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1.
Bol. méd. postgrado ; 36(2): 43-47, dic.2020. tab, graf
Article in Spanish | LILACS, LIVECS | ID: biblio-1117899

ABSTRACT

La uroflujometría es un estudio no invasivo del tracto urinario inferior que entrega información objetiva del flujo urinario y es ampliamente recomendado por las guías europeas en el estudio de pacientes con sintomatología urinaria baja. Se realizó un estudio descriptivo transversal cuyo propósito fue describir el uso de la uroflujometría en el estudio de síntomas del tracto urinario bajo en pacientes masculinos que acudieron a la consulta de Servicio de Urología del Hospital Central Universitario Dr. Antonio María Pineda de la ciudad de Barquisimeto, estado Lara durante el lapso 2018- 2019. La muestra estuvo conformada por 150 pacientes. Los resultados indican que el 62% de la muestra corresponde a pacientes entre 60 y 70 años de edad de los cuales 52% manifestaron síntomas urinarios leves. La uroflujometría evidenció que 56% de los pacientes tienen un flujo máximo entre 10 y 20 ml/seg lo cual sugiere una probable obstrucción al flujo de salida; 78% de los pacientes presentan un flujo promedio entre 0 a 10 ml/seg. El 53% de los pacientes mostró un volumen de vaciado < 300 ml y 49% un tiempo de flujo máximo entre 30 y 50 segundos. En conclusión, la uroflujometría es un examen simple y rápido que proporciona información útil sobre la salud de las vías urinarias inferiores(AU)


Uroflowmetry is a non-invasive study of the lower urinary tract that provides objective information on urinary flow and is widely recommended by European guidelines for the study of patients with lower urinary tract symptoms. We performed a cross-sectional descriptive study to describe the use of uroflowmetry for the study of lower urinary tract symptoms in males who attended the Servicio de Urología of the Hospital Central Universitario Dr. Antonio María Pineda (Barquisimeto, Lara state) during the 2018- 2019 period. The sample was made up of 150 males. The results show that 62% of the sample included males between 60 and 70 years old and 52% complained of mild urinary symptoms. Uroflowmetry results showed that 56% of patients had a maximum flow between 10 and 20 ml/sec suggestive of urinary tract obstruction; 78% had an average flow between 0 and 10 ml/sec while 53% had a micturition volume < 300 ml and 49% had a maximum flow time between 30 and 50 seconds. Uroflowmetry is a simple and fast test which provides useful information about the health of lower urinary tract(AU)


Subject(s)
Humans , Male , Middle Aged , Aged , Urethral Obstruction , Urinary Tract , Prostatism/diagnostic imaging , Conservative Treatment/methods , Urination , Urologic Diseases , Ultrasonography
2.
VozAndes ; 31(1): 55-56, 2020.
Article in Spanish | LILACS | ID: biblio-1118259

ABSTRACT

Contexto: Al momento existen pocos datos científicos que comparen las tres modalidades de tratamiento en Hiperplasia Prostática Benigna para determinar el mejor resultado clínico, considerando que se trata de una patología cuya incidencia aumenta a medida que aumenta la esperanza de vida poblacional. Objetivo: Comparar los resultados clínicos entre el tratamiento inicial farmacológico, no farmacológico y quirúrgico, basándose en la clínica de prostatismo en pacientes con Hiperplasia Prostática Benigna durante el período de enero 2014 a diciembre 2016. Diseño: Estudio Observacional, tipo Cohorte Retrospectiva. Pacientes y Métodos: Se procedió a dividir a 399 pacientes de acuerdo a la modalidad de tratamiento recibida. Se comparó la disminución del cuadro clínico en la primera consulta postratamiento utilizando una matriz de evaluación de síntomas urinarios elaborada por los autores, basada en la escala IPSS, que estratificó a los pacientes por el grado de severidad de la sintomatología. Se utilizó el software SPSS®. Resultados: Dentro del tratamiento no farmacológico, existió una diferencia de medias de 1,67 (IC 95% 0,49 ­ 2,85, p < 0,05); para el farmacológico fue de 0,21 (IC 95% 0,92 ­ 1,34, p = 0,713) y para el quirúrgico fue de 8,23 (IC 95% 7,19 ­ 9,27, p < 0,05). Se encontraron diferencias significativas entre los tres grupos durante la fase pretratamiento, tras estratificarlos de acuerdo al grado de severidad. Post- intervención, se compararon los resultados clínicos de cada tratamiento hallando que en pacientes con síntomas leves no existieron diferencias significativas (p = 0,087), no así para pacientes con sintomatología moderada y severa en donde se encontró una diferencia estadísticamente significativa. Conclusión: En pacientes con sintomatología urinaria catalogada como moderada y severa dentro de esta muestra, el tratamiento quirúrgico disminuyó la sintomatología urinaria en mayor proporción en comparación con el tratamiento farmacológico y el no farmacológico


Background: Currently there are few scientific data comparing the three therapeutic modalities of Benign Prostatic Hyperplasia to determine the best clinical outcome, considering that it is a pathology whose incidence increases as population life expectancy arise. Objectives: To compare the clinical results between the initial pharmacological, nonpharmacological and surgical treatment, based on clinical signs of prostatism in patients with benign prostatic hyperplasia during the period between January 2014 and December 2016. Study Design: Retrospective Cohort Study. Methods: 399 patients were divided according to the modality of treatment received: nonpharmacological, pharmacological and surgical. The decrease of the symptoms was compared with the first post-treatment consultation by using a matrix of evaluation of urinary symptoms elaborated by the authors, based on SPSS International Score; this tool stratified the patients by the severity of the symptomatology. SPSS® software was used. Results: Within the non-pharmacological treatment, there was a mean difference of 1.67 (95% CI 0.49 - 2.85, p <0.05); for the pharmacological it was 0.21 (95% CI 0.92 - 1.34, p = 0.713) and for the surgical was 8.23 (95% CI 7.19 - 9.27, p <0.05). Significant differences were found between the three groups during the pretreatment phase, after stratifying them according to the degree of severity. Post-intervention, the clinical results of each treatment were compared, finding that in patients with mild symptoms there were no significant differences (p = 0.087), not so for patients with moderate and severe symptoms where a statistically significant difference was found. Conclusion: In patients with urinary symptoms classified as moderate and severe within this sample, surgical treatment decreased urinary symptomatology in greater proportion compared to pharmacological and non-pharmacological treatment


Subject(s)
Humans , Male , Prostatic Hyperplasia , Pathology , General Surgery , Therapeutics , Comparative Study , Prostatism
3.
Rom J Intern Med ; 57(3): 220-232, 2019 Sep 01.
Article in English | MEDLINE | ID: mdl-30990789

ABSTRACT

A significant workforce shortage of urologists available to serve the US population has been projected to occur over the next decade. Accordingly, much of the management of urologic patients will need to be assumed by other specialties and practitioners. Since primary care physicians are often first evaluate common urologic complaints, it makes sense that these physicians are in an excellent position to intervene in the management of these patients when appropriate. One of the most common complaints in urology is voiding dysfunction. The incidence of voiding dysfunction increases with age, with conservative estimates showing that over 50% of elderly patients suffer. Despite this high prevalence and its negative impact on quality of life, however, few seek or receive treatment, as many do not readily disclose these impactful yet personal symptoms. We sought to summarize the typical presentation, evaluation, assessment and therapeutic options for both male and female patients presenting with voiding dysfunction.


Subject(s)
Prostatism/therapy , Urinary Bladder, Overactive/therapy , Urination Disorders/diagnosis , Urination Disorders/therapy , Cystitis, Interstitial/diagnosis , Cystitis, Interstitial/etiology , Cystitis, Interstitial/therapy , Female , Humans , Male , Prostatism/diagnosis , Prostatism/etiology , Urinary Bladder, Overactive/diagnosis , Urinary Bladder, Overactive/etiology , Urinary Bladder, Underactive/diagnosis , Urinary Bladder, Underactive/etiology , Urinary Bladder, Underactive/therapy , Urinary Incontinence, Stress/diagnosis , Urinary Incontinence, Stress/etiology , Urinary Incontinence, Stress/therapy , Urination Disorders/etiology
4.
Int Urol Nephrol ; 45(1): 39-43, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23108604

ABSTRACT

OBJECTIVES: To evaluate the effect of association of tamsulosin/tadalafil taken daily compared with tamsulosin/placebo in the lower urinary tract with urodynamic study (UDS). METHODS: All patients underwent baseline UDS before randomization to tamsulosin 0.4 mg/tadalafil 5 mg (Group 1; n = 20) or tamsulosin 0.4 mg/placebo (Group 2; n = 20) once daily for 30 days. End-of-study UDS were performed on completion of the treatment period. The primary end point was to demonstrate changes in urodynamic variables in the voiding phase, detrusor pressure at maximum flow (PdetQmax), and maximum flow rate (Qmax), from baseline to week four. RESULTS: The primary outcome measure of this clinical trial, PdetQmax, showed a significant reduction in tamsulosin/tadalafil group (13 ± 17.0) compared to tamsulosin/placebo (-1.2 ± 14.35) group (P = 0.03). Qmax increased in both groups, tamsulosin/tadalafil (1.0 ± 2.4) and tamsulosin/placebo (1.4 ± 2.4), but the difference was not significant between treatment groups (P = 0.65). Total IPSS, storage, and voiding sub-score improved significantly in tamsulosin/tadalafil compared with tamsulosin/placebo group. CONCLUSIONS: The association of tamsulosin/tadalafil reduces detrusor pressure at maximum flow without changing the maximum flow rate during micturition and significantly improves lower urinary tract symptoms compared with the isolated use of tamsulosin.


Subject(s)
Adrenergic alpha-1 Receptor Antagonists/pharmacology , Carbolines/pharmacology , Phosphodiesterase 5 Inhibitors/pharmacology , Prostatism/drug therapy , Sulfonamides/pharmacology , Urodynamics/drug effects , Adrenergic alpha-1 Receptor Antagonists/therapeutic use , Carbolines/therapeutic use , Double-Blind Method , Drug Therapy, Combination , Humans , Male , Middle Aged , Phosphodiesterase 5 Inhibitors/therapeutic use , Prostatic Hyperplasia/complications , Prostatism/etiology , Tadalafil , Tamsulosin , Urinary Bladder, Overactive/drug therapy , Urination/drug effects , Urination/physiology
5.
BJU Int ; 107(7): 1104-9, 2011 Apr.
Article in English | MEDLINE | ID: mdl-20883484

ABSTRACT

OBJECTIVE: • To review the evidence in support of the effectiveness of phosphodiesterase 5 inhibitors in lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). METHODS: • Relevant studies were identified by performing a literature search using MEDLINE® and The Cochrane Library®. The criteria used during the search included randomized, placebo-controlled trials of treatment for LUTS secondary to BPH using the International Prostate Symptom Score as an outcome measure. RESULTS: • Four trials that included a total of 1928 patients met the inclusion criteria. All four studies showed a statistically significant difference in the International Prostate Symptom Score, quality of life and erectile function in favour of phosphodiesterase 5 inhibitors. • No study showed a statistically significant improvement of the maximum urinary flow. • Meta-analysis of the results was not possible because of heterogeneity across the studies. CONCLUSIONS: • Phosphodiesterase 5 inhibitors used in the clinical setting can significantly improve LUTS secondary to BPH, erectile function and quality of life. Maximum urinary flow improvement is not statistically significant. • Future research should focus on pathophysiological principles and cost analysis.


Subject(s)
Phosphodiesterase 5 Inhibitors/therapeutic use , Prostatic Hyperplasia/drug therapy , Prostatism/drug therapy , Aged , Humans , Male , Middle Aged , Prostatic Hyperplasia/complications , Prostatism/etiology , Randomized Controlled Trials as Topic , Treatment Outcome
6.
BJU Int ; 108(6): 864-7, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21166745

ABSTRACT

OBJECTIVE: • To evaluate the correlation between ultrasound-estimated bladder weight (UEBW) in patients with different degrees of bladder outlet obstruction (BOO). METHODS: • We evaluated 50 consecutive non-neurogenic male patients with lower urinary tract symptoms (LUTS) referred to urodynamic study (UDS). All patients self-answered the International Prostate Score Symptoms (IPSS) questionnaire. After the UDS, the bladder was filled with 150 mL to determine UEBW. • Patients with a bladder capacity under 150 mL, a previous history of prostate surgery or pelvic irradiation, an IPSS score <8, a bladder stone or urinary tract infection were excluded. • After a pressure-flow study, the Schafer linear passive urethral resistance relation nomogram was plotted to determine the grade of obstruction: Grades I-II/VI were defined as mild obstruction, Grades III-IV/VI as moderate obstruction, and Grades V-VI/VI as severe obstruction. RESULTS: • The UEBW was 51.7 ± 26.9, 54.1 ± 30.0 and 54.8 ± 28.2 in patients with mild, moderate and severe BOO, respectively (P= 0.130). The UEBW allowed us to define four groups: (i) UEBW <35 g; (ii) 35 g ≤ UEBW < 50 g; (iii) 50 g ≤ UEBW < 70 g; and (4) UEBW ≥ 70 g. • We did not find any differences in age, prostate weight, IPSS, PVR, cystometric bladder capacity, presence of detrusor overactive and degree of obstruction in the aforementioned groups. CONCLUSION: • Despite the fact that some studies have emphasized the value of UEBW as an efficient non-invasive method for evaluating lower urinary tract obstruction, our study suggests that UEBW does not present any individual correlation with LUTS or objective measurements of BOO.


Subject(s)
Urinary Bladder Neck Obstruction/pathology , Aged , Humans , Male , Organ Size , Prostatism/diagnostic imaging , Prostatism/pathology , Prostatism/physiopathology , Quality of Life , Reproducibility of Results , Ultrasonography , Urinary Bladder Neck Obstruction/diagnostic imaging , Urinary Bladder Neck Obstruction/physiopathology , Urodynamics
7.
Urol Int ; 83(4): 404-9, 2009.
Article in English | MEDLINE | ID: mdl-19996646

ABSTRACT

INTRODUCTION: The prevalence of bladder outlet obstruction in men has been overestimated leading to improper clinical results after transurethral resection of the prostate. PATIENTS AND METHODS: 3,830 consecutive male cases submitted for urodynamic evaluation were prospectively analyzed using a Schaefer nomogram. The prevalence of detrusor overactivity and the occurrence of obstruction were prospectively studied using standardized urodynamic practice. RESULTS: Infravesical obstruction was diagnosed in 44.8% of the studied population: 0.7% of the obstructed cases were obstructed at the sphincter zone and 7.9% showed obstruction as a high-pressure, high-flow-rate pattern. Detrusor overactivity was demonstrated in 73.9% of the obstructed cases and in 22% of the unobstructed. Older patients (>60 years) seemed more likely (odds ratio: 2.8) to present detrusor overactivity, but at the same time showed less frequent obstruction. The oldest subjects (>80 years) showed a lower prevalence of obstruction, although overactive bladder was a common finding. CONCLUSION: Infravesical obstruction is less frequent than previously stated. The common assumption that obstruction is the cause of lower urinary tract symptoms in older men is wrong. Older men are more likely to suffer from detrusor overactivity resulting from lower urinary tract symptoms rather than infravesical obstruction. Urodynamic studies seem to be crucial for a proper diagnosis in men considered candidates for surgical treatment.


Subject(s)
Prostatism/diagnosis , Urinary Bladder Neck Obstruction/diagnosis , Urinary Bladder Neck Obstruction/epidemiology , Aged , Aged, 80 and over , Humans , Male , Middle Aged , Prevalence , Prospective Studies , Prostatism/complications , Prostatism/physiopathology , Urinary Bladder Neck Obstruction/complications , Urinary Bladder Neck Obstruction/physiopathology , Urodynamics
8.
Prostate Cancer Prostatic Dis ; 12(4): 369-74, 2009.
Article in English | MEDLINE | ID: mdl-19901936

ABSTRACT

This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged > or =50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score > or =12), prostate volume (PV) > or =30 cm(3) and PSA 1.5-10 ng ml(-1). After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to <42, 42 to <58, > or =58 cm(3)). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin.


Subject(s)
Azasteroids/therapeutic use , Prostatic Hyperplasia/drug therapy , Prostatism/drug therapy , Sulfonamides/therapeutic use , Urination/drug effects , Adrenergic alpha-Antagonists/administration & dosage , Adrenergic alpha-Antagonists/therapeutic use , Aged , Azasteroids/administration & dosage , Double-Blind Method , Drug Therapy, Combination , Dutasteride , Enzyme Inhibitors/administration & dosage , Enzyme Inhibitors/therapeutic use , Humans , Male , Middle Aged , Sulfonamides/administration & dosage , Tamsulosin , Urinary Bladder, Overactive/drug therapy
9.
BJU Int ; 104(8): 1130-3, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19426190

ABSTRACT

OBJECTIVE: To determine the prevalence of erectile dysfunction (ED) in a large cohort of Brazilian men who were screened for prostate cancer, and to determine risk factors in this population, as there are large cultural differences among countries in reporting the frequency of ED, and it is likely that the prevalence of ED among men screened for prostate cancer cannot be generally applied across countries. SUBJECTS AND METHODS: The analysis focused on the baseline characteristics of 1008 consecutive South American men from Brazil with no known prostate disease who had routine screening for prostate cancer by urologists. The variables analysed were patient age, urinary symptoms, patient health-related quality of life (HRQL), prostate-specific antigen (PSA) levels, prostate volume and erectile function. To assess lower urinary tract symptoms (LUTS) and HRQL, we used the American Urological Association symptom score and its appended eighth question, respectively. Benign prostatic hyperplasia was defined as a prostate volume of >30 g. Sexual function was assessed using the five-item version of the International Index of Erectile Function questionnaire. Thus, ED was considered to absent for scores of 22-25, mild for 17-21, mild to moderate for 12-16, moderate for 8-11, or severe for 5-7. Obesity was defined by calculating the body mass index (BMI), and categorized as underweight (<18.5 kg/m(2)), normal weight (18.5-24.9 kg/m(2)), overweight (25-29.9 kg/m(2)) or obese (= 30 kg/m(2)). The mean (sd) PSA level was 4.3 (6.7) ng/mL and the mean prostate volume 37.8 (21.8) mL. The correlation of ED with these variables was estimated using unconditional logistic regression models. RESULTS: Information about erectile function was available for 908 patients. ED was considered to be absent, mild, mild to moderate, moderate and severe in 169 (18.6%), 210 (23.1%), 169 (18.6%), 138 (15.2%) and 222 (24.5%) patients, respectively. The ED was severe in 18.4%, 25.7% and 43.4% of patients with mild, moderate and severe LUTS, respectively (P < 0.001). The answer to the HRQL question was also significantly associated with ED; ED was severe in 16.5% of patients feeling delighted/pleased and in 35.8% of patients feeling unhappy/terrible (P < 0.001). The prostate volume was significantly related to ED. The BMI category showed that normal weight, overweight and obese patients had similar rates of ED (P = 0.415); ED was severe in about a quarter of the patients in each of these categories, and 50% and 24% of patients in the underweight and greater BMI groups had severe ED, respectively. CONCLUSIONS: Of men screened for prostate cancer in Brazil, approximately 40% have moderate or severe ED. Severe LUTS, higher HRQL scores, a large prostate volume, a low BMI and higher PSA levels might be associated with higher rates of ED. These variables should be considered when analysing the erectile function of patients screened for prostate cancer.


Subject(s)
Impotence, Vasculogenic/epidemiology , Prostatic Neoplasms/epidemiology , Prostatism/epidemiology , Aged , Aged, 80 and over , Body Mass Index , Brazil/epidemiology , Epidemiologic Methods , Humans , Impotence, Vasculogenic/etiology , Male , Mass Screening , Middle Aged , Obesity/complications , Obesity/epidemiology , Prostatic Neoplasms/complications , Prostatic Neoplasms/diagnosis , Prostatism/etiology , Quality of Life
10.
Córdoba; s.n; 2009. 159 p. ilus, 28 cm.
Thesis in Spanish | LILACS | ID: lil-515037

ABSTRACT

La próstata es el sitio más propenso a desarrollar procesos inflamatorios y alteraciones del crecimiento celular dentro del tracto genital masculino. Las prostatis, sindrome clínico que experimentan los pacientes con inflamación de la próstata, constituyen una importante causa deterioro en la calidad de vida en hombres de todas las edades y un proceso de difícil tratamiento. Estudios recientes han postulado que los epitelios expuestos a injurias poseen mecanismos de defensa propios de la inmunidad innata, con la participación de moléculas específicas tales como TLR4 para reconocimiento bacteriano, los antibacterianos SP-D y defensinas, citocinas proinflamatorias y las inmunomoduladoras UG, PBP y Gal-1.


Subject(s)
Humans , Male , Prostatic Hyperplasia/complications , Inflammation/complications , Prostate , Prostate/pathology , Prostatism/pathology
11.
Córdoba; s.n; 2009. 159 p. ilus. (125209).
Thesis in Spanish | BINACIS | ID: bin-125209

ABSTRACT

La próstata es el sitio más propenso a desarrollar procesos inflamatorios y alteraciones del crecimiento celular dentro del tracto genital masculino. Las prostatis, sindrome clínico que experimentan los pacientes con inflamación de la próstata, constituyen una importante causa deterioro en la calidad de vida en hombres de todas las edades y un proceso de difícil tratamiento. Estudios recientes han postulado que los epitelios expuestos a injurias poseen mecanismos de defensa propios de la inmunidad innata, con la participación de moléculas específicas tales como TLR4 para reconocimiento bacteriano, los antibacterianos SP-D y defensinas, citocinas proinflamatorias y las inmunomoduladoras UG, PBP y Gal-1.(AU)


Subject(s)
Humans , Male , Prostate , Inflammation/complications , Prostate/pathology , Prostatism/pathology , Prostatic Hyperplasia/complications
14.
Int Braz J Urol ; 33(4): 493-500; discussion 501, 2007.
Article in English | MEDLINE | ID: mdl-17767753

ABSTRACT

OBJECTIVE: To determine the efficacy of Bixa Orellana (BO) in patients with benign prostatic hyperplasia (BPH) presenting moderate lower urinary tract symptoms (LUTS). MATERIALS AND METHODS: It is a prospective double-blind randomized placebo-controlled study. One thousand four hundred and seventy eight patients presenting moderate LUTS associated to BPH were interviewed, from whom we selected 136 to fulfill the criteria of inclusion and exclusion. Assignation was performed at random in blocks of four to receive B0 at a dose of 250 mg 3 times a day or placebo (Pbo) for 12 months, 68 patients were assigned to each group. From the patients in the study we obtained data of demographic, epidemiologic, symptom score, uroflowmetry and post void residual urine variables. RESULTS: Basically both groups were compared clinically, demographically and biochemically. Throughout the study variations of symptom score, mean delta symptom score during each visit and the final average delta were similar for both groups (BO - 0.79 +/- 1.87 and Pbo - 1.07 +/- 1.49) (p = 0.33). Similarly variations of Qmax mean, Qmax average delta and final average delta were similar (BO 0.44 +/- 1.07 and Pbo 0.47 +/- 1.32) (p = 0.88). Variations of post void residual urine mean, post void residual urine average delta in each visit and the final average delta were similar for both groups (BO 4.24 +/- 11.69 and Pbo 9.01 +/- 18.66) (p = 0.07). No differences were found in the answers of clinically significant improvement assessed with relative risk and risk differences, even though the proportion of adverse effects was similar for both groups. CONCLUSION: Patients with BPH that present moderate LUTS did not show any benefit receiving BO when compared to placebo.


Subject(s)
Bixaceae/chemistry , Phytotherapy , Plant Extracts/therapeutic use , Prostatic Hyperplasia/complications , Prostatism/drug therapy , Urinary Bladder Neck Obstruction/drug therapy , Aged , Double-Blind Method , Humans , Male , Middle Aged , Peru , Placebos , Plant Extracts/adverse effects , Plant Leaves/chemistry , Prospective Studies , Prostatism/etiology , Treatment Outcome , Urinary Bladder Neck Obstruction/etiology
15.
Int. braz. j. urol ; 33(4): 493-501, July-Aug. 2007. ilus, tab
Article in English | LILACS | ID: lil-465785

ABSTRACT

OBJECTIVE: To determine the efficacy of Bixa Orellana (BO) in patients with benign prostatic hyperplasia (BPH) presenting moderate lower urinary tract symptoms (LUTS). MATERIALS AND METHODS: It is a prospective double-blind randomized placebo-controlled study. One thousand four hundred and seventy eight patients presenting moderate LUTS associated to BPH were interviewed, from whom we selected 136 to fulfill the criteria of inclusion and exclusion. Assignation was performed at random in blocks of four to receive B0 at a dose of 250 mg 3 times a day or placebo (Pbo) for 12 months, 68 patients were assigned to each group. From the patients in the study we obtained data of demographic, epidemiologic, symptom score, uroflowmetry and post void residual urine variables. RESULTS: Basically both groups were compared clinically, demographically and biochemically. Throughout the study variations of symptom score, mean delta symptom score during each visit and the final average delta were similar for both groups (BO - 0.79 ± 1.87 and Pbo - 1.07 ± 1.49) (p = 0.33). Similarly variations of Qmax mean, Qmax average delta and final average delta were similar (BO 0.44 ± 1.07 and Pbo 0.47 ± 1.32) (p = 0.88). Variations of post void residual urine mean, post void residual urine average delta in each visit and the final average delta were similar for both groups (BO 4.24 ± 11.69 and Pbo 9.01 ± 18.66) (p = 0.07). No differences were found in the answers of clinically significant improvement assessed with relative risk and risk differences, even though the proportion of adverse effects was similar for both groups. CONCLUSION: Patients with BPH that present moderate LUTS did not show any benefit receiving BO when compared to placebo.


Subject(s)
Aged , Humans , Male , Middle Aged , Bixaceae/chemistry , Phytotherapy , Plant Extracts/therapeutic use , Prostatic Hyperplasia/complications , Prostatism/drug therapy , Urinary Bladder Neck Obstruction/drug therapy , Double-Blind Method , Peru , Placebos , Prospective Studies , Plant Extracts/adverse effects , Plant Leaves/chemistry , Prostatism/etiology , Treatment Outcome , Urinary Bladder Neck Obstruction/etiology
16.
Urology ; 69(4): 697-702, 2007 Apr.
Article in English | MEDLINE | ID: mdl-17445654

ABSTRACT

OBJECTIVES: To determine whether disparities exist in the reporting of lower urinary tract symptoms (LUTS) in non-Hispanic white (NHW), Mexican-American (MA), and African-American (AA) men. METHODS: Data were collected from a prospective, community-based cohort assembled to study risk factors associated with prostate cancer. Measures included demographics, prostate-specific antigen (PSA), body mass index (BMI), and family history of prostate cancer. Lower urinary tract symptom severity was assessed in 2804 men (1485 NHW, 964 MA, 355 AA) without prostate cancer according to the American Urological Association Symptom Index. RESULTS: No significant difference (P = 0.998) was seen in the prevalence of moderate or severe LUTS in NHW (34%), MA (34%), and AA (33%) men. No differences were found in either obstructive or irritative symptoms among the three groups. Age, PSA level, BMI, and family history did not affect symptom severity. CONCLUSIONS: Rates of moderate to severe LUTS symptoms in this cohort were similar to those in other community-based populations of NHW men. Lower rates of moderate or severe symptoms were noted in AA men than previously reported. Mexican-American men had similar degrees of LUTS as the general population, and with their increased risk for diabetes and renal disease, in-depth study of this population is warranted.


Subject(s)
Black or African American , Mexican Americans , Prostatism/epidemiology , White People , Adult , Aged , Aged, 80 and over , Humans , Male , Middle Aged , Severity of Illness Index
17.
Medicina (Guayaquil) ; 6(3): 199-204, 2000.
Article in Spanish | LILACS | ID: lil-651952

ABSTRACT

Propósito: proponemos una prostatectomía extracapsular aplicando suturas transfictivas capsulares laterales después de la enucleación del adenoma con hemorragia operatoria mínima.Materiales y métodos: 117 pacientes con Hipertrofia Prostática fueron operados. Después de la adenomectomía se colocaron suturas transfictivas en el labio posterior del cuello vesical, en el borde superior de la cápsula prostática y a las 3 y a las 9 en la esfera del reloj de la cápsula prostática (hilios prostáticos). Varias variables indicadoras (hematócrito, hemoglobina, hemorragia intra-operatoria, hemorragia post-operatoria) cuantificaron la hemorragia atribuible a la prostatectomía.Resultados: la pérdida de sangre intra-operatoria promedio fue de 175cc con un descenso promedio del hematócrito y de la hemoglobina de 3.9 por ciento y 2g/dl respectivamente. La mayoría de los pacientes tuvieron escaso sangrado post-operatorio por las sondas uretral y suprapúbica.Conclusiones: la técnica hemostática propuesta, provocó mínima hemorragia operatoria debido al abordaje extracapsular minimizando la injuria quirúrgica a la ricamente vascularizada cápsula prostática y a la ligadura de los hilios prostáticos usando suturas transfictivas capsulares laterales después de la adenomectomía.


Purpose: We propose an extracapsular prostatectomy using lateral capsular transfictive sutures after the adenomectomy with little surgical hemorrhage.Materials and methods: 117 patients with Prostatic Hypertrophy were operated. Transfictive sutures were placed on the posterior edge of the vesical neck, on the superior border of the prostatic capsule and at 3 and 9 clockwise on the prostatic capsule (prostatic hilum) after the adenomectomy. Several indicators (hematocrit, hemoglobine, operatory hemorrhage, post-operatory hemorrhage) measured the surgical hemorrhage.Results: the operatory average blood loss was 175 mililiters with a hematocrit and hemoglobine average decrease of 3.9 percent and 2 g/dl respectively. Most of the patients had scarce post-operatory bleeding through the urethral and suprapubic catheters.Conclusions: the proposed hemostatic technique caused little operatory hemorrhage because of the extracapsular approach reducing the surgical injury to the extensively vascularized prostatic capsule and on account of the lateral capsular transfictive sutures placed on the prostatic hilium after the adenomectomy.


Subject(s)
Male , Middle Aged , Blood Loss, Surgical , Postoperative Hemorrhage , Prostatectomy , Prostatic Hyperplasia , Monitoring, Intraoperative , Prostatism
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