Subject(s)
Behcet Syndrome/diagnostic imaging , Laryngeal Diseases/diagnostic imaging , Oral Ulcer/diagnostic imaging , Adult , Behcet Syndrome/drug therapy , Deglutition Disorders , Drug Therapy, Combination , Fever , Humans , Laryngeal Diseases/drug therapy , Laryngoscopy , Male , Oral Ulcer/drug therapyABSTRACT
BACKGROUND: This meta-analysis describes the validity of narrow band imaging (NBI) in the assessment of suspicious oral lesions. METHODS: Medline, EMBASE, and Scopus were searched for trial studies comparing NBI with conventional modalities in the oral cavity (OC) and oropharynx (OP) for the detection of dysplastic and malignant change. RESULTS: Seven studies were found, and generally supported the utility of NBI in different clinical settings, although there were exceptions. Pooled data from 4 studies of NBI validity demonstrated high summary specificity and sensitivity for a wide range of suspicious lesions of the OC or OP (75.7% with 95% CI 65.1%-83.9%, and 91.5% with 95% CI 81.8%-96.3%, respectively). Summary positive likelihood ratio (LR+) was 8.91 (95% CI 4.1-19.6) and 0.27 (95% CI 0.18-0.39), respectively. CONCLUSIONS: NBI is a promising diagnostic and surveillance tool for suspicious lesions in the OC or OP; however, higher powered studies will define precise NBI criterion and clinical recommendations.
Subject(s)
Mouth Neoplasms/diagnostic imaging , Narrow Band Imaging , Oropharyngeal Neoplasms/diagnostic imaging , Humans , Leukoplakia, Oral/diagnostic imaging , Oral Ulcer/diagnostic imaging , Precancerous Conditions/diagnostic imaging , Sensitivity and SpecificityABSTRACT
We report the development of optical coherence tomography- (OCT) based angiography (OCTA) to image blood flow within microcirculatory tissue beds in human oral cavity in vivo with a field of view at 10 mm × 10 mm. Three-dimensional (3D) structural and vascular images of labial mucosa tissue are obtained at a single 3D acquisition. Pathologic mucosal sites with mouth ulcers are examined using the OCT tomograms and angiograms, upon which to monitor the lesion healing process over a period of 2 weeks. Quantitative metrics of the capillary loop density within the lamina propria layer are evaluated, providing statistically significant difference between healthy and diseased conditions over time. Furthermore, tissue anatomy and vessel morphology of other susceptible sites to ulcer, such as tongue, alveolar mucosa, and labial frenulum, are also imaged to demonstrate the promise of the proposed method as a clinically useful tool for the diagnosis and monitoring of therapeutic treatment of oral tissue abnormalities.
Subject(s)
Angiography/methods , Imaging, Three-Dimensional , Microvessels/diagnostic imaging , Mouth Mucosa/blood supply , Mouth Mucosa/pathology , Tomography, Optical Coherence/methods , Adult , Disease Progression , Humans , Male , Microcirculation , Oral Ulcer/diagnostic imaging , Oral Ulcer/pathologyABSTRACT
This paper reports a very rare case of isolated ulcerative lesion of the palate in a patient with type 2 diabetes mellitus. The patient refused to run any radiological tests, other than the periapical radiograph. This rendered the diagnostic dilemma more challenging. Through histochemical and immunohsitochemical stains, the case could be non-invasively diagnosed as caliber-persistent artery. All differential diagnoses were excluded based on concrete findings.
Subject(s)
Diabetes Mellitus, Type 2/complications , Oral Ulcer/diagnostic imaging , Aged , Arteries/abnormalities , Arteries/diagnostic imaging , Arteries/pathology , Diagnosis, Differential , Egypt , Female , Humans , Immunohistochemistry , Mouth/diagnostic imaging , Mouth/pathology , Oral Ulcer/complications , Oral Ulcer/pathology , Palate/diagnostic imaging , Palate/pathology , RadiographyABSTRACT
Raoultella ornithinolytica is an encapsulated gram-negative aerobic bacillus belonging to the Enterobacteriaceae family. It is one of the three species of Raoultella. Human infections related to R. ornithinolytica are exceedingly rare. This case report describes an ENT infection caused by R. ornithinolytica successfully treated with antibiotic therapy.
Subject(s)
Enterobacteriaceae Infections/microbiology , Enterobacteriaceae/isolation & purification , Facial Nerve Diseases/microbiology , Oral Ulcer/microbiology , Otitis Externa/microbiology , Vocal Cord Paralysis/microbiology , Administration, Intravenous , Aged , Anti-Bacterial Agents/therapeutic use , Endoscopy , Enterobacteriaceae Infections/drug therapy , Facial Nerve Diseases/diagnostic imaging , Female , Humans , Laryngoscopy , Oral Ulcer/diagnostic imaging , Otitis Externa/diagnostic imaging , Piperacillin/administration & dosage , Piperacillin/therapeutic use , Tazobactam/administration & dosage , Tazobactam/therapeutic use , Treatment Outcome , Vocal Cord Paralysis/diagnostic imagingABSTRACT
We report a case and present a literature search of the relatively newly reported condition of Epstein Barr Virus (EBV)-related mucocutaneous ulceration. EBV-related mucocutaneous ulcers clinically present as oral squamous cell carcinoma (OSCC) in immunocompromised elderly patients but usually resolve by stopping or modifying the medication. As the two conditions can present in a similar way, and the management of each is totally different, this case highlights the importance of recognising this condition at an early stage.
Subject(s)
Epstein-Barr Virus Infections/diagnosis , Oral Ulcer/diagnosis , Oral Ulcer/virology , Aged, 80 and over , Antirheumatic Agents/adverse effects , Biopsy , Carcinoma, Squamous Cell/diagnosis , Diagnosis, Differential , Disease Progression , Epstein-Barr Virus Infections/diagnostic imaging , Humans , Immunohistochemistry , Male , Methotrexate/adverse effects , Mouth Neoplasms/diagnosis , Oral Ulcer/diagnostic imaging , Prednisolone/adverse effects , Radiography, PanoramicSubject(s)
Exostoses/therapy , Mandibular Diseases/therapy , Oral Ulcer/therapy , Anti-Infective Agents, Local/therapeutic use , Chlorhexidine/therapeutic use , Clindamycin/therapeutic use , Cone-Beam Computed Tomography , Diagnosis, Differential , Exostoses/diagnostic imaging , Exostoses/pathology , Female , Humans , Mandibular Diseases/diagnostic imaging , Mandibular Diseases/pathology , Middle Aged , Necrosis , Oral Ulcer/diagnostic imaging , Oral Ulcer/pathology , Radiography, PanoramicSubject(s)
Carcinoma, Squamous Cell/diagnostic imaging , Mouth Neoplasms/diagnostic imaging , Basement Membrane/diagnostic imaging , Basement Membrane/pathology , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/secondary , Epithelium/diagnostic imaging , Epithelium/pathology , Forecasting , Humans , Lymphatic Metastasis/pathology , Mouth Neoplasms/pathology , Neoplasm Grading , Neoplasm Invasiveness , Oral Ulcer/diagnostic imaging , Oral Ulcer/pathology , UltrasonographyABSTRACT
Extranodal Nasal NK/T cell lymphoma, relatively uncommon type of non-Hodgkin's lymphoma, is highly aggressive disease with poor outcomes. Early stage disease may response to radiotherapy alone. However the treatments are usually chemotherapy and radiotherapy combination and late stage disease may not response to any available therapy. We reported a 45-year-old woman with extranodal nasal type NK/T cell lymphoma. The patient presented with chronic nasal stuffiness and mucous bloody discharge. The nasal mass is extensively involved periorbital and sinonasal soft tissue. Due to the extensively involved of tumor, combination chemotherapy was used to induce response. This patient was involved by complicated infection and palatal ulcer with likely perforation. The salvage chemotherapy was given and the treatment of NK/T cell lymphoma from other reports and literatures were reviewed.
Subject(s)
Killer Cells, Natural/pathology , Nose Neoplasms/pathology , Oral Ulcer/diagnostic imaging , Salvage Therapy , Biopsy , Female , Follow-Up Studies , Humans , Middle Aged , Nose Neoplasms/therapy , Palate/diagnostic imaging , Tomography, X-Ray Computed , Treatment OutcomeSubject(s)
Carcinoma, Squamous Cell/radiotherapy , Oral Ulcer/diagnostic imaging , Pemphigus/diagnostic imaging , Radiotherapy/adverse effects , Aged , Carcinoma, Squamous Cell/pathology , Humans , Male , Neoplasm Metastasis/radiotherapy , Pemphigus/pathology , Radionuclide Imaging , Skin/pathology , Skin/radiation effects , Skin Neoplasms/pathology , Skin Neoplasms/radiotherapyABSTRACT
PURPOSE: The purpose was to illustrate the sonographic changes of tongue cancer after radical radiotherapy. MATERIALS AND METHODS: In 24 patients with tongue cancer treated by interstitial brachytherapy (BRT) (uneventful recovery n = 16 , recurrence n = 5, severe soft tissue complication n = 3), follow-up examination were performed and both the margin and the vascular pattern were retrospectively assessed. We basically performed US examination at least once every 3 months after BRT within 1 year during follow-up period. RESULTS: In the healing process, intraoral sonography shows an unclear margin immediately after brachytherapy and a transient increase of the vascularity lasted within 6 months after BRT, followed by a decrease in the vascularity. The large difference in echogenicity between the primary site and the surrounding tissue and the increased difference suggested the possibility of either radiation ulceration or recurrence. CONCLUSION: Intraoral sonography could depict the sequence changes of the tongue after BRT, and it was thus useful to confirm the clinical findings of either radiation ulcers or recurrence.