ABSTRACT
Pus discharge containing black granular materials (1-2 mm in diameter) was found in the abdominal skin of a 13-year-old sterilized female cat. Abdominal ultrasonography revealed a large intra-abdominal mass with abundant blood flow beneath the skin lesion. Laparotomy revealed a large mass that adhered to the spleen and left kidney. Similar small lesions were found in the abdominal wall and mesentery. The masses were surgically removed along with the spleen and kidney. Histopathologically, the mass lesions consisted of granulomas with lesional pigmented fungi, and the cat was diagnosed with phaeohyphomycosis. Uisng genetic analysis, the Exophiala dermatitidis was identified as the causative pathogen.
Subject(s)
Cat Diseases , Exophiala , Phaeohyphomycosis , Animals , Phaeohyphomycosis/veterinary , Phaeohyphomycosis/microbiology , Phaeohyphomycosis/diagnosis , Phaeohyphomycosis/pathology , Cat Diseases/microbiology , Cat Diseases/diagnosis , Cat Diseases/pathology , Female , Cats , Exophiala/isolation & purificationSubject(s)
Phaeohyphomycosis , Humans , Phaeohyphomycosis/microbiology , Phaeohyphomycosis/diagnosis , Phaeohyphomycosis/drug therapy , Phaeohyphomycosis/pathology , Male , Magnetic Resonance Imaging , Antifungal Agents/therapeutic use , Cerebellum/microbiology , Cerebellum/diagnostic imaging , Cerebellum/pathology , Cerebral Phaeohyphomycosis/microbiology , Cerebral Phaeohyphomycosis/diagnosis , Cerebral Phaeohyphomycosis/pathology , Middle AgedABSTRACT
ABSTRACT: Fungal infection is a rare condition in immunocompetent individuals, and it is associated with high rates of morbidity and mortality. We report on a case of cutaneous phaeohyphomycosis in healthy 25-year-old man. Based on the clinical findings, the case was first thought to be cervico-facial actinomycosis, but Alternaria was identified on the culture after debridement. Simple surgical excision resulted in the complete cure without administration of systemic antifungals.
Subject(s)
Alternaria , Face , Phaeohyphomycosis , Humans , Male , Adult , Phaeohyphomycosis/diagnosis , Phaeohyphomycosis/microbiology , Phaeohyphomycosis/drug therapy , Phaeohyphomycosis/pathology , Alternaria/isolation & purification , Face/microbiology , Face/pathology , Debridement , Microscopy , Histocytochemistry , Dermatomycoses/diagnosis , Dermatomycoses/microbiology , Dermatomycoses/pathology , Dermatomycoses/drug therapy , Immunocompetence , Skin/pathology , Skin/microbiologyABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Phaeohyphomycosis/drug therapy , Phaeohyphomycosis/microbiology , Erythema/diagnosis , Hand Injuries/diagnosis , Alternaria/isolation & purification , Biopsy , Blood Culture , Antifungal Agents/therapeutic use , Erythema/etiology , Erythema/microbiology , Phaeohyphomycosis/pathology , Hand Injuries/microbiology , Hand Injuries/pathologyABSTRACT
Abstract This communication reports the second known case of oral phaeohyphomycosis in a patient with squamocellular carcinoma of the lip. The patient, an 82-year-old black woman, a former smoker (for more than 30 years), suffering from an ulcerous vegetative lesion in the middle third of the lower lip for approximately 12 months. The result of the histopathological analysis indicated carcinoma, with well-differentiated keratinized squamous cells and the presence of septate mycelial filaments. In the direct mycological examination, thick and dematiaceous septate mycelial filaments were observed. After the resection surgery, the patient did not need to use an antifungal drug to treat the phaeohyphomycosis, and no follow-up radiotherapy was needed to treat the squamocellular carcinoma. We stress that the presence of the squamocellular lesion of the lip was a possible contributing factor to the infection.
Subject(s)
Humans , Female , Aged, 80 and over , Lip Neoplasms/complications , Carcinoma, Squamous Cell/complications , Phaeohyphomycosis/diagnosis , Phaeohyphomycosis/pathology , Lip/pathology , Brazil , Lip Neoplasms/surgery , Carcinoma, Squamous Cell/surgery , Microbiological Techniques , Treatment Outcome , Phaeohyphomycosis/surgery , Histocytochemistry , Lip/surgery , MicroscopyABSTRACT
Abstract Phaeohyphomycosis is an infection caused by a filamentous fungus that contains pigment melanin in its cell wall. We report two cases caused by Exophiala sp. emphasizing the clinical variability of the disease, as well as diagnostic and therapeutic difficulties of this opportunistic infection in immunosuppressed patients (kidney transplant).
Subject(s)
Humans , Male , Middle Aged , Exophiala/isolation & purification , Kidney Transplantation/adverse effects , Phaeohyphomycosis/pathology , Antifungal Agents/therapeutic use , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Opportunistic Infections/immunology , Opportunistic Infections/pathology , Opportunistic Infections/therapy , Phaeohyphomycosis/immunology , Phaeohyphomycosis/therapy , Skin/pathologyABSTRACT
Phaeohyphomycosis is a disease caused by dematiaceous fungi with a worldwide geographic distribution and broad spectrum. It is most commonly found in adult individuals of both genders and all races. We report the case of a 57-year-old woman with phaeohyphomycosis in the ungual apparatus.
Subject(s)
Female , Humans , Middle Aged , Nail Diseases/microbiology , Phaeohyphomycosis/microbiology , Skin/microbiology , Antifungal Agents/therapeutic use , Nail Diseases/drug therapy , Nail Diseases/pathology , Phaeohyphomycosis/drug therapy , Phaeohyphomycosis/pathology , Skin/pathology , Treatment OutcomeABSTRACT
Subcutaneous phaeohyphomycosis is an infection caused by dematiaceous fungi which mainly affects immunosuppressed patients. We report a case of subcutaneous phaeohyphomycosis on the back of the left hand in a kidney transplant patient who had been taking prednisone, tacrolimus, and azathioprine daily for 3 years.
Subject(s)
Humans , Female , Middle Aged , Phaeohyphomycosis/pathology , Hand Dermatoses/pathology , Biopsy , Immunosuppression Therapy/adverse effects , Kidney Transplantation , Immunocompromised Host , Phaeohyphomycosis/surgery , Hand Dermatoses/surgeryABSTRACT
The goal of this study was to review 18 cases of phaeohyphomycosis in Rio Grande do Sul. The records of all of the patients with a diagnosis of phaeohyphomycosis between 1995-2010 were reviewed. Twelve of the 18 patients (66.6%) were male. The average age of the patients was 50 years old (range: 16-74 years). Eleven patients (61%) presented with subcutaneous lesions. Seven patients (38.8%) had received a solid organ transplant. In all of the cases, the presence of melanin in the fungal cells was determined by Fontana-Masson staining of tissue sections and documented. Among the 18 patients, a total of 11 different fungal species were isolated. The causative organisms included Exophiala jeanselmei, Alternaria, Curvularia, Cladophialophora and Colletotrichum gloeosporioides. To our knowledge, this review reports the first case of subcutaneous phaeohyphomycosis caused by C. gloeosporioides in a lung transplant patient. The number of reported cases of phaeohyphomycosis has increased in the last decade. In a number of cases, this increased incidence may be primarily attributed to iatrogenic immunodeficiency.