ABSTRACT
O Brasil representa uma das áreas endêmicas para o vírus linfotrópico de células T humanas do tipo 1 (HTLV-1) e a cidade de Salvador, Bahia, possui a maior prevalência nacional da infecção por este retrovírus (1,8%), com cerca de 50.000 pessoas infectadas. O HTLV-1 foi o primeiro retrovírus humano descrito e está classicamente associado à leucemia/linfoma de células T do adulto (ATLL) e à mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP). A HAM/TSP é uma doença inflamatória do sistema nervoso central, cujos mecanismos imunopatogênicos não estão completamente elucidados. O papel dos linfócitos T citotóxicos na patogênese desta doença ainda não está bem definido. Neste estudo, foram avaliados o fenótipo e a função de linfócitos T citotóxicos de pacientes infectados pelo HTLV-1 com HAM/TSP...
Brazil represents one of the largest endemic areas for human T-lymphotropic virus cells type 1 (HTLV-1) infection and associated diseases. Salvador, Bahia, is considered as the Brazilian city with the highest national HTLV-1prevalence (around 1.8% in the general population). HTLV -1 was the first human retrovirus described and is classically associated with adult Tcell leukemia/lymphoma (ATLL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is a chronic and progressive inflammatory disease of the central nervous system and your immunopathogenic mechanisms are not completely understood. The role of cytotoxic T-lymphocytes (CTLs) in the pathogenesis of this disease is still undefined. In this study we evaluated the phenotype and function of cytotoxic Tlymphocytes from HTLV-1-infected patients with HAM/TSP...
Subject(s)
Humans , Spinal Cord Diseases/immunology , Spinal Cord Diseases/pathology , Spinal Cord Diseases/prevention & control , Spinal Cord Diseases/blood , T-Lymphocytes, Cytotoxic/cytology , T-Lymphocytes, Cytotoxic/immunology , T-Lymphocytes, Cytotoxic/pathology , Human T-lymphotropic virus 1/immunologyABSTRACT
O vírus linfotrópico das células T humanas do tipo 1 (HTLV-1) é o agente etiológico da mielopatia associada ao HTLV / paraparesia espástica tropical (HAM / TSP ), que ocorre em menos de 5 % dos indivíduos infectados. A resposta imune controla parcialmente a infecção, porém pode estar ligada a patogênese da doença. O objetivo deste estudo foi caracterizar fenotipicamente as subpopulações de linfócitos T, em pacientes assintomáticos e com diagnóstico de HAM/TSP. Foram avaliados 103 pacientes acompanhados no Centro de HTLV da Escola Bahiana de Medicina e Saúde Pública (EBMSP) e 19 controles não infectados. Os pacientes foram categorizados de acordo com o grau de certeza do diagnóstico de HAM/TSP: possível (Ps), provável (Pb) e definido (D), além de pacientes assintomáticos (ASS). O perfil fenotípico (CD25, CD45RA, CD45RO, HLA-DR, CD25, CCR-7, CD62L)...
The human T-cell lymphotropic vírus type 1(HTLV-1) is the etiological agent of HTLV- associated myelopathy/ Tropical spastic paraparesis(HAM/TSP), wich occurs in less then 5% of the infected individuals. The immune response partially controls the infection, but may be linked to the pathogenesis of disease. The aim of this study was to characterize phenotipically T lymphocyte subpopulations in asymptomatic and in patients diagnosed with HAM/TSP. We evaluated 103 patients treated at the center for HTLV of Bahia School of Medicine and Public Health (EBMSP) and 19 uninfected controls. Patients were categorized as asymptomatic and according to the degree of certainty of the diagnosis of HAM/TSP: Possible(Ps), Probable(Pb) and Definite(D). The phenotypic profile (CD25, CD45RA, CD45RO, HLA-DR, CCR-7, CD62L)...
Subject(s)
Humans , Spinal Cord Diseases/diagnosis , Spinal Cord Diseases/immunology , Spinal Cord Diseases/pathology , Spinal Cord Diseases/prevention & control , Spinal Cord Diseases/virology , Receptors, Antigen, T-Cell , Receptors, Antigen, T-Cell/administration & dosage , Receptors, Antigen, T-Cell/analysis , Receptors, Antigen, T-Cell/immunology , Human T-lymphotropic virus 1/pathogenicityABSTRACT
BACKGROUND AND OBJECTIVES: Spinal hematomas are rare and they affect the central nervous system. They can cause permanent neurologic sequelae and death if they are not treated properly. Early diagnosis and treatment are fundamental for a good neurologic prognostic. The objective of this report was to emphasize for anesthesiologists the importance of early diagnosis and treatment of spinal hematomas, besides improving their prevention. CASE REPORTS: Case 1: The patient underwent epidural lumbar anesthesia for femoropopliteal revascularization. He was being treated with acetylsalicylic acid, clopidogrel, and enoxaparin, which were discontinued before the surgery. The patient developed paraplegia in the immediate postoperative period. Neurosurgical decompression was performed after the diagnosis, but without recovery in the long run. Case 2: The patient underwent epidural lumbar anesthesia for right knee osteotomy, without intercurrences. The patient remained without neurological complaints until approximately 48 hours after the surgery when he developed urinary retention, pain in the right lower limb, paresthesias, and difficulty moving both feet. The MRI showed an epidural lumbar hematoma, and the patient underwent immediate surgical decompression. He showed complete neurological recovery after 10 months of rehabilitation. CONCLUSIONS: The clinical cases presented here showed different outcomes, indicating the importance of early diagnosis and treatment for a good evolution. Diagnosis by MRI with early decompression shortly after the development of the first clinical manifestations remains the standard treatment. Identification of patients at risk for neuraxial bleeding and change in anesthetic technique, as well as the establishment of postoperative neurologic evaluation protocols in patients undergoing neuraxial anesthesia can contribute for prevention of severe neurologic sequelae.
Subject(s)
Anesthesia, Epidural/adverse effects , Hematoma/etiology , Hematoma/prevention & control , Lumbar Vertebrae , Spinal Cord Diseases/etiology , Spinal Cord Diseases/prevention & control , Aged , Humans , Male , Middle AgedABSTRACT
JUSTIFICATIVA E OBJETIVOS: Os hematomas espinais são raros e acometem o sistema nervoso central. Podem causar sequelas neurológicas permanentes e morte se não tratados adequadamente. O diagnóstico e tratamento precoces são fundamentais para o bom prognóstico neurológico. O objetivo deste trabalho foi despertar no anestesiologista maior sensibilidade para o diagnóstico e o tratamento precoces dos hematomas espinais, além de aperfeiçoar sua prevenção. RELATO DOS CASOS: Caso 1: Paciente submetido à anestesia peridural lombar para a realização de revascularização fêmuro-poplítea. Estava em uso de ácido acetilsalicílico, clopidogrel e enoxaparina, medicamentos suspensos antes da operação. O paciente evoluiu com paraplegia no pós-operatório imediato. Realizou-se descompressão neurocirúrgica após o diagnóstico, porém sem recuperação do quadro em longo prazo. Caso 2: Paciente submetido à anestesia peridural lombar para osteotomia em joelho direito, sem intercorrências. O paciente permaneceu sem queixas neurológicas até aproximadamente 48 horas, quando iniciou quadro de retenção urinária, dor em membro inferior direito, parestesias e dificuldade de movimentação dos pés. Foi feita ressonância nuclear magnética, a qual evidenciou hematoma peridural lombar, sendo realizada a descompressão cirúrgica imediata. Após 10 meses de reabilitação, houve recuperação neurológica completa. CONCLUSÕES: Os casos clínicos apresentados mostraram desfechos diferentes, destacando a importância do diagnóstico e do tratamento precoces para a boa evolução do quadro clínico. O diagnóstico pela ressonância nuclear magnética, com a descompressão precoce logo após as primeiras manifestações clínicas, permanece como tratamento padrão. A identificação dos pacientes de risco para sangramentos neuroaxiais, a mudança de técnica anestésica, assim como o estabelecimento de protocolos de avaliação neurológica pós-operatória nos pacientes submetidos aos bloqueios de neuroeixo...
BACKGROUND AND OBJECTIVES: Spinal hematomas are rare and they affect the central nervous system. They can cause permanent neurologic sequelae and death if they are not treated properly. Early diagnosis and treatment are fundamental for a good neurologic prognostic. The objective of this report was to emphasize for anesthesiologists the importance of early diagnosis and treatment of spinal hematomas, besides improving their prevention. CASE REPORTS: Case 1: The patient underwent epidural lumbar anesthesia for femoropopliteal revascularization. He was being treated with acetylsalicylic acid, clopidogrel, and enoxaparin, which were discontinued before the surgery. The patient developed paraplegia in the immediate postoperative period. Neurosurgical decompression was performed after the diagnosis, but without recovery in the long run. Case 2: The patient underwent epidural lumbar anesthesia for right knee osteotomy, without intercurrences. The patient remained without neurological complaints until approximately 48 hours after the surgery when he developed urinary retention, pain in the right lower limb, paresthesias, and difficulty moving both feet. The MRI showed an epidural lumbar hematoma, and the patient underwent immediate surgical decompression. He showed complete neurological recovery after 10 months of rehabilitation. CONCLUSIONS: The clinical cases presented here showed different outcomes, indicating the importance of early diagnosis and treatment for a good evolution. Diagnosis by MRI with early decompression shortly after the development of the first clinical manifestations remains the standard treatment. Identification of patients at risk for neuraxial bleeding and change in anesthetic technique, as well as the establishment of postoperative neurologic evaluation protocols in patients undergoing neuraxial anesthesia can contribute for prevention of severe neurologic sequelae.
JUSTIFICATIVA Y OBJETIVOS: Los hematomas espinales son raros y acometen el sistema nervioso central. Pueden causar secuelas neurológicas permanentes e incluso la muerte si no se tratan adecuadamente. El diagnóstico y el tratamiento precoces son elementos fundamentales para el buen pronóstico neurológico. El objetivo de este trabajo fue despertar en el anestesiólogo una mayor sensibilidad hacia el diagnóstico y el tratamiento precoces de los hematomas espinales, además de perfeccionar su prevención. RELATO DE LOS CASOS: Caso 1: Paciente que fue sometido a la anestesia epidural lumbar para la realización de la revascularización femoro-poplítea. Estaba usando ácido acetilsalicílico, clopidogrel y enoxaparina, medicamentos que fueron suspendidos antes de la operación. El paciente evolucionó con paraplejia en el postoperatorio inmediato. Se realizó la descompresión neuro-quirúrgica posterior al diagnóstico, pero sin la recuperación del cuadro a largo plazo. Caso 2: Paciente que fue sometido a la anestesia epidural lumbar para la osteotomía en la rodilla derecha, sin intercurrencias. El paciente no presentó quejas neurológicas durante aproximadamente 48 horas, cuando inició el cuadro de retención urinaria, dolor en el miembro inferior derecho, parestesias y dificultad para mover los pies. Se realizó la resonancia nuclear magnética, que arrojó hematoma epidural lumbar, siendo realizada la descompresión quirúrgica inmediata. Después de 10 meses de rehabilitación, se verificó una recuperación neurológica completa. CONCLUSIONES: Los casos clínicos presentados aquí, arrojaron diferentes desenlaces, destacando la importancia del diagnóstico y del tratamiento precoces para una buena evolución del cuadro clínico. El diagnóstico por la resonancia nuclear magnética, con la rápida descompresión inmediatamente después de las primeras manifestaciones clínicas, permanece como un tratamiento estándar. La identificación de los pacientes de riesgo para sangramientos neuroaxiales...