[Bowenoid papulosis in men. Sexually transferred intra-epithelial neoplasia of the ano-genital region]. / Bowenoid papulose hos maend. Seksuelt overførbar intraepitelial neoplasi i genito-analregionen.

The clinical picture in three cases of Bowenoid papulosis is reported. Histology indicates carcinoma in situ changes and koilocytosis. Evidence points to the role of human Papillomavirus in the etiology of the disease.

Bowenoid papulosis and squamous cell carcinoma of the genitalia: suspected sexual transmission.

The human papillomavirus causes a variety of genital lesions: condyloma acuminatum, bowenoid papulosis (carcinoma in situ), and squamous cell carcinoma. Only condylomata have been documented to be sexually transmitted. We report clinical and histopathologic evidence of suspected female to male transmission of bowenoid papulosis to the penis from a woman with condylomata acuminata, squamous cell carcinoma in situ, and focally invasive squamous cell carcinoma of the vulva. These findings indicate a need for thorough clinical and histopathologic evaluation of any anogenital lesions resembling condylomata and occurring in sexual partners. Conservative yet thorough destruction of bowenoid papulosis and squamous cell carcinoma in situ appears to be the treatment of choice.

Bowenoid papulosis in three-year-old girl.

A three-year-old girl presented with perianal bowenoid papulosis that was presumed to be induced by sexual contact. The lesion was treated by biopsy only and regressed over 8 months without further therapy. The importance of this case with respect to the viral cause, venereal transmission, and spontaneous regression is discussed. This case represents the youngest known patient with bowenoid papulosis reported to date.

[Sexual transmissibility of papillomaviruses]. / Untersuchungen zur sexuellen Ubertragbarkeit von Papillomviren.

Papillomavirus infections in the genitoanal region are detectable by the demonstration of type-specific HPVDNA (DNA-DNA hybridization, in situ hybridization on cell smears) or by a peroxidase-antiperoxidase assay using formalin-fixed paraffin sections for demonstration of common structural antigens of papillomaviruses. Using these methods an epidemiological study on sexual partners with genitoanal papillomavirus infections has been initiated.

Transmission of the white-tailed deer cutaneous fibroma.

Cutaneous fibromas were successfully transmitted to 7 white-tailed deer (Odocoileus virginianus) inoculated with crude fibroma extracts (2 deer) or with partially purified deer fibroma virus (5 deer). The fibromas were transmitted by intradermal and subcutaneous inoculation and by rubbing the virus preparation into tattoo sites. Inoculation by scarification was not successful. The induced tumors resembled those of naturally occurring fibromas. Tattoo inoculation sites underwent an initial acute inflammatory response followed by mesenchymal proliferation, perivascular lymphocytic infiltration, and finally regression. The deer developed antibody titers against deer fibroma virus as determined by hemagglutination inhibition, using mouse RBC. Viral antigens could not be detected by indirect immunofluorescence in any induced fibroma.

Kaposi's sarcoma in homosexual men-a report of eight cases.

The clinical findings in eight young homosexual men in New York with Kaposi's sarcoma showed some unusual features. Unlike the form usually seen in North America and Europe, it affected younger men (4th decade rather than 7th decade); the skin lesions wee generalised rather than being predominantly in the lower limbs, and the disease was more aggressive (survival of less than 20 months rather 8-13 years). All eight had had a variety of sexually transmitted diseases. All those tested for cytomegalovirus antibodies and hepatitis B surface antigen of anti-hepatitis B antibody gave positive results. This unusual occurrence of Kaposi's sarcoma in a population much exposed to sexually transmissible diseases suggests that such exposure may play a role in its pathogenesis.

[General facts on mastocytoma in the dog. Apropos of the first Tunisian case]. / Données générales sur le mastocytome du chien. A propos du premier cas tunisien.

After anatomo-pathologic, épidemiologic and etiopathogenic description of canine Mast-cell tumor, the authors insist on the importance of this neoplasm in comparative pathology. Such animal model observation can be eventually used both in cancer Research and in allergo-dermatology.

Experimental transmission of bovine papilloma virus (BPV) extracted from morphologically distinct teat and cutaneous lesions and the effects of inoculation of BPV transformed fetal bovine cells.

Bovine papilloma virus (BPV) was extracted from five cattle each affected with only one of five morphologically distinct lesion types. When inoculated into experimental calves either by scarification or intradermal injection, the BPV extracts produced lesions macroscopically and microscopically similar to those from which individual extracts were made. Fetal bovine cells, transformed in vitro with BPV, failed to produce fibromas, fibropapillomas or papillomas when inoculated into experimental calves. When calves inoculated with virus or BPV transformed cells were challenged with the five original BPV extracts, a differential immunity was demonstrated, while control calves were susceptible to all extracts. Post mortem examination revealed the presence of upper alimentary tract papillomas in three of eight calves forming one group. These results suggest that different strains of BVP, causing morphologically separable lesion types, exist. There may be additional BPV variants causing fibropapillomas of the teat and anogenital regions of cattle. The inoculation of BPV transformed fetal bovine cells conferred a relative immunity to later challenge with some but not all BPV extracts.