ABSTRACT
La sífilis es causada por Treponema pallidum, es reconocida por la variedad de sus manifestaciones clínicas; compromete el sistema nervioso, tegumentario y cardiovascular. Las alteraciones cardiovasculares ocurren en 70% de los casos con sífilis no tratada, el 71% de las aortitis sifilíticas desarrollan aneurismas aórticos y la complicación más frecuente es la insuficiencia aórtica. El tratamiento va dirigido a la enfermedad subyacente, con manejo antibiótico para la sífilis terciaria y las complicaciones tromboembólicas y si requiere reparación quirúrgica. Presentamos un caso poco frecuente de un paciente diagnosticado de infección por el virus de la inmunodeficiencia humana y complicaciones cardiovasculares típicas de la sífilis terciaria, que precisó tratamiento médico y quirúrgico, que fue exitoso. Destacamos la pericia clínica de los profesionales de nuestra institución para diagnosticar e identificar las complicaciones cardiovasculares de la sífilis terciaria.
Syphilis is caused by Treponema pallidum and is recognized by the variety of its clinical manifestations; it involves the nervous, integumentary and cardiovascular systems. Cardiovascular alterations occur in 70% of cases with untreated syphilis, 71% of syphilitic aortitis develop aortic aneurysms and the most frequent complication is aortic insufficiency. Treatment is directed at the underlying disease, with antibiotic treatment for tertiary syphilis and thromboembolic complications and if necessary surgical repair. We present a rare case of a patient diagnosed with human immunodeficiency virus infection and cardiovascular complications typical of tertiary syphilis, who required medical and surgical treatment, which was successful. We highlight the clinical experience of our institution's professionals in the diagnosis and identification of cardiovascular complications of tertiary syphilis.
A sífilis é causada pelo Treponema pallidum e é reconhecida pela variedade de suas manifestações clínicas; ela afeta os sistemas nervoso, tegumentar e cardiovascular. As alterações cardiovasculares ocorrem em 70% dos casos de sífilis não tratada, 71% dos casos de aortite sifilítica desenvolvem aneurismas aórticos e a complicação mais frequente é a insuficiência aórtica. O tratamento é direcionado para a doença subjacente, com tratamento antibiótico para sífilis terciária e complicações tromboembólicas e, se necessário, reparo cirúrgico. Apresentamos um caso raro de um paciente diagnosticado com infecção pelo vírus da imunodeficiência humana e complicações cardiovasculares típicas da sífilis terciária, que precisou de tratamento médico e cirúrgico, que foi bem-sucedido. Apresentamos um caso raro de um paciente com diagnóstico de infecção pelo vírus da imunodeficiência humana e complicações cardiovasculares típicas da sífilis terciária, que necessitou de tratamento médico e cirúrgico, o qual foi bem-sucedido. Destacamos a experiência clínica dos profissionais de nossa instituição no diagnóstico e na identificação das complicações cardiovasculares da sífilis terciária.
Subject(s)
Humans , Male , Adult , Aortic Aneurysm/surgery , Aortic Aneurysm/diagnostic imaging , Aortic Valve Insufficiency/surgery , Aortic Valve Insufficiency/diagnostic imaging , Aortic Aneurysm/etiology , Aortic Valve Insufficiency/etiology , Penicillin G Benzathine/therapeutic use , Syphilis, Cardiovascular/complications , Syphilis, Cardiovascular/diagnosis , Syphilis, Cardiovascular/drug therapySubject(s)
Aortic Valve Insufficiency , Coronary Stenosis , Syphilis, Cardiovascular , Constriction, Pathologic , Coronary Stenosis/diagnostic imaging , Coronary Stenosis/etiology , Coronary Stenosis/surgery , Humans , Syphilis, Cardiovascular/complications , Syphilis, Cardiovascular/diagnostic imaging , Syphilis, Cardiovascular/drug therapy , Treatment OutcomeABSTRACT
RATIONALE: In recent decades, the incidence of advanced syphilis has declined due to early recognition and the application of effective antibiotics. Advanced syphilis often manifests in the cardiovascular system as simple aortitis, aortic valve insufficiency, coronary artery stenosis or obstruction, Aortic aneurysm and mucinous myocarditis. In most case reports on the subject, acute myocardial infarction caused by syphilis was reported to be due to aortic valve insufficiency and coronary stenosis as a result of the involvement of the aorta. PATIENT CONCERNS: The patient was a 48-year-old woman. She was admitted to our hospital because of intermittent upper abdominal pain with chest tightness for 3âhours. The patient reported a past syphilis infection, when she was hospitalized for hysteromyoma surgery four years ago, and had no related treatment. DIAGNOSIS: According to the characteristics of coronary angiography and results of lab tests and echocardiography, she was finally diagnosed with myocardial infarction associated with syphilis. INTERVENTIONS: At the first diagnosis of syphilis, the patient did not received antibiotics treatment. After the diagnosis of myocardial infarction, she received the percutaneous coronary intervention (PCI) operation assisted by extracorporeal membrane oxygenation (ECMO) technology, successfully got drug -eluted stents in right coronary artery ostium and left main ostium. Then the patient received penicillin to treat the syphilis infection. OUTCOMES: After coronary revascularization, the cardiac function of the patients was gradually improved, and the left ventricular ejection fraction was gradually improved after combined with optimized drug therapy. LESSONS: The cardiovascular system is often involved in the stages of advanced syphilis with severe complications like myocardial infarction. Standard treatment should be given as soon as syphilis is diagnosis. For stenosis of coronary ostium, the PCI assisted by ECMO technology did not only ensure the effectiveness of the treatment, but also reduce the surgical risk of the patient. This case indicated the effectiveness of ECMO-assisted PCI, and thus may provide a reference for future patient treatment.
Subject(s)
Myocardial Infarction/etiology , Syphilis, Cardiovascular/complications , Coronary Angiography , Echocardiography , Extracorporeal Membrane Oxygenation , Female , Humans , Middle Aged , Myocardial Infarction/therapy , Penicillins/therapeutic use , Percutaneous Coronary Intervention , Syphilis, Cardiovascular/drug therapy , Treatment OutcomeABSTRACT
Se presenta el caso de un varón de 60 años de doble lesión aórtica que fue sometido a recambio valvular aórtico. Durante la intervención se observó engrosamiento e inflamación de la pared de la aorta ascendente. El análisis serológico resultó positivo para Treponema pallidum. El estudio histológico de la pared aórtica y de la válvula demostró infiltrado inflamatorio mixto linfoplasmocitario. La insuficiencia aórtica sifilítica constituye una complicación infrecuente de la sífilis terciaria que debe ser sospechada en presencia de inflamación aórtica
We report the case of a a 60-year-old male with double aortic lesion who underwent an aortic valve replacement. Thickening and inflammation of the ascending aorta wall was observed. Serological analyses were positive for Treponema pallidum. The histological study of the aortic wall and aortic valve showed mixed inflammatory lymphoplasmacytic infiltrate. Syphilitic aortic insufficiency is a rare complication of tertiary syphilis but should be suspected in the presence of aortic inflammation
Subject(s)
Humans , Male , Middle Aged , Syphilis, Cardiovascular/complications , Aortic Valve Insufficiency/microbiology , Syphilis, Cardiovascular/drug therapy , Syphilis, Cardiovascular/pathology , Aortic Valve Insufficiency/surgery , Transcatheter Aortic Valve Replacement , Penicillin G Benzathine/therapeutic use , Anti-Bacterial Agents/therapeutic useSubject(s)
Aortic Valve Insufficiency/history , Phytotherapy/history , Plant Preparations/history , Syphilis, Cardiovascular/history , Aortic Valve Insufficiency/diagnosis , Aortic Valve Insufficiency/drug therapy , Aortic Valve Insufficiency/physiopathology , Digitalis/chemistry , History, 17th Century , History, 18th Century , Humans , Literature, Modern/history , Plant Preparations/therapeutic use , Plants, Medicinal/chemistry , Syphilis, Cardiovascular/diagnosis , Syphilis, Cardiovascular/drug therapy , Syphilis, Cardiovascular/physiopathologySubject(s)
Atrial Fibrillation/etiology , Echocardiography, Transesophageal/methods , Magnetic Resonance Imaging, Cine/methods , Syphilis, Cardiovascular/complications , Atrial Fibrillation/diagnosis , Diagnosis, Differential , Follow-Up Studies , Humans , Male , Middle Aged , Penicillins/therapeutic use , Risk Assessment , Syphilis Serodiagnosis/methods , Syphilis, Cardiovascular/diagnostic imaging , Syphilis, Cardiovascular/drug therapyABSTRACT
BACKGROUND: Even though reported cases of syphilis have been increasing, cases of tertiary syphilis remain extremely rare. The majority of our knowledge with regard to complications of syphilis such as aortitis was acquired before the advent of relatively modern technologies such as CT, MRI and PET. This case report presents a rare case of syphilitic aortitis associated with a renal infarct caused by a peripheral arterial embolism diagnosed by CT. CASE PRESENTATION: We present a young man with sudden abdominal pain and flank tenderness without fever. Blood tests showed acute kidney failure. Computed tomography showed a right renal infarct and a non-circular thickening of the descending thoracic aortic wall with intra-luminal thrombus. Serology confirmed the diagnosis of syphilis. Treatment with anticoagulant and penicillin resulted in a good outcome. Follow-up PET-MRI showed resolution of the thrombus with a metabolically inactive atheromatous plaque. CONCLUSION: Technologies, such as CT, PET-CT and PET-MRI, that were not present during the pre-antibiotic era, can provide new insights into rare presentations of tertiary syphilis such as aortitis. These imaging modalities show promise for early radiological diagnosis of aortitis in syphilis and may be useful for determining the response to treatment in specific cases.
Subject(s)
Aortitis/diagnostic imaging , Aortitis/microbiology , Infarction/diagnostic imaging , Syphilis, Cardiovascular/diagnostic imaging , Adult , Anti-Bacterial Agents/therapeutic use , Aortitis/drug therapy , Humans , Infarction/drug therapy , Infarction/microbiology , Kidney/blood supply , Kidney/diagnostic imaging , Magnetic Resonance Imaging , Male , Penicillins/therapeutic use , Positron-Emission Tomography , Syphilis/diagnostic imaging , Syphilis/drug therapy , Syphilis, Cardiovascular/drug therapy , Syphilis, Cardiovascular/pathology , Tomography, X-Ray ComputedSubject(s)
Aortic Diseases/microbiology , Coronary Restenosis/microbiology , Coronary Stenosis/microbiology , Syphilis, Cardiovascular/microbiology , Angioplasty, Balloon, Coronary , Anti-Bacterial Agents/therapeutic use , Aortic Diseases/diagnosis , Aortic Diseases/drug therapy , Computed Tomography Angiography , Coronary Angiography/methods , Coronary Restenosis/diagnostic imaging , Coronary Restenosis/therapy , Coronary Stenosis/diagnostic imaging , Coronary Stenosis/therapy , Drug-Eluting Stents , Humans , Male , Middle Aged , Penicillin G/therapeutic use , Percutaneous Coronary Intervention/instrumentation , Syphilis, Cardiovascular/diagnosis , Syphilis, Cardiovascular/drug therapy , Treatment OutcomeABSTRACT
Positron emission tomography (PET) has been used to aid in diagnosis of inflammatory and infectious disease. We describe the case of a patient with early latent syphilis with increased metabolic activity along the aorta detected via PET, suggesting probable aortitis. Three months after treatment, the PET showed apparent resolution of the aortitis.
Subject(s)
AIDS-Related Opportunistic Infections/diagnostic imaging , Anti-Bacterial Agents/therapeutic use , Aortitis/diagnostic imaging , Aortitis/microbiology , Penicillin G Benzathine/therapeutic use , Positron-Emission Tomography , Syphilis, Cardiovascular/diagnostic imaging , AIDS-Related Opportunistic Infections/drug therapy , AIDS-Related Opportunistic Infections/metabolism , Aortitis/drug therapy , Aortitis/metabolism , Fluorodeoxyglucose F18/administration & dosage , Homosexuality, Male , Humans , Male , Middle Aged , Peru , Positron-Emission Tomography/methods , Radiopharmaceuticals/administration & dosage , Reproducibility of Results , Syphilis, Cardiovascular/drug therapy , Syphilis, Cardiovascular/metabolism , Treatment OutcomeABSTRACT
Aortitis is an established manifestation of tertiary syphilis. We report a rare case of aortitis with ostial occlusion and left ventricular failure in secondary syphilis. Her management required a true multidisciplinary approach from multiple specialities due to complications of concomitant psychosis and a history of anaphylaxis to penicillin. This case illustrates the complexities of diagnosing and managing a rare presentation of this increasingly prevalent infection.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Aortic Valve Insufficiency/microbiology , Coronary Stenosis/drug therapy , Methylprednisolone/therapeutic use , Syphilis, Cardiovascular/diagnosis , Syphilis/diagnosis , Adult , Aortic Valve Insufficiency/diagnostic imaging , Coronary Stenosis/diagnosis , Coronary Stenosis/microbiology , Coronary Stenosis/surgery , Echocardiography, Doppler, Color , Female , Humans , Syphilis/complications , Syphilis/drug therapy , Syphilis, Cardiovascular/complications , Syphilis, Cardiovascular/drug therapy , Treatment OutcomeSubject(s)
Fluorescent Treponemal Antibody-Absorption Test , Iliac Aneurysm/etiology , Syphilis, Cardiovascular/complications , Syphilis/complications , Aged, 80 and over , Angiography , Anti-Bacterial Agents/therapeutic use , Antibodies, Bacterial/blood , Endovascular Procedures , Fluorescent Antibody Technique, Indirect , Humans , Iliac Aneurysm/diagnostic imaging , Iliac Aneurysm/therapy , Male , Penicillin G Benzathine/therapeutic use , Syphilis/diagnosis , Syphilis/drug therapy , Syphilis, Cardiovascular/diagnosis , Syphilis, Cardiovascular/drug therapy , Tomography, X-Ray Computed , Treponema pallidum/immunology , UltrasonographyABSTRACT
Cardiovascular syphilis is associated with the tertiary stage of syphilis infection; it involves the ascending aorta and can cause aortic aneurysm, aortic regurgitation, and coronary ostial stenosis. We report here a case in which bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis was diagnosed; coronary artery bypass graft was then performed.
Subject(s)
Coronary Stenosis/microbiology , Syphilis, Cardiovascular/microbiology , Adult , Anti-Bacterial Agents/therapeutic use , Aortic Valve Insufficiency/microbiology , Coronary Artery Bypass , Coronary Stenosis/diagnosis , Coronary Stenosis/surgery , Echocardiography, Doppler, Color , Humans , Male , Penicillins/therapeutic use , Syphilis, Cardiovascular/complications , Syphilis, Cardiovascular/diagnosis , Syphilis, Cardiovascular/drug therapy , Tomography, X-Ray Computed , Treatment OutcomeSubject(s)
Anti-Bacterial Agents/therapeutic use , Penicillin G/therapeutic use , Polymerase Chain Reaction/methods , Syphilis, Cardiovascular/diagnosis , Treponema pallidum/isolation & purification , Adult , Australia , Bacterial Proteins/genetics , DNA, Bacterial/genetics , Diagnosis, Differential , Humans , Male , Species Specificity , Syphilis, Cardiovascular/drug therapy , Syphilis, Cardiovascular/microbiology , Treponema pallidum/geneticsSubject(s)
Angina Pectoris/diagnosis , Angina Pectoris/etiology , Syphilis, Cardiovascular/complications , Syphilis, Cardiovascular/diagnosis , Coronary Angiography , Diagnosis, Differential , Echocardiography , Humans , Male , Middle Aged , Radiography, Thoracic , Syphilis, Cardiovascular/drug therapy , Tomography, X-Ray ComputedABSTRACT
A 40-year-old man was admitted to our hospital for surgical treatment of aortic insufficiency and coronary ostial stenosis. Histopathology and serological tests revealed a syphilitic aortitis. F-FDG PET/CT was performed to assess the extent of aortitis, showing increased radiopharmaceutical uptake along the ascending aortic wall. A repeated FDG PET/CT after antibiotic therapy showed a markedly reduced uptake in the aortic wall, suggesting resolution of the infection according to clinical and serological data. This case highlights the usefulness of FDG PET/CT for the assessment of disease extent and treatment response in patients with syphilitic aortitis.
Subject(s)
Fluorodeoxyglucose F18 , Multimodal Imaging , Positron-Emission Tomography , Syphilis, Cardiovascular/diagnostic imaging , Tomography, X-Ray Computed , Adult , Humans , Male , Penicillins/therapeutic use , Syphilis, Cardiovascular/drug therapy , Syphilis, Cardiovascular/pathology , Treatment OutcomeSubject(s)
Aortic Valve Insufficiency/etiology , Hypertrophy, Left Ventricular/etiology , Syphilis, Cardiovascular/physiopathology , Syphilis/physiopathology , Aged , Aortic Valve Insufficiency/physiopathology , Cardiomegaly/etiology , Cardiomegaly/pathology , Electrocardiography , Heart Failure/etiology , Heart Failure/physiopathology , Humans , Hypertrophy, Left Ventricular/pathology , Male , Penicillins/therapeutic use , Syphilis/drug therapy , Syphilis, Cardiovascular/drug therapySubject(s)
Aortic Valve Insufficiency/diagnosis , Coronary Occlusion/diagnosis , Diagnostic Imaging/methods , Imaging, Three-Dimensional/methods , Syphilis, Cardiovascular/complications , Adult , Aortic Valve Insufficiency/etiology , Aortic Valve Insufficiency/surgery , Combined Modality Therapy , Coronary Artery Bypass/methods , Coronary Occlusion/etiology , Coronary Occlusion/surgery , Echocardiography, Transesophageal/methods , Follow-Up Studies , Heart Valve Prosthesis Implantation/methods , Humans , Male , Penicillins/therapeutic use , Severity of Illness Index , Syphilis, Cardiovascular/diagnosis , Syphilis, Cardiovascular/drug therapy , Tomography, X-Ray Computed/methods , Treatment Outcome , User-Computer Interface , Video RecordingSubject(s)
Aortic Aneurysm, Thoracic/surgery , Endovascular Procedures/methods , Syphilis, Cardiovascular/drug therapy , Syphilis/drug therapy , Aged , Anti-Bacterial Agents/therapeutic use , Aortic Aneurysm, Thoracic/microbiology , Female , Humans , Penicillins/therapeutic use , Positron-Emission Tomography , Stents , Tomography, X-Ray ComputedABSTRACT
Syphilis was once the most common cause of aortic aneurysm. For the last 60 years syphilis has been well controlled in the UK population. However, we present the recent case of a 52-year-old female black South African immigrant who was found to have a syphilitic aneurysm.
Subject(s)
Aneurysm, Infected/diagnosis , Aorta, Thoracic/microbiology , Aortic Aneurysm/diagnosis , Syphilis, Cardiovascular/diagnosis , Aneurysm, Infected/drug therapy , Aneurysm, Infected/microbiology , Aortic Aneurysm/drug therapy , Aortic Aneurysm/microbiology , Female , Humans , Magnetic Resonance Angiography , Middle Aged , Penicillin G Benzathine/therapeutic use , Syphilis, Cardiovascular/complications , Syphilis, Cardiovascular/drug therapy , United KingdomABSTRACT
To describe the morphologic features so the process can be easily identified during surgery, we studied 34 patients with cardiovascular syphilis, 32 of whom underwent excision and replacement of the ascending aorta or aortic valve or both. Of the 34 patients, 22 were treated at Baylor University Medical Center from 1998 to 2008 and 12 at non-Baylor University Medical Center hospitals from 1958 to 1987. In all 34 patients, the tubular portion of the aorta was diffusely thickened and the sinus portion of the aorta was apparently uninvolved. The process involved all 3 layers of the aorta, with thickening of the adventitia, mainly by fibrous tissue. Within the fibrous tissue were collections of plasma cells and lymphocytes, focal destruction of the media without thickening, and marked thickening of the intima by atherosclerotic-appearing lesions. Serologic tests for syphilis were done in only 14 patients (41%) and were positive (reactive) in 6 (43%) of them. The ascending aorta, however, was similar in all 34 patients. In conclusion, cardiovascular syphilis has not disappeared. Its identification during surgery can prompt appropriate antibiotic therapy postoperatively. Although the serologic test results for syphilis might be negative, antibiotic therapy is recommended for patients with panaortitis requiring resection of the ascending aorta with or without aortic regurgitation.