Subject(s)
Cystitis/therapy , Drainage/adverse effects , Granulomatous Disease, Chronic/therapy , Pyelitis/therapy , Sepsis/etiology , Stents/adverse effects , Anti-Bacterial Agents/therapeutic use , Cystitis/complications , Cystitis/diagnosis , Follow-Up Studies , Granulomatous Disease, Chronic/complications , Granulomatous Disease, Chronic/diagnosis , Humans , Male , Middle Aged , Pyelitis/etiology , Pyelitis/physiopathology , Risk Assessment , Sepsis/drug therapy , Sepsis/physiopathology , Severity of Illness Index , Treatment Outcome , Ultrasonography , Urethral Stricture/diagnostic imaging , Urethral Stricture/therapyABSTRACT
The study was made of the action of electromagnetic decimetric waves (DMW) of mild and strong heat power and placebo on intraorganic circulation using functional polyrheography and morphological examination of the kidneys with infectious-inflammatory process. DMW of the above power have a marked hemodynamic action via stimulation of the circulation of the intermediary zone with an effect of redistribution of the intrarenal blood flow. Weak heat DMW in experimental pyelonephritis exhibit a distinct antiinflammatory effect while strong DMW impact aggravates vascular reaction associated with inflammation. This deteriorates the inflammation and gives rise to hyperimmune reactions. The findings provide pathogenetic grounds for DMW therapy. It is recommended for treatment of patients with chronic pyelonephritis with dynamic obstruction of the upper urinary tracts allowing for the power of the impact and activity of the inflammation.
Subject(s)
Kidney Medulla/radiation effects , Pyelitis/radiotherapy , Radiofrequency Therapy , Animals , Chronic Disease , Female , Kidney Medulla/blood supply , Kidney Medulla/pathology , Pyelitis/pathology , Pyelitis/physiopathology , Rabbits , Regional Blood Flow/radiation effectsABSTRACT
The validity of the Giusti-Hayton method for dosage regimen adjustment in patients with renal impairment was investigated using ranitidine. Five normal healthy volunteers received a single ranitidine recommended dose of 150 mg, and 20 patients with renal disease received single administration in doses individually calculated by the Giusti-Hayton method from each patient's creatinine clearance level, and the various pharmacokinetic parameters were compared. As a result, the area under the time-concentration curve 0----infinity (AUC0----infinity) in the renal disease patients was almost comparable to that in the normal healthy volunteers. The Giusti-Hayton method was considered useful to keep both the AUC0----infinity constant and the mean blood level of the drug in a steady state, in any degree of renal impairment.
Subject(s)
Creatinine/metabolism , Kidney Diseases/metabolism , Ranitidine/administration & dosage , Administration, Oral , Adult , Aged , Chronic Disease , Female , Glomerulonephritis/physiopathology , Humans , Infusions, Intravenous , Kidney/metabolism , Male , Metabolic Clearance Rate , Middle Aged , Nephritis/physiopathology , Nephrotic Syndrome/physiopathology , Pyelitis/physiopathology , Ranitidine/pharmacokinetics , Time FactorsABSTRACT
Renal tubular function tests were performed in 45 children suffering from upper and lower urinary tract infections. Determinations were made of the urinary carbon dioxide tension in maximally alkaline urine as an index of distal tubular H+-ion secretion, of urinary protein excretion, and of urinary sodium and phosphate handling. Urinary PCO2 was low (2.7 +/- 13.9 mmHg) in acute pyelonephritis compared to values in healthy children (52 +/- 32 mmHg) or those with cystitis (48 +/- 34 mmHg). At the onset of pyelonephritis an elevated fractional excretion of sodium (1.38 +/- 0.38 vs. 0.50 +/- 0.20%) and decreased phosphate reabsorption (69.2 +/- 7.1 vs. 90.4 +/- 4.9%) were also observed. Significantly elevated urinary low molecular weight protein excretion was also found in pyelonephritis. These data indicate the existence of proximal and distal tubular dysfunction at the onset of acute bacterial pyelonephritis.
Subject(s)
Carbon Dioxide/urine , Electrolytes/metabolism , Kidney Tubules/physiopathology , Kidney/metabolism , Proteinuria , Pyelonephritis/physiopathology , Acute Disease , Child , Child, Preschool , Female , Humans , Male , Molecular Weight , Partial Pressure , Pyelitis/physiopathology , Pyelonephritis/diagnosis , Pyelonephritis/urineABSTRACT
Se presentan tres casos de pieloureteritis quística; se hace una amplia revisión bibliográfica y se expone un resumen de su patogénesis. Se propone un cambio de la denominación de esta afección por no corresponderse a nomenclatura actual con la realidad observada
Subject(s)
Middle Aged , Humans , Female , Cysts/physiopathology , Ureteral Diseases/physiopathology , Pyelitis/physiopathology , Urethritis/physiopathologyABSTRACT
Se presentan tres casos de pieloureteritis quística; se hace una amplia revisión bibliográfica y se expone un resumen de su patogénesis. Se propone un cambio de la denominación de esta afección por no corresponderse a nomenclatura actual con la realidad observada (AU)
