculo liso. El diagnóstico fue de miofiobroblastoma intraganglionar. Hubo una recidiva local, 2 años después con nueva resección. No hay recurrencias tras 3 años de la segunda intervención. Conclusión. El miofiobroblastoma intraganglionar es una neoplasia mesenquimal benigna rara, sin casos conocidos en edad pediátrica y que hace diagnóstico diferencial con otros tumores de partes blandas. Los estudios inmunohistoquímicos son indispensables para establecer su naturaleza miofiobroblástica (AU)

Introduction. Myofiobroblastomas are part of the heterogeneous group of myofiobroblastic tumours, having first been described in 1989. They may be malignant or present a benign behaviour. Clinically they appear as a painless progressively growing mass in the soft tissue. Case Report. A 12-year-old female teenager was referred to our hospital with a 1-year history of a painless growing mass in the inguinal region. A surgical excision was performed; its histological study revealed a proliferation of spindle cells arrayed in a fascicular pattern and with nuclear palisading, occupying the lymph nodes. Immunohistochemichal analysis demonstrated reactivity for vimentin, focally positive for CD34 and smooth muscle actin. She was then diagnosed with intranodal myofibroblastoma. Two years after the surgical excision there was a local recurrence followed by another resection. There have been no new recurrences 3 years after the second intervention. Conclusion. The intranodal myofibroblastoma is a rare benign mesenchymal neoplasm, without known pediatric cases and presenting differential diagnosis with other soft tissue tumours. Immunohistochemical studies are essential to establish its myofibroblastic nature (AU)

Tumor miofibroblástico de pulmón: aspectos clínicos y resultados en 9 niños / Myofibroblastic tumor of the lung: clinical features and results in 9 children

Introducción. El tumor miofibroblástico (TMF) está descrito como el tumor primario de pulmón más frecuente en pediatría. Sin embargo, la literatura al respecto es escasa y en su mayoría consiste en reportes de casos. Nuestro objetivo es describir los resultados obtenidos en un grupo de pacientes con este tipo de tumor tratados en un hospital pediátrico de derivación en 20 años. Material y métodos. Se realizó una revisión retrospectiva de las historias clínicas de niños tratados entre 1990 y 2010 con diagnóstico de TMF de pulmón. Se registraron edad, síntomas al momento del diagnóstico, tratamiento quirúrgico, complicaciones peri y postoperatorias, análisis histopatológico y evolución clínica. Resultados. Fueron intervenidos en nuestra institución 9 pacientes con diagnóstico de TMF con una relación varón/mujer de 1,25:1. Las presentaciones más frecuentes fueron tos y fiebre (n=6) y convulsiones(n=2). El tratamiento realizado consistió en la resección quirúrgica completa en 8 e incompleta en 1. Para lograrlo se realizaron 3 neumonectomías y 6 lobectomías. Dos de los pacientes neumonectomizados requirieron resección parcial de aurícula izquierda y ambos pacientes presentaron metástasis cerebrales. El seguimiento promedio fue de 2,8años (r:0,16-12) y todos los pacientes que continúan en control (66%)se encuentran vivos en el momento del estudio. Discusión. La resección quirúrgica completa de los TMF de pulmónes posible, si bien puede requerir cirugías complejas y un abordaje multidisciplinario. Si bien la diseminación a distancia no está claramente descrita, creemos que es un tema que debe ser cuidadosamente revisado (AU)

Introduction. Primary lung tumors in children are rare, being themyofibroblastic lung tumor (MLT) reported as the most common. Nevertheless the literature about it is scarce, and mostly consistent of case reports. The aim of this article is to describe the results obtained in a group of patients with this tumor treated in a tertiary pediatric hospital. Methods. A single institution retrospective chart review was performed with institutional review board approval. All patients treated between 1990 and 2010 with diagnosis of MLT were included. Age, symptoms at presentation, surgical procedures, complications, histopathology and follow-up were reviewed. Results. 9 patients were identified. The commonest symptoms at presentation were fever and cough (n=6), and seizures (n=2). Surgical treatment consisted in complete resection in 8 patients and partial resection in 1. To achieve this 3 patients underwent pneumonectomy and 6 lobectomy. Two of the patients with pneumonectomy required also a partial resection of the right atrium and both had cerebral lesions. The mean follow-up was 2.8 years (r:0.16-12) and all the patients thatremained in follow-up (66%) are alive at the moment. Discussion. Complete surgical resection in MLT is possible, however, to achieve this complex procedures and a multidisciplinary approach might be needed. Although the potential of distant metastasis is not clearly reported,we think that it is a topic that must be carefully revised (AU)