Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 216
Filter
1.
Neurol India ; 70(Supplement): S318-S321, 2022.
Article in English | MEDLINE | ID: mdl-36412389

ABSTRACT

Meningeal melanomatosis is an infrequent tumor originating from the melanocytes in the leptomeninges and one of the recognized primary melanocytic tumors of the central nervous system. The average survival has known to be about 5 months. It can be associated with solid tumors, such as meningeal melanocytomas. The patient we present was diagnosed of a meningeal melanomatosis that developed two solid tumors related to an in vitro fertilization. The clinical course was rapidly fatal. Although the use of comprehensive diagnostic procedures, usually the final diagnosis of primary diffuse meningeal melanomatosis is postmortem, it would be advisable for the appropriate management of the patient to make a differential diagnosis and to be aware of the behavior of the tumor.


Subject(s)
Fertilization in Vitro , Melanoma , Meningeal Neoplasms , Spinal Cord Neoplasms , Adult , Humans , Fatal Outcome , Fertilization in Vitro/adverse effects , Melanoma/diagnosis , Melanoma/etiology , Meningeal Neoplasms/diagnosis , Meningeal Neoplasms/etiology , Spinal Cord Neoplasms/diagnosis , Spinal Cord Neoplasms/etiology
2.
Medicina (Kaunas) ; 58(11)2022 Oct 28.
Article in English | MEDLINE | ID: mdl-36363510

ABSTRACT

Background and Objectives: Spinal meningiomas, which are well characterized and are most frequently intradural extramedullary tumors, represent 25% of all intradural spinal tumors. The goal of this study was to compare the outcomes of surgically treated patients with spinal meningiomas in two time intervals with special emphasis on postoperative functional outcomes. Methods: Patients with spinal meningiomas admitted to our department between 1990 and 2020 were enrolled and divided into a historic cohort (HC; treated 1990−2007) and a current cohort (CC; treated 2008−2020). Patients' clinical data and surgical and radiological reports were retrospectively analyzed up to 5 years. Preoperative and postoperative neurological function were assessed using the modified McCormick Scale (mMCS). The Charlson Comorbidity Index (CCI) was used to evaluate the effect of comorbidities on the preoperative status and postoperative outcome. Results: We included 300 patients. Participants in the CC (n = 144) were significantly younger compared to those in the HC (n = 156), with twice as many patients <50 years of age (p < 0.001). The most common tumor location was the thoracic spine (n = 204). The median follow-up was 38.1 months (±30.3 standard deviation). A symptom duration until surgery <12 months was significantly associated with an earlier improvement in the mMCS (p = 0.045). In the CC, this duration was shorter and patients' neurological function at the first and last follow-ups was significantly better than for those in the HC (p < 0.001 for both). Conclusions: Our study results suggested that the impact of surgical management and postoperative rehabilitation on spinal meningioma patients' long-term neurological outcome has reached important milestones over the last decades. An earlier diagnosis led to earlier surgical treatment and improved patients' postoperative neurological recovery. Our results exposed that surgical therapy for spinal meningioma should be performed within 12 months after appearance of symptoms to achieve a better recovery.


Subject(s)
Meningeal Neoplasms , Meningioma , Spinal Cord Neoplasms , Humans , Meningioma/surgery , Meningioma/diagnosis , Meningioma/pathology , Retrospective Studies , Treatment Outcome , Neurosurgical Procedures/adverse effects , Neurosurgical Procedures/methods , Spinal Cord Neoplasms/surgery , Spinal Cord Neoplasms/etiology , Meningeal Neoplasms/surgery , Meningeal Neoplasms/diagnosis , Meningeal Neoplasms/pathology
3.
J Neurosurg Sci ; 66(5): 447-455, 2022 Oct.
Article in English | MEDLINE | ID: mdl-31565906

ABSTRACT

BACKGROUND: Intramedullary spinal cord tumors are rare lesions of the central nervous system. Anatomical, molecular and radiological features are well defined, but correct management is still matter of debate. Pertinent literature has reported conflicting opinions regarding the use of intraoperative electrophysiological monitoring (IONM) in the surgical treatment of this kind of lesions, recently. We report a retrospective study from two Italian centers, in order to highlight the usefulness of IONM in the management of intramedullary lesions. METHODS: We performed a retrospective review of patients with intramedullary spinal tumor who underwent surgical resection from February 2011 to February 2018 in two different institutions. Clinical and radiological data, lesion features, timing of symptom onset and IONM findings were recorded. The IONM included somatosensory-evoked potentials (SSEP), motor-evoked potentials (MEP) and D-Wave whenever possible. We evaluated the outcome according to the Modified McCormick scale. We also evaluated the accuracy and relevance of surgical outcomes for each evoked potential (SSEP, MEP, D-Wave). RESULTS: A total of 57 patients were included. A gross total removal was achieved in 46 cases. Neurological follow-up was assessment at 3 days, and 3 and 6 months after surgery. Comparing the preoperative status and 6 months follow-up: the modified McCormick scale showed a neurological stability for 30 patients (52.63%), a worsening of neurological status for 7 patients (12.28%) and an improvement for 20 patients (35.08%). IONM presented high accuracy (sensibility of 100% and specificity of 95.65%) and significantly predicted postoperative permanent motor deficits (P<0.0001; AUC=0.978). D-Wave appeared to have significant greater predictive value than MEP and especially SSEP alone (0.967 vs 0.722 vs 0.542; P=0.044 and P<0.001 respectively). CONCLUSIONS: The gold standard in the intramedullary lesion treatment is maximal safe resection with good neurological outcome, as shown in our patients. The use of IONM is helpful in intramedullary tumors resection in order to minimize postoperative neurological deficits and our analysis suggests that the use of D-Wave presents a statistically significant higher accuracy for predicting postoperative deficits than SSEP and MEP alone.


Subject(s)
Intraoperative Neurophysiological Monitoring , Spinal Cord Neoplasms , Evoked Potentials, Somatosensory/physiology , Humans , Neurosurgical Procedures/adverse effects , Retrospective Studies , Spinal Cord Neoplasms/etiology , Spinal Cord Neoplasms/surgery
4.
Int J Mol Sci ; 22(23)2021 Nov 30.
Article in English | MEDLINE | ID: mdl-34884748

ABSTRACT

Intramedullary spinal cord tumors are a rare and understudied cancer with poor treatment options and prognosis. Our prior study used a combination of PDGF-B, HRAS, and p53 knockdown to induce the development of high-grade glioma in the spinal cords of minipigs. In this study, we evaluate the ability of each vector alone and combinations of vectors to produce high-grade spinal cord gliomas. Eight groups of rats (n = 8/group) underwent thoracolumbar laminectomy and injection of lentiviral vector in the lateral white matter of the spinal cord. Each group received a different combination of lentiviral vectors expressing PDGF-B, a constitutively active HRAS mutant, or shRNA targeting p53, or a control vector. All animals were monitored once per week for clinical deficits for 98 days. Tissues were harvested and analyzed using hematoxylin and eosin (H&E) and immunohistochemical (IHC) staining. Rats injected with PDGF-B+HRAS+sh-p53 (triple cocktail) exhibited statistically significant declines in all behavioral measures (Basso Beattie Bresnahan scoring, Tarlov scoring, weight, and survival rate) over time when compared to the control. Histologically, all groups except the control and those injected with sh-p53 displayed the development of tumors at the injection site, although there were differences in the rate of tumor growth and the histopathological features of the lesions between groups. Examination of immunohistochemistry revealed rats receiving triple cocktail displayed the largest and most significant increase in the Ki67 proliferation index and GFAP positivity than any other group. PDGF-B+HRAS also displayed a significant increase in the Ki67 proliferation index. Rats receiving PDGF-B alone and PDGF-B+ sh-p53 displayed more a significant increase in SOX2-positive staining than in any other group. We found that different vector combinations produced differing high-grade glioma models in rodents. The combination of all three vectors produced a model of high-grade glioma more efficiently and aggressively with respect to behavioral, physiological, and histological characteristics than the rest of the vector combinations. Thus, the present rat model of spinal cord glioma may potentially be used to evaluate therapeutic strategies in the future.


Subject(s)
Glioma/etiology , Lentivirus/genetics , Spinal Cord Neoplasms/etiology , Animals , Biomarkers, Tumor/genetics , Biomarkers, Tumor/metabolism , Cell Proliferation , Genetic Vectors , Glioma/pathology , Glioma/physiopathology , Mutation , Neoplasms, Experimental/etiology , Neoplasms, Experimental/pathology , Neoplasms, Experimental/physiopathology , Oncogene Proteins/genetics , Oncogene Proteins/metabolism , Platelet-Derived Growth Factor/genetics , Platelet-Derived Growth Factor/metabolism , RNA, Small Interfering/administration & dosage , RNA, Small Interfering/genetics , Rats , Rats, Sprague-Dawley , Spinal Cord Neoplasms/pathology , Spinal Cord Neoplasms/physiopathology , Tumor Suppressor Protein p53/antagonists & inhibitors , Tumor Suppressor Protein p53/genetics , Tumor Suppressor Protein p53/metabolism , ras Proteins/genetics , ras Proteins/metabolism
5.
BMJ Case Rep ; 13(12)2020 Dec 17.
Article in English | MEDLINE | ID: mdl-33334766

ABSTRACT

Radiation-induced spinal glioblastoma is an extremely rare disease with only four previously published reports in the literature. We report the fifth case, a 69-year-old woman who previously underwent treatment with brachytherapy for cervical cancer, and thereafter presented with neurologic deficits from a conus medullaris tumour. Biopsy and histopathology confirm glioblastoma, not otherwise specified. Treatment of spinal glioblastoma consists of surgery, either biopsy or excision and chemoradiation. However, results are still unsatisfactory and prognosis remains poor.


Subject(s)
Brachytherapy/adverse effects , Glioblastoma/diagnosis , Neoplasms, Radiation-Induced/diagnosis , Spinal Cord Neoplasms/diagnosis , Uterine Cervical Neoplasms/radiotherapy , Aged , Biopsy , Cytoreduction Surgical Procedures , Female , Glioblastoma/etiology , Glioblastoma/pathology , Glioblastoma/surgery , Humans , Laminectomy , Magnetic Resonance Imaging , Neoplasms, Radiation-Induced/etiology , Neoplasms, Radiation-Induced/pathology , Neoplasms, Radiation-Induced/surgery , Spinal Cord/diagnostic imaging , Spinal Cord/pathology , Spinal Cord/radiation effects , Spinal Cord/surgery , Spinal Cord Neoplasms/etiology , Spinal Cord Neoplasms/pathology , Spinal Cord Neoplasms/surgery
6.
World Neurosurg ; 143: 129-133, 2020 11.
Article in English | MEDLINE | ID: mdl-32745650

ABSTRACT

BACKGROUND: We sought to analyze the clinical data and imaging features from a rare case presenting an intravertebral mobile nerve sheath tumor of the lumbar spine, review the relevant literature, discuss the imaging features and possible causes of the tumor, and propose preventive measures and solutions. CASE DESCRIPTION: The clinical data and imaging data of a patient with a lumbar spinal canal mobile nerve sheath tumor were retrospectively analyzed in conjunction with the relevant literature. The first preoperative lumbar spine magnetic resonance imaging (MRI) showed the tumor located at level L1-2. Further lumbar spine MRI, which was performed 5 days later, showed the tumor was at level L3-4, with a range of motion of 8 cm. End spinal resection of the tumor was performed under general anesthesia, and a tumor, which was cystic solid, was found to be located at level L3-4. The tumor originated from a distinctly twisted and elongated posterior root of the spinal cord, with complete fusion of the tumor-bearing nerve. Both the tumor and tumor-carrying nerve were removed. Postoperative pathologic examination confirmed that the tumor was a nerve sheath tumor. Lumbar MRI on postoperative day 10 showed complete resection of the tumor in the L3-4 spinal canal. The patient was discharged with normal urination and defecation, normal sensation in both lower extremities, grade 5 muscle strength, normal muscle tone, and normal reflexes in both knee and Achilles tendons. CONCLUSIONS: Intravertebral mobile nerve sheath tumors are rare, and the marked distortion and elongation of the carrier nerve seen on MRI are important imaging features of this disease. The possible causes of tumor movement include tumor texture, location, positional changes, and altered cerebrospinal fluid dynamics. Acute changes in intraabdominal pressure caused by forceful defecation may be a high-risk factor for tumor migration. Multiple preoperative MRIs to localize the tumor are particularly important.


Subject(s)
Nerve Sheath Neoplasms/therapy , Spinal Cord Neoplasms/therapy , Aged , Humans , Lumbosacral Region/diagnostic imaging , Magnetic Resonance Imaging , Male , Nerve Sheath Neoplasms/diagnosis , Nerve Sheath Neoplasms/etiology , Neurosurgical Procedures , Preoperative Care , Spinal Cord Neoplasms/diagnosis , Spinal Cord Neoplasms/etiology , Spinal Nerves/diagnostic imaging , Spinal Nerves/surgery , Treatment Outcome
7.
World Neurosurg ; 141: 318-322, 2020 09.
Article in English | MEDLINE | ID: mdl-32592964

ABSTRACT

BACKGROUND: Radiation-induced spinal cord cavernous malformations (CMs) are rare pathologies compared with radiation-induced cerebral CMs. We present a case of a radiation-induced spinal cord CM developed 31 years after radiation therapy for medulloblastoma. CASE DESCRIPTION: A 37-year-old man developed a symptomatic spinal hemorrhagic lesion 31 years after radiation therapy for medulloblastoma. Magnetic resonance imaging revealed an intramedullary cystic lesion with a fluid-fluid level in the C7 area. Surgery was performed leading to an unclear diagnosis. Two years later, the patient had a relapse and underwent a second operation, allowing a definitive diagnosis of radiation-induced spinal cord CM. This is believed to be the second case of de novo intramedullary CM formation following spinal radiation therapy for medulloblastoma. CONCLUSIONS: Radiation-induced spinal cord CMs should be recognized as a possible late adverse effect in patients treated with radiation therapy for medulloblastoma.


Subject(s)
Arteriovenous Malformations/surgery , Cerebellar Neoplasms/surgery , Medulloblastoma/pathology , Neoplasm Recurrence, Local/pathology , Radiation , Adult , Arteriovenous Malformations/diagnosis , Arteriovenous Malformations/pathology , Cerebellar Neoplasms/diagnosis , Cerebellar Neoplasms/pathology , Humans , Male , Medulloblastoma/complications , Medulloblastoma/surgery , Neoplasm Recurrence, Local/surgery , Spinal Cord Neoplasms/diagnosis , Spinal Cord Neoplasms/etiology , Spinal Cord Neoplasms/surgery
8.
J Neurooncol ; 143(3): 547-552, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31089924

ABSTRACT

INTRODUCTION: Hemangioblastomas are uncommon tumors of the central nervous system that can be seen in Von Hippel-Lindau (VHL) disease. Despite their benign histology, hemangioblastomas can cause substantial morbidity due to involvement of critical structures. In order to better understand the clinical behavior of spinal cord hemangioblastomas, we have analyzed the clinical, pathologic, radiologic characteristics and management of sporadic and VHL-associated cases at our institution. METHODS: We performed a database search to identify all spinal hemangioblastomas at our institution between 1997 and 2016. Tumor characteristics were analyzed for sporadic and VHL-associated tumors separately in order to understand the differences in groups. RESULTS: We included 20 patients with VHL-associated spinal hemangioblastomas, and 22 patients with sporadic spinal hemangioblastomas. VHL-associated patients were significantly younger at time of presentation compared to sporadic patients (p < 0.0025). Thirty-two patients (76.2%) presented with focal weakness, 34 (81.0%) with sensory loss, and 22 (52.4%) with pain. VHL patients were more likely to present with multiple symptoms (p < 0.001). Median follow-up time was 20.9 months, during which 17 tumors recurred. The median recurrence free interval was 44 months. There were no differences in gross total resection rates between sporadic and VHL-associated cases (p = 0.197). VHL-associated cases had a higher rate of repeat surgery for recurrence (14 patients-73.6%) compared to sporadic cases (3 patients-13.6%; p < 0.001). CONCLUSION: VHL-associated spinal hemangioblastomas differ from sporadic tumors in terms of age, presenting symptoms, multifocality, and rate of recurrence. Recurrences seem to be unrelated to the extent of resection, indicating the need for life-long follow up for VHL patients.


Subject(s)
Hemangioblastoma/surgery , Neoplasm Recurrence, Local/epidemiology , Reoperation/statistics & numerical data , Spinal Cord Neoplasms/surgery , von Hippel-Lindau Disease/complications , Adolescent , Adult , Aged , Databases, Factual , Female , Follow-Up Studies , Hemangioblastoma/etiology , Hemangioblastoma/pathology , Humans , Incidence , Male , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Retrospective Studies , San Francisco/epidemiology , Spinal Cord Neoplasms/etiology , Spinal Cord Neoplasms/pathology , Survival Rate , Treatment Outcome , Young Adult
9.
World Neurosurg ; 117: e187-e193, 2018 Sep.
Article in English | MEDLINE | ID: mdl-29886300

ABSTRACT

OBJECTIVE: Hemangioblastomas (HBs) are benign vascular tumors of the central nervous system and histologically contain abundant microvessels. Therefore, they clinically exhibit vascular malformation-like characteristics. It has been described that endothelial-to-mesenchymal transition (EndMT) contributes to the pathogenesis of cerebral cavernous malformations. However, it remains unknown whether EndMT contributes to the pathogenesis of central nervous system HBs. The aim of our study was to investigate whether EndMT occurs in central nervous system HBs. METHODS: Ten central nervous system HBs were immunohistochemically investigated. RESULTS: Cluster of differentiation (CD) 31 (an endothelial marker) and EndMT markers, such as α-smooth muscle actin (a mesenchymal marker) and CD44 (a mesenchymal stem cell marker), were expressed in the endothelial layer of microvessels in all cases. These findings suggest that endothelial cells (ECs) of microvessels in central nervous system HBs have acquired mesenchymal and stem cell-like characteristics and undergone EndMT. In all cases, both ephrin-B2 and EphB4, which are not detected in adult normal brain vessels, were expressed in the endothelial layer of microvessels. These data suggest that ECs of microvessels in central nervous system HBs are immature or malformed cells and have both arterial and venous characteristics. CONCLUSIONS: To our knowledge, this is the first report showing the possibility that EndMT contributes to the pathogenesis of central nervous system HBs. It is likely that ECs of microvessels in central nervous system HBs are immature or malformed cells and have both arterial and venous characteristics. EndMT is expected to be a new therapeutic target in central nervous system HBs.


Subject(s)
Cerebellar Neoplasms/etiology , Epithelial-Mesenchymal Transition/physiology , Hemangioblastoma/etiology , Spinal Cord Neoplasms/etiology , Adult , Aged , Endothelium, Vascular/physiology , Female , Humans , Hyaluronan Receptors/metabolism , Immunohistochemistry , Male , Microvessels/physiology , Middle Aged , Platelet Endothelial Cell Adhesion Molecule-1/metabolism , Receptor, Notch1/metabolism , Signal Transduction/physiology
10.
Pediatr Blood Cancer ; 65(10): e27250, 2018 10.
Article in English | MEDLINE | ID: mdl-29797651

ABSTRACT

Compared to cerebral radiation-induced cavernous hemangiomas (RICHs), little is known about intraspinal RICHs. A 13-year-old male suddenly developed symptomatic spinal hemorrhage eight years after hematopoietic stem cell transplantation using a total body irradiation (TBI) based myeloablative regimen. A solitary small hemangioma was detected on follow-up T2 star weighted magnetic resonance imaging of the spine. His neurological symptoms gradually improved with supportive treatment and rehabilitation, although he experienced rebleeding 2 years later. Intraspinal RICH is very rare but should be recognized as a possible late adverse effect in pediatric patients who received TBI.


Subject(s)
Hemangioma, Cavernous, Central Nervous System/etiology , Hemorrhage/etiology , Neoplasms, Radiation-Induced/etiology , Spinal Cord Neoplasms/etiology , Whole-Body Irradiation/adverse effects , Adolescent , Humans , Male , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
13.
Curr Treat Options Oncol ; 18(9): 53, 2017 08 10.
Article in English | MEDLINE | ID: mdl-28795286

ABSTRACT

OPINION STATEMENT: Malignant epidural spinal cord compression (MESCC) is an oncologic emergency with the potential for devastating consequences for patients if not promptly diagnosed and treated. MESCC is diagnosed by imaging. MRI is by far the most sensitive test, preferably with gadolinium. Once the diagnosis of MESCC is suspected, patients with neurologic deficits should receive prompt administration of dexamethasone with a 10-mg IV loading dose followed by 4 mg every 6 h. Quick taper is recommended once the definitive treatment is established. Consultation with medical oncology, radiation oncology, and neurosurgery is imperative in order to facilitate a multidisciplinary approach. Although spine surgery is the most effective method for relief of cord compression and is necessary if there is spinal instability, surgery is only used in selected patients because most patients have a poor overall condition and short life expectancy. Radiation therapy, therefore, is the most commonly used therapy for patients with MESCC after surgical decompression or in patients who are not surgical candidates. Conventional fractionated radiation alone can achieve modest neurologic outcomes in selected radiosensitive tumors. Radiosurgery techniques which deliver intense focal irradiation to a delimited area with imaging guidance and contoured radiation delivery to the shape of the tumor have recently emerged as increasing effective treatments in MESCC, especially in radioresistant tumors. Stereotactic radiosurgery and different radiation technologies have been studied in recent clinical trials.


Subject(s)
Spinal Cord Compression/diagnosis , Spinal Cord Compression/etiology , Spinal Cord Compression/therapy , Clinical Trials as Topic , Combined Modality Therapy/methods , Disease Management , Humans , Multimodal Imaging/methods , Spinal Cord Neoplasms/complications , Spinal Cord Neoplasms/etiology , Spinal Cord Neoplasms/secondary , Spinal Neoplasms/complications , Spinal Neoplasms/etiology , Spinal Neoplasms/secondary , Treatment Outcome
14.
Acta Neurochir (Wien) ; 159(9): 1603-1611, 2017 09.
Article in English | MEDLINE | ID: mdl-28752202

ABSTRACT

BACKGROUND: Pediatric hemangioblastomas are rare, and the clinical features, timing of surgical intervention, optimal treatment, and clinical outcomes are still unclear. METHODS: We performed a retrospective study of all patients with CNS hemangioblastomas who were treated at West China Hospital from January 2003 to March 2015. Patients under the age of 16 years were included in the study. The medical records of these patients were reviewed and statistically analyzed. RESULTS: Twenty-five children (15 females and ten males, [mean age 12.6 ± 4.7 years, range 1-16 years]) presented with hemangioblastomas. Tumors were detected in the cerebellum, brainstem, and spinal cord in 40, 28, and 32% of patients, respectively. Sixteen children (64%) had VHL syndrome. The most frequent symptoms were those related to increased intracranial pressure. The mean duration of symptoms was 1.5 ± 2.1 months. Preoperative hydrocephalus was noted in 11 children (44%). Gross total resection was achieved in all children. Clinical symptoms improved in 19 children (76%), unchanged in four children (16%), and aggravated in two children (8%), respectively. The mean follow-up was 44.5 ± 32.3 months. Five patients (20%) experienced disease progression. Using univariate analysis, both tumor-associated cysts (P = 0.027) and VHL disease (P = 0.032) were significantly related to postoperative outcomes. CONCLUSIONS: Pediatric hemangioblastomas have many different clinical features compared with adult cases. A high degree of suspicion for VHL disease should be raised in pediatric hemangioblastomas. Despite many challenges involved, surgical outcomes for pediatric hemangioblastomas are favorable. Lifelong follow-up is mandatory to detect the disease progression.


Subject(s)
Central Nervous System Neoplasms/surgery , Hemangioblastoma/surgery , von Hippel-Lindau Disease/complications , Adolescent , Brain Stem Neoplasms/etiology , Brain Stem Neoplasms/surgery , Central Nervous System Neoplasms/etiology , Cerebellar Neoplasms/etiology , Cerebellar Neoplasms/surgery , Child , Child, Preschool , China , Cysts/complications , Disease Progression , Female , Follow-Up Studies , Hemangioblastoma/etiology , Humans , Hydrocephalus/etiology , Infant , Magnetic Resonance Imaging , Male , Prognosis , Retrospective Studies , Spinal Cord Neoplasms/etiology , Spinal Cord Neoplasms/surgery
15.
World J Surg Oncol ; 15(1): 131, 2017 Jul 17.
Article in English | MEDLINE | ID: mdl-28716031

ABSTRACT

BACKGROUND: Spinal epidermoid cysts are benign tumors, which are rarely seen as an intradural extramedullary spinal cord tumor in the conus medullaris region. Acquired spinal epidermoid cysts are mostly caused by iatrogenic procedures, such as lumbar puncture, and the majority of acquired spinal epidermoid cysts have been reported below the L1 level, because lumbar puncture is usually performed around the iliac crest. Here, we report an extremely rare case of an epidermoid cyst that occurred as an intradural and extramedullary spinal cord tumor attached to the conus medullaris after repetitive epidural anesthesia. CASE PRESENTATION: A 67-year-old female presented with a low back pain and left sciatica. Although the patient had experienced occasional mild low back pain for several years, her low back pain markedly worsened 2 months before her visit, as well as newly developed left sciatica resulting in intermittent claudication. She had a history of several abdominal surgeries. All abdominal procedures were performed under general anesthesia with epidural anesthesia in her thoracolumbar spine. Magnetic resonance imaging of her lumbar spine demonstrated an intradural extramedullary spinal cord tumor at the T12-L1 level. Because her symptoms deteriorated, the tumor excision was performed using microscopy. Histological examination of the specimens demonstrated that the cyst walls lined with stratified squamous keratinizing epithelium surrounded by the outer layer of collagenous tissue with the absence of skin adnexa. A diagnosis of epidermoid cysts was confirmed. Her MRI showed complete resection of the tumor, and there was no recurrence at 2-year follow-up. CONCLUSIONS: In this case report, epidermoid cells might be contaminated into the spinal canal during repetitive epidural anesthesia. The patient was successfully treated by complete resection, and there was no recurrence at 2-year follow-up with a good clinical outcome. However, long-term follow-up is required for a potential risk of tumor recurrence.


Subject(s)
Anesthesia, Epidural/adverse effects , Sciatica/surgery , Spinal Cord Neoplasms/etiology , Aged , Female , Humans , Magnetic Resonance Imaging , Prognosis , Spinal Cord Neoplasms/pathology , Spinal Cord Neoplasms/surgery
18.
In Vivo ; 30(5): 717-9, 2016.
Article in English | MEDLINE | ID: mdl-27566097

ABSTRACT

BACKGROUND/AIM: Adrenocortical cancer is a rare aggressive type of cancer. The prognosis is poor, particularly for metastatic disease. This study focused on metastatic spinal cord compression (MSCC) from adrenocortical carcinoma. PATIENTS AND METHODS: Data of three patients who received palliative irradiation of MSCC from adrenocortical carcinoma were retrospectively analyzed for motor function, ambulatory status and survival. RESULTS: One patient died before completion of radiotherapy. The other two patients died two weeks and four weeks, respectively, following irradiation. In these patients, pre-radiotherapy pain scores were 9 and 10 points. In both patients, partial pain relief was achieved (scores of 5 and 4 points). All three patients were non-ambulatory before irradiation. In assessable patients, motor function remained unchanged following irradiation. CONCLUSION: Palliative irradiation resulted in considerable pain relief, whereas motor function did not improve. Considering the extremely poor survival, supportive care alone may be considered if pain relief is achieved without irradiation.


Subject(s)
Adrenocortical Carcinoma/radiotherapy , Prognosis , Spinal Cord Compression/pathology , Spinal Cord Neoplasms/pathology , Adrenocortical Carcinoma/complications , Adrenocortical Carcinoma/pathology , Aged , Female , Humans , Male , Middle Aged , Pain Management , Palliative Care , Radiotherapy/adverse effects , Spinal Cord Compression/etiology , Spinal Cord Neoplasms/etiology , Spinal Cord Neoplasms/secondary , Walking/physiology
19.
J Neurooncol ; 130(1): 229-236, 2016 10.
Article in English | MEDLINE | ID: mdl-27531350

ABSTRACT

Cavernous angiomas of the spinal cord exhibit imaging characteristics that may overlap with those of hemorrhagic ependymoma. In the present study, we aimed to identify specific magnetic resonance imaging (MRI) findings that could be used to differentiate cavernous angioma from hemorrhagic ependymoma, and to evaluate serial MRI changes in cases of cavernous angioma. We retrospectively evaluated MR images of spinal cord tumors collected at our hospital from 2007 to 2015. From this cohort of images, 11 pathologically confirmed cavernous angiomas and 14 pathologically confirmed hemorrhagic ependymomas were compared with respect to the size of the tumor, longitudinal location, axial location, enhancement pattern, syrinx, edema, tumor margin, signal intensity of T2WI, signal intensity of T1WI, and longitudinal spreading of the hemorrhage. Serial MR images of seven spinal cavernous angiomas were reviewed. Small size, eccentric axial location, minimal enhancement, and absence of edema were more frequently observed on images of cavernous angioma compared to those of hemorrhagic ependymoma (p < 0.01). Serial MRI changes in cases of cavernous angioma included increased longitudinal spreading of the hemorrhage (6/7, 86 %) and emergence of high signal intensity on T1WI (1/7, 14 %). Small size, eccentric axial location, minimal enhancement, and absence of edema are significant MRI findings that may be used to distinguish Type I and Type II spinal cavernous angiomas from hemorrhagic ependymomas. Furthermore, longitudinal spreading of the hemorrhage may be observed on follow-up MRIs of cavernous angiomas.


Subject(s)
Ependymoma/diagnostic imaging , Ependymoma/etiology , Hemangioma, Cavernous/complications , Hemangioma, Cavernous/therapy , Hemorrhagic Disorders/complications , Magnetic Resonance Imaging , Spinal Cord Neoplasms/diagnosis , Spinal Cord Neoplasms/etiology , Adult , Aged , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Image Processing, Computer-Assisted , Male , Middle Aged , Retrospective Studies
20.
Clin Imaging ; 40(6): 1108-1111, 2016.
Article in English | MEDLINE | ID: mdl-27450443

ABSTRACT

Central neurocytomas comprise nearly half of adult intraventricular neoplasms. The median age of onset is 34 years. It is typically a low-grade neoplasm (World Health Organization grade II), although some cases of malignant neurocytomas have been described. We present a rare case of an atypical central neurocytoma with craniospinal dissemination, including both imaging and pathologic findings.


Subject(s)
Cerebral Ventricle Neoplasms/pathology , Neurocytoma/pathology , Spinal Cord Neoplasms/etiology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Invasiveness
SELECTION OF CITATIONS
SEARCH DETAIL