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1.
JNCI Cancer Spectr ; 5(6)2021 12.
Article in English | MEDLINE | ID: mdl-34805743

ABSTRACT

Background: Upper tract urothelial carcinoma (UTUC) is a heterogeneous disease that presents a clinical management challenge for the urologic surgeon. We assessed treatment patterns, costs, and survival outcomes among patients with nonmetastatic UTUC. Methods: We identified 4114 patients diagnosed with nonmetastatic UTUC from 2004 to 2013 in the Survival Epidemiology, and End Results-Medicare population-based database. Patients were stratified into low- or high-risk disease groups. Median total costs from 30 days prior to diagnosis through 365 days after diagnosis were compared between groups. Overall and cancer-specific survival were evaluated using Cox proportional hazards regression. All statistical tests were 2-sided. Results: After risk stratification, 1027 (24.9%) and 3087 (75.0%) patients were classified into low- vs high-risk UTUC groups. Most patients underwent at least 1 surgical intervention (95.1%); 68.4% underwent at least 1 endoscopic intervention. Patients diagnosed with high- vs low-risk UTUC were more likely to undergo nephroureterectomy (83.6% vs 72.0%; P < .001); few patients with low-risk disease were exclusively managed endoscopically (16.9%). At 365 days after diagnosis, costs of care for high- vs low-risk UTUC were statistically significantly higher ($108 520 vs $91 233; median difference $16 704, 95% confidence interval [CI] = $11 619 to $21 778; P < .001). Those with high-risk UTUC had worse cancer-specific and overall survival compared with patients with low-risk UTUC (cancer-specific survival hazard ratio [HR] = 4.14, 95% CI = 3.19 to 5.37; overall survival HR = 1.78, 95% CI = 1.62 to 1.96). Conclusions: UTUC continues to be managed primarily with nephroureterectomy, regardless of risk stratification, and patients with high-risk UTUC have worse overall and cancer-specific survival. Substantial costs are associated with management of low- and high-risk UTUC, with the latter being more costly up to 1 year from diagnosis.


Subject(s)
Carcinoma, Transitional Cell , Kidney Neoplasms , Nephroureterectomy , Ureteral Neoplasms , Aged , Aged, 80 and over , Ambulatory Surgical Procedures/economics , Carcinoma, Transitional Cell/economics , Carcinoma, Transitional Cell/mortality , Carcinoma, Transitional Cell/pathology , Carcinoma, Transitional Cell/surgery , Costs and Cost Analysis , Female , Hospitalization/economics , Humans , Kidney Neoplasms/economics , Kidney Neoplasms/mortality , Kidney Neoplasms/pathology , Kidney Neoplasms/surgery , Male , Medicare/economics , Nephroureterectomy/economics , Nephroureterectomy/methods , Nephroureterectomy/statistics & numerical data , Organ Sparing Treatments/economics , Proportional Hazards Models , Retrospective Studies , Risk Assessment , SEER Program , Sex Factors , Treatment Outcome , United States , Ureteral Neoplasms/economics , Ureteral Neoplasms/mortality , Ureteral Neoplasms/pathology , Ureteral Neoplasms/surgery
2.
Surg Today ; 51(6): 862-871, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33185799

ABSTRACT

Advances in multi-modality treatments incorporating systemic chemotherapy, endocrine therapy, and radiotherapy for the management of breast cancer have resulted in a surgical-management paradigm change toward less-aggressive surgery that combines the use of breast-conserving or -reconstruction therapy as a new standard of care with a higher emphasis on cosmesis. The implementation of skin-sparing and nipple-sparing mastectomies (SSM, NSM) has been shown to be oncologically safe, and breast reconstructive surgery is being performed increasingly for patients with breast cancer. NSM and breast reconstruction can also be performed as prophylactic or risk-reduction surgery for women with BRCA gene mutations. Compared with conventional breast construction followed by total mastectomy (TM), NSM preserving the nipple-areolar complex (NAC) with breast reconstruction provides psychosocial and aesthetic benefits, thereby improving patients' cosmetic appearance and body image. Implant-based breast reconstruction (IBBR) has been used worldwide following mastectomy as a safe and cost-effective method of breast reconstruction. We review the clinical evidence about immediate (one-stage) and delayed (two-stage) IBBR after NSM. Our results suggest that the postoperative complication rate may be higher after NSM followed by IBBR than after TM or SSM followed by IBBR.


Subject(s)
Breast Implantation/methods , Breast Implants , Breast Neoplasms/surgery , Mammaplasty/methods , Mastectomy, Segmental/methods , Nipples , Organ Sparing Treatments/methods , Adult , Aged , Breast Neoplasms/genetics , Combined Modality Therapy , Cost-Benefit Analysis , Female , Humans , Mastectomy, Segmental/economics , Middle Aged , Mutation , Organ Sparing Treatments/economics , Prophylactic Mastectomy/economics , Prophylactic Mastectomy/methods , Safety , Treatment Outcome , Ubiquitin-Protein Ligases/genetics
3.
Plast Reconstr Surg ; 146(5): 588e-598e, 2020 11.
Article in English | MEDLINE | ID: mdl-33141535

ABSTRACT

BACKGROUND: The authors conducted a cost-effectiveness analysis to answer the question: Which motion-preserving surgical strategy, (1) four-corner fusion, (2) proximal row carpectomy, or (3) total wrist arthroplasty, used for the treatment of wrist osteoarthritis, is the most cost-effective? METHODS: A simulation model was created to model a hypothetical cohort of wrist osteoarthritis patients (mean age, 45 years) presenting with painful wrist and having failed conservative management. Three initial surgical treatment strategies-(1) four-corner fusion, (2) proximal row carpectomy, or (3) total wrist arthroplasty-were compared from a hospital perspective. Outcomes included clinical outcomes and cost-effectiveness outcomes (quality-adjusted life-years and cost) over a lifetime. RESULTS: The highest complication rates were seen in the four-corner fusion cohort: 27.1 percent compared to 20.9 percent for total wrist arthroplasty and 17.4 percent for proximal row carpectomy. Secondary surgery was common for all procedures: 87 percent for four-corner fusion, 57 percent for proximal row carpectomy, and 46 percent for total wrist arthroplasty. Proximal row carpectomy generated the highest quality-adjusted life-years (30.5) over the lifetime time horizon, compared to 30.3 quality-adjusted life-years for total wrist arthroplasty and 30.2 quality-adjusted life-years for four-corner fusion. Proximal row carpectomy was the least costly; the mean expected lifetime cost for patients starting with proximal row carpectomy was $6003, compared to $11,033 for total wrist arthroplasty and $13,632 for four-corner fusion. CONCLUSIONS: The authors' analysis suggests that proximal row carpectomy was the most cost-effective strategy, regardless of patient and parameter level uncertainties. These are important findings for policy makers and clinicians working within a universal health care system.


Subject(s)
Arthrodesis/economics , Arthroplasty, Replacement/economics , Organ Sparing Treatments/economics , Osteoarthritis/surgery , Osteotomy/economics , Wrist Joint/surgery , Adult , Arthrodesis/methods , Arthroplasty, Replacement/methods , Carpal Bones/surgery , Computer Simulation , Cost-Benefit Analysis , Female , Hand Strength/physiology , Hospital Costs , Humans , Male , Markov Chains , Middle Aged , Models, Economic , Organ Sparing Treatments/methods , Osteoarthritis/economics , Osteotomy/methods , Range of Motion, Articular/physiology , Treatment Outcome , Wrist Joint/physiology
4.
J Surg Res ; 250: 125-134, 2020 06.
Article in English | MEDLINE | ID: mdl-32044509

ABSTRACT

BACKGROUND: In prior reports from population-based databases, black patients with extremity soft tissue sarcoma (ESTS) have lower reported rates of limb-sparing surgery and adjuvant treatment. The objective of this study was to compare the multimodality treatment of ESTS between black and white patients within a universally insured and equal-access health care system. METHODS: Claims data from TRICARE, the US Department of Defense insurance plan that provides health care coverage for 9 million active-duty personnel, retirees, and dependents, were queried for patients younger than 65 y with ESTS who underwent limb-sparing surgery or amputation between 2006 and 2014 and identified as black or white race. Multivariable logistic regression analysis was used to evaluate the impact of race on the utilization of surgery, chemotherapy, and radiation. RESULTS: Of the 719 patients included for analysis, 605 patients (84%) were white and 114 (16%) were black. Compared with whites, blacks had the same likelihood of receiving limb-sparing surgery (odds ratio [OR], 0.861; 95% confidence interval [95% CI], 0.284-2.611; P = 0.79), neoadjuvant radiation (OR, 1.177; 95% CI, 0.204-1.319; P = 0.34), and neoadjuvant (OR, 0.852; 95% CI, 0.554-1.311; P = 0.47) and adjuvant (OR, 1.211; 95% CI, 0.911-1.611; P = 0.19) chemotherapy; blacks more likely to receive adjuvant radiation (OR, 1.917; 95% CI, 1.162-3.162; P = 0.011). CONCLUSIONS: In a universally insured population, racial differences in the rates of limb-sparing surgery for ESTS are significantly mitigated compared with prior reports. Biologic or disease factors that could not be accounted for in this study may contribute to the increased use of adjuvant radiation among black patients.


Subject(s)
Healthcare Disparities/statistics & numerical data , Not-For-Profit Insurance Plans/statistics & numerical data , Patient Acceptance of Health Care/statistics & numerical data , Sarcoma/therapy , United States Department of Defense/statistics & numerical data , Administrative Claims, Healthcare/statistics & numerical data , Adult , Black or African American/statistics & numerical data , Age Factors , Databases, Factual/statistics & numerical data , Extremities , Female , Humans , Male , Middle Aged , Not-For-Profit Insurance Plans/economics , Organ Sparing Treatments/economics , Organ Sparing Treatments/statistics & numerical data , Radiotherapy, Adjuvant/economics , Radiotherapy, Adjuvant/statistics & numerical data , Retrospective Studies , United States , United States Department of Defense/economics , White People/statistics & numerical data , Young Adult
5.
J Am Coll Surg ; 228(4): 547-556.e8, 2019 04.
Article in English | MEDLINE | ID: mdl-30639302

ABSTRACT

BACKGROUND: Although diverting stomas have reduced anastomotic leak rates after sphincter-preserving proctectomy in some series, the effectiveness of routine diversion among a broad population of rectal cancer patients remains controversial. We hypothesized that routine temporary diversion is not associated with decreased rates of leak or reintervention in cancer patients at large undergoing sphincter-sparing procedures. STUDY DESIGN: The Florida State Inpatient Database (AHRQ, Healthcare Cost and Utilization Project) was queried for patients undergoing sphincter-preserving proctectomy for cancer (2005 to 2014). Matched cohorts defined by diversion status were created using propensity scores based on patient and hospital characteristics. Incidence of anastomotic leak, nonelective reintervention, and readmission were compared, and cumulative 90-day inpatient costs were calculated. RESULTS: Of 8,620 eligible sphincter-sparing proctectomy patients, 1,992 matched pairs were analyzed. Leak rates did not significantly vary between groups (4.5% vs 4.3%; p = 0.76), but diversion was associated with significantly higher odds of nonelective reintervention (2.37; 95% CI 1.90 to 2.96) and readmission (1.55; 95% CI 1.33 to 1.81) compared with undiverted patients. Median costs were higher among those diverted (US$21,325 vs US$15,050; p < 0.01). CONCLUSIONS: No association between diversion and anastomotic leak was found. However, temporary diversion was associated with increased incidence of nonelective reinterventions, readmissions, and higher costs. We therefore challenge the paradigm of routine diversion in rectal cancer operations. Additional study is needed to identify which patients would benefit most from diversion.


Subject(s)
Anal Canal/surgery , Organ Sparing Treatments/methods , Proctectomy/methods , Rectal Neoplasms/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Anastomotic Leak/economics , Anastomotic Leak/epidemiology , Anastomotic Leak/etiology , Anastomotic Leak/prevention & control , Databases, Factual , Female , Florida , Follow-Up Studies , Hospital Costs/statistics & numerical data , Humans , Male , Matched-Pair Analysis , Middle Aged , Organ Sparing Treatments/economics , Patient Readmission/economics , Patient Readmission/statistics & numerical data , Proctectomy/economics , Propensity Score , Rectal Neoplasms/economics , Reoperation/economics , Reoperation/statistics & numerical data , Retrospective Studies , Risk Factors , Young Adult
6.
Hum Reprod ; 34(2): 261-267, 2019 02 01.
Article in English | MEDLINE | ID: mdl-30520964

ABSTRACT

STUDY QUESTION: Is conservative surgery (laparoscopic salpingotomy) cost-effective, using fertility as the endpoint compared with medical management (Methotrexate) in women with an early tubal pregnancy? SUMMARY ANSWER: Conservative surgery appeared slightly, but not statistically significantly, more effective than medical management but also more costly. WHAT IS KNOWN ALREADY: Women with an early tubal pregnancy treated with medical therapy (Methotrexate) or conservative surgery (laparoscopic salpingotomy) have comparable future intrauterine pregnancy rates by natural conception. Also, cost-minimisation studies have shown that medical therapy was less expensive than conservative surgery, but there is no cost-effectiveness study comparing these two treatments with fertility as the endpoint. STUDY DESIGN, SIZE, DURATION: A multicentre randomised controlled trial-based (DEMETER study) cost-effectiveness analysis of conservative surgery compared with medical therapy in women with an early tubal pregnancy was performed. PARTICIPANTS/MATERIALS, SETTINGS, METHODS: Included women had an ultrasound that confirmed an early tubal pregnancy. They were randomly allocated to conservative surgery or to medical therapy. The study clinical outcome was the intrauterine pregnancy rate. The payer's perspective was considered. Costs of conservative surgery and medical therapy were compared. The analysis was performed according to the intention-to-treat principle. Missing variables were imputed using the fully conditional method. To characterise uncertainty and to provide a summary of it, a non-parametric bootstrap resampling was executed and cost-effectiveness accessibility curves were constructed. MAIN RESULTS AND THE ROLE OF CHANCE: At baseline, costs per woman in the conservative surgery group and in the medical therapy group were 2627€ and 2463€, respectively, with a statistically significant difference of +164€. Conservative surgery resulted in a marginally, but non-significant (P = 0.46), higher future intrauterine pregnancy rate compared to medical therapy (0.700 vs. 0.649); leading, after bootstrap, to an incremental cost-effectiveness ratio of 1299€ (95% CI = -29 252; +29 919). Acceptability curves showed that conservative surgery could be considered a cost-effective treatment at a threshold of 3201€ for one additional future intrauterine pregnancy. LIMITATIONS, REASONS FOR CAUTION: A limitation was that monetary valuation was carried out using 2016 euros while the DEMETER study took place from 2005 to 2009. Anyway, the results would not have been very different given the marginal changes in the health insurance reimbursement tariffs during this period. WIDER IMPLICATIONS OF THE FINDINGS: Conservative surgery can be considered a cost-effective treatment, if the additional cost of 3201€ per additional future intrauterine pregnancy is an acceptable financial effort for the payer. STUDY FUNDING/COMPETING INTEREST(S): None. TRIAL REGISTRATION NUMBER: NCT 00137982.


Subject(s)
Cost-Benefit Analysis , Gynecologic Surgical Procedures/methods , Laparoscopy/methods , Methotrexate/therapeutic use , Organ Sparing Treatments/methods , Pregnancy, Tubal/therapy , Fallopian Tubes/surgery , Female , France , Gynecologic Surgical Procedures/economics , Humans , Laparoscopy/economics , Methotrexate/economics , National Health Programs/economics , Organ Sparing Treatments/economics , Pregnancy , Pregnancy Rate , Treatment Outcome
7.
Int Urogynecol J ; 29(8): 1161-1171, 2018 08.
Article in English | MEDLINE | ID: mdl-29480429

ABSTRACT

INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) is a common diagnosis that imposes high and ever-growing costs to the healthcare economy. Numerous surgical techniques for the treatment of POP exist, but there is no consensus about which is the ideal technique for treating apical prolapse. The aim of this study was to estimate hospital costs for the most frequently performed operation, vaginal hysterectomy with uterosacral ligament suspension (VH) and the uterus-preserving Manchester-Fothergill procedure (MP), when including costs of postoperative activities. METHODS: The study was based on a historical matched cohort including 590 patients (295 pairs) who underwent VH or MP during 2010-2014 owing to apical prolapse. The patients were matched according to age and preoperative prolapse stage and followed for a minimum of 20 months. Data were collected from four national registries and electronic medical records. Unit costs were obtained from relevant departments, hospital administration, calculated, or estimated by experts. The hospital perspective was applied for costing the resource use. RESULTS: Total costs for the first 20 months after operation were 3,514 € per VH patient versus 2,318 € per MP patient. The cost difference between the techniques was 898 € (95% confidence interval [CI]: 818-982) per patient when analyzing the primary operation only and 1,196 € (CI: 927-1,465) when including subsequent activities within 20 months (p < 0.0001). CONCLUSIONS: The MP is substantially less expensive than the commonly used VH from a 20-month time perspective. Healthcare costs can be reduced by one third if MP is preferred over VH in the treatment of apical prolapse.


Subject(s)
Hospital Costs , Hysterectomy, Vaginal/economics , Organ Sparing Treatments/economics , Pelvic Organ Prolapse/surgery , Cohort Studies , Denmark , Female , Humans , Hysterectomy, Vaginal/methods , Ligaments , Organ Sparing Treatments/methods , Organ Sparing Treatments/statistics & numerical data , Pelvic Organ Prolapse/economics , Treatment Outcome
8.
World J Gastroenterol ; 23(31): 5798-5808, 2017 Aug 21.
Article in English | MEDLINE | ID: mdl-28883706

ABSTRACT

AIM: To assess the efficacy of a modified approach with transanal total mesorectal excision (taTME) using simple customized instruments in male patients with low rectal cancer. METHODS: A total of 115 male patients with low rectal cancer from December 2006 to August 2015 were retrospectively studied. All patients had a bulky tumor (tumor diameter ≥ 40 mm). Forty-one patients (group A) underwent a classical approach of transabdominal total mesorectal excision (TME) and transanal intersphincteric resection (ISR), and the other 74 patients (group B) underwent a modified approach with transabdominal TME, transanal ISR, and taTME. Some simple instruments including modified retractors and an anal dilator with a papilionaceous fixture were used to perform taTME. The operative time, quality of mesorectal excision, circumferential resection margin, local recurrence, and postoperative survival were evaluated. RESULTS: All 115 patients had successful sphincter preservation. The operative time in group B (240 min, range: 160-330 min) was significantly shorter than that in group A (280 min, range: 200-360 min; P = 0.000). Compared with group A, more complete distal mesorectum and total mesorectum were achieved in group B (100% vs 75.6%, P = 0.000; 90.5% vs 70.7%, P = 0.008, respectively). After 46.1 ± 25.6 mo follow-up, group B had a lower local recurrence rate and higher disease-free survival rate compared with group A, but these differences were not statistically significant (5.4% vs 14.6%, P = 0.093; 79.5% vs 65.1%, P = 0.130). CONCLUSION: Retrograde taTME with simple customized instruments can achieve high-quality TME, and it might be an effective and economical alternative for male patients with bulky tumors.


Subject(s)
Mesocolon/surgery , Postoperative Complications/epidemiology , Rectal Neoplasms/surgery , Rectum/surgery , Transanal Endoscopic Surgery/instrumentation , Anal Canal/surgery , Disease-Free Survival , Follow-Up Studies , Humans , Incidence , Laparoscopy/adverse effects , Laparoscopy/methods , Male , Neoplasm Recurrence, Local/epidemiology , Neoplasm Staging , Operative Time , Organ Sparing Treatments/adverse effects , Organ Sparing Treatments/economics , Organ Sparing Treatments/instrumentation , Organ Sparing Treatments/methods , Postoperative Complications/etiology , Rectal Neoplasms/mortality , Rectal Neoplasms/pathology , Retrospective Studies , Transanal Endoscopic Surgery/adverse effects , Transanal Endoscopic Surgery/economics , Transanal Endoscopic Surgery/methods , Treatment Outcome
9.
Int Urogynecol J ; 28(8): 1183-1195, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28091710

ABSTRACT

INTRODUCTION AND HYPOTHESIS: Hysterectomy is often performed at the time of pelvic organ prolapse (POP) surgery; yet, there is insufficient evidence regarding the specific effect of hysterectomy on outcomes. We sought to determine the outcomes and associated short-term complications of mesh-based POP surgery with and without concurrent hysterectomy. METHODS: We utilized the New York Statewide Planning and Research Cooperation System (SPARCS) database to identify patients under 55 years of age undergoing surgeries for POP with mesh between 2009 and 2014. Patients who had a hysterectomy at the time of mesh-based POP surgery were compared with those who underwent mesh-based POP surgery without hysterectomy. Outcome measures of the patient groups before and after propensity score matching were compared. We assessed the difference Chi-squared tests and log-rank tests in the entire cohort and Mantel-Haenszel stratified Chi-squared tests and Prentice-Wilcoxon tests in the matched cohort. RESULTS: A total of 1,601 women underwent mesh-based POP surgery. 921 patients underwent concurrent hysterectomy, whereas 680 had mesh-based uterine-preserving POP surgery. After propensity score matching, there was no difference in reintervention rates between groups for up to 3 years. Concurrent hysterectomy with mesh-based POP repair was consistently associated with longer hospitalization (20.0% vs 12.8% stayed longer than 2 days) and higher charges (median charges were $22,689 vs $19,273). CONCLUSIONS: Concurrent hysterectomy during mesh-based POP surgery in patients under 55 years led to more expensive charges and a longer stay compared with uterine-preserving mesh surgery. There was no difference in reintervention rates between groups for up to 3 years.


Subject(s)
Hysterectomy, Vaginal/methods , Organ Sparing Treatments/methods , Pelvic Organ Prolapse/surgery , Surgical Mesh , Vagina/surgery , Adult , Cohort Studies , Combined Modality Therapy , Costs and Cost Analysis/statistics & numerical data , Databases, Factual , Female , Humans , Hysterectomy, Vaginal/economics , Length of Stay , Middle Aged , New York , Organ Sparing Treatments/economics , Pelvic Organ Prolapse/economics , Treatment Outcome , Uterus/surgery
10.
Endocr Pract ; 23(4): 451-457, 2017 Apr 02.
Article in English | MEDLINE | ID: mdl-28095037

ABSTRACT

OBJECTIVE: Encapsulated non-invasive follicular variant papillary thyroid cancer (ENIFVPTC) has recently been retermed noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). This designation specifically omits the word "cancer" to encourage conservative treatment since patients with NIFTP tumors have been shown to derive no benefit from completion thyroidectomy or adjuvant radio-active iodine (RAI) therapy. METHODS: This was a retrospective study of consecutive cases of tumors from 2007 to 2015 that met pathologic criteria for NIFTP. The conservative management (CM) group included patients managed with lobectomy alone or appropriately indicated total thyroidectomy. Those included in the aggressive management (AM) group received either completion thyroidectomy or RAI or both. RESULTS: From 100 consecutive cases of ENIFVPTC reviewed, 40 NIFTP were included for the final analysis. Of these, 10 (27%) patients treated with initial lobectomy received completion thyroidectomy and 6 of 40 (16%) also received postsurgical adjuvant RAI. The mean per-patient cost of care in the AM group was $17,629 ± 2,865, nearly twice the $8,637 ± 309 costs in the CM group, and was largely driven by the cost of completion thyroidectomy and RAI. CONCLUSION: The term NIFTP has been recently promulgated to identify a type of thyroid neoplasm, formerly identified as a low-grade cancer, for which initial surgery represents adequate treatment. We believe that since the new NIFTP nomenclature intentionally omits the word "cancer," the clinical indolence of these tumors will be better appreciated, and cost savings will result from more conservative and appropriate clinical management. ABBREVIATIONS: AM = aggressive management CM = conservative management ENIFVPTC = encapsulated noninvasive form of FVPTC FVPTC = follicular variant of papillary thyroid carcinoma NIFTP = noninvasive follicular thyroid neoplasm with papillary-like nuclear features PTC = papillary thyroid carcinoma PTMC = papillary thyroid microcarcinoma RAI = radio-active iodine US = ultrasound.


Subject(s)
Carcinoma, Papillary, Follicular , Thyroid Neoplasms , Adult , Carcinoma, Papillary, Follicular/economics , Carcinoma, Papillary, Follicular/pathology , Carcinoma, Papillary, Follicular/radiotherapy , Carcinoma, Papillary, Follicular/surgery , Cell Nucleus/pathology , Female , Health Care Costs , Health Resources/statistics & numerical data , Humans , Iodine Radioisotopes/therapeutic use , Male , Middle Aged , Neoplasm Invasiveness , Organ Sparing Treatments/economics , Organ Sparing Treatments/methods , Retrospective Studies , Thyroid Neoplasms/economics , Thyroid Neoplasms/pathology , Thyroid Neoplasms/radiotherapy , Thyroid Neoplasms/surgery , Thyroidectomy/methods , Tumor Burden
11.
Am J Clin Oncol ; 39(5): 484-90, 2016 10.
Article in English | MEDLINE | ID: mdl-27322701

ABSTRACT

Costs of surgery for small renal masses (SRMs) are high. This study aimed to systematically review and evaluate the cost-effectiveness analyses of management options for SRMs. Six databases were searched from inception to August 2015. Inclusion criteria were full original research, full economic evaluation of management options for SRM, and written in English. Among 776 studies screened, 6 met the inclusion criteria. Ablation was cost-effective versus nephron-sparing surgery. Laparoscopic partial nephrectomy was cost-effective versus the open approach. Renal mass biopsy dominated immediate treatment in the United States, but not in Canada. According to the Consolidated Health Economic Evaluation Reporting Standards, all the studies had relatively good quality. Despite the observed evidence, future research is needed to fill in the knowledge gap. A few suggestions should be kept in mind such as conducting the cost-effectiveness analysis in a variety of countries.


Subject(s)
Kidney Neoplasms/economics , Kidney Neoplasms/surgery , Nephrectomy/economics , Organ Sparing Treatments/economics , Tumor Burden , Watchful Waiting/economics , Cost-Benefit Analysis , Humans , Kidney Neoplasms/pathology , Nephrectomy/methods , Organ Sparing Treatments/methods
12.
J Endourol ; 30 Suppl 1: S18-22, 2016 May.
Article in English | MEDLINE | ID: mdl-26872591

ABSTRACT

Upper tract urothelial carcinoma (UTUC) is rare and its management presents many challenges. Outside of distal ureterectomy for select cases, management has been primarily radical nephroureterectomy. Endoscopic nephron sparing management (NSM) is recognized to have some role in UTUC treatment; however, it is yet to gain firm footing in the treatment algorithm. In this review, we discuss the benefits of NSM with regards to oncologic outcomes, renal function preservation, and cost savings. Finally, we propose recognition of endoscopic NSM as a first-line treatment in selected patients with low risk disease.


Subject(s)
Carcinoma/surgery , Kidney Neoplasms/surgery , Nephrectomy/methods , Nephrons , Organ Sparing Treatments/methods , Ureteral Neoplasms/surgery , Female , Humans , Male , Middle Aged , Nephrectomy/economics , Organ Sparing Treatments/economics , Treatment Outcome
13.
Ann Surg Oncol ; 23(2): 490-3, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26438436

ABSTRACT

BACKGROUND: Permanent paraffin subareolar biopsy during nipple-sparing mastectomy (NSM) tests for occult cancer at the nipple-areolar complex. Intraoperative subareolar frozen section can provide earlier detection intraoperatively. Cost analysis for intraoperative subareolar frozen section has never been performed. METHODS: NSM cases from 2006-2013 were reviewed. Patient records including financial charges were analyzed. RESULTS: Of 480 subareolar biopsies for NSM from 2006-2013, 21 were abnormal (4.4 %). A total of 307 of the subareolar biopsies included intraoperative frozen section. Of the 307, 12 (3.9 %) were abnormal with 7 of 12 detected on intraoperative frozen section. The median baseline charge for an intraoperative subareolar frozen section was $309 for an estimated total cost of $94,863 in 307 breasts. The median baseline charge for interval operative resection of a nipple-areolar complex following an abnormal subareolar pathology result was $11,021. Intraoperative subareolar biopsy avoided an estimated six return trips to the operating room for savings of $66,126. At our institution, routine use of intraoperative frozen section resulted in an additional $28,737 in healthcare charges or $95 per breast. CONCLUSIONS: We present the first cost analysis to evaluate intraoperative subareolar frozen section in NSM. This practice obviated an estimated six return trips to the operating room. With our institutional frequency of abnormal subareolar pathology, intraoperative frozen sections resulted in a marginal increased charge per mastectomy.


Subject(s)
Breast Neoplasms/economics , Costs and Cost Analysis , Intraoperative Care/economics , Mastectomy/economics , Nipples/pathology , Organ Sparing Treatments/economics , Biopsy, Needle , Breast Neoplasms/diagnosis , Breast Neoplasms/surgery , Female , Follow-Up Studies , Frozen Sections , Humans , Neoplasm Staging , Prognosis , Retrospective Studies
14.
J Surg Oncol ; 113(2): 223-8, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26696270

ABSTRACT

BACKGROUND AND OBJECTIVES: There is paucity of studies on the predictors of bladder cancer (BC) management costs. We aimed to determine predictors of costs associated with radical cystectomy (RC) for BC. METHODS: We conducted a retrospective analysis in a cohort of 2,759 patients who underwent RC for BC between 2000 and 2009. We analyzed predictors of pre-surgery, RC, post-surgery, and total costs. The following variables were considered as potential predictors: age, gender, hospital/surgeon case load, academic hospital, and geo-administrative region. Multivariate linear regression was used to determine predictors. RESULTS: Predictors of pre-surgery costs were: age (ß = 808.64, P < 0.0001) and having surgery in an academic hospital (ß = 511.42, P = 0.003). Increased RC costs were associated with age (ß = 196.73, P = 0.0006), hospital/surgeon annual load (ß = 484.45 and ß = 254.21, P < 0.0001, respectively). Having surgery in academic hospitals and geographic region were significant predictors of low RC costs (ß = -1085.82 and ß = -449.31, P < 0.0001, respectively). Increasing age and the presence of post-operative complications were predictors of high post-operative costs (ß = 623.48, ß = 5781.44, P = 0.01, respectively), while hospital load was associated with low post-surgery costs (ß = -949.79, P < 0.0001). CONCLUSION: Patients' age and surgery performed by high-volume health providers were predictive factors of high RC costs. Low RC costs were associated with surgeries performed in academic hospitals.


Subject(s)
Cystectomy/economics , Direct Service Costs , Hospital Costs , Urinary Bladder Neoplasms/economics , Urinary Bladder Neoplasms/surgery , Age Factors , Aged , Aged, 80 and over , Cystectomy/adverse effects , Cystectomy/methods , Female , Health Care Costs , Hospitals, High-Volume , Humans , Linear Models , Male , Middle Aged , Organ Sparing Treatments/economics , Predictive Value of Tests , Quebec , Retrospective Studies , Risk Factors
15.
HPB (Oxford) ; 17(8): 723-31, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26082095

ABSTRACT

BACKGROUND: A pancreatoduodenectomy (PD) is a highly advanced procedure associated with considerable post-operative complications and substantial costs. In this study the hospital costs associated with complications after PD were assessed. METHODS: A retrospective cohort study was conducted on 100 consecutive patients who underwent a pylorus-preserving (PP)PD between January 2012 and July 2013. Per patient, all complications occurring during admission or in the 30-day period after discharge were documented. All hospital costs related to the (PP)PD were defined as the costs of all medical interventions and resources during the hospitalisation period as recorded by the electronic supply tracking system. RESULTS: The median hospital costs ranged from €17 482 for a patient without complications to €55 623 for a patient with a post-operative haemorrhage. A post-operative haemorrhage was associated with a 39.6% increase in total hospital costs after adjusting for patient characteristics. Other factors significantly associated with an increase in total hospital costs were: the presence of a malignancy other than a pancreatic adenocarcinoma (29.4% cost increase), the severity grade of a complication (34.3-70.6% increase) and the presence of a post-operative infection (32.4% increase). CONCLUSIONS: This study provides an in-depth analysis of hospital costs and identifies factors that are associated with substantial cost consequences of specific complications occurring after a PD.


Subject(s)
Blood Loss, Surgical , Hospital Costs , Length of Stay/economics , Pancreaticoduodenectomy/economics , Surgical Wound Infection/economics , Adenocarcinoma/surgery , Aged , Female , Humans , Male , Middle Aged , Netherlands , Organ Sparing Treatments/economics , Pancreatic Neoplasms/surgery , Pancreaticoduodenectomy/adverse effects , Pylorus , Retrospective Studies
16.
Int J Radiat Oncol Biol Phys ; 89(5): 989-996, 2014 Aug 01.
Article in English | MEDLINE | ID: mdl-25035201

ABSTRACT

The purpose of this review was to describe cost-effectiveness and cost analysis studies across treatment modalities for squamous cell carcinoma of the head and neck (SCCHN), while placing their results in context of the current clinical practice. We performed a literature search in PubMed for English-language studies addressing economic analyses of treatment modalities for SCCHN published from January 2000 to March 2013. We also performed an additional search for related studies published by the National Institute for Health and Clinical Excellence in the United Kingdom. Identified articles were classified into 3 clinical approaches (organ preservation, radiation therapy modalities, and chemotherapy regimens) and into 2 types of economic studies (cost analysis and cost-effectiveness/cost-utility studies). All cost estimates were normalized to US dollars, year 2013 values. Our search yielded 23 articles: 13 related to organ preservation approaches, 5 to radiation therapy modalities, and 5 to chemotherapy regimens. In general, studies analyzed different questions and modalities, making it difficult to reach a conclusion. Even when restricted to comparisons of modalities within the same clinical approach, studies often yielded conflicting findings. The heterogeneity across economic studies of SCCHN should be carefully understood in light of the modeling assumptions and limitations of each study and placed in context with relevant settings of clinical practices and study perspectives. Furthermore, the scarcity of comparative effectiveness and quality-of-life data poses unique challenges for conducting economic analyses for a resource-intensive disease, such as SCCHN, that requires a multimodal care. Future research is needed to better understand how to compare the costs and cost-effectiveness of different modalities for SCCHN.


Subject(s)
Antineoplastic Agents/therapeutic use , Carcinoma, Squamous Cell/therapy , Head and Neck Neoplasms/therapy , Neck Dissection/economics , Organ Sparing Treatments/economics , Radiotherapy/economics , Antineoplastic Agents/economics , Brachytherapy/economics , Carcinoma, Squamous Cell/pathology , Chemoradiotherapy/economics , Cost-Benefit Analysis , Costs and Cost Analysis , Head and Neck Neoplasms/pathology , Humans , Neck Dissection/methods , Neoplasm Recurrence, Local/drug therapy , Organ Sparing Treatments/methods , Quality-Adjusted Life Years , Radiotherapy/methods , Radiotherapy, Intensity-Modulated/economics , Squamous Cell Carcinoma of Head and Neck , Surgical Procedures, Operative/economics
17.
J Radiat Res ; 55(2): 320-7, 2014 Mar 01.
Article in English | MEDLINE | ID: mdl-24187330

ABSTRACT

BACKGROUND: The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. METHODS: We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after treatment with proton or X-ray radiotherapy. The risks of hearing loss were calculated on cochlear dose for each treatment. Three types of health-related quality of life (HRQOL) of EQ-5D, HUI3 and SF-6D were used for estimation of quality-adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) for proton beam therapy compared with X-ray radiotherapy was calculated for each HRQOL. Sensitivity analyses were performed to model uncertainty in these parameters. RESULTS: The ICER for EQ-5D, HUI3 and SF-6D were $21 716/QALY, $11 773/QALY, and $20 150/QALY, respectively. One-way sensitivity analyses found that the results were sensitive to discount rate, the risk of hearing loss after proton therapy, and costs of proton irradiation. Cost-effectiveness acceptability curve analysis revealed a 99% probability of proton therapy being cost effective at a societal willingness-to-pay value. CONCLUSIONS: Proton beam therapy with cochlear dose reduction improves health outcomes at a cost that is within the acceptable cost-effectiveness range from the payer's standpoint.


Subject(s)
Cerebellar Neoplasms/economics , Cerebellar Neoplasms/radiotherapy , Hearing Loss/economics , Medulloblastoma/economics , Medulloblastoma/radiotherapy , Quality of Life , Radiation Injuries/economics , Cerebellar Neoplasms/mortality , Child , Cochlea/radiation effects , Cost-Benefit Analysis/classification , Cost-Benefit Analysis/economics , Female , Health Care Costs/statistics & numerical data , Hearing Loss/mortality , Hearing Loss/prevention & control , Humans , Japan , Male , Medulloblastoma/mortality , Models, Economic , Organ Sparing Treatments/economics , Organ Sparing Treatments/methods , Organs at Risk/radiation effects , Proton Therapy , Radiation Injuries/prevention & control , Radiation Protection/economics , Radiotherapy Dosage , Radiotherapy, High-Energy/economics , Radiotherapy, High-Energy/mortality , Retrospective Studies , Survival Rate , Treatment Outcome
18.
Thyroid ; 23(6): 727-33, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23173840

ABSTRACT

BACKGROUND: Traditionally, thyroid surgery has been an inpatient procedure due to the risk of several well-documented complications. Recent research suggests that for selected patients, outpatient thyroid surgery is safe and feasible, with the additional potential benefit of cost savings. In recognition of these observations, we hypothesized that there would be an increase in U.S. outpatient thyroidectomies with a concurrent decline in inpatient thyroidectomies over time. METHODS: Comparative cross-sectional analyses of the National Survey of Ambulatory Surgery (NSAS) and Nationwide Inpatient Sample (NIS) databases from 1996 and 2006 were performed. All cases of thyroid surgery were extracted, as well as data on age, sex, and insurance status. Diagnoses and surgical cases were identified using International Classification of Diseases, Ninth Revision (ICD-9) diagnostic and treatment codes. Hospital charges were acquired from the NIS 1996 and 2006 and NSAS 2006 releases, using imputed data where necessary. After survey weights were applied, patient characteristics, diagnoses, and procedures were compared for inpatient versus outpatient procedures. RESULTS: The total number of thyroidectomies increased 39%, from 66,864 to 92,931 cases per year during the study timeframe. Outpatient procedures increased by 61%, while inpatient procedures increased by 30%. The proportion of privately insured inpatients declined slightly from 63.8% to 60.1%, while those covered by Medicare increased from 22.8% to 25.8%. In contrast, the proportion of privately insured outpatients declined sharply from 76.8% to 39.9%, while those covered by Medicare rose from 17.2% to 45.7%. These trends coincided with a small increase in the mean inpatient age from 50.2 to 52.3 years and a larger increase in the mean outpatient age from 50.7 to 58.1 years. Inflation-adjusted per-capita charges for inpatient thyroidectomies more than doubled from $9,934 in 1996 to $22,537 in 2006, while aggregate national inpatient charges tripled from $464 million to $1.37 billion. By comparison, per-capita charges for outpatient thyroidectomy totaled $7,222 in 2006. CONCLUSIONS: From 1996 to 2006, there has been a concurrent modest increase in inpatient and pronounced increase in outpatient thyroidectomies in the United States, with a consequential demographic shift and economic impact.


Subject(s)
Health Care Costs/trends , Thyroid Diseases/surgery , Thyroidectomy/trends , Age Factors , Ambulatory Surgical Procedures , Cohort Studies , Cost Savings , Cross-Sectional Studies , Databases, Factual , Female , Health Care Surveys , Humans , Insurance, Health , Male , Medicaid , Medicare , Middle Aged , Organ Sparing Treatments/economics , Organ Sparing Treatments/statistics & numerical data , Organ Sparing Treatments/trends , Surgery Department, Hospital , Thyroid Diseases/economics , Thyroidectomy/economics , Thyroidectomy/statistics & numerical data , United States
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