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1.
PLoS One ; 19(4): e0299561, 2024.
Article in English | MEDLINE | ID: mdl-38630663

ABSTRACT

This study identifies the health effect of rising housing prices on individual physical health using the Chinese General Social Survey (CGSS) data. Exploiting exogenous housing prices, I find that rising housing prices adversely affect physical health status. Heterogeneity analyses yield interesting findings. First, the adverse effects of high housing prices are pronounced in the group owning only one house. Second, significant effects of housing prices on health for the group aged 20 to 45 are observed, with no effects for the elderly group above 45. Third, males are more sensitive to high housing prices due to the intensified competition and traditional gender norm in marriage markets. I also further investigate the channel through which housing prices affect individual physical health. The findings indicate that rising housing prices can damage individual physical health via lowering social status, reducing physical exercise time and increasing mental health risk.


Subject(s)
Housing , Mental Health , Male , Humans , Aged , China , Health Status , Social Status
2.
Front Public Health ; 12: 1325441, 2024.
Article in English | MEDLINE | ID: mdl-38638481

ABSTRACT

Introduction: Although the relationship between subjective social status and depression in university students has been well-established, this association could be seen as a spurious one. Previous studies have shown that key variables like financial resources and age could play key roles in explaining the variances in social status and mental health outcomes. In this research, we assessed the complex interrelationships between subjective social status, financial resources at their disposal and depressive symptoms among university students within their young and middle adulthood stages. Methods: A cross-sectional survey was conducted in a university in Ghana to sample 1134 university students through accidental sampling. The McArthur Scale and WHO-5 Well-being measure were used for the data collection. Results: The results revealed that higher levels of subjective social status were associated with lower levels of depression. It was further found that the interaction between students' pocket money and age played unique roles in the relationship between subjective social status and depression. Conclusion: The study findings call on stakeholders in education to explore funding opportunities and to examine ways of empowering parents (financially) to adequately support the students. Health educationists and promoters, including psychologists, school counsellors and parents could compliment these efforts by helping to train and empower students through self-regulation or management skills to help improve their well-being. Continuous efforts are required to improve the financial status and mental health of students.


Subject(s)
Depression , Social Status , Humans , Adult , Universities , Cross-Sectional Studies , Ghana , Students/psychology
3.
Sci Rep ; 14(1): 9065, 2024 04 20.
Article in English | MEDLINE | ID: mdl-38643251

ABSTRACT

Autistic people frequently experience negative judgements from non-autistic people, often fuelled by misconceptions that autistic people lack empathy. Understanding responses to negative social judgement among autistic people is crucial because of the potential negative impact on wellbeing and future interactions. We investigated the role of autistic traits, social anxiety, and depression on behavioural indices of social rejection in 20 autistic (AUT; 11 males) and 40 non-autistic (N-AUT; 21 males) university students. Participants completed the Social Judgement Task (SJT) where they predicted whether they were liked by another person, then received feedback on whether those evaluations were correct. Participants also completed an Age Judgement Task (AJT) where they estimated the age of the pictured person. The AUT group had lower positive expectation scores, meaning less tendency to predict being liked. Across the whole sample, higher social anxiety predicted greater tendency to anticipate rejection from others, not autistic traits. These findings suggest early experiences of rejection might lead to a negative self-bias in autistic people and emphasise the importance of using a transdiagnostic approach by showing that social anxiety rather than autistic traits is associated with expectation of social rejection.


Subject(s)
Autistic Disorder , Depression , Male , Adult , Humans , Social Status , Emotions/physiology , Anxiety
4.
PLoS One ; 19(3): e0299225, 2024.
Article in English | MEDLINE | ID: mdl-38427682

ABSTRACT

In this cross-sectional study, we aimed to I) investigate the dual-factor model of mental health by forming and describing four participant groups and II) examine associations between mental health status and background factors, school-related factors, stress, and resilience among adolescents in a community population in Sweden. Data were collected through a survey completed by 2,208 students in lower and upper secondary school on the Swedish island of Gotland. After missing data were removed, a total of 1,833 participants were included in the study. The survey included the Mental Health Continuum Short Form (MHC-SF) for the assessment of mental well-being and the Strengths and Difficulties Questionnaire (SDQ) for the assessment of mental health problems. These two measures were combined into a dual-factor model, forming four mental health status subgroups: Vulnerable (47.5%), Complete mental health (36.2%), Troubled (13.9%), and Symptomatic but content (2.5%). Associations between these groups were explored regarding background factors, school-related factors, stress, and resilience through chi-squared tests and logistic regressions. Girls (OR: 1.88) and participants with high stress levels (OR: 2.23) had elevated odds for Vulnerable mental health status, whereas higher resilience (OR: 0.87) and subjective social status in school (OR: 0.76) were factors associated with reduced odds for this mental health status classification. Female gender (OR: 5.02) was also associated with Troubled mental health status. Similarly, a high level of stress (ORs: 4.08 and 11.36) was associated with Symptomatic but content and Troubled mental health status, and participants with higher levels of resilience had decreased odds for being classified into these groups (ORs: 0.88 and 0.81). The findings highlight the importance of interventions to increase resilience, reduce stress, and address stereotypic gender norms as well as social status hierarchies to support adolescents' mental health.


Subject(s)
Resilience, Psychological , Social Status , Humans , Female , Adolescent , Cross-Sectional Studies , Sweden/epidemiology , Health Status
5.
Commun Biol ; 7(1): 313, 2024 Mar 28.
Article in English | MEDLINE | ID: mdl-38548860

ABSTRACT

In mammalian societies, dominance hierarchies translate into inequalities in health, reproductive performance and survival. DNA methylation is thought to mediate the effects of social status on gene expression and phenotypic outcomes, yet a study of social status-specific DNA methylation profiles in different age classes in a wild social mammal is missing. We tested for social status signatures in DNA methylation profiles in wild female spotted hyenas (Crocuta crocuta), cubs and adults, using non-invasively collected gut epithelium samples. In spotted hyena clans, female social status influences access to resources, foraging behavior, health, reproductive performance and survival. We identified 149 differentially methylated regions between 42 high- and low-ranking female spotted hyenas (cubs and adults). Differentially methylated genes were associated with energy conversion, immune function, glutamate receptor signalling and ion transport. Our results provide evidence that socio-environmental inequalities are reflected at the molecular level in cubs and adults in a wild social mammal.


Subject(s)
Hyaenidae , Animals , Female , Hyaenidae/genetics , Social Status , Social Dominance , Epigenesis, Genetic
6.
Int. j. morphol ; 42(1): 93-97, feb. 2024. tab, graf
Article in English | LILACS | ID: biblio-1528840

ABSTRACT

SUMMARY: Height and body weight measurements are among the most important anthropometric variables when assessing a population's growth, development and body composition. This study aimed to evaluate the height and body weight variability of male entities aged 17-18 years within 35 years. This goal was realized by comparing the height and body weight of the population of the same gender and age in three different time studies. The descriptive statistical parameters and T-test for independent groups show systematic and significant differences in measured variables between three measurements in different timelines. Both in body height and body weight, from measurement to measurement, significant systematic and statistically significant differences (p<0.01) have been identified (1985: BH= 172.8cm, BW= 61.7kg; 2004: BH=176.8 cm, BW=66.9 kg; 2019: BH=178.5 cm, BW=72 kg). The results of this study prove that the change in the socio-economic status of a population over a period time of 35 years can significantly affect the growth and development of children/adolescents.


Las medidas de altura y peso corporal se encuentran entre las variables antropométricas más importantes a la hora de evaluar el crecimiento, el desarrollo y la composición corporal de una población. Este estudio tuvo como objetivo evaluar la variabilidad de la altura y el peso corporal de entidades masculinas de 17 a 18 años dentro de 35 años. Este objetivo se logró comparando la altura y el peso corporal de la población del mismo sexo y edad en tres estudios temporales diferentes. Los parámetros estadísticos descriptivos y la prueba T para grupos independientes muestran diferencias sistemáticas y significativas en las variables medidas entre tres mediciones en diferentes líneas de tiempo. Tanto en la altura como en el peso corporal, de medición en medición, se han identificado diferencias significativas sistemáticas y estadísticamente significativas (p<0,01) (1985: BH= 172,8 cm, BW= 61,7 kg; 2004: BH=176,8 cm, BW=66,9 kg; 2019: BH=178,5 cm, BW=72 kg). Los resultados de este estudio demuestran que el cambio en el estatus socioeconómico de una población durante un período de 35 años puede afectar significativamente el crecimiento y desarrollo de niños/ adolescentes.


Subject(s)
Humans , Male , Adolescent , Body Height , Body Weight , Anthropometry , Socioeconomic Factors , Time Factors , Cross-Sectional Studies , Kosovo , Social Status
7.
Psychol Bull ; 150(3): 253-283, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38330345

ABSTRACT

Theories have proposed diverse reasons for why individual differences such as personality traits lead to social status attainment in face-to-face groups. We integrated these different theoretical standpoints into a model with four paths from individual differences to status: a dominance, a competence, a virtue, and a micropolitics path. To investigate these paths, we meta-analyzed over 100 years of research on bivariate associations of personality traits, cognitive abilities, and physical size with the attainment of status-related outcomes in face-to-face groups (1,064 effects from 276 samples including 56,153 participants). The status-related outcome variables were admiring respect, social influence, popularity (i.e., being liked by others), leadership emergence, and a mixture of outcome variables. The meta-analytic correlations we found were largely in line with the micropolitics path, tentatively in line with the competence and virtue paths, and only partly in line with the dominance path. These findings suggest that status attainment depends not only on the competence and virtue of an individual but also on how individuals can enhance their apparent competence or virtue by behaving assertively, by being extraverted, or through self-monitoring. We also investigated how the relations between individual differences and status-related outcomes were moderated by kind of status-related outcome, nature of the group task, culture (collectivism/individualism), and length of acquaintance. The moderation analysis yielded mixed and inconclusive results. The review ends with directions for research, such as the need to separately assess and study the different status-related outcomes. (PsycInfo Database Record (c) 2024 APA, all rights reserved).


Subject(s)
Personality , Social Status , Humans , Intelligence , Leadership , Personality Disorders
8.
Suicide Life Threat Behav ; 54(2): 233-249, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38180127

ABSTRACT

INTRODUCTION: While negative affect and problem-solving deficits have been consistently linked to suicidal thoughts and behaviors, the latter are often conceptualized and studied as time- and/or context-invariant. Though requiring additional empirical support, theory suggests that discrimination may strengthen the relation between rejection sensitivity and increases in negative affect as well as declines in problem-solving abilities following rejection. The aim of the current study was to test this claim using a social rejection paradigm (i.e., Cyberball) with young adults experiencing past-month suicidal ideation. METHODS: The sample consisted of 50 participants. Lifetime discrimination and rejection sensitivity were assessed prior to Cyberball. Negative affect and problem-solving abilities were assessed pre- and post-Cyberball. SPSS and the PROCESS macro were used to test relations among variables of interest. RESULTS: Rejection sensitivity predicted greater problem-solving decrements, but not negative affect, following rejection among individuals who had experienced higher (vs. lower) levels of lifetime discrimination. CONCLUSION: Addressing rejection sensitivity and sources of discrimination within the context of treatment may reduce the impact of social rejection on problem-solving abilities among young adults at risk for suicide.


Subject(s)
Social Status , Suicide , Young Adult , Humans , Social Isolation , Suicidal Ideation , Problem Solving
9.
J Nutr Educ Behav ; 56(3): 184-192, 2024 03.
Article in English | MEDLINE | ID: mdl-38244011

ABSTRACT

OBJECTIVE: Examine the associations between subjective social status (SSS), diet, and health outcomes in college students. METHODS: Cross-sectional study of 841 students enrolled at a large Midwestern university. Subjective social status within the US, as well as within the university, was measured using the MacArthur Scale of SSS. Outcomes included dietary intake (assessed using the Dietary Screening Questionnaire), body mass index, sleep, physical activity, alcohol use, and vaping behavior. Generalized linear models adjusting for students' sociodemographic characteristics were used to assess associations between SSS and outcomes of interest. RESULTS: Higher SSS-US was associated with 4%, 3%, and 1% higher intake of fruits, whole grains, and fiber, respectively (P < 0.05). Higher SSS-US and SSS-university rankings were both significantly associated with lower body mass index and better sleep duration (P < 0.05). Higher SSS-university rankings were also associated with more days of physical activity and alcohol consumption (P < 0.05). CONCLUSIONS AND IMPLICATIONS: In this exploratory study, higher SSS, apart from alcohol intake, was associated with more favorable health outcomes. More research is needed to consider additional psychological and biological mediators and dynamic aspects of SSS, examine potential interactions between SSS and racial and ethnic identities, and explore potential mechanisms underlying the observed associations.


Subject(s)
Social Class , Social Status , Humans , Cross-Sectional Studies , Health Behavior , Students , Health Status
10.
BMC Public Health ; 24(1): 49, 2024 01 02.
Article in English | MEDLINE | ID: mdl-38166786

ABSTRACT

BACKGROUND: The exploration of discrimination, social acceptance, and their impact on the psychological well-being of older men who have sex with men (MSM) is a critical area of study within the broader field of LGBTQ+ research. This demographic, comprising individuals who identify as both male and homosexual and are aged in the older spectrum of the population, faces unique challenges that intersect age, sexual orientation, and societal attitudes. Objectives This study aimed to explore the relationship between social acceptance and isolation with discrimination and the impact on the psychological well-being of older MSM. METHODS: A cross-sectional survey was administered among older MSM residing in three distinct regions: the People's Republic of China (PRC), Hong Kong, and Taiwan, with a total sample size of N = 453 participants, evenly distributed with N = 151 individuals from each region. The survey included the General Health Questionnaire-12 (GHQ-12), the Discrimination and Self-Stigma Evaluation Scale (DSSES), and the Perceived Acceptance Scale (PAS) which measures the perceived social acceptance from friends, mother, father, and family. The data were analyzed using descriptive statistics, ANOVA, and regression analysis. RESULTS: The mean scores of the GHQ-12 indicated that the participants had a moderate level of psychological distress, with a mean score of 6.38 (SD = 2.55). The DSSES mean score was 27.78 (SD = 8.73), indicating that participants experienced discrimination in their everyday lives. The PAS mean score was 3.08 (SD = 0.48), indicating that participants had a moderate level of perceived social acceptance. These results suggest that discrimination and social acceptance differ among older MSM in different areas in PRC, Hong Kong, and Taiwan. CONCLUSIONS: The study highlights the impact of discrimination and social acceptance on the psychological well-being of older MSM. The findings suggest that interventions aimed at reducing discrimination and promoting social acceptance may improve the psychological well-being of older MSM. These results have important implications for healthcare providers and policymakers in developing strategies to promote social acceptance and reduce discrimination towards older MSM.


Subject(s)
HIV Infections , Sexual and Gender Minorities , Male , Humans , Female , Aged , Homosexuality, Male , Cross-Sectional Studies , Psychological Well-Being , Social Status , HIV Infections/psychology , Social Stigma , Social Discrimination
11.
MMWR Suppl ; 73(1): 21-33, 2024 01 25.
Article in English | MEDLINE | ID: mdl-38261572

ABSTRACT

Psychosocial and structural syndemic conditions, including polydrug use and experiencing homelessness, frequently co-occur and might jointly increase HIV risk. Limited studies have assessed racial and ethnic differences in exposure to syndemic conditions and behaviors associated with HIV transmission among transgender women. This report examines the relation between syndemic conditions and condomless anal intercourse (CAI) among transgender women in seven urban areas in the United States to develop HIV prevention interventions for transgender women. During 2019-2020, transgender women in seven urban areas were recruited using respondent-driven sampling for a biobehavioral survey. Reported syndemic conditions (psychosocial: polydrug use, sexual violence, and psychological distress; structural: homelessness, incarceration, and exchange sex) were summed to create a syndemic score. Using modified Poisson regression to account for RDS, the study assessed whether the strength of the association between syndemic score and CAI differed by race and ethnicity. To assess additive interaction, the relative excess prevalence owing to interaction (REPI) and 95% CIs for selected pairs of syndemic conditions on CAI prevalence stratified by race and ethnicity were estimated. Of 1,348 transgender women (Black = 546, White = 176, and Hispanic = 626), 55% reported CAI; and 24% reported ≥3 syndemic conditions. Reporting additional syndemic conditions was associated with CAI for White, Hispanic, and Black participants. The association was significantly stronger for White than Black and Hispanic participants. Limited significant superadditive interactions were found, although the majority were between structural syndemic conditions. Racial and ethnic differences in REPI estimates were observed. Reporting more syndemic conditions was associated with increased CAI across racial and ethnic groups, demonstrating that HIV prevention efforts for transgender women should address structural and psychosocial syndemic conditions. Results differed by race and ethnicity, indicating that syndemic-focused interventions for transgender women should be tailored to racial and ethnic groups.


Subject(s)
HIV Infections , Transgender Persons , Female , United States , Humans , Syndemic , Social Status , Ethnicity
12.
Behav Brain Sci ; 47: e12, 2024 Jan 15.
Article in English | MEDLINE | ID: mdl-38224095

ABSTRACT

I challenge the idea by Glowacki that "strong sanctions" such as fines, physical punishment, or execution are more effective in promoting peace than "weak punishments" like social rejection. Reviewing evidence that social rejection can have significant social and psychological costs for norm violators, I propose that social rejection can serve as a powerful reputational sanction in fostering peace in society.


Subject(s)
Social Conditions , Social Status , Humans , Punishment/psychology
13.
J Youth Adolesc ; 53(4): 940-954, 2024 Apr.
Article in English | MEDLINE | ID: mdl-37957459

ABSTRACT

Academic engagement in adolescence is shaped by influences from the peer environment, yet the types of peers impacting engagement remain unclear. This study explores the roles of friends, popular students, and intelligent students in shaping peers' behavioral and emotional (dis)engagement. Data were analyzed from 3409 Flemish eighth-grade students (Mage = 13.48 years, SD = 0.46, 50.09% female), utilizing self-reports and peer nominations to measure (dis)engagement and map friendship, popularity, and intelligence networks in the fall and spring. Longitudinal network analysis revealed that, while accounting for selection and network structure, friends influenced all dimensions of engagement. Popular students influenced emotional disengagement, and intelligent students impacted emotional engagement. These findings underscore the intricate nature of peer dynamics, highlighting the need for a multidimensional approach to studying peer influences on engagement.


Subject(s)
Adolescent Behavior , Friends , Humans , Adolescent , Female , Male , Friends/psychology , Social Status , Peer Influence , Adolescent Behavior/psychology , Peer Group
14.
Environ Res ; 241: 117609, 2024 Jan 15.
Article in English | MEDLINE | ID: mdl-37949287

ABSTRACT

The research assessed waste-based briquettes consumption compared to conventional fuels in the Andes. Laboratory tests were conducted together with on-field analysis in Colquencha (Bolivia). The laboratory study shows that the performances of briquettes are better in terms of PM2.5 (933.4 ± 50.8 mg kg-1) and CO emissions (22.89 ± 2.40 g kg-1) compared to animal dung (6265.7 ± 1273.5 mgPM2.5 kg-1 and 48.10 ± 12.50 gCO kg-1), although the boiling time increased due to the lower fuel consumption rate and firepower compared to shrubs. The social survey organized with 150 Bolivian citizens suggested that low-income households are not able to pay for an alternative fuel: about 40% would pay less than 4 USD per month, while methane use for cooking is positively correlated with the income level (r = 0.244, p < 0.05). On field analysis suggested that local cookstoves are not appropriate for briquettes combustion since indoor air pollution overcomes 30 ppm of CO and 10 mgPM2.5 m-3. On balance, local small manufactures can be the main target for selling waste-based briquettes to reduce shrubs and wood consumption. However, briquettes production costs seem not yet competitive to natural easy-to-obtain fuels (i.e., animal dung). The research encourages the use of cellulosic and biomass waste-based briquettes in the Andean area for cooking, heating, or manufacturing and strongly advises policy-makers to introduce economic incentives for the recovery of secondary raw materials.


Subject(s)
Air Pollution, Indoor , Social Status , Air Pollution, Indoor/analysis , Wood/chemistry , Poverty , Family Characteristics , Cooking , Particulate Matter/analysis
15.
Psychol Health Med ; 29(4): 754-764, 2024 Apr.
Article in English | MEDLINE | ID: mdl-37195214

ABSTRACT

Past research regarding the relationship between different constructs of social status and different aspects of pain has yielded divergent results. So far, there are few experimental studies to investigate the causal relationship between social status and pain. Therefore, the present study aimed to examine the effect of perceived social status on pain thresholds by experimentally manipulating participants' subjective social status (SSS). 51 female undergraduates were randomly assigned to a low- or high-status condition. Participants' perceived social standing was temporarily elevated (high SSS condition) or reduced (low SSS condition). Before and after experimental manipulation participants' pressure pain thresholds were assessed. The manipulation check confirmed that participants in the low-status condition reported significantly lower SSS than participants in the high-status condition. A linear mixed model revealed a significant group x time interaction for pain thresholds: Whereas participants' pain thresholds in the low SSS condition increased post manipulation, pain thresholds of participants in the high SSS condition decreased post manipulation (ß = 0.22; 95% CI, 0.002 to 0.432; p < .05). Findings suggest that SSS may have a causal effect on pain thresholds. This effect could either be due to a change in pain perception or a change in pain expression. Future research is needed to determine the mediating factors.


Subject(s)
Pain Threshold , Social Class , Female , Humans , Linear Models , Pain , Social Status
16.
Epilepsy Behav ; 150: 109554, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38041998

ABSTRACT

OBJECTIVES: People with epilepsy (PWE) not only suffer from seizures but also from various psycho-social issues containing facets such as social functioning, anxiety, depression or stigmatization, and consequently quality of life. (1) Assessing reliable change of these issues is crucial to evaluate their course and potential treatment effects. As most psycho-social self-report questionnaires have been validated in separate samples, their clinical-socio-demographic differences may limit the comparability and generalizability of the scales' internal consistency, which is important for the reliable change index (RCI). Using a co-normalized approach, we provide the internal consistency and RCIs for a large set of questionnaires targeting quality of life (QOLIE-31-P), depressive symptoms (NDDI-E), anxiety (GAD-7), seizure severity (LSSS), subjective antiseizure medication adverse events (LAEP), stigma, epilepsy-related fear, and restrictions in daily life (PESOS), and subjective cognition (FLei). As for some German versions of these measures, psychometric data is still missing, we also add important information for the German language area. (2) In addition, knowledge about intercorrelations of these constructs is needed to shape questionnaire usage and treatment approaches. We thus investigate associations of these scales and compare weighted and unweighted subscales of the QOLIE-31-P. METHODS: In our prospective study, 202 adult in-patients of the Epilepsy-Center Berlin-Brandenburg with a reliable diagnosis of epilepsy filled out a set of self-report questionnaires between 03/2018 and 03/2021. We calculated Cronbach's α, RCIs, and bivariate intercorrelations and compared the respective correlations of weighted and unweighted scales of the QOLIE-31-P. RESULTS: For most of the scales, good to excellent internal consistency was identified. Furthermore, we found intercorrelations in the expected directions with strong links between scales assessing similar constructs (e.g., QOLIE-31-P Cognition and FLei), but weak relationships between measures for different constructs (e.g., QOLIE-31-P Seizure worry and FLei). The QOLIE-31-P Total score was highly correlated with most of the other scales. Some differences regarding their correlational patterns for weighted and unweighted QOLIE-31-P scales were identified. CONCLUSIONS: Psycho-social constructs share a large amount of common variance, but still can be separated from each other. The QOLIE-31-P Total score represents an adequate measure of general psycho-social burden.


Subject(s)
Epilepsy , Quality of Life , Adult , Humans , Prospective Studies , Social Status , Epilepsy/drug therapy , Surveys and Questionnaires , Seizures , Language , Psychometrics , Reproducibility of Results
17.
Autism ; 28(4): 1051-1052, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38142445

ABSTRACT

LAY ABSTRACT: Human social organizations are complex. Yet little research exists on autistic people's attitudes about social hierarchies. Clinicians and the medical establishment regard social deficits as a key aspect of autism. If social deficits are paramount, then we expect autistic people to have difficulty navigating social hierarchies. We reject the premise of social deficits (while acknowledging that social misunderstandings interfere in the daily life of autistics) but suggest that researchers learn by listening to what autistic adults say about social hierarchies. We review writings by autistic people, including advice books, memoirs, book reviews, online discussion posts, and the mission-statement of an autistic-led organization. These suggest that autistic people find status-seeking illogical and prefer egalitarian relationships. The consistency of these themes across different types of writings is a reason for researchers to systematically study reduced status-seeking in autistic individuals.


Subject(s)
Autism Spectrum Disorder , Autistic Disorder , Child Development Disorders, Pervasive , Adult , Child , Humans , Learning , Social Status
18.
J Affect Disord ; 345: 467-476, 2024 01 15.
Article in English | MEDLINE | ID: mdl-37852590

ABSTRACT

BACKGROUND: Although social rejection is among the strongest proximal precipitants of major depressive disorder (MDD), little is known about the underlying neurobiological mechanisms and whether neural sensitivity to social rejection may help explain differences in MDD risk. To address this issue, we tested whether neural responses to social threat differed in female adolescents at high vs. low maternal risk for MDD. METHOD: Female adolescents with (high-risk; n = 22, Mage = 14.68) and without (low-risk; n = 30, Mage = 15.07) a maternal history of depression were experimentally exposed to negative and neutral social evaluation while undergoing an fMRI scan. Neural responses were assessed by event-related activity and functional connectivity, as well as multivoxel pattern analysis. Activity and functional connectivity analyses focused on a priori-selected regions of interest implicated in self-referential processing and emotion regulation. RESULTS: Compared to low-risk female adolescents, high-risk female adolescents exhibited greater increases in self-reported depression and social disconnection following social evaluation. Moreover, compared to low-risk female adolescents, high-risk female adolescents exhibited greater amygdala responses to negative social evaluation and a differential pattern of functional connectivity in brain regions related to emotion regulation, self-referential processing, and negative affect. Additionally, these markers of neural threat reactivity were related to depressive symptoms. LIMITATIONS: A cross-sectional study design and relatively small, Western sample. CONCLUSIONS: These results suggest that exaggerated neural reactivity to social threat-and an atypical pattern of related functional connectivity-is evident in individuals with a preclinical risk factor for depression. Targeting such responding may thus be a fruitful strategy for preventing depression in at-risk youth.


Subject(s)
Depressive Disorder, Major , Humans , Adolescent , Female , Depressive Disorder, Major/psychology , Emotions/physiology , Depression/diagnostic imaging , Cross-Sectional Studies , Social Status , Risk Factors , Magnetic Resonance Imaging/methods
19.
Physiol Behav ; 273: 114406, 2024 Jan 01.
Article in English | MEDLINE | ID: mdl-37949308

ABSTRACT

Mice naturally form social hierarchies, and their experiences as subordinate or dominant mice inform future behavioural strategies. To better understand the neural bases of social dominance, we investigated hippocampal gene and protein expression of histone deacetylase 2 (HDAC2), an epigenetic regulator that decreases expression of synaptic plasticity genes and reduces excitatory synaptic function. Hdac2 in hippocampus was associated with social status. The gene for a closely related histone deacetylase (Hdac1), and HDAC2 protein expression, were not associated with social rank in hippocampus. These findings suggest that Hdac2 expression in hippocampus is distinctly linked with social status.


Subject(s)
Histone Deacetylase 1 , Social Status , Animals , Mice , Male , Female , Histone Deacetylase 1/genetics , Histone Deacetylase 1/metabolism , Histone Deacetylase 2/genetics , Histone Deacetylase 2/metabolism , Hippocampus/metabolism
20.
Physiol Behav ; 273: 114410, 2024 Jan 01.
Article in English | MEDLINE | ID: mdl-37977252

ABSTRACT

Social stress plays an important role in the etiology of many neuropsychiatric disorders and can lead to a variety of behavioral deficits such as social withdrawal. One way that social stress may contribute to psychiatric disorders is by reducing social motivation and the rewarding properties of social interactions. We investigated the impact of social stress on social reward in the context of winning versus losing agonistic encounters in Syrian hamsters (Mesocricetus auratus). First, we tested the hypothesis that social stress resulting from either stable low, or subordinate, social status or from social defeat reduces the rewarding properties of social interactions. Using an Operant Social Preference (OSP) task to measure social reward/motivation, we found that both subordinate and socially defeated males made significantly fewer entries into chambers containing novel, same-sex conspecifics compared to males who were dominant (i.e., stably won the agonistic encounters). In females, however, there were no differences in social entries between winners and losers. In a second experiment, we found more activation of the mesolimbic dopamine system (MDS) as assessed with cFos immunohistochemistry in the lateral ventral tegmental area (lVTA) and the nucleus accumbens (NAc) shell of male winners compared to losers. In females, however, there were no differences in activation in the lVTA between winners and losers. Surprisingly, however, winning females displayed significantly more activation in the NAc shell as compared to losing females, despite the lack of behavioral differences. Thus, behavioral and histological data suggest that there are sex differences in the impact of social status on social reward and associated mesolimbic activation.


Subject(s)
Sex Characteristics , Social Status , Cricetinae , Animals , Male , Female , Humans , Reward , Mesocricetus , Nucleus Accumbens/physiology , Ventral Tegmental Area/physiology
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