ABSTRACT
Abstract Metastatic ovarian cancer uncommonly presents with skin metastasis. When present, skin metastases of ovarian cancer are usually localized in the vicinity of the primary tumor. We report a case of a 58-year-old woman with a rapid growing erythematous, well-defined nodule localized on the left nasal ala. A skin biopsy was performed and histopathological and immunohistochemical findings were compatible with a cutaneous metastasis of adenocarcinoma. A systematic investigation revealed a bilateral ovarian cystadenocarcinoma associated with visceral dissemination, likely associated with nose cutaneous metastasis. We report a very uncommon case because of the presentation of ovarian carcinoma as cutaneous metastasis. To our knowledge, this atypical localization on the nose has not been described yet in the literature.
Subject(s)
Humans , Female , Middle Aged , Ovarian Neoplasms/pathology , Skin Neoplasms/secondary , Carcinoma/secondary , Nose Neoplasms/secondary , Ovarian Neoplasms/diagnostic imaging , Skin/pathology , Skin Neoplasms/pathology , Biopsy , Carcinoma/diagnostic imaging , Tomography, X-Ray Computed , Nose Neoplasms/pathologyABSTRACT
Metastatic ovarian cancer uncommonly presents with skin metastasis. When present, skin metastases of ovarian cancer are usually localized in the vicinity of the primary tumor. We report a case of a 58-year-old woman with a rapid growing erythematous, well-defined nodule localized on the left nasal ala. A skin biopsy was performed and histopathological and immunohistochemical findings were compatible with a cutaneous metastasis of adenocarcinoma. A systematic investigation revealed a bilateral ovarian cystadenocarcinoma associated with visceral dissemination, likely associated with nose cutaneous metastasis. We report a very uncommon case because of the presentation of ovarian carcinoma as cutaneous metastasis. To our knowledge, this atypical localization on the nose has not been described yet in the literature.
Subject(s)
Carcinoma/secondary , Nose Neoplasms/secondary , Ovarian Neoplasms/pathology , Skin Neoplasms/secondary , Biopsy , Carcinoma/diagnostic imaging , Female , Humans , Middle Aged , Nose Neoplasms/pathology , Ovarian Neoplasms/diagnostic imaging , Skin/pathology , Skin Neoplasms/pathology , Tomography, X-Ray ComputedSubject(s)
Carcinoma, Renal Cell/secondary , Kidney Neoplasms/pathology , Nose Neoplasms/secondary , Skin Neoplasms/secondary , Aged , Angiogenesis Inhibitors/therapeutic use , Biomarkers, Tumor/analysis , Biopsy , Carcinoma, Renal Cell/chemistry , Carcinoma, Renal Cell/therapy , Fatal Outcome , Humans , Immunohistochemistry , Indazoles , Kidney Neoplasms/chemistry , Kidney Neoplasms/therapy , Male , Neoplasm Recurrence, Local , Nose Neoplasms/chemistry , Nose Neoplasms/therapy , Pyrimidines/therapeutic use , Skin Neoplasms/chemistry , Skin Neoplasms/therapy , Sulfonamides/therapeutic use , Time Factors , Treatment OutcomeABSTRACT
Renal cell carcinoma is an uncommon tumor in adults. Metastasis in the nasal fossa is rare, and can become apparent as a result of repeated epistaxis. We report a patient with renal cell carcinoma presenting with epistaxis secondary to a metastasis in the right nasal fossa. The primary tumor was treated with nephrectomy and the nasal fossa metastasis was treated successfully with embolization, chemoimmunotherapy, surgery, and radiotherapy. The presence of repeated epistaxis may very occasionally be the first symptom of renal cell carcinoma, and systemic treatment combined with local treatment may enable adequate control of the disease.