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1.
Int J Legal Med ; 135(3): 929-937, 2021 May.
Article in English | MEDLINE | ID: mdl-33025098

ABSTRACT

Age-at-death estimation methods are important in forensic anthropology. However, age assessment is problematic due to inter-individual variation. The subjectivity of visual scoring systems can affect the accuracy and reliability of methods as well. One of the most studied skeletal regions for age assessment is the pubic symphysis. Few studies on Spanish pubic symphysis collections have been conducted, making further research necessary as well as the sampling of more forensic skeletal collections. This study is a preliminary development of an age-at-death estimation method from the pubic symphysis based on a new simple scoring system. A documented late twentieth century skeletal collection (N = 29) and a twenty-first century forensic collection (N = 76) are used. Sixteen traits are evaluated, and a new trait (microgrooves) is described and evaluated for the first time in this study. All traits are scored in a binary manner (present or absent), thus reducing ambiguity and subjectivity. Several data sets are constructed based on different age intervals. Machine learning methods are employed to evaluate the scoring system's performance. The results show that microgrooves, macroporosity, beveling, lower extremity, ventral and dorsal margin decomposition, and lipping are the best preforming traits. The new microgroove trait proves to be a good age predictor. Reliable classification results are obtained for three age intervals (≤ 29, 30-69, ≥ 70). Older individuals are reliably classified with two age intervals (< 80, ≥ 80). The combination of binary attributes and machine learning algorithms is a promising tool for gaining objectivity in age-at-death assessment.


Subject(s)
Age Determination by Skeleton/methods , Forensic Anthropology/methods , Pubic Symphysis/anatomy & histology , Pubic Symphysis/physiology , Adult , Aged , Aged, 80 and over , Datasets as Topic , Decision Trees , Female , Humans , Machine Learning , Male , Middle Aged , Spain
2.
Sci Rep ; 10(1): 12403, 2020 07 24.
Article in English | MEDLINE | ID: mdl-32709949

ABSTRACT

In mouse pregnancy, pubic symphysis (PS) remodels into an elastic interpubic ligament (IpL) in a temporally regulated process to provide safe delivery. It restores at postpartum to assure reproductive tract homeostasis. Recently, macrophage localization in the IpL and dynamic changes in the expression of inflammatory mediators observed from the end of pregnancy (D18, D19) to early days postpartum (1dpp, 3dpp) highlighted the necessity of the identification of the key molecules involved in innate immune processes in PS remodeling. Therefore, this study uses morphological and high-sensitivity molecular techniques to identify both macrophage association with extracellular matrix (ECM) remodeling and the immunological processes involved in PS changes from D18 to 3dpp. Results showed macrophage association with active gelatinases and ECM components and 25 differentially expressed genes (DEGs) related to macrophage activities in interpubic tissues from D18 to 3dpp. Additionally, microarray and proteomic analysis showed a significant association of interpubic tissue DEGs with complement system activation and differentially expressed proteins (DEPs) with phagocytosis, highlighting the involvement of macrophage-related activities in mouse PS remodeling. Therefore, the findings suggest that PS ECM remodeling is associated with evidence of macrophage modulation that ensures both IpL relaxation and fast PS recovery postpartum for first labor.


Subject(s)
Bone Remodeling/immunology , Macrophages/cytology , Postpartum Period/physiology , Pubic Symphysis/physiology , Animals , Extracellular Matrix/metabolism , Female , Immunity, Innate , Mice , Postpartum Period/immunology , Pregnancy , Pubic Symphysis/cytology
3.
Int J Numer Method Biomed Eng ; 36(4): e3319, 2020 04.
Article in English | MEDLINE | ID: mdl-32017442

ABSTRACT

This study focuses on the influence of the softening and stiffening of pubic symphysis on the load distribution within the bones of the pelvic ring under the physiological loadings of the single leg stance. Muscle forces and joint reaction forces were first determined by inverse dynamics and applied to a linear finite element model of the pelvis. With normal pubic symphysis stiffness, high Von Mises stresses are located on the anterior surface to the sacrum around the sacroiliac joint and on the superior ramus, both on the side of the weight-bearing leg. Softening of the pubic symphysis redirects the load backward, decreases the stresses at the anterior pelvis, and increases them at the posterior pelvis. A stiffening of the pubic symphysis redirects the load forward, increases the load on the posterior pelvis, and decreases them at the anterior pelvis. This investigation highlights the significance of the pubic symphysis on the load distribution of the pelvis and in maintaining the integrity of the structures. Its role should not be neglected when analyzing the pelvis.


Subject(s)
Finite Element Analysis , Humans , Pelvis/physiology , Pubic Symphysis/physiology , Weight-Bearing/physiology
4.
Med Sci Sports Exerc ; 52(6): 1330-1337, 2020 06.
Article in English | MEDLINE | ID: mdl-31895302

ABSTRACT

PURPOSE: The sudden rise in the injury incidence during adolescence is also evident in soccer-related injuries to the groin. Submaximal passing applies high stress on the adductor muscles and pubic symphysis and is therefore likely to be connected to the occurrence of groin injuries. Therefore, the purpose of the study was to compare hip joint kinematics and adductor muscle forces of different adolescent age groups during submaximal soccer passing. METHODS: Sixty participants, in four groups, younger than 12, 15, 16. and 23 yr (U12, U15, U16, U23), were analyzed. A Footbonaut, equipped with a 3D motion capture system consisting of 16 cameras, was used to capture kinematic data of short passes. Inverse dynamic analysis was performed to calculate muscle forces of 10 passes of each subject. RESULTS: The U15 group showed reduced angular velocities. A rise in hip adductor muscle forces was evident from the youngest group up to the oldest groups. The largest increase (49%) was found between U12 and U15. Lower-limb mass was identified as the best predictor for the increasing adductor force. CONCLUSIONS: The reduced angular velocities of the U15 and the increase in muscle forces between all age groups were attributed to the increasing segment masses and length. This increases the moments of inertia of the leg segments thereby demanding higher forces to accelerate the segments. Most likely, the stress put upon the adductors apophyses increases during adolescence, as tendons are known to adapt slower than muscles, increasing the risk for overuse injuries. Coaches could use lower-limb mass as an indicator for fast increases in the force demand to identify players who would benefit from a reduced training volume.


Subject(s)
Adolescent Development/physiology , Groin/injuries , Hip Joint/physiology , Muscle, Skeletal/physiology , Soccer/injuries , Adolescent , Age Factors , Anthropometry , Biomechanical Phenomena , Child , Cross-Sectional Studies , Humans , Lower Extremity/anatomy & histology , Lower Extremity/growth & development , Male , Pubic Symphysis/physiology , Sprains and Strains/physiopathology , Time and Motion Studies , Young Adult
5.
Am J Obstet Gynecol ; 222(1): 3-16, 2020 01.
Article in English | MEDLINE | ID: mdl-31251927

ABSTRACT

Without cesarean delivery, obstructed labor can result in maternal and fetal injuries or even death given a disproportion in size between the fetus and the maternal birth canal. The precise frequency of obstructed labor is difficult to estimate because of the widespread use of cesarean delivery for indications other than proven cephalopelvic disproportion, but it has been estimated that at least 1 million mothers per year are affected by this disorder worldwide. Why is the fit between the fetus and the maternal pelvis so tight? Why did evolution not lead to a greater safety margin, as in other primates? Here we review current research and suggest new hypotheses on the evolution of human childbirth and pelvic morphology. In 1960, Washburn suggested that this obstetrical dilemma arose because the human pelvis is an evolutionary compromise between two functions, bipedal gait and childbirth. However, recent biomechanical and kinematic studies indicate that pelvic width does not considerably affect the efficiency of bipedal gait and thus is unlikely to have constrained the evolution of a wider birth canal. Instead, bipedalism may have primarily constrained the flexibility of the pubic symphysis during pregnancy, which opens much wider in most mammals with large fetuses than in humans. We argue that the birth canal is mainly constrained by the trade-off between 2 pregnancy-related functions: while a narrow pelvis is disadvantageous for childbirth, it offers better support for the weight exerted by the viscera and the large human fetus during the long gestation period. We discuss the implications of this hypothesis for understanding pelvic floor dysfunction. Furthermore, we propose that selection for a narrow pelvis has also acted in males because of the role of pelvic floor musculature in erectile function. Finally, we review the cliff-edge model of obstetric selection to explain why evolution cannot completely eliminate cephalopelvic disproportion. This model also predicts that the regular application of life-saving cesarean delivery has evolutionarily increased rates of cephalopelvic disproportion already. We address how evolutionary models contribute to understanding and decision making in obstetrics and gynecology as well as in devising health care policies.


Subject(s)
Biological Evolution , Cephalopelvic Disproportion/physiopathology , Gait/physiology , Parturition/physiology , Pelvic Bones/anatomy & histology , Animals , Cephalopelvic Disproportion/epidemiology , Cephalopelvic Disproportion/surgery , Cesarean Section , Female , Hominidae , Humans , Pelvic Bones/physiology , Pelvimetry , Pelvis/anatomy & histology , Pelvis/physiology , Pregnancy , Pubic Symphysis/anatomy & histology , Pubic Symphysis/physiology , Selection, Genetic
6.
Biol Reprod ; 101(2): 466-477, 2019 08 01.
Article in English | MEDLINE | ID: mdl-31201427

ABSTRACT

Appropriate remodeling of the female lower reproductive tract and pelvic floor is essential during normal mammalian pregnancy, labor, and postpartum recovery. During mouse pregnancy, in addition to reproductive tract modifications, the pubic symphysis (PS) is remodeled into a soft interpubic ligament (IpL) to provide safe delivery of the offspring and fast postpartum recovery. Although temporal changes in the phenotypes of myeloid cells, such as mononuclear phagocytes, are crucial to remodeling the lower reproductive tract organs in preparation for a safe delivery, little is known about the involvement of recruited monocytes or macrophages in mouse PS remodeling. We used combined light microscopy, electron microscopy, and qPCR analysis to investigate the profile of recruited monocytes and macrophage polarization markers in C57Bl6 mouse interpubic tissues during pregnancy (D12, D18, and D19) and early days postpartum (1 dpp and 3 dpp) to better identify their presence in proper remodeling of the mouse PS. Our morphological data show that the number of recruited monocytes is increased in interpubic tissues and that recruited monocytes differentiate into proinflammatory or anti-inflammatory macrophage phenotypes from D18 to 3 dpp, which may contribute to dynamic changes in the gene expression of specific inflammatory mediators involved in interpubic tissue remodeling at these time points. Therefore, our morphological and quantitative gene expression data suggest that both differentiated macrophages from recruited monocytes and polarized macrophages may collaborate for IpL relaxation at labor and the appropriate repair of the PS after the first pregnancy.


Subject(s)
Macrophages/physiology , Monocytes/physiology , Postpartum Period/physiology , Pubic Symphysis/physiology , Animals , Female , Ligaments/cytology , Mice , Pregnancy
7.
Clin Biomech (Bristol, Avon) ; 58: 69-73, 2018 10.
Article in English | MEDLINE | ID: mdl-30048857

ABSTRACT

BACKGROUND: Total hip arthroplasty is one of the most successful and cost effective procedures in orthopedics. The purpose of this study is to investigate force transmission through the sacroiliac joint as a possible source of post-operative pain after total hip arthroplasty through the following three questions: Does the ipsilateral sacroiliac joint, contralateral sacroiliac joint, or pubic symphysis experience more force during placement? Does the larger mallet used to seat the implant generate a higher force? Does the specimen's bone density or BMI alter force transmission? METHODS: A solid design acetabular component was impacted into five human cadaver pelves with intact soft tissues. The pressure at both sacroiliac joints and the pubic symphysis was measured during cup placement. This same procedure was replicated using an existing pelvis finite element model to use for comparison. FINDINGS: The location of the peak force for each hammer strike was found to be specimen specific. The finite model results indicated the ipsilateral sacroiliac joint had the highest pressure and strain followed by the pubic symphysis over the course of the full simulation. The heft of the mallet and bone mineral density did not predict force values or locations. The largest median force was generated in extremely obese specimens. INTERPRETATION: Contrary to previous ideas, it is highly unlikely that forces experienced at the pelvic joints are large enough to contribute post-operative pain during impaction of an acetabular component. These results indicate more force is conveyed to the pubic symphysis compared to the sacroiliac joints.


Subject(s)
Arthroplasty, Replacement, Hip/adverse effects , Pain, Postoperative/etiology , Pelvic Bones/physiology , Pubic Symphysis/physiology , Sacroiliac Joint/physiology , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip/methods , Cadaver , Female , Humans , Male , Pilot Projects , Rotation
8.
J Back Musculoskelet Rehabil ; 27(2): 147-52, 2014.
Article in English | MEDLINE | ID: mdl-23963270

ABSTRACT

BACKGROUND AND OBJECTIVES: Osteitis pubis refers to a painful, inflammatory condition involving the pubic bones, pubic symphysis, and adjacent structures. So, the aims of the study were to evaluate the strength of trunk muscles of soccer players suffering from osteitis pubis, and to compare the agonist/antagonist ratio of trunk muscles in osteitis pubis athletes with that of healthy athletes. MATERIALS AND METHODS: Twenty-five soccer male athletes with osteitis pubis, and 25 healthy soccer athletes. Peak torque/body weight (PT/BW) was recorded from trunk muscles during isokinetic concentric and eccentric contraction modes at a speed of 120°/s for healthy and osteitis pubis soccer players. RESULTS: There was a significant decrease in concentric contraction of back muscles in osteitis pubis group (p=0.01). A significant decrease in eccentric contraction of abdominal muscles was also recorded in osteitis pubis group (p=0.008). Concentric abdominal/back muscles ratio was significantly higher in osteitis pubis group (p=0.016), with no significant difference in eccentric abdominal/back muscles ratio between both groups (p>0.05). CONCLUSION: Osteitis pubis group displayed concentric weakness of back muscle and eccentric weakness of abdominal muscles that lead to disturbance of the normal concentric abdominal/back ratio.


Subject(s)
Abdominal Muscles/physiopathology , Athletes , Back Muscles/physiopathology , Muscle Weakness/physiopathology , Osteitis/physiopathology , Soccer/physiology , Adolescent , Athletic Injuries/diagnosis , Athletic Injuries/physiopathology , Biomechanical Phenomena , Humans , Male , Muscle Contraction/physiology , Muscle Weakness/complications , Osteitis/etiology , Pubic Bone/injuries , Pubic Bone/physiology , Pubic Symphysis/injuries , Pubic Symphysis/physiology , Torque , Torso/physiology , Young Adult
9.
J Biomech ; 47(2): 380-6, 2014 Jan 22.
Article in English | MEDLINE | ID: mdl-24290178

ABSTRACT

The dorsal component of the pelvic ring is considered to be the most essential element for the stability of the pelvic ring. None of the current biomechanical set-ups include the effect of shear stresses by alternating loads that the pelvic ring has to withstand during walking. We hypothesize that a biomechanical test set-up with two-leg alternate loading will lead to stress imitation at the pubic symphysis that are more similar to existing strains than other test set-ups, and would, therefore, be more adequate for biomechanical testing of fixation methods. A new biomechanical two-leg standing test set-up with an alternate pelvic loading was constructed and was validated with six human pelvises from fresh frozen cadavers. Three-dimensional motion tracking was performed. The specimens were subjected to a non-destructive quasi-static test and a non-destructive cyclic test with progressive load amplitude from 170 N to 340 N over 1000 cycles. The initial rotational 'range of motion' and 'mean displacement' around the vertical axis for a pre-load of 170 N was about 0.3° and 0.2°, respectively, increasing by 0.1-0.2° at a load of 340 N. The rotation around the vertical axis and the translation along the frontal horizontal axis confirmed the stability of the pubic symphysis. The rate of ascend of displacements decreased, once the rotation reached 1° or the translation reached 1mm. The current biomechanical test set-up was compared with previous clinical findings, and the method was found valid for measuring inter-segmentary movements at the pubic symphysis.


Subject(s)
Pelvic Bones/physiology , Pubic Symphysis/physiology , Aged , Aged, 80 and over , Biomechanical Phenomena , Female , Fracture Fixation, Internal , Humans , Leg/physiology , Male , Movement , Posture , Range of Motion, Articular/physiology , Rotation , Stress, Mechanical
10.
Clin Biomech (Bristol, Avon) ; 28(3): 262-7, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23312210

ABSTRACT

BACKGROUND: The transversus abdominis muscle is thought to exert a stiffening effect on the sacroiliac joints. However, it is unknown whether this muscle is capable of increasing pubic symphysis and innominate bone stiffness during load exerted on the pelvis. The objective of this study is to investigate whether in vitro simulated force of transversely oriented fibres of the transversus abdominis increases stiffness of the pubic symphysis and innominate bone. METHODS: In 15 embalmed specimens an incremental moment was applied in the sagittal plane to one innominate with respect to the fixated contralateral innominate. For pubic symphysis motion and innominate bone deformation load-deformation curves were plotted and slopes of adjusted linear regression lines were calculated. The slopes are considered to be a measure of pubic symphysis and innominate bone stiffness. Slopes were tested for significant differences before and after simulation of the transversus abdominis force. FINDINGS: Stiffness of pubic symphysis and innominate bone does not change under influence of simulated force of the transversus abdominis. For pubic symphysis, the slope of the regression line hardly changes, from 0.0341mm/Nm (SD 0.0277) before transversus abdominis force simulation to 0.0342mm/Nm (SD 0.0273) during simulation. For innominate bone, the mean slope increases minimally, from 0.0368mm/Nm (SD 0.0369) to 0.0413mm/Nm (SD 0.0395), respectively. INTERPRETATION: Simulation of the force of a single muscle - transversus abdominis - does not increase stiffness of the pubic symphysis and innominate bone. The hypothesized stiffening influence of the transversus abdominis on the pelvic ring was not confirmed in vitro.


Subject(s)
Abdominal Muscles/physiology , Pelvic Bones/physiology , Pelvis/physiology , Pubic Symphysis/physiology , Sacroiliac Joint/physiology , Aged , Elasticity , Female , Humans , Male , Models, Anatomic , Movement/physiology , Weight-Bearing/physiology
11.
Birth ; 38(1): 80-3, 2011 Mar.
Article in English | MEDLINE | ID: mdl-21332778

ABSTRACT

A Swiss study attempted to establish normal values for the uterine involution expected during the first 5 days postpartum. Two methods were used, apparently independently and without validation. One, named the finger method, consisted of estimating the height of the uterine fundus in finger breadths above or below the umbilicus. The other, the tape method, consisted of marking the distance between the uterine fundus and the pubic symphysis on a blank tape, which was subsequently read in centimeters against a measuring tape. The authors contend that normal uterine involution postpartum is governed by different factors according to whether it is measured by fingers or by tape. Thus, gestational age affected uterine involution when measured with fingers, but not when measured with a tape, whereas maternal age did the reverse. Apart from being based on a study population that defies any criteria of normality, a comparison of the results from finger and tape methods shows data that are incompatible with the anatomy of human fingers and the uterus postpartum. Yet, the authors suggest that these data should be used to differentiate electronically between normal and abnormal uterine involution, without considering what the consequences of such nonvalidated programming might be.


Subject(s)
Anthropometry/methods , Postnatal Care/methods , Postpartum Period/physiology , Pubic Symphysis/physiology , Uterus/physiology , Female , Gestational Age , Humans , Nursing Assessment/methods , Palpation/methods , Pregnancy , Reference Values
12.
Int J Gynaecol Obstet ; 110(3): 231-4, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20537328

ABSTRACT

OBJECTIVE: To compare the accuracy of the reported date of the last menstrual period (LMP) with that of symphysis-fundal height (SFH) in the estimation of gestational age (GA), using an ultrasound (US) scan as reference. METHODS: Gestational age was concurrently assessed by the 3 methods in this prospective, population-based, pregnancy-outcome study conducted in Hyderabad, Pakistan, from June 18, 2003, through August 31, 2005, with 1128 women between 20 and 26 weeks of a singleton pregnancy. RESULTS: The mean GA was less by ultrasound than by SFH measurement or the reported LMP, and the mean differences with the US result were statistically significant (P<0.001 for both). At delivery, about 75% of the GA values estimated by SFH measurement were within 7 days and almost 91% were within 14 days of the estimation by ultrasound, compared with 65% and 82% for the GA estimated by the reported LMP. Moreover, using the US as reference, the SFH correctly classified 84% of the term, 68% of the preterm, and 86% of the post-term deliveries (weighted kappa=0.58) compared with the corresponding 79%, 61%, and 55% predicted by the reported LMP (weighted kappa=0.44). CONCLUSION: The SFH measurement was found to be more accurate than the reported LMP as a tool to estimate GA and therefore date of delivery, but neither were as accurate as a US scan.


Subject(s)
Gestational Age , Pregnancy/physiology , Adult , Female , Humans , Menstrual Cycle , Pakistan , Pregnancy Trimester, Second , Prospective Studies , Pubic Symphysis/physiology , Ultrasonography, Prenatal , Urban Population , Young Adult
13.
J Perinat Med ; 38(2): 173-7, 2010 03.
Article in English | MEDLINE | ID: mdl-20121539

ABSTRACT

AIM: To measure puerperal symphysis fundus distance (SFD) by two manual methods and to calculate individual normal values. STUDY DESIGN: Prospective cohort study including women after single pregnancy without special problems in uterine involution. METHODS: SFD was daily measured on the 1(st)-5(th) postpartum days by counting the number of midwife's fingers put horizontally on the mother's abdomen and by a paper tape, respectively. Linear mixed model analysis was performed to determine SFD normal values. RESULTS: Independent variables determining the SFD on different days after delivery were the gestational age and the delivery mode (finger method) and the maternal age, body mass index (BMI), delivery mode and birth weight (tape method). Individual normal values were calculated by regression equation including the coefficients for the independent variables. CONCLUSION: Puerperal SFD values measured by tape have more independent variables than those measured by fingers and reflect better the actual situation of the patient. It should be verified whether values deviating from normal values of tape measurements may prevent postpartum complications.


Subject(s)
Anthropometry/methods , Pubic Symphysis/anatomy & histology , Uterus/anatomy & histology , Adult , Cohort Studies , Female , Humans , Infant, Newborn , Male , Postpartum Period , Pregnancy , Prospective Studies , Pubic Symphysis/physiology , Reference Values
14.
J Perinat Med ; 37(4): 370-3, 2009.
Article in English | MEDLINE | ID: mdl-19290847

ABSTRACT

We studied changes in the width of the symphysis pubis in 32 women examined serially by ultrasound during labor. Measurements were made at the superior border of the symphysis and at its narrowest breadth in the latent phase, the active phase, and the second stage of labor. There was a significant increase in the width of the symphysis between the first and second stages of labor at both measured levels. Widening was observed in 94% at the superior symphyseal breadth and in 59% at the narrowest. Of those cases in which the width of the symphysis increased, there was a large spectrum of change, ranging from 9 to 98% of the original width at the narrowest measurement site and from 2 to 139% at the superior breadth. There was a strong inverse correlation between maternal age and the degree of symphyseal widening in nulliparas, but not in multiparas. We conclude that labor is associated with a substantial widening of the symphysis pubis in most, but not all women.


Subject(s)
Labor, Obstetric/physiology , Pubic Symphysis/physiology , Adolescent , Adult , Female , Humans , Maternal Age , Pregnancy , Pubic Symphysis/diagnostic imaging , Ultrasonography , Young Adult
15.
J Bone Joint Surg Am ; 90(10): 2114-8, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18829908

ABSTRACT

BACKGROUND: Chronic pelvic instability is a relatively uncommon cause of pelvic and low-back pain. Patients present with feelings of instability and mechanical symptoms. Static radiographs are often inadequate to detect abnormal relative motion between the hemipelves consistent with chronic pelvic instability; dynamic views of the pelvis are required. We assessed the amount of physiologic motion present at the pubic symphysis in normal adult men and nulliparous and multiparous women with alternating-single-leg-stance radiographs. METHODS: Forty-five asymptomatic adult volunteers (fifteen in each group) were evaluated with a standing anteroposterior pelvic radiograph as well as with anteroposterior pelvic radiographs made with the subjects assuming both right and left single-leg stance. The subjects completed a questionnaire to determine their eligibility for participation in the study, and an examination was performed to exclude certain physical anomalies that might alter the radiographic findings. RESULTS: The mean total translation (and standard deviation) at the pubic symphysis, as measured by three blinded observers, was 1.4 +/- 1.0, 1.6 +/- 0.8, and 3.1 +/- 1.5 mm for the men, nulliparous women, and multiparous women, respectively. With the numbers available, we found no significant difference between the translation in the men and that in the nulliparous women (p = 0.63). The multiparous women had significantly more translation than did either the nulliparous women (p = 0.002) or the men (p = 0.0005). There was a significant positive association between the number of pregnancies and the total translation (p < 0.0001). CONCLUSIONS: The use of anteroposterior pelvic radiographs made with the subject alternating between right and left single-leg stance demonstrated, with high interobserver reliability, that multiparous women had a significantly different physiologic range of pubic translation as compared with men and nulliparous women. The ranges of physiologic motion at the pubic symphysis measured on the single-leg-stance radiographs in this study can be used to identify pathologic amounts of motion at this site. CLINICAL RELEVANCE: This investigation suggests that up to 5 mm of physiologic motion can occur at the pubic symphysis in asymptomatic individuals, as demonstrated by alternating-single-leg-stance radiographs.


Subject(s)
Joint Instability/diagnostic imaging , Posture/physiology , Pubic Symphysis/diagnostic imaging , Range of Motion, Articular/physiology , Adult , Female , Humans , Joint Instability/physiopathology , Male , Observer Variation , Parity , Pregnancy , Pubic Symphysis/physiology , Radiography , Reference Values , Reproducibility of Results , Sex Factors
16.
Microsc Res Tech ; 71(3): 169-78, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18044701

ABSTRACT

In some animals, such as mice and guinea pigs, a hormonally controlled mechanism increases the flexibility of the pubic symphysis and enhances the cervical remodeling necessary for safe delivery. Cervical ripening during pregnancy is associated with a paradoxical influx of leukocytes. However, the changes in cell metabolism during relaxation of the mouse pubic symphysis for delivery have not been extensively studied. In this work, we used light microscopy and transmission and scanning electron microcopy, as well as immunohistochemistry and Western blotting for MMP-8, to investigate the involvement of granulocytes or resident stromal cells in the relaxation of the virgin pubic symphysis during late pregnancy (days 18 and 19, before delivery) in vivo and in explanted joints. MMP-8 was studied because this collagenase is a hallmark for cervical ripening associated with the influx of granulocytes during late pregnancy. Extensive dissolution and disorganization of the extracellular matrix was seen around fibroblastic-like cells in late pregnancy. In contrast to the cervix (positive control), morphological and immunohistochemical analyses revealed that there was no characteristic cellular inflammatory response in the interpubic tissue. Staining for MMP-8 was observed in chondroid and fibroblastic-like cells of virgin and relaxed interpubic ligament, respectively. However, no granulocytes were seen during the extensive remodeling of the pubic joint in late pregnancy. These results indicate that constitutive stromal cells may have an important role in tissue relaxation during remodeling of the pubic symphysis in pregnancy.


Subject(s)
Granulocytes/ultrastructure , Pregnancy, Animal/physiology , Pubic Symphysis/physiology , Pubic Symphysis/ultrastructure , Animals , Blotting, Western , Female , Immunohistochemistry , Matrix Metalloproteinase 8/metabolism , Mice , Microscopy, Electron , Pregnancy , Pubic Symphysis/cytology
17.
Cell Tissue Res ; 330(1): 161-7, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17704950

ABSTRACT

Marked changes in mice pubic symphysis occur by the end of pregnancy. Tissue remodeling involves a dynamic balance between cell proliferation and programmed cell death as well as changes in the extracellular matrix components. Therefore, it is important to consider both of these cellular behaviors when investigating the mechanism that regulates interpubic tissue remodeling, growth during late pregnancy and partus ensuring involution during the postpartum period. Proliferating and programmed death cells were identified by immunohistochemistry (proliferating cell nuclear antigen and TUNEL detection, respectively) and the rates at which these processes occurred were determined by morphometric analysis. The results demonstrated that cellular proliferation was intense during the period of ligament formation, from D15 to D18, thereafter abruptly declining on D19. From parturition (D19) onwards, an ever-increasing decline in the cellular proliferation levels could be observed. The quantitative analyses of cellular death showed opposite results when compared to cellular proliferation. During early pregnancy the cycle of cellular renovation was clearly proliferative and during late mouse pregnancy the cycle was directed by programmed cellular death. Although the high levels of cellular death during postpartum involution could be shown by the TUNEL-positive cells, we were unable to observed picnotic nucleus at the light microscopy.


Subject(s)
Cell Death/physiology , Cell Division/physiology , Postpartum Period/physiology , Pubic Symphysis/cytology , Pubic Symphysis/physiology , Animals , Apoptosis/physiology , Female , In Situ Nick-End Labeling , Mice , Models, Animal , Pregnancy , Proliferating Cell Nuclear Antigen/analysis
18.
Spine (Phila Pa 1976) ; 32(15): E397-404, 2007 Jul 01.
Article in English | MEDLINE | ID: mdl-17621195

ABSTRACT

STUDY DESIGN: A descriptive study of the sacral anatomic orientation (SAO) and its association with pelvic incidence (PI). OBJECTIVE: To introduce the concept of SAO, establish a method for measuring it, and evaluate its association with pelvic orientation. SUMMARY OF BACKGROUND DATA: Pelvic orientation (PO) is considered a key factor in spinal shape and balance. Sacral slope (SS), PI, and pelvic tilt (PT) are the most frequently used parameters for evaluating PO. Nevertheless, the association between the anatomic orientation of the sacrum and these parameters has never been established. The aim of the present study is to define the anatomic orientation of the sacrum, to establish a reliable method for measuring it, and to examine its association with PI. METHODS: SAO was defined as the angle created between the intersection of a line running parallel to the superior endplate surface of the sacrum and a line running between the anterior superior iliac spine (ASIS) and the anterior-superior edge of the symphysis pubis. Methods for measuring SAO and PI on both skeletal populations and living individuals are described. The study was carried out on 424 skeletons (articulated pelves) using a three-dimensional digitizer and on 20 adult individuals using CT three-dimensional images (volume-rendering method). Reliability (intratester and intertester) was assessed using intraclass correlation test. A regression analysis was carried out to evaluate the association between the two measurements. RESULTS: The mean SAO and PI in the human skeletal population were found to be 48.46 degrees +/- 10.17 degrees and 54.08 degrees +/- 12.64 degrees , respectively and of the living individuals (CT) 52.76 degrees +/- 10.31 degrees and 57.14 degrees +/- 13.08 degrees , respectively. SAO and PI measurements were highly correlated (r = -0.824, and r = -0.828, P < 0.001 for skeletal material and living individuals, respectively). PI can be predicted via SAO, i.e., PI = [-0.971 x SAO] + 101.16 degrees . CONCLUSIONS: The newly suggested parameter (SAO) may be an important tool in defining the sagittal shape of the spine and understanding its association with spinal diseases.


Subject(s)
Pelvis/anatomy & histology , Sacrum/anatomy & histology , Adult , Anthropometry/methods , Female , Humans , Ilium/anatomy & histology , Ilium/diagnostic imaging , Ilium/physiology , Image Processing, Computer-Assisted , Ischium/anatomy & histology , Ischium/diagnostic imaging , Ischium/physiology , Male , Pelvis/diagnostic imaging , Pelvis/physiology , Pubic Bone/anatomy & histology , Pubic Bone/diagnostic imaging , Pubic Bone/physiology , Pubic Symphysis/anatomy & histology , Pubic Symphysis/diagnostic imaging , Pubic Symphysis/physiology , Reference Values , Sacroiliac Joint/anatomy & histology , Sacroiliac Joint/diagnostic imaging , Sacroiliac Joint/physiology , Sacrum/diagnostic imaging , Sacrum/physiology , Tomography, X-Ray Computed
19.
Rev. bras. ortop ; 36(11/12): 438-445, nov.-dez. 2001. ilus, tab
Article in Portuguese | LILACS | ID: lil-335075

ABSTRACT

Os autores estudaram os elementos anatômicos que compäem a articulação da sinfise pebica, salientando sua importancia na estabilidade estrutural e funcional. Realizaram tambem uma revisão critica da literatura pertinente. Foram estudadas 10 articulações de cadaveres a fresco, sendo realizada a dissecção pormenorizada de todos os elementos anatomicos, procurando salientar as estruturas de suporte ligamentar, m£sculos periarticulares, bem como a estrutura macroscopica do disco intra-articular. O estudo an tomo-funcional dessa articulação é essencial para o diagnostico e tratamento das sindromes dolorosas que ocorrem, principalmente, na pratica esportiva


Subject(s)
Humans , Male , Female , Athletic Injuries , Osteitis , Pubic Symphysis/anatomy & histology , Cadaver , Diagnosis, Differential , Pubic Symphysis/physiology
20.
Kinesiologia ; (58): 13-21, mar. 2000. ilus
Article in Spanish | LILACS | ID: lil-267637

ABSTRACT

El dolor lumbo pélvico es una de las patologías más frecuentes de consulta médica. Evidencia clínica importante señala que la articulación sacroilíaca es fuente de origen de dolor lumbar y de otras disfunciones de la cintura pélvica. El presente trabajo revisa la biomecánica funcional y los elementos anatómicos que participan en la estabilidad, tanto dinámica como estática de la cintura pélvica. Además se mencionan las estructuras pasivas y activas que intervienen en dicha estabilización. La evaluación de la cintura pélvica por medio de tests funcionales engloba a todas las articulaciones que la componen. Gran relevancia se da a las disfunciones que pueden emanar de las articulaciones sacroilíacas dado a que estas modifican los patrones biomecánicos de los segmentos supra e infrayacentes. Para que exista una mayor fiabilidad en la evaluación, se sugiere la aplicación de al menos cuatro tests para determinar el lado y tipo de disfunción


Subject(s)
Humans , Pelvis/physiology , Physical Fitness/physiology , Sacroiliac Joint/physiopathology , Low Back Pain/etiology , Physical Examination/methods , Physical Therapy Specialty , Sacrum/physiology , Pubic Symphysis/physiology
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