ABSTRACT
Objetivo: Demostrar la eficacia terapéutica del bromuro de propantelina para evitar recurrencia en síncope vagotónico. Lugar: HGZ No. 3 IMSS, Mazatlán, Sinaloa, México de 1992 a 1995. Pacientes: De 41 pacientes con síncope se incluyeron 10 con síncope vagotónico. Diseño: longitudinal prospectivo. Procedimiento: Se realizó historia clínica, valoración cardiológica y neurológica, electrocardiograma, electroencefalograma, T.A.C., Holter, prueba de esfuerzo y Rx de tórax. Se realizó seguimiento de 10 pacientes por espacio de 12 meses y se midió recurrencia, mejoría de síntomas clínicas y efectos colaterales de bromuro de propantelina 15 a 30 mg cada 8 horas vía oral. Resultados: De 10 pacientes 7 son mujeres, edad promedio 18 años, no hubo recurrencia de síncope en 9 de ellos (p < 0.005), 1abandodó tratamiento, 4 con efectos colaterales leves. Conclusiones: El bromuro de propantelina disminuye la recurrencia de síncope vagotónico con pocos efectos colaterales a 1 año de seguimiento
Subject(s)
Humans , Male , Female , Adolescent , Adult , Parasympatholytics/therapeutic use , Propantheline/therapeutic use , Prospective Studies , Syncope , Syncope, VasovagalABSTRACT
OBJECTIVE: To study propanthelin bromide efficacy in preventing vasovagal syncope relapse. SETTING: HGZ No. 3 IMSS, Mazatlán, Sinaloa, México, from 1992 to 1995. PATIENTS: 10 patients with vasovagal syncope were selected from 41 syncope patients. DESIGN: Prospective longitudinal. MEASURES: clinical charts, neurologic and cardiologic evaluation, electrocardiogram, electroencephalogram, C.A.T., Holter, stress test and chest X rays were made. In 10 patients, 15 to 30 mg of propanthelin bromide thrice a day were administered, 12 month survey on was made measured. RESULTS: Of the 10 patients, 7 were women mean age 18 years. In 9 of them no recurrence was evident abandoned 1 treatment, 4 had side effects. CONCLUSIONS: Propanthelin bromide decreases vasovagal syncope episodes with few side effects.
Subject(s)
Parasympatholytics/therapeutic use , Propantheline/therapeutic use , Syncope, Vasovagal/drug therapy , Adolescent , Adult , Female , Humans , Male , Prospective StudiesABSTRACT
Syncope or near-syncope can be the manifestation of a benign problem or a symptom of a life-threatening disease. Vasovagal syncope accounting for almost 70 per cent of cases. We identified 5 young patients who were presented to us with syncope or near-syncope. Diagnostic test, such as electrocardiogram, Holter monitoring and electrophysiological study identified only markers of hypervagotonia. We treated them with oral propantheline. By the time of follow up (20 months) none had recurrent episodes of syncope. Propantheline can be useful in patients with symptomatic vagotonia.