Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 68
Filter
1.
J Cardiovasc Electrophysiol ; 35(7): 1393-1400, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38741382

ABSTRACT

INTRODUCTION: Inappropriate sinus tachycardia (IST) is a common condition with frequently not tolerated beta-blockers or ivabradine and a high rate of complication in ablation strategy; we describe an alternative anatomical approach of sinus node (SN) modulation. METHODS: This retrospective study describes a case series of 6 patients from two centers diagnosed with symptomatic IST undergoing SN ablation. RESULTS: The mean age was 40.6 ± 13.9 years; five of the six patients were female, 100% of patients reported heart palpitations, and 66% reported dizziness, the average heart rate (HR) on a 24-h Holter was 93.2 ± 7.9 bpm. HR during the first stage of a stress test using a standard Bruce protocol was 150 ± 70 bpm, The average HR on 24-h Holter postablation was 75 ± 5.6 bpm, the sinus rate HR during stage 1 of a Bruce protocol exercise stress test was 120 ± 10 bpm. CONCLUSION: This is the first case series reporting the acute and long-term results of a novel anatomical approach for SN modulation to treat IST targeting the arcuate ridge (AR) under intracardiac echography (ICE) guidance. The novel anatomic ICE-guided catheter ablation approach aimed to identify the earliest activation at the AR with an extension of RF lesions toward its septal region seems effective and safe to modulate the SN in symptomatic patients with IST refractory to medical treatment.


Subject(s)
Catheter Ablation , Heart Rate , Tachycardia, Sinus , Humans , Female , Tachycardia, Sinus/surgery , Tachycardia, Sinus/physiopathology , Retrospective Studies , Male , Middle Aged , Adult , Treatment Outcome , Action Potentials , Predictive Value of Tests , Anti-Arrhythmia Agents/therapeutic use , Time Factors , Ultrasonography, Interventional , Electrocardiography, Ambulatory , Drug Resistance , Sinoatrial Node/surgery , Sinoatrial Node/physiopathology , Echocardiography
2.
J Interv Card Electrophysiol ; 52(3): 263-270, 2018 Aug.
Article in English | MEDLINE | ID: mdl-30112616

ABSTRACT

PURPOSE: The purpose of this report was to review the basic mechanisms underlying cardiac automaticity. Second, we describe our clinical observations related to the anatomical and functional characteristics of sinus automaticity. METHODS: We first reviewed the main discoveries regarding the mechanisms responsible for cardiac automaticity. We then analyzed our clinical experience regarding the location of sinus automaticity in two unique populations: those with inappropriate sinus tachycardia and those with a dominant pacemaker located outside the crista terminalis region. RESULTS: We studied 26 patients with inappropriate sinus tachycardia (age 34 ± 8 years; 21 females). Non-contact endocardial mapping (Ensite 3000, Endocardial Solutions) was performed in 19 patients and high-density contact mapping (Carto-3, Biosense Webster with PentaRay catheter) in 7 patients. The site of earliest atrial activation shifted after each RF application within and outside the crista terminalis region, indicating a wide distribution of atrial pacemaker sites. We also analyzed 11 patients with dominant pacemakers located outside the crista terminalis (age 27 ± 7 years; five females). In all patients, the rhythm was the dominant pacemaker both at rest and during exercise and located in the right atrial appendage in 6 patients, in the left atrial appendage in 4 patients, and in the mitral annulus in 1 patient. Following ablation, earliest atrial activation shifted to the region of the crista terminalis at a slower rate. CONCLUSIONS: Membrane and sub-membrane mechanisms interact to generate cardiac automaticity. The present observations in patients with inappropriate sinus tachycardia and dominant pacemakers are consistent with a wide distribution of pacemaker sites within and outside the boundaries of the crista terminalis.


Subject(s)
Adaptation, Physiological/physiology , Body Surface Potential Mapping , Cardiac Pacing, Artificial/methods , Tachycardia, Sinus/diagnostic imaging , Tachycardia, Sinus/therapy , Adult , Cardiac Catheterization , Catheter Ablation/methods , Cohort Studies , Echocardiography/methods , Female , Humans , Male , Prognosis , Prospective Studies , Sinoatrial Node/physiopathology , Treatment Outcome , Ultrasonography, Interventional
3.
RELAMPA, Rev. Lat.-Am. Marcapasso Arritm ; 29(2): 49-56, mai.-jun.2016. tab, graf
Article in Portuguese | LILACS | ID: lil-794470

ABSTRACT

O presente estudo examinou pacientes submetidos a implante de marcapasso dupla-câmara em decorrência de doença do nó sinusal ou bloqueio atrioventricular de 3o ou 2o graus do tipo 2 na doençarenal crônica em estágios 2, 3 e 4. O estudo teve como objetivo registrar os eventos arrítmicos durante 12 mesesde acompanhamento e comparar a incidência e a gravidade deles nas diferentes fases da doença renal crônica.Método: No total, 305 pacientes foram avaliados a cada 4 meses até 12 meses de acompanhamento. Os eventosarrítmicos foram avaliados em cada visita de acompanhamento. Resultados: Dentro do mesmo grupo de estágio da doença renal crônica não houve diferença entre as causas doença do nó sinusal e bloqueio atrioventricular, a respeito da ocorrência de qualquer arritmia. No entanto, menor incidência de taquicardia atrial/fibrilação atrial foi observada para todas as comparações entre todos os pacientes e os mesmos subgrupos em pacientes no estágio 2 (total: 58%; doença do nó sinusal: 63%; bloqueio atrioventricular: 51%), comparativamente aos estágios 3 (total:87%, P < 0,0001; doença do nó sinusal: 89%, P = 0,0020; bloqueio atrioventricular: 84%, P = 0,0019) e 4 (total: 85%, P < 0,0001; doença do nó sinusal: 81%, P = 0,0409; bloqueio atrioventricular: 90%, P < 0,0001). Em relação à taquicardia ventricular não sustentada/taquicardia ventricular sustentada, foi observada incidência mais elevada para todas as comparações entre todos os pacientes e os mesmos subgrupos em pacientes no estágio 4 (total: 32%; doença do nó sinusal: 16%; bloqueio atrioventricular: 16%), comparativamente aos estágios 3 (total: 11%, P = 0,0007; doença do nó sinusal: 9%, P = 0,0110; bloqueio atrioventricular: 14%, P = 0,0441) e 2 (total: 3%, P < 0,0001; doença do nó sinusal: 3%, P < 0,0001; bloqueio atrioventricular: 4%, P < 0,0001). Conclusão: Nossos resultados sugerem que quanto mais avançado o estágio da doença renal crônica maior a incidência de arritmias malignas...


The present study evaluated patients who had received a dual chamber pacemaker implant due to sinus node disease or 3rd/2nd degree type 2 atrioventricular block in chronic kidney disease stages 2, 3 and 4. The study was aimed at registering arrhythmic events for 12 months of follow-up and comparing their incidence and severity in different stages of chronic kidney disease. Method: Three hundred and five patients were evaluated every 4 months up to 12 months of follow-up. Arrhythmic events were assessed at each follow-up visit. Results: Within the same chronic kidney disease stage group there was no difference between the causes ofsinus node disease and atrioventricular block for the occurrence of any arrhythmia. However, a lower incidence of atrial fibrillation/tachycardia was observed for all comparisons among all patients and the same subgroups in stage 2 patients (total: 58%; sinus node disease: 63%; atrioventricular block: 51%) compared to stages 3 (total: 87%,P < 0.0001; sinus node disease: 89%, P = 0.0020; atrioventricular block: 84%, P = 0.0019) and 4 (total: 85%,P < 0.0001; sinus node disease: 81%, P = 0.0409; atrioventricular block: 90%, P < 0.0001). Regarding nonsustained/ sustained ventricular tachycardia, a higher incidence was observed for all comparisons among all patients and the same subgroups in stage 4 patients (total: 32%; sinus node disease: 16%; atrioventricular block: 16%) compared to stages 3 (total: 11%, P = 0.0007; sinus node disease: 9%, P = 0.0110; atrioventricular block: 14%, P = 0.0441) and 2 (total: 3%, P < 0.0001; sinus node disease: 3%, P < 0.0001; atrioventricular block: 4%,P < 0.0001). Conclusion: Our findings suggest that the more advanced the stage of chronic kidney disease, thegreater the incidence of malignant arrhythmias...


Subject(s)
Humans , Arrhythmias, Cardiac/complications , Arrhythmias, Cardiac/diagnosis , Renal Insufficiency, Chronic/complications , Sinoatrial Node/physiopathology , Pacemaker, Artificial , Patients , Heart Atria/surgery , Sinoatrial Block/physiopathology , Cohort Studies , Risk Factors , Data Interpretation, Statistical , Treatment Outcome , Heart Ventricles/surgery
4.
J Emerg Med ; 49(2): 143-6, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25802161

ABSTRACT

BACKGROUND: Heat stroke has been associated with stress-induced cardiomyopathy and electrocardiogram ST segment elevation and depression. Laboratory studies with dogs have demonstrated heat stroke-induced sinoatrial node dysfunction in the setting of hyperkalemia. No prior case report has described heat stroke-induced complete sinoatrial node dysfunction that resolved in the emergency department. CASE REPORT: An 87-year-old female presented to the emergency department with heat stroke and severe bradycardia. Initial electrocardiogram demonstrated complete sinoatrial node dysfunction. The bradycardia responded to external cardiac pacing and the sinoatrial node dysfunction resolved with aggressive cooling. Emergency physicians should be aware that heat stroke can cause complete sinoatrial node dysfunction and that this bradydysthrmia can be treated with aggressive cooling.


Subject(s)
Bradycardia/physiopathology , Heat Stroke/physiopathology , Sinoatrial Node/physiopathology , Aged, 80 and over , Bradycardia/therapy , Cardiac Pacing, Artificial , Electrocardiography , Emergency Service, Hospital , Female , Humans , Hypothermia, Induced
5.
J Pediatr ; 166(4): 960-4.e1-2, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25648293

ABSTRACT

OBJECTIVE: To compare 4 heart rate correction formulas for calculation of the rate corrected QT (QTc) interval among infants and young children. STUDY DESIGN: R-R and QT intervals were measured from digital electrocardiograms. QTc were calculated with the Bazett, Fridericia, Hodges, and Framingham formulas. QTc vs R-R graphs were plotted, and slopes of the regression lines compared. Slopes of QTc-R-R regression lines close to zero indicate consistent QT corrections over the range of heart rates. RESULTS: We reviewed electrocardiograms from 702 children, with 233 (33%) <1 year of age and 567 (81%) <2 years. The average heart rate was 122 ± 20 bpm (median 121 bpm). The slopes of the QTc-R-R regression lines for the 4 correction formulas were -0.019 (Bazett); 0.1028 (Fridericia); -0.1241 (Hodges); and 0.2748 (Framingham). With the Bazett formula, a QTc >460 ms was 2 SDs above the mean, compared with "prolonged" QTc values of 414, 443, and 353 ms for the Fridericia, Hodges, and Framingham formulas, respectively. CONCLUSIONS: The Bazett formula calculated the most consistent QTc; 460 ms is the best threshold for prolonged QTc. The study supports continued use of the Bazett formula for infants and children and differs from the use of the Fridericia correction during clinical trials of new medications.


Subject(s)
Algorithms , Electrocardiography/statistics & numerical data , Heart Rate/physiology , Long QT Syndrome/diagnosis , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Long QT Syndrome/physiopathology , Male , Nonlinear Dynamics , Reproducibility of Results , Signal Processing, Computer-Assisted , Sinoatrial Node/physiopathology
6.
PLoS One ; 8(8): e72005, 2013.
Article in English | MEDLINE | ID: mdl-23951278

ABSTRACT

The present study aimed to investigate whether running performance in different environments is dependent on intact arterial baroreceptor reflexes. We also assessed the exercise-induced cardiovascular and thermoregulatory responses in animals lacking arterial baroafferent signals. To accomplish these goals, male Wistar rats were subjected to sinoaortic denervation (SAD) or sham surgery (SHAM) and had a catheter implanted into the ascending aorta to record arterial pressure and a telemetry sensor implanted in the abdominal cavity to record core temperature. After recovering from these surgeries, the animals were subjected to constant- or incremental-speed exercises performed until the voluntary interruption of effort under temperate (25° C) and warm (35° C) conditions. During the constant-speed exercises, the running time until the rats were fatigued was shorter in SAD rats in both environments. Although the core temperature was not significantly different between the groups, tail skin temperature was higher in SAD rats under temperate conditions. The denervated rats also displayed exaggerated increases in blood pressure and double product compared with the SHAM rats; in particular, in the warm environment, these exaggerated cardiovascular responses in the SAD rats persisted until they were fatigued. These SAD-mediated changes occurred in parallel with increased variability in the very low and low components of the systolic arterial pressure power spectrum. The running performance was also affected by SAD during the incremental-speed exercises, with the maximal speed attained being decreased by approximately 20% in both environments. Furthermore, at the maximal power output tolerated during the incremental exercises, the mean arterial pressure, heart rate and double product were exaggerated in the SAD relative to SHAM rats. In conclusion, the chronic absence of the arterial baroafferents accelerates exercise fatigue in temperate and warm environments. Our findings also suggest that an augmented cardiovascular strain accounted for the early interruption of exercise in the SAD rats.


Subject(s)
Arteries/physiopathology , Baroreflex/physiology , Physical Conditioning, Animal/physiology , Running/physiology , Analysis of Variance , Animals , Blood Pressure/physiology , Body Temperature Regulation/physiology , Denervation , Heart Rate/physiology , Male , Rats , Rats, Wistar , Sinoatrial Node/innervation , Sinoatrial Node/physiopathology , Temperature
10.
Obes Surg ; 19(3): 332-8, 2009 Mar.
Article in English | MEDLINE | ID: mdl-18719968

ABSTRACT

BACKGROUND: Obesity is associated with increased sympathetic activity and higher mortality. Treatment of this condition is often frustrating. Roux-en-Y gastric bypass is the most effective technique nowadays for treatment of obesity. The aim of the present study is to assess the effects of this surgery on the cardiac autonomic activity, including the influence of gender and age, through heart rate variability (HRV) analysis. METHODS: The study group consisted of 71 obese patients undergoing gastric bypass. Time domain measures of HRV, obtained from 24-h Holter recordings, were evaluated before and 6 months after surgery, and the results were compared. Percentage of interval differences of successive normal sinus beats greater than 50 ms (pNN50) and square root of the mean squared differences of successive normal sinus beat intervals (rMSSD) was used to estimate the short-term components of HRV, related to the parasympathetic activity. Standard deviation of intervals between all normal sinus beats (SDNN) was related to overall HRV. RESULTS: SDNN, pNN50, and rMSSD showed significant increase 6 months after surgery (p<0.001, p=0.001 and p=0.002, respectively). Men presented a greater increase of SDNN than women (p=0.006) during the follow-up. There was a difference in rMSSD evolution for age groups (p=0.002). Only younger patients presented significant increase of rMSSD. CONCLUSION: Overall HRV increased 6 months after surgery; this increase was more evident in men. Cardiac parasympathetic activity increased also, but in younger patients only.


Subject(s)
Autonomic Nervous System/physiopathology , Gastric Bypass , Obesity, Morbid/physiopathology , Obesity, Morbid/surgery , Sinoatrial Node/physiopathology , Adolescent , Adult , Age Factors , Body Mass Index , Cohort Studies , Female , Heart Rate/physiology , Humans , Male , Middle Aged , Sex Factors , Waist Circumference , Weight Loss/physiology , Young Adult
11.
Acta Cir Bras ; 23 Suppl 1: 126-32; discussion 132, 2008.
Article in English | MEDLINE | ID: mdl-18516460

ABSTRACT

PURPOSE: To study the interatrial conduction times and atrial node performance in patients submitted to mitral valve surgery with the aid of temporary atrial epicardic electrodes. METHODS: The atriograms were carried out in the first postoperative day and before the hospital discharge of ten consecutive patients. RESULTS: Sixty percent of the patients could complete the post-operative study protocol. The main results were: a) Post-operative arrhythmias were detected in 50% of the patients; b) There were no statistical differences between the pre and post-operative 12 lead EKGs. c) The interatrial conduction time (IACT) ranged from 90 to 140ms in the first post-operative day, and from 110 to 130ms at hospital discharge; d) The sinus node recovery time (SNRT) ranged from 250 to 560ms in the first post-operative day and from 180 to 360ms at hospital discharge; e) The sinus atrial conduction time (SACT) remained between 70 and 140ms, both in the first post-operative day and at hospital discharge, and; f) The IACT was normal in patients whose left atrium (LA) was less than 50mm in diameter but supra normal in the remaining cases. CONCLUSIONS: Sinus node function and inter-atrial conduction are not altered by mitral valve operation. Post-operative programmed epicardic atrial stimulation is easy and safe.


Subject(s)
Electrocardiography/methods , Electrodes , Heart Valve Diseases/surgery , Heart Valve Prosthesis Implantation/adverse effects , Mitral Valve/surgery , Sinoatrial Node/physiopathology , Adult , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/physiopathology , Atrial Fibrillation/etiology , Atrial Fibrillation/physiopathology , Female , Heart Valve Diseases/physiopathology , Humans , Male , Mitral Valve/physiopathology , Postoperative Period , Prospective Studies , Sinoatrial Node/surgery , Treatment Outcome
12.
Acta cir. bras. ; 23(supl.1): 126-132, 2008. ilus, tab
Article in English | VETINDEX | ID: vti-3847

ABSTRACT

PURPOSE: To study the interatrial conduction times and atrial node performance in patients submitted to mitral valve surgery with the aid of temporary atrial epicardic electrodes. METHODS: The atriograms were carried out in the first postoperative day and before the hospital discharge of ten consecutive patients. RESULTS: Sixty percent of the patients could complete the post-operative study protocol. The main results were: a) Post-operative arrhythmias were detected in 50 percent of the patients; b) There were no statistical differences between the pre and post-operative 12 lead EKGs. c) The interatrial conduction time (IACT) ranged from 90 to 140ms in the first post-operative day, and from 110 to 130ms at hospital discharge; d) The sinus node recovery time (SNRT) ranged from 250 to 560 ms in the first post-operative day and from 180 to 360ms at hospital discharge; e) The sinus atrial conduction time (SACT) remained between 70 and 140ms, both in the first post-operative day and at hospital discharge, and; f) The IACT was normal in patients whose left atrium (LA) was less than 50mm in diameter but supra normal in the remaining cases. CONCLUSIONS: Sinus node function and inter-atrial conduction are not altered by mitral valve operation. Post-operative programmed epicardic atrial stimulation is easy and safe.(AU)


OBJETIVO: Estudar os tempos de condução interatrial e a função do nó sinusal em pacientes submetidos a tratamento cirúrgico. MÉTODOS: Foram estudados 10 pacientes adultos consecutivos submetidos à operação de correção de valvopatia mitral. Registraram-se atriogramas usando eletrodos epimiocárdicos cirurgicamente implantados. Os atriogramas foram obtidos no primeiro dia do pós-operatório e antes da alta hospitalar. RESULTADOS: Os principais achados foram: a) A incidência de arritmias atriais até alta hospitalar foi de 50 por cento; b) O tempo de condução interatrial (TCIA) variou de 90 a 140 ms no 1ºPO e 110 a130 ms antes da alta hospitalar; c) O tempo de recuperação do nó sinusal (TRNS) variou de 250 a 560 ms no 1ºPO e180 a 360 ms antes da alta hospitalar; d) O tempo de condução sinoatrial (TCSA) variou de 70 a 140 ms tanto no 1ºPO, como antes da alta hospitalar e; d) O tempo de condução interatrial (TCIA) foi normal em pacientes com átrio esquerdo menores do que 50 mm e supranormal nos outros casos. CONCLUSÃO: As funções do nó sinusal e a condução interatrial não foram alteradas pelo tratamento cirúrgico da valvopatia mitral. A estimulação atrial epicárdica programada é segura de fácil realização.(AU)


Subject(s)
Humans , Male , Female , Adult , Electrocardiography/methods , Electrodes , Heart Valve Diseases/surgery , Heart Valve Prosthesis Implantation/adverse effects , Mitral Valve/surgery , Sinoatrial Node/physiopathology , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/physiopathology , Atrial Fibrillation/etiology , Atrial Fibrillation/physiopathology , Heart Valve Diseases/physiopathology , Mitral Valve/physiopathology , Postoperative Period , Prospective Studies , Sinoatrial Node/surgery , Treatment Outcome
13.
Acta cir. bras ; Acta cir. bras;23(supl.1): 126-132, 2008. ilus, tab
Article in English | LILACS | ID: lil-483135

ABSTRACT

PURPOSE: To study the interatrial conduction times and atrial node performance in patients submitted to mitral valve surgery with the aid of temporary atrial epicardic electrodes. METHODS: The atriograms were carried out in the first postoperative day and before the hospital discharge of ten consecutive patients. RESULTS: Sixty percent of the patients could complete the post-operative study protocol. The main results were: a) Post-operative arrhythmias were detected in 50 percent of the patients; b) There were no statistical differences between the pre and post-operative 12 lead EKGs. c) The interatrial conduction time (IACT) ranged from 90 to 140ms in the first post-operative day, and from 110 to 130ms at hospital discharge; d) The sinus node recovery time (SNRT) ranged from 250 to 560 ms in the first post-operative day and from 180 to 360ms at hospital discharge; e) The sinus atrial conduction time (SACT) remained between 70 and 140ms, both in the first post-operative day and at hospital discharge, and; f) The IACT was normal in patients whose left atrium (LA) was less than 50mm in diameter but supra normal in the remaining cases. CONCLUSIONS: Sinus node function and inter-atrial conduction are not altered by mitral valve operation. Post-operative programmed epicardic atrial stimulation is easy and safe.


OBJETIVO: Estudar os tempos de condução interatrial e a função do nó sinusal em pacientes submetidos a tratamento cirúrgico. MÉTODOS: Foram estudados 10 pacientes adultos consecutivos submetidos à operação de correção de valvopatia mitral. Registraram-se atriogramas usando eletrodos epimiocárdicos cirurgicamente implantados. Os atriogramas foram obtidos no primeiro dia do pós-operatório e antes da alta hospitalar. RESULTADOS: Os principais achados foram: a) A incidência de arritmias atriais até alta hospitalar foi de 50 por cento; b) O tempo de condução interatrial (TCIA) variou de 90 a 140 ms no 1°PO e 110 a130 ms antes da alta hospitalar; c) O tempo de recuperação do nó sinusal (TRNS) variou de 250 a 560 ms no 1°PO e180 a 360 ms antes da alta hospitalar; d) O tempo de condução sinoatrial (TCSA) variou de 70 a 140 ms tanto no 1ºPO, como antes da alta hospitalar e; d) O tempo de condução interatrial (TCIA) foi normal em pacientes com átrio esquerdo menores do que 50 mm e supranormal nos outros casos. CONCLUSÃO: As funções do nó sinusal e a condução interatrial não foram alteradas pelo tratamento cirúrgico da valvopatia mitral. A estimulação atrial epicárdica programada é segura de fácil realização.


Subject(s)
Adult , Female , Humans , Male , Electrodes , Electrocardiography/methods , Heart Valve Diseases/surgery , Heart Valve Prosthesis Implantation/adverse effects , Mitral Valve/surgery , Sinoatrial Node/physiopathology , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/physiopathology , Atrial Fibrillation/etiology , Atrial Fibrillation/physiopathology , Heart Valve Diseases/physiopathology , Mitral Valve/physiopathology , Postoperative Period , Prospective Studies , Sinoatrial Node/surgery , Treatment Outcome
14.
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;40(6): 665-671, nov.-dez. 2007. ilus, graf, tab
Article in Portuguese | LILACS | ID: lil-471349

ABSTRACT

Estudos mostram que anticorpos IgG agonistas muscarínicos, de pacientes chagásicos, alteram a atividade elétrica de células cardíacas in vitro. Outros consideram sua presença, e a da síndrome do nódulo sinusal, conseqüências da lesão cardíaca progressiva. Objetivou-se avaliar a relação entre os anticorpos e as disfunções nodal e ventricular esquerda, em 65 pacientes chagásicos crônicos divididos em grupo I, composto de 31 pacientes portadores da síndrome do nódulo sinusal, e grupo II, de não portadores. A análise dos dados, pelo modelo log linear, mostrou uma interdependência entre a disfunção do nódulo sinusal e os anticorpos (p=0,0021) e entre a disfunção nodal e a ventricular (p=0,0005), mas não houve relação entre esta última e os anticorpos. Idade e sexo não tiveram influência sobre as outras variáveis. Chagásicos crônicos com a síndrome do nódulo sinusal têm maior prevalência de anticorpos agonistas muscarínicos, independentemente da presença de disfunção miocárdica.


Studies have shown that muscarinic agonist IgG antibodies from Chagas disease patients alter the electrical activity of cardiac cells in vitro. Others have considered their presence, along with sinus node dysfunction, to be consequences of progressive cardiac lesions. The aim of this study was to evaluate the relationship between these antibodies and sinus node and left ventricular dysfunction in 65 chronic Chagas disease patients. These patients were divided into group I, composed of 31 patients with sinus node dysfunction, and group II, composed of the patients without this syndrome. Data analysis using the log linear model showed interdependence between sinus node dysfunction and the antibodies (p = 0.0021) and between nodal and ventricular dysfunction (p = 0.0005). However, no relationship was found between the antibodies and ventricular function. Age and sex did not influence any other variables. The chronic Chagas disease patients with sinus node dysfunction had higher prevalence of muscarinic agonist antibodies, independent of the presence of myocardial dysfunction.


Subject(s)
Adult , Aged , Humans , Middle Aged , Chagas Cardiomyopathy/immunology , Immunoglobulin G/blood , Muscarinic Agonists/blood , /blood , Sinoatrial Node/physiopathology , Ventricular Dysfunction, Left/physiopathology , Autoantibodies/blood , Chronic Disease , Chagas Cardiomyopathy/physiopathology , Electrocardiography , Immunoglobulin G/metabolism , Linear Models , Muscarinic Agonists/metabolism , /agonists
15.
Rev Soc Bras Med Trop ; 40(6): 665-71, 2007.
Article in Portuguese | MEDLINE | ID: mdl-18200422

ABSTRACT

Studies have shown that muscarinic agonist IgG antibodies from Chagas disease patients alter the electrical activity of cardiac cells in vitro. Others have considered their presence, along with sinus node dysfunction, to be consequences of progressive cardiac lesions. The aim of this study was to evaluate the relationship between these antibodies and sinus node and left ventricular dysfunction in 65 chronic Chagas disease patients. These patients were divided into group I, composed of 31 patients with sinus node dysfunction, and group II, composed of the patients without this syndrome. Data analysis using the log linear model showed interdependence between sinus node dysfunction and the antibodies (p = 0.0021) and between nodal and ventricular dysfunction (p = 0.0005). However, no relationship was found between the antibodies and ventricular function. Age and sex did not influence any other variables. The chronic Chagas disease patients with sinus node dysfunction had higher prevalence of muscarinic agonist antibodies, independent of the presence of myocardial dysfunction.


Subject(s)
Chagas Cardiomyopathy/immunology , Immunoglobulin G/blood , Muscarinic Agonists/blood , Receptor, Muscarinic M2/blood , Sinoatrial Node/physiopathology , Ventricular Dysfunction, Left/physiopathology , Adult , Aged , Autoantibodies/blood , Chagas Cardiomyopathy/physiopathology , Chronic Disease , Electrocardiography , Humans , Immunoglobulin G/metabolism , Linear Models , Middle Aged , Muscarinic Agonists/metabolism , Receptor, Muscarinic M2/agonists
16.
Arq Bras Cardiol ; 87(4): e122-3, 2006 Oct.
Article in English, Portuguese | MEDLINE | ID: mdl-17128297

ABSTRACT

We report the case of an asymptomatic six-year-old child with left atrial isomerism and sinus venosus atrial septal defect. The physical examination revealed several periods of bradycardia. During a 24-hour electrocardiographic monitoring the patient presented a significant sinus node dysfunction with sinus pauses of up to 2.4 seconds. A permanent pacemaker was implanted, with a satisfactory outcome.


Subject(s)
Heart Septal Defects, Atrial/complications , Sinoatrial Node/physiopathology , Cardiac Pacing, Artificial , Child , Female , Heart Atria/abnormalities , Heart Septal Defects, Atrial/physiopathology , Humans , Sinoatrial Node/surgery , Treatment Outcome
17.
Arq. bras. cardiol ; Arq. bras. cardiol;87(4): e122-e123, out. 2006. ilus
Article in Portuguese, English | LILACS | ID: lil-438251

ABSTRACT

É relatado o caso de uma criança com seis anos de idade, assintomática, portadora de isomerismo atrial esquerdo e comunicação interatrial do tipo seio venoso. Ao exame físico, apresentava vários períodos de ritmo bradicárdico. Durante monitorização eletrocardiográfica de 24 horas, apresentou importante disfunção sinusal, com pausas sinusais de até 2,4 segundos. Foi implantado marcapasso definitivo com evolução satisfatória.


We report the case of an asymptomatic six-year-old child with left atrial isomerism and sinus venosus atrial septal defect. The physical examination revealed several periods of bradycardia. During a 24-hour electrocardiographic monitoring the patient presented a significant sinus node dysfunction with sinus pauses of up to 2.4 seconds. A permanent pacemaker was implanted, with a satisfactory outcome.


Subject(s)
Humans , Child , Heart Septal Defects, Atrial/complications , Sinoatrial Node/physiopathology , Cardiac Pacing, Artificial , Sinoatrial Node/surgery , Treatment Outcome
18.
J Cardiovasc Electrophysiol ; 17(6): 678-81, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16836722

ABSTRACT

A patient with palpitations and narrow QRS tachycardia was evaluated. In the EP study an atrioventricular reentrant tachycardia mediated by a left lateral accessory pathway was identified and catheter ablation was performed with success. A week later she returned with palpitations and pre-syncope. The resting ECG showed a sinus tachycardia with 110 bpm. After unsuccessful clinical treatment with beta-blockers, diltiazem and digoxin she underwent sinus node modification using radiofrequency catheter ablation with success. We postulated that RF application to ablate the lateral accessory pathway damaged the parasympathetic innervation in the left atrioventricular groove, causing inappropriate sinus tachycardia.


Subject(s)
Catheter Ablation/adverse effects , Tachycardia, Atrioventricular Nodal Reentry/surgery , Tachycardia, Sinus/etiology , Adolescent , Electrocardiography, Ambulatory , Electrophysiologic Techniques, Cardiac , Female , Ganglia, Parasympathetic/injuries , Heart Conduction System/physiopathology , Heart Rate , Humans , Sinoatrial Node/innervation , Sinoatrial Node/physiopathology , Sinoatrial Node/surgery , Tachycardia, Atrioventricular Nodal Reentry/physiopathology , Tachycardia, Sinus/physiopathology , Tachycardia, Sinus/surgery , Time Factors
19.
Arq Bras Cardiol ; 86(4): 261-7, 2006 Apr.
Article in Portuguese | MEDLINE | ID: mdl-16680290

ABSTRACT

OBJECTIVE: To present a technical proposal based on the experience of 130 implantations using a simplified technique for coronary sinus catheterization, based on the atrial component of the intracavitary electrogram and radiological anatomy. METHODS: From October, 2001 to October, 2004, 130 biventricular pacemaker implantations were performed, using radiological anatomy and observation of the intracavitary electrogram, focusing on the atrial component. RESULTS: The implantation of the system using left ventricular pacing via coronary sinus was not possible in 8 patients. Difficulties on the cannulation of the coronary ostium were felt in 12 patients and difficulties of lead advancement through the coronary sinus were felt in 15 patients. The mean time of radioscopy utilization was 18.69 min. CONCLUSION: The implantation technique, using the atrial component morphology of the intracavitary electrogram and radiological anatomy showed to be workless, safe and effective for the cannulation of the coronary sinus ostium requesting reduced time of radioscopy.


Subject(s)
Cardiac Catheterization/methods , Electrocardiography , Heart Conduction System/physiology , Heart Failure/therapy , Pacemaker, Artificial , Adult , Aged , Aged, 80 and over , Bundle-Branch Block/physiopathology , Bundle-Branch Block/therapy , Cardiomyopathy, Dilated/physiopathology , Cardiomyopathy, Dilated/therapy , Female , Heart Atria/physiopathology , Heart Conduction System/physiopathology , Heart Failure/physiopathology , Heart Ventricles/physiopathology , Humans , Male , Middle Aged , Radiography , Retrospective Studies , Sinoatrial Node/diagnostic imaging , Sinoatrial Node/physiopathology , Treatment Outcome , Ventricular Function, Left/physiology
20.
Arq. bras. cardiol ; Arq. bras. cardiol;86(4): 261-267, abr. 2006. ilus
Article in Portuguese | LILACS | ID: lil-426202

ABSTRACT

OBJETIVO: Apresentar uma proposição técnica baseada na experiência de 130 implantes utilizando técnica simplificada para cateterização do seio coronariano, baseada no componente atrial do eletrograma intracavi-tário e anatomia radiológica. MÉTODOS: De outubro de 2001 a outubro de 2004 foram realiza-dos 130 implantes de marcapasso biventricular, utilizando-se anatomia radiológica e observação de eletrograma intracavitário, com prioridade ao componente atrial. RESULTADOS: O implante do sistema, utilizando-se a estimulação do ventrículo esquerdo via seio coronariano, não foi possível em 8 pacientes. Em 12 pacientes foram observadas dificuldades na canulação do óstio coronário e em 15 pacientes observaram-se dificuldades de progressão do eletrodo através do seio coronariano. O tempo médio de utilização de radioscopia foi de 18,69 min. CONCLUSÃO: A técnica de implante, utilizando a morfologia do componente atrial do eletrograma intracavitário e anatomia radiológica, demonstrou ser pouco trabalhosa, segura e eficaz para canulação do óstio do seio coronariano, necessitando de reduzido tempo de radioscopia.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged, 80 and over , Cardiac Catheterization/methods , Electrocardiography , Heart Failure/therapy , Pacemaker, Artificial , Heart Conduction System/physiology , Heart Atria/physiopathology , Bundle-Branch Block/physiopathology , Bundle-Branch Block/therapy , Cardiomyopathy, Dilated/physiopathology , Cardiomyopathy, Dilated/therapy , Ventricular Function, Left/physiology , Heart Failure/physiopathology , Sinoatrial Node/physiopathology , Sinoatrial Node , Retrospective Studies , Heart Conduction System/physiopathology , Treatment Outcome , Heart Ventricles/physiopathology
SELECTION OF CITATIONS
SEARCH DETAIL