ABSTRACT
El Neurocitoma Central (NC) es un tumor del SNC infrecuente, de estirpe neuronal, frecuentemente intraventricular, que generalmente afecta adultos jòvenes, tiene crecimiento lento y que al momento del diagnóstico tiene con frecuencia un volumen considerable. Su comportamiento es poco agresivo y una exéresis quirúrgica conservadora permite mejorar sustancialmente la calidad y espectativa vital. Presentamos aquí dos casos clínicos de pacientes con cuadros clínicos compatibles a los decritos en la literatura. Se realizaron estudios inmunohistoquímicos de las lesiones que confirman el diagnóstico.
Central Neurocytoma (CN) it's a rare Central Nervous System Tumor, derivated of the neuron, frequently intraventricular, it generally affects young adults, has a slow pattern of growth and at diagnosis is frequently voluminous. It's a less aggressive kind of tumor and a conservative surgery exeresis allows a better quality and expectative of life. We present two cases of patients with similar clinical presentation with the descriptions find in the literature and with histologyc and immunohistochemistry studies that confirms the diagnosis.
Subject(s)
Humans , Adult , Middle Aged , Neurocytoma/surgery , Neurocytoma/diagnosis , Neurocytoma/history , Neurocytoma/immunology , Neurocytoma/chemistry , Neurocytoma/therapy , Synaptophysin , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , Central Nervous System/pathologyABSTRACT
Neurocytoma accounts for 0.5% of all tumors of the central nervous system. 18 such tumors are described. Homogeneous expression of neuron-specific enolase and synaptophysin and heterogeneous expression of PCNA and some proteins are characteristic for these tumors. Two immunophenotypic variants are distinguished: p30-32 positive tumors with high values of PCNA; c-er B-2 HSPh-highly positive variant with lower indices of the "growth fractions".
Subject(s)
Antigens, Neoplasm/analysis , Brain Neoplasms/immunology , Neurocytoma/immunology , Phosphopyruvate Hydratase/analysis , Proliferating Cell Nuclear Antigen/analysis , Adolescent , Adult , Brain Neoplasms/diagnosis , Child , Child, Preschool , Diagnosis, Differential , Female , Humans , Immunohistochemistry , Immunophenotyping , Infant , Male , Middle Aged , Neurocytoma/diagnosis , Synaptophysin/analysisABSTRACT
The role of inflammatory reactions in brain tumors is still unclear. In particular, there is little information about the participation of the microglia/macrophage cell system. We therefore investigated 72 surgical biopsy samples of brain tumors (astrocytoma, glioblastoma, oligodendroglioma, ependymoma, medulloblastoma, cerebral lymphoma, gangliocytoma, neurocytoma and germinoma) and the brains of eight cases with malignant gliomas that came to autopsy, using immunohistochemical markers for the monocyte/macrophage lineage (Ki-M1P, HLA-DR, KP1, My4, My7, Ki-M1, Ki-M6, EBM 11). These markers allowed us to characterize four subtypes of the microglia/macrophage cell system: ramified microglia, ameboid microglia, perivascular microglia and brain macrophages. Among the different tumors, glioblastomas and anaplastic gliomas showed the largest number of mixed cell populations, which consisted of macro-phages and ramified and ameboid microglia. In glial tumors of low malignancy fewer, predominantly ameboid, microglia were found. Neuronal tumors showed only a mild increase of microglia. Cerebral lymphomas contained macrophages diffusely distributed within the tumor center, while activated microglia were prominent at the border zone and in the adjacent brain tissue. The autopsy cases were used to study the morphometric distribution of microglia/macrophages. There was a significant increase of microglia/macrophages within the tumor, but no differences were seen between central and peripheral tumor areas. The non-neoplastic gray and white matter contained more microglial cells than controls. We conclude that the distribution pattern of ameboid and ramified microglial cells and macrophages is distinct in most of the investigated tumor types, underlining the complex immunological function of the microglia/macrophage cell system.
