Short report: penile lymphoma following local injections for erectile dysfunction.

We report a case of high grade lymphoma which appeared at the site of prior injections of medications into the shaft of the penis for erectile dysfunction. We discuss the possible mechanisms of causation for this unusual form of lymphoma.

[Penis carcinoma in a young chimney sweep. Case report 200 years following the description of the first occupational disease]. / Peniskarzinom bei jungem Schornsteinfeger. Fallbericht 200 Jahre nach Beshreibung der ersten Berufskrankheit.

We report on a 32-year-old patient who, following exposure to soot over a total of 78 weeks as a professional chimney sweep, developed squamous cell carcinoma of the penis. Since the epoch-making description of occupational cancer of the scrotum by Percivall Pott in 1775, soot-related cancer of the scrotum and penis has become anecdotal. As our patient presented with inguinal lymph node metastases, a wide circumcision was performed, followed by preoperative chemotherapy and bilaterial lymphadenectomy. The patient has been free of disease for over 9 years with no functional loss.

Development of human papillomavirus-associated Buschke-Löwenstein penile carcinoma during cyclosporine therapy for generalized pustular psoriasis.

Buschke-Löwenstein-type giant penile condyloma developed in a human immunodeficiency virus-negative, 25-year-old man after 4 years of intermittent cyclosporine therapy (5 mg/kg/day) for pustular psoriasis. Microscopic examination showed multifocal areas of invasive squamous cell carcinoma. Dot blot analysis of amplified polymerase chain reaction products with primers directed at the L1 region demonstrated signals for several human papillomavirus genotypes, including human papillomavirus type 16, that correlated with different histologic patterns consisting of verrucous and bowenoid changes and invasive carcinoma. This case conforms to the enhanced risk of cutaneous carcinogenesis from either papillomavirus infection or chronic actinic damage that has become evident in patients with organ allografts and cyclosporine therapy.

Tumor induction with hexanal methylformylhydrazone of Gyromitra esculenta.

Hexanal methylformylhydrazone (HMFH) was administered to Swiss mice by intragastric instillations at weekly intervals of 52 times at 50 or 100 micrograms/g body weight. The treatment induced tumors of the lungs, liver and preputial glands. The tumor incidences in the group that received the lower dose were 74, 4 and 0% in females and 78, 8 and 6% in the males. In the group with the higher dose, the incidences were 90, 28 and 0% in females and 70, 6 and 86% in males. The corresponding tumor incidences in the untreated animals were 26, 0 and 0% in females and 26, 0 and 0% in males. The histopathological examination revealed adenomas and adenocarcinomas of lungs, benign hepatomas and liver cell carcinomas, and squamous cell papillomas and carcinomas and adenomas of preputial glands. HMFH is the sixth carcinogenic ingredient found in one of the false morel mushrooms, Gyromitra esculenta. Because this fungus is considered edible, the health hazard implications cannot be discounted.

Pyogenic granuloma: an unusual complication of papaverine injection therapy for impotence.

An unusual complication of papaverine injection therapy is reported. A pyogenic granuloma formed after a single test dose of papaverine. Diagnosis, therapy and course of the patient are outlined.

Malignant melanoma of the glans penis in a chronic myeloid leukemia patient after busulfan therapy.

There are many case reports of secondary neoplasms occurring after treatment with alkylating agents. A case of malignant melanoma of the glans penis in a chronic myeloid leukemia (CML) Ph'-positive patient after 13 years on busulfan treatment is described. Since neither impairment of immune status nor increased incidence of secondary neoplasm have hitherto been reported in CML, the suggestion that busulfan has a carcinogenetic effect is discussed.

Carcinogenesis by pentanal methylformylhydrazone of Gyromitra esculenta in mice.

Pentanal methylformylhydrazone (PMFH) given in propylene glycol as 52 weekly intragastric instillations on a 50 micrograms/g body weight basis, induced tumors of the lungs, liver and preputial glands in Swiss mice. The tumor incidences in these tissues were 72, 16 and 0% in the treated females, while these tumor incidences in the males of this group were 60, 2 and 12%, respectively. The corresponding tumor incidences in the propylene glycol instilled solvent control females were 26, 0 and 0%, whereas in the males of this group they were 22, 0 and 0%, respectively. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs, benign hepatomas and squamous cell papillomas and carcinomas of the preputial glands. Pentanal methylformylhydrazone is an ingredient of the edible wild mushroom Gyromitra esculenta which is consumed by a segment of the human population around the world.

Angiosarcoma of the penis with hepatic angiomas in a patient with low vinyl chloride exposure.

A case of angiosarcoma of the penis associated with two hepatic angiomata in a 61-year-old man is presented. The patient had worked in a polyvinyl chloride factory as an accountant for ten years. The relationship of this low vinyl chloride exposure to the development of the vascular lesions is discussed with a review of the experimental and epidemiologic data on this subject.

Gyromitrin as a tumor inducer.

Acetaldehyde methylformylhydrazone (gyromitrin) was administered in propylene glycol as 12 weekly subcutaneous injections of 50 micrograms/g weight to randomly bred Swiss mice. The treatment induced lung and preputial gland tumors in incidences of 51 and 0% in females and 46 and 28% in males, respectively. In the propylene glycol injected control groups, the corresponding tumor incidences were 28 and 0% in females and 32 and 0% in males. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs and squamous cell papillomas and carcinomas and adenocarcinomas of preputial glands. Gyromitrin is an ingredient of the wild edible false morel mushroom Gyromitrin esculenta. The environmental significance of the findings is discussed.

Tumorigenesis by N-n-propyl-N-formylhydrazine in mice.

Continuous administration of 0.04% N-n-propyl-N-formylhydrazine (PFH) for life in drinking water to 6-week-old randomly bred Swiss mice induced tumours of the lungs, preputial glands, liver and gallbladder. The tumour incidences in these 4 tissues were 91, 22, 8 and 6%, whereas in the untreated controls they were 25, 0, 0.5 and 0.5%, respectively. The higher dose of 0.08% PFH, given under identical conditions, induced only tumours of the lungs, liver and gall bladder in low incidences, since the compound was too toxic for the mice. Histopathologically, the tumours were classified as adenomas and adenocarcinomas of the lungs, squamous-cell papillomas, and carcinomas and fibrosarcoma of preputial glands, benign hepatomas and liver-cell carcinoma, as well as adenomas and adenocarcinoma of the gall bladder. The investigation is part of our structure/activity relationship inquiry aimed at revealing the mechanism of action of the N-alkyl-N-formylhydrazine series of chemicals.

Tumorigenic action of N-n-butyl-N-formylhydrazine in mice.

Continuous administration of 0.04% N-n-butyl-N-formylhydrazine (BFH) in drinking water to 6-week-old randomly bred Swiss mice for life produced tumors of the lungs, preputial and clitoral glands. The tumor incidences in these three tissues of the treated animals were 87, 66, and 10%, whereas in the untreated controls they were 25, 0, and 0%, respectively. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs, squamous cell papillomas and carcinomas, angio-, fibro-, and myxo- sarcomas of preputial glands and squamous cell papillomas and carcinomas of clitoral glands. N-n-Butyl-N-formylhydrazine is a structural homologue of the carcinogenic N-methyl-N-formylhydrazine and N-ethyl-N-formylhydrazine. These studies are integral parts of structure activity relationship inquiries.

Carcinogenesis by a single dose of N-methyl-N-formylhydrazine.

Single sc injections of N-methyl-N-formylhydrazine were given to randomly bred Swiss mice. The females received 180 micrograms per gram of body weight, while two groups of males were treated with either 120 or 100 micrograms per gram of body weight. The treatment resulted in induction of tumors of lungs with an incidence of 40% in the females. In males treated with the higher and lower doses, the incidences of preputial gland tumors were 12 and 12%, respectively. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of lungs, squamous cell papillomas, and carcinomas of preputial glands. N-Methyl-N-formylhydrazine is a constituent of the edible wild false morel mushroom Gyromitra esculenta, to which the human population is exposed in measurable quantities, sometimes at a single meal.