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1.
Eur Endod J ; 9(1): 35-43, 2024 01 01.
Article in English | MEDLINE | ID: mdl-38157279

ABSTRACT

OBJECTIVE: To evaluate the effect of diode laser (GaAlAs-980 nm) for full coronal pulpotomy (FCP) compared to conventional crown pulpotomy (CCP) in mature teeth with symptomatic irreversible pulpitis (SIP) and assess dentine bridge formation after FCP using CBCT. METHODS: A total of 86 patients (43 per group) with SIP in permanent mandibular molars were included. Access opening and FCP were done, after which haemostasis was achieved with 2.5% NaOCl in the CCP group and a diode laser (GaAlAs-980 nm) in the laser crown pulpotomy group (LCP). Biodentine (Septodont, Saint-Maur-des-Fossés, France) was placed, and the cavity was sealed. Clinical and radiographic follow-ups were done at 6, 12, and 18 months, with additional CBCT evaluation at 18 months. Statistical analysis was performed using the Mann-Whitney U test, and survival rates were assessed using Kaplan-Meier analysis. The Cox proportional model was used to determine the effect of possible covariates on pulpotomy outcomes. P<0.05 was considered to be statistically significant. RESULTS: The overall success rate for CCP and LCP at 18 months was 88.4% and 93% respectively. At the end of 18 months, 8 cases (5 in CCP, 3 in LCP) failed. The postoperative pain score at 48 hours was significantly higher for CCP (mean +- standard deviation: 1.7+-1.4; p<0.001). CBCT analysis at 18 months revealed thicker dentine bridge formation for LCP (Median & IQR: 0.89, 1.06) compared to CCP (p=0.0479). The Kaplan-Meier curve showed a more rapid decline in the survival rate of CCP (0.89) compared to that of LCP (0.93). Postoperative pain at 48 hours, PAI scores at 6, 12, 18 months, and age were found to affect the hazard ratio based on the Cox regression model. CONCLUSION: Within the limitations of this trial, there was no significant difference in the outcome between diode laser and conventional pulpotomy. However, LCP resulted in lesser postoperative pain at 48 hours and thicker dentine bridge formation at 18 months, with a longer estimated survival rate. (EEJ-2023-01-011).


Subject(s)
Pulpitis , Spiral Cone-Beam Computed Tomography , Humans , Pulpotomy/methods , Pulpitis/diagnostic imaging , Pulpitis/surgery , Follow-Up Studies , Lasers, Semiconductor/therapeutic use , Pain, Postoperative/prevention & control
2.
Oral Health Prev Dent ; 21(1): 357-364, 2023 Sep 27.
Article in English | MEDLINE | ID: mdl-37916546

ABSTRACT

PURPOSE: With success rates comparable to that of root canal treatment, vital pulp therapy (VPT) has gained clinical interest and has been used in the management of young permanent teeth with inflamed pulps. The aim of the present study was to retrospectively evaluate the radiographic success of VPT in young first permanent molars 24 months post-treatment and correlate findings with tooth and treatment-related characteristics. MATERIALS AND METHODS: Dental records of all patients with first permanent molars which received VPT in the Department of Paediatric Dentistry (National and Kapodistrian University of Athens) were retrieved. Demographic characteristics and data regarding the treatment performed were recorded. Patients' radiographs were evaluated at 6, 12 and 24 months post-treatment by two qualified paediatric dentists blinded regarding the treatment performed. Radiographic success, reasons for failure and continuation of root development were evaluated. Differences were tested using the Χ2 and Student's t-test, and possible correlations were determined by calculating the odds ratio. RESULTS: Overall radiographic success rate at 24 months was 77%, ranging between 50% for direct pulp capping and 92% for full pulpotomy. Differences were not statistically significant. Continuation of root development was recorded in almost 1/3 of the teeth and completion in almost 1/5. No statistically significant association was recorded between the outcome and any tooth and treatment-related variables. CONCLUSION: VPT seems to be a reliable option in the long term for the treatment of deep carious lesions in young permanent molars.


Subject(s)
Dental Caries , Pulpitis , Child , Humans , Retrospective Studies , Pulpitis/diagnostic imaging , Pulpitis/therapy , Pulpitis/pathology , Treatment Outcome , Dental Pulp Exposure/pathology , Dental Pulp Exposure/therapy , Molar/diagnostic imaging , Dental Caries/diagnostic imaging , Dental Caries/therapy , Dental Caries/pathology
3.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 41(2): 218-224, 2023 Apr 01.
Article in English, Chinese | MEDLINE | ID: mdl-37056189

ABSTRACT

OBJECTIVES: This study aims to predict the risk of deep caries exposure in radiographic images based on the convolutional neural network model, compare the prediction results of the network model with those of senior dentists, evaluate the performance of the model for teaching and training stomatological students and young dentists, and assist dentists to clarify treatment plans and conduct good doctor-patient communication before surgery. METHODS: A total of 206 cases of pulpitis caused by deep caries were selected from the Department of Stomatological Hospital of Tianjin Medical University from 2019 to 2022. According to the inclusion and exclusion criteria, 104 cases of pulpitis were exposed during the decaying preparation period and 102 cases of pulpitis were not exposed. The 206 radiographic images collected were randomly divided into three groups according to the proportion: 126 radiographic images in the training set, 40 radiographic images in the validation set, and 40 radiographic images in the test set. Three convolutional neural networks, visual geometry group network (VGG), residual network (ResNet), and dense convolutional network (DenseNet) were selected to analyze the rules of the radiographic images in the training set. The radiographic images of the validation set were used to adjust the super parameters of the network. Finally, 40 radiographic images of the test set were used to evaluate the performance of the three network models. A senior dentist specializing in dental pulp was selected to predict whether the deep caries of 40 radiographic images in the test set were exposed. The gold standard is whether the pulp is exposed after decaying the prepared hole during the clinical operation. The prediction effect of the three network models (VGG, ResNet, and DenseNet) and the senior dentist on the pulp exposure of 40 radiographic images in the test set were compared using receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1 score to select the best network model. RESULTS: The best network model was DenseNet model, with AUC of 0.97. The AUC values of the ResNet model, VGG model, and the senior dentist were 0.89, 0.78, and 0.87, respectively. Accuracy was not statistically different between the senior dentist (0.850) and the DenseNet model (0.850)(P>0.05). Kappa consistency test showed moderate reliability (Kappa=0.6>0.4, P<0.05). CONCLUSIONS: Among the three convolutional neural network models, the DenseNet model has the best predictive effect on whether deep caries are exposed in imaging. The predictive effect of this model is equivalent to the level of senior dentists specializing in dental pulp.


Subject(s)
Deep Learning , Pulpitis , Humans , Neural Networks, Computer , Pulpitis/diagnostic imaging , Reproducibility of Results , ROC Curve , Random Allocation
4.
Pediatr Dent ; 45(1): 46-52, 2023 Jan 15.
Article in English | MEDLINE | ID: mdl-36879376

ABSTRACT

PURPOSE: The purpose of this study was to assess the outcome of coronal pulpotomy using mineral trioxide aggregate (MTA) in mature and immature teeth with symptoms indicative of irreversible pulpitis. METHODS: Fifty permanent molars with symptomatic irreversible pulpitis were divided into two groups according to complete or incomplete radicular growth (25 teeth in each group). Coronal pulpotomy was performed with MTA. Clinical follow-up evaluations were scheduled at the third, sixth, ninth, 12th, 18th, and 24th months. Follow-up radiographs were taken at the sixth, 12th, 18th, and 24th months. Pain levels were scored preoperatively and two days post-treatment. RESULTS: At two years of recall, 10 patients were lost to follow-up and the success of molars with complete or incomplete radicular growth were 100 percent and 95 percent, respectively. All teeth with periapical rarefaction were present preoperatively and showed complete radiographic healing. Radiographic evidence of dentin bridge formation was discernable in 31 of 38 cases. CONCLUSIONS: Full coronal pulpotomy using mineral trioxide aggregate was successful in controlling pain and any infections after two years in 39 of 40 teeth regardless of whether they had immature or mature roots.


Subject(s)
Pulpitis , Humans , Pulpitis/diagnostic imaging , Pulpitis/surgery , Pulpotomy , Molar/diagnostic imaging , Mental Recall , Pain
5.
Indian J Dent Res ; 34(4): 405-409, 2023 Oct 01.
Article in English | MEDLINE | ID: mdl-38739821

ABSTRACT

AIM: To estimate the working length of teeth using conventional tactile technique, radiovisiography technique, Apex locator, and confirmation of working length by cone beam computed tomography technique. MATERIALS AND METHODS: Forty patients with the age group between 20 and 50 years with irreversible pulpitis were included in this study. After taking a preoperative radiograph, the procedure was started. The cavity wall buildup was done using composite in the cases needed and then rubber dam application was done. The working length of mesiobuccal and mesiolingual canal was taken using cone beam computed tomography and this was considered as the standard value. Then using tactile method, length of the canal was measured using radiovisiographic software followed by apexlocator. RESULT: The Apex locator has showed best result as compared to tactile and radiovisiography. CONCLUSION: Apex locator values were closest to cone beam computed tomography working length measurement values and electronic apexlocator can be used efficiently as an alternative method for working length determination. The quality of various techniques according to ranks of working length determination was found to be Cone beam computed tomography (CBCT) > Apexloc > Radiovisiography (RVG) > Tactile. Thus, Apex locator can be used as an alternative to cone beam computed tomography for working length determination.


Subject(s)
Cone-Beam Computed Tomography , Humans , Cone-Beam Computed Tomography/methods , Adult , Middle Aged , Young Adult , Female , Male , Dental Pulp Cavity/diagnostic imaging , Dental Pulp Cavity/anatomy & histology , Odontometry/methods , Odontometry/instrumentation , Pulpitis/diagnostic imaging , Tooth Apex/diagnostic imaging , Tooth Apex/anatomy & histology
6.
Article in English | WPRIM (Western Pacific) | ID: wpr-981115

ABSTRACT

OBJECTIVES@#This study aims to predict the risk of deep caries exposure in radiographic images based on the convolutional neural network model, compare the prediction results of the network model with those of senior dentists, evaluate the performance of the model for teaching and training stomatological students and young dentists, and assist dentists to clarify treatment plans and conduct good doctor-patient communication before surgery.@*METHODS@#A total of 206 cases of pulpitis caused by deep caries were selected from the Department of Stomatological Hospital of Tianjin Medical University from 2019 to 2022. According to the inclusion and exclusion criteria, 104 cases of pulpitis were exposed during the decaying preparation period and 102 cases of pulpitis were not exposed. The 206 radiographic images collected were randomly divided into three groups according to the proportion: 126 radiographic images in the training set, 40 radiographic images in the validation set, and 40 radiographic images in the test set. Three convolutional neural networks, visual geometry group network (VGG), residual network (ResNet), and dense convolutional network (DenseNet) were selected to analyze the rules of the radiographic images in the training set. The radiographic images of the validation set were used to adjust the super parameters of the network. Finally, 40 radiographic images of the test set were used to evaluate the performance of the three network models. A senior dentist specializing in dental pulp was selected to predict whether the deep caries of 40 radiographic images in the test set were exposed. The gold standard is whether the pulp is exposed after decaying the prepared hole during the clinical operation. The prediction effect of the three network models (VGG, ResNet, and DenseNet) and the senior dentist on the pulp exposure of 40 radiographic images in the test set were compared using receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1 score to select the best network model.@*RESULTS@#The best network model was DenseNet model, with AUC of 0.97. The AUC values of the ResNet model, VGG model, and the senior dentist were 0.89, 0.78, and 0.87, respectively. Accuracy was not statistically different between the senior dentist (0.850) and the DenseNet model (0.850)(P>0.05). Kappa consistency test showed moderate reliability (Kappa=0.6>0.4, P<0.05).@*CONCLUSIONS@#Among the three convolutional neural network models, the DenseNet model has the best predictive effect on whether deep caries are exposed in imaging. The predictive effect of this model is equivalent to the level of senior dentists specializing in dental pulp.


Subject(s)
Humans , Deep Learning , Neural Networks, Computer , Pulpitis/diagnostic imaging , Reproducibility of Results , ROC Curve , Random Allocation
7.
Sci Rep ; 12(1): 20280, 2022 11 24.
Article in English | MEDLINE | ID: mdl-36434032

ABSTRACT

This study aimed to investigate the factors affecting the success rate of full pulpotomy in permanent posterior teeth with pulpitis. The study included 105 permanent posterior teeth clinically diagnosed as reversible or irreversible pulpitis in 92 patients aged 18-82 years. All teeth underwent a full pulpotomy using mineral trioxide aggregate as a capping material and were recalled for clinical and radiographic evaluation at 3, 6, 12, and 24 months postoperatively. The overall success rate after the 12-month review was above 90%, and failed cases mainly occurred during the first 12 months after treatment. In this study, the treatment outcome of pulpotomy was not related to sex, or tooth position and the cause of pulpitis. To analyze the influence of age on the treatment outcome, all the teeth were allocated to three groups: group 1 (18-39 years); group 2 (40-59 years); and group 3 (≥ 60 years). A significant difference in success rate was found between groups 1 and 3 (P = 0.014). These results suggest that pulpotomy can be used as an alternative treatment for permanent mature teeth diagnosed with pulpitis and that aging is one factor affecting the treatment outcome.


Subject(s)
Pulpitis , Humans , Pulpitis/diagnostic imaging , Pulpitis/surgery , Pulpotomy/methods , Dentition, Permanent , Treatment Outcome
8.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 57(3): 287-291, 2022 Mar 09.
Article in Chinese | MEDLINE | ID: mdl-35280007

ABSTRACT

To assess the treatment effectiveness of vital inflamed pulp therapy (VIPT) in immature permanent teeth with irreversible pulpitis and apical periodontitis. The faculty members in the Department of Pediatric Dentistry, the Ninth People's Hospital were invited to submit consecutive VIPT cases from June 2015 to June 2016 (follow-up periods>12 months). The cases were retrospectively reviewed, clinical symptoms and radiographic changes in periapical radiolucency were evaluated, meanwhile, the data of radiographic changes such as apical diameter and root length were calculated and analyzed with ANOVA. Totally thirteen submitted patients/cases were included (6 males and 7 females) in the present study,. The average age of patients was (9.9±1.4) years old. The average follow-up time was (26.5±6.8) months (17-37 months). At the 12-month visit, all 13 treated teeth survived, 9 out of 11 teeth with apical periodontitis showed normal radiographic manifestation. At the 3, 6 and 12 months visits, the within-case percentage changes in apical diameter were (8.0±5.1)%, (24.1±9.1)% and (70.3±10.7)%, respectively, while the within-case percentage changes in root length were (11.4±9.8)%, (14.5±9.8)% and (27.4±14.2)%, respectively. There were statistically significant differences in the changes of apical diameter (F=18.80, P<0.001) and root length (F=4.64, P=0.047) from the preoperative time to the postoperative follow-ups. VIPT might improve clinical outcomes, even achieve continued root development. VIPT can be an option in treating immature teeth with irreversible pulpitis and apical periodontitis.


Subject(s)
Periapical Periodontitis , Pulpitis , Child , Dentition, Permanent , Female , Humans , Male , Periapical Periodontitis/diagnostic imaging , Periapical Periodontitis/therapy , Pulpitis/diagnostic imaging , Pulpitis/therapy , Retrospective Studies , Root Canal Therapy
9.
Cient. dent. (Ed. impr.) ; 18(2): 119-125, abr. 2021. ilus, tab
Article in Spanish | IBECS | ID: ibc-216978

ABSTRACT

La pulpotomía total o parcial es una opción terapéutica conservadora para los dientes permanentes con ápice cerrado con signos y síntomas de pulpitis irreversible. Permite preservar los mecanismos de defensa inmune y el potencial regenerativo del tejido pulpar sano remanente, mantiene la integridad estructural del diente y disminuye las complicaciones asociadas al tratamiento de conductos.En el presente caso clínico se describe el tratamiento de un 3.7 con diagnóstico de pulpitis irreversible y periodontitis apical sintomática en el que se llevó a cabo una pulpotomía parcial con Biodentine® (Septodont, Sant-Maur-des-Fossés, Francia) durante las prácticas clínicas del Máster de Odontología Restauradora Estética y Endodoncia de la Universidad Rey Juan Carlos. Se presenta el seguimiento a 18 meses. (AU)


Complete or partial pulpotomy is a conservative therapeutic option for permanent teeth with closed apex with signs and symptoms of irreversible pulpitis. It preserves the immune defence mechanisms and regenerative potential of the remaining healthy pulp tissue, maintains the structural integrity of the tooth and reduces complications associated with root canal treatment.This case report describes the treatment of a 3.7 with a diagnosis of irreversible pulpitis and symptomatic apical periodontitis in which a partial pulpotomy was performed with Biodentine® (Septodont, Sant-Maur-des-Fossés, France) during the clinical practice of the Master’s Degree in Aesthetic Restorative Dentistry and Endodontics at the Rey Juan Carlos University. The 18-month follow-up is presented. (AU)


Subject(s)
Humans , Male , Middle Aged , Pulpotomy , Pulpitis/drug therapy , Pulpitis/diagnostic imaging , Dentition, Permanent
10.
Eur J Clin Invest ; 51(4): e13437, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33089506

ABSTRACT

BACKGROUND: Rheumatoid arthritis (RA) is associated with increased risk of infections. Screening for oral (dental and/or sinus) infection could be proposed before biologic disease-modifying antirheumatic drugs (bDMARDs) initiation but is not systematically recommended. The aim of our study was to assess the prevalence of oral infection in RA patients requiring bDMARDs. MATERIALS AND METHODS: This was a monocentric retrospective study. We included patients with RA and active disease requiring bDMARDs. Dental infection and sinusitis were assessed by a stomatologist and otorhinolaryngologist after clinical, panoramic dental X-ray and sinus CT evaluation. Factors associated with oral infections were analysed in uni- and multivariate models, estimating odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: We included 223 RA patients (79.4% women, mean disease duration 8.9 ± 8.6 years). The mean age was 54.4 ± 10.9 years and mean Disease Activity Score in 28 joints 5.5 ± 2.6. Systematic dental screening revealed infection requiring treatment before bDMARDs initiation in 46 (20.9%) patients. Sinusitis was diagnosed by the otorhinolaryngologist in 33 (14.8%) patients. Among the 223 patients, 69 (30.9%) had dental and/or sinus infection. On univariate analysis, active smoking was associated with increased probability of oral infection (OR = 2.16 [95% CI 1.02-4.57], P = .038) and methotrexate with reduced probability (OR = 0.43 [95% CI 0.23-0.81], P = .006). On multivariate analysis, no RA variables were associated with oral infection. CONCLUSION: In our study, asymptomatic oral infection was confirmed in one third of RA patients.


Subject(s)
Antirheumatic Agents/therapeutic use , Arthritis, Rheumatoid/drug therapy , Biological Products/therapeutic use , Dental Caries/diagnostic imaging , Focal Infection, Dental/diagnostic imaging , Pulpitis/diagnostic imaging , Sinusitis/diagnostic imaging , Adult , Aged , Arthritis, Rheumatoid/epidemiology , Dental Caries/diagnosis , Dental Caries/epidemiology , Dental Caries/therapy , Female , Focal Infection, Dental/diagnosis , Focal Infection, Dental/epidemiology , Humans , Male , Mass Screening , Middle Aged , Pulpitis/diagnosis , Pulpitis/epidemiology , Pulpitis/therapy , Radiography, Panoramic , Retrospective Studies , Severity of Illness Index , Sinusitis/diagnosis , Sinusitis/epidemiology , Sinusitis/therapy , Smoking/epidemiology , Tomography, X-Ray Computed
11.
J Endod ; 46(10): 1522-1529, 2020 Oct.
Article in English | MEDLINE | ID: mdl-32668311

ABSTRACT

This article reports on an unusual case of dens invaginatus in a maxillary third molar that was causing severe symptoms of irreversible pulpitis. This malformation was not clinically or radiographically identified, and the occurrence of referred pain made the early identification of the responsible tooth difficult. Determination of the tooth that was the source of symptoms was only possible after an observation period and fast aggravation of the pathologic process to cause pulp necrosis and extreme tenderness to percussion. The diagnosis of dens invaginatus was made only after extraction and sectioning. Histopathologic and histobacteriologic features of this case are illustrated.


Subject(s)
Dens in Dente/complications , Dens in Dente/diagnostic imaging , Dens in Dente/diagnosis , Pulpitis/complications , Pulpitis/diagnostic imaging , Pulpitis/diagnosis , Dental Pulp , Dental Pulp Necrosis/complications , Dental Pulp Necrosis/diagnosis , Dental Pulp Necrosis/diagnostic imaging , Humans , Incisor
12.
Braz Oral Res ; 33: e002, 2019 Feb 11.
Article in English | MEDLINE | ID: mdl-30758402

ABSTRACT

This study evaluated clinical and radiographic twelve-month outcomes of root canal treatments (CT) with smear layer removal, performed in primary teeth, using two different root canal filling materials. Pulpectomy was performed on 27 primary teeth with necrosis or irreversible pulpitis, caused by dental caries or trauma, in 23 children (2-7 years old). A single trained operator performed the CT in a single visit in cases without periapical or interradicular radiolucency (PIR) or in multiple visits in cases with PIR. Participants were selected based on specific inclusion and exclusion criteria, and randomly allocated into two groups: Group 1 (G1) - iodoform paste (iodoform + camphorated parachlorophenol + ointment comprising prednisolone acetate 5.0 mg and rifamycin 1.5 mg); Group 2 (G2) - Calen®/ZO paste. Treated teeth were restored with composite resin immediately after the root canal filling. The outcomes were evaluated clinically and radiographically according to specific criteria. Two blinded and standardized evaluators assessed the radiographic outcomes. We used descriptive analyses due to the small sample size. CTs were performed due to caries lesions in 70.4% of the cases and due to trauma in 29.6%. Only one tooth of G1 was unsuccessful; hence, pulpectomy performance in both groups was not influenced by the filling material, nor by any other analyzed variable. The level of the root canal filling was better in the Calen®/ZO group. The clinical and radiographic twelve-month outcomes indicated successful treatment, independently of the root filling material used.


Subject(s)
Calcium Hydroxide/therapeutic use , Hydrocarbons, Iodinated/therapeutic use , Pulpectomy/methods , Root Canal Filling Materials/therapeutic use , Root Canal Therapy/methods , Zinc Oxide/therapeutic use , Child , Child, Preschool , Dental Caries/diagnostic imaging , Dental Caries/therapy , Female , Humans , Male , Ointments , Pulpitis/diagnostic imaging , Pulpitis/therapy , Radiography, Dental , Reproducibility of Results , Smear Layer/surgery , Tooth Injuries/diagnostic imaging , Tooth Injuries/therapy , Tooth, Deciduous , Treatment Outcome
13.
Braz. oral res. (Online) ; 33: e002, 2019. tab, graf
Article in English | LILACS | ID: biblio-989476

ABSTRACT

Abstract This study evaluated clinical and radiographic twelve-month outcomes of root canal treatments (CT) with smear layer removal, performed in primary teeth, using two different root canal filling materials. Pulpectomy was performed on 27 primary teeth with necrosis or irreversible pulpitis, caused by dental caries or trauma, in 23 children (2-7 years old). A single trained operator performed the CT in a single visit in cases without periapical or interradicular radiolucency (PIR) or in multiple visits in cases with PIR. Participants were selected based on specific inclusion and exclusion criteria, and randomly allocated into two groups: Group 1 (G1) - iodoform paste (iodoform + camphorated parachlorophenol + ointment comprising prednisolone acetate 5.0 mg and rifamycin 1.5 mg); Group 2 (G2) - Calen®/ZO paste. Treated teeth were restored with composite resin immediately after the root canal filling. The outcomes were evaluated clinically and radiographically according to specific criteria. Two blinded and standardized evaluators assessed the radiographic outcomes. We used descriptive analyses due to the small sample size. CTs were performed due to caries lesions in 70.4% of the cases and due to trauma in 29.6%. Only one tooth of G1 was unsuccessful; hence, pulpectomy performance in both groups was not influenced by the filling material, nor by any other analyzed variable. The level of the root canal filling was better in the Calen®/ZO group. The clinical and radiographic twelve-month outcomes indicated successful treatment, independently of the root filling material used.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Pulpectomy/methods , Root Canal Filling Materials/therapeutic use , Root Canal Therapy/methods , Zinc Oxide/therapeutic use , Calcium Hydroxide/therapeutic use , Hydrocarbons, Iodinated/therapeutic use , Ointments , Pulpitis/therapy , Pulpitis/diagnostic imaging , Tooth, Deciduous , Radiography, Dental , Reproducibility of Results , Treatment Outcome , Smear Layer/surgery , Tooth Injuries/therapy , Tooth Injuries/diagnostic imaging , Dental Caries/therapy , Dental Caries/diagnostic imaging
14.
PLoS One ; 13(10): e0205534, 2018.
Article in English | MEDLINE | ID: mdl-30308037

ABSTRACT

Successful disinfection alongside complete endodontic tissue regeneration and revascularization are the most desired clinical outcomes of regenerative endodontics. Despite reported clinical successes, significant limitations to the current regenerative endodontic procedure (REP) have been elucidated. To improve the current REP, an antibiotics and nitric oxide (NO) releasing biomimetic nanomatrix gel was developed. The study evaluates antibacterial effects of an antibiotics and NO releasing biomimetic nanomatrix gel on multispecies endodontic bacteria. Antibiotics, ciprofloxacin (CF) and metronidazole (MN) were mixed and encapsulated within the NO releasing biomimetic nanomatrix gel. The gel was synthesized and self-assembled from peptide amphiphiles containing various functional groups. Antibacterial effects of the antibiotics and NO releasing biomimetic nanomatrix gel were evaluated using bacterial viability assays involving endodontic microorganisms including clinical samples. Pulp-dentin regeneration was evaluated via animal-model experiments. The antibiotics and NO releasing biomimetic nanomatrix gel demonstrated a concentration dependent antibacterial effect. In addition, NO alone demonstrated a concentration dependent antibacterial effect on endodontic microorganism. An in vivo analysis demonstrated the antibiotics and NO releasing biomimetic nanomatrix gel promoted tooth revascularization with maturation of root canals. An optimal concentration of and NO releasing nanomatrix gel is suggested for its potential as a root treatment material for REP and an appropriate protocol for human trials. Further investigation is required to obtain a larger sample size and decide upon ideal growth factor incorporation.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Dental Pulp/drug effects , Dentin/drug effects , Gels , Nitric Oxide/administration & dosage , Regeneration/drug effects , Animals , Biofilms/drug effects , Biomimetic Materials/chemical synthesis , Dental Pulp/diagnostic imaging , Dental Pulp/pathology , Dental Pulp/physiopathology , Dentin/diagnostic imaging , Dentin/pathology , Dentin/physiopathology , Dogs , Drug Delivery Systems , Enterococcus faecalis/drug effects , Enterococcus faecalis/physiology , Gels/chemical synthesis , Gram-Positive Bacterial Infections/diagnostic imaging , Gram-Positive Bacterial Infections/drug therapy , Gram-Positive Bacterial Infections/pathology , Gram-Positive Bacterial Infections/physiopathology , Humans , Nanostructures , Neovascularization, Physiologic/drug effects , Neovascularization, Physiologic/physiology , Pilot Projects , Pulpitis/diagnostic imaging , Pulpitis/drug therapy , Pulpitis/pathology , Pulpitis/physiopathology , Regeneration/physiology , Treponema denticola/drug effects , Treponema denticola/physiology
15.
J Indian Soc Pedod Prev Dent ; 36(2): 173-180, 2018.
Article in English | MEDLINE | ID: mdl-29970635

ABSTRACT

CONTEXT: Despite modern advancement in material and technical aspect, management of infected primary molars is of prime concern in pediatric endodontics. An effective root canal material plays the major role in achieving the fluid impervious seal by defending against variant microflora and maintaining the tooth in function for longer duration. AIMS: This study aims to evaluate and compare the success of endoflas as root canal filling material in infected primary molars with zinc oxide eugenol (ZOE). MATERIALS AND METHODS: Primary molars with necrotic pulp in healthy, cooperative children were selected. Ethical clearance and informed consent was obtained. Standardized pulpectomy procedure was done and root canals were filled with either ZOE or endoflas. Further follow-up with clinical and radiographic evaluation was carried at 0, 3, 6, 12, and 24 months. The findings obtained were statistically analyzed using Chi-square test. RESULTS: Endoflas showed acceptable results as root canal filling material in primary molars even at 2-year follow-up, though overfilling of root canals led to low success rate compared to teeth with combined optimal and under fillings. There was no significant difference between the two materials (P > 0.05). CONCLUSIONS: Endoflas could be a potential alternative to ZOE for preserving infected primary molars.


Subject(s)
Anti-Infective Agents/therapeutic use , Barium Sulfate/therapeutic use , Dental Pulp Necrosis/prevention & control , Eugenol/therapeutic use , Hydrocarbons, Iodinated/therapeutic use , Pulpectomy/methods , Pulpitis/prevention & control , Root Canal Filling Materials/therapeutic use , Zinc Oxide-Eugenol Cement/therapeutic use , Child , Child, Preschool , Dental Pulp Necrosis/diagnostic imaging , Drug Combinations , Humans , Infection Control , Molar/diagnostic imaging , Pulpitis/diagnostic imaging , Tooth, Deciduous/diagnostic imaging
16.
Shanghai Kou Qiang Yi Xue ; 27(1): 73-78, 2018 Feb.
Article in Chinese | MEDLINE | ID: mdl-29946647

ABSTRACT

PURPOSE: The present study was aimed to clinically evaluate transitional treatment of pulpitis during pregnancy. METHODS: Sixty pregnant women with pulpitis were divided into the first, second and third trimester. They were anesthetized locally using STA system combined with psychological intervention during treatment. The teeth were given one-appointment root canal preparation and filled with vitapex pasta. Normal obturation of the root canal was conducted after delivery. The effects of dental treatment, pregnancy outcomes and neonatal health status were observed. Data of the survey were analyzed by SPSS 20.0 software package, including Student's t test and chi-square test. RESULTS: The symptoms of pulpitis were significantly improved 24h after treatment,and the effective rate was 96.7%. The difference of VAS before and after treatment was statistically significant (P<0.05). Patients had no discomfort till the end of pregnancy,and the success rate was 98.3%. No adverse pregnancy outcomes were observed after treatment during different periods of pregnancy. Neonatal health was good. Significant differences were not found in birth gestational age, body weight, malformations, and neonatal complications between three treatment periods (P>0.05). CONCLUSIONS: Transitional treatment of pulpitis during pregnancy is a safe and effective procedure and worthy of wide use clinically.


Subject(s)
Elasticity Imaging Techniques , Pregnancy Complications , Pulpitis , Sjogren's Syndrome , Female , Humans , Pregnancy , Pregnancy Complications/diagnostic imaging , Pulpitis/diagnostic imaging , Salivary Glands/diagnostic imaging , Sjogren's Syndrome/diagnostic imaging , Ultrasonics
17.
J Contemp Dent Pract ; 19(2): 233-236, 2018 Feb 01.
Article in English | MEDLINE | ID: mdl-29422476

ABSTRACT

BACKGROUND: Root canal anatomy is a complex entity. The main objective of root canal treatment is to get rid of the infection and have a good apical and coronal seal with an appropriate filling. Inability to achieve thorough cleaning and shaping followed by three-dimensional obturation of the root canal system usually causes root canal treatment failure. For this reason, clinicians should be aware of these anatomical variations to achieve successful treatment. AIM: The aim of this article is to report on the successful treatment and follow-up of mandibular first molar with additional middle mesial (MM) and middle distal (MD) canals. CASE REPORT: A 29-year-old white male patient reported with a complaint of pain in relation with tooth #19. On clinical examination, diagnosis of symptomatic irreversible pulpitis with symptomatic apical periodontitis and condensing osteitis was made and nonsurgical root canal treatment was planned. Initially, two mesial and two distal canals were located, and the patient was planned for the obturation in the second visit. The complaint of mild persistent symptoms gave a possibility of additional canals. Under the dental operating microscope and selective troughing on the floor of the pulp chamber with ultrasonic tips, additional canals were located as MM and MD canals. CONCLUSION: Leaving some area of the root canal system untreated is found to be one of the main reasons for root canal treatment failure. Dentists should take advantage of new tools, such as dental operating microscope and ultrasonic tips to be able to locate and treat the hidden and unusual anatomy. CLINICAL SIGNIFICANCE: Mandibular first molar with six canals is very rare to encounter. Clinician should have a thorough knowledge of these unusual anatomy to avoid treatment failure due to incomplete disinfection of the root canal system.


Subject(s)
Dental Pulp Cavity/anatomy & histology , Dental Pulp Cavity/surgery , Molar/anatomy & histology , Molar/surgery , Pulpitis/surgery , Root Canal Therapy/methods , Adult , Dental Pulp Cavity/diagnostic imaging , Humans , Male , Mandible , Molar/diagnostic imaging , Pulpitis/diagnostic imaging
19.
J Indian Soc Pedod Prev Dent ; 35(4): 327-331, 2017.
Article in English | MEDLINE | ID: mdl-28914245

ABSTRACT

INTRODUCTION: Pulpotomy technique is most widely accepted clinical procedure for treating primary teeth with coronal pulp inflammation caused by caries with no involvement of the radicular pulp. AIM AND OBJECTIVE: The aim of the study was to evaluate the success and efficacy of mineral trioxide aggregate (MTA) and antioxidant mix as pulpotomy agents both clinically and radiographically. MATERIALS AND METHODS: A total of forty primary molars in children aged between 6 and 9 years, requiring for pulpotomy procedures, were selected. Random samples distribution was done, antioxidant mix (n = 20) and MTA (n = 20) both were used as pulpotomy agent. Under rubber dam isolation, pulpotomy procedure was performed in all samples followed by restoration with stainless steel crowns. Later, the patients were recalled after 6 and 12 months for clinical and radiographic evaluation. The data were evaluated using Fisher's exact test. RESULTS: Statistically analysis shows no significant difference between the two groups (P > 0.05) with respect to clinical and radiographic success rate, but antioxidant mix showed more efficient result than MTA. CONCLUSION: Antioxidant mix pulpotomy is more biocompatible and cost effective than any other commercially available medicament.


Subject(s)
Aluminum Compounds/therapeutic use , Antioxidants/therapeutic use , Calcium Compounds/therapeutic use , Oxides/therapeutic use , Pulpitis/drug therapy , Pulpotomy , Silicates/therapeutic use , Child , Child, Preschool , Drug Combinations , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Male , Molar , Prospective Studies , Pulpitis/diagnostic imaging , Pulpotomy/methods , Remission Induction , Time Factors , Tooth, Deciduous
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