ABSTRACT
Syringomatous tumor of the nipple is a benign, locally infiltrative tumor. There are reports in the literature of tumor recurrence in cases of incomplete excision. Clinical and mammographic findings in syringomatous tumors are like those of breast carcinoma and the pathologist has a fundamental role in final tumor diagnosis. Therefore, the aim of this study was to report a case of syringoma located in the areolar region. A 33-year-old woman reported that she had noticed a nodule in her left areolar region 4 years previously (February 2019). A breast ultrasound was performed, detecting intraparenchymatous breast cysts. Surgical resection of the nodule was indicated although it was not performed. Two years later, in August 2021, the patient underwent a mastopexy with prosthesis inclusion. Histopathology study of the surgical specimen revealed a syringomatous tumor with positive margins. Thirteen (13) months after diagnosis (September 3, 2021 - October 16, 2022), the patient is doing well and receives clinical follow-up.
Subject(s)
Breast Neoplasms , Nipples , Syringoma , Ultrasonography, Mammary , Humans , Female , Adult , Breast Neoplasms/pathology , Breast Neoplasms/diagnosis , Breast Neoplasms/surgery , Nipples/pathology , Syringoma/pathology , Syringoma/diagnosis , Syringoma/surgery , Sweat Gland Neoplasms/pathology , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/surgery , Follow-Up Studies , Mammaplasty/methodsABSTRACT
Syringomas are benign neoplasms derived from eccrine sweat glands. Eruptive syringomas are a subtype of syringomas and are typically located on the chest, neck, and abdomen during puberty or childhood. Herein, we present a 20-year-old African American female with an atypical case of eruptive syringomas, characterized by an unusual distribution on her chest, abdomen, and anterior and posterior bilateral extremities. This case underscores the importance of recognizing diverse presentations of skin conditions in patients with skin of color and adds to the limited reports of eruptive syringoma in these populations. We present and emphasize this atypical manifestation of eruptive syringomas in an individual with darker skin to promote awareness and improve diagnosis and patient outcomes.J Drugs Dermatol. 2024;23(7):564-566. doi:10.36849/JDD.8103.
Subject(s)
Skin Pigmentation , Sweat Gland Neoplasms , Syringoma , Humans , Syringoma/pathology , Syringoma/diagnosis , Female , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/pathology , Young Adult , Black or African AmericanSubject(s)
Sweat Gland Neoplasms , Syringoma , Vulvar Neoplasms , Humans , Syringoma/pathology , Syringoma/diagnosis , Female , Sweat Gland Neoplasms/pathology , Sweat Gland Neoplasms/diagnosis , Vulvar Neoplasms/pathology , Vulvar Neoplasms/diagnosis , Vulvar Neoplasms/surgery , Diagnosis, Differential , Adult , KeratosisABSTRACT
An 11-year-old boy presented generalized eruptive syringomas (ESs) associated with multiple milia-like whitish palmar papules corresponding to dermal calcium deposits. A relationship between calcium deposits distribution to an underlying eccrine duct was noted on pathology. The observation of dermal calcium deposits and its association with generalized ESs may support a possible sweat duct origin of this uncommon and peculiar form of superficial calcinosis cutis.
Subject(s)
Calcinosis , Sweat Gland Neoplasms , Syringoma , Humans , Male , Calcinosis/pathology , Calcinosis/etiology , Syringoma/pathology , Child , Sweat Gland Neoplasms/pathology , Sweat Gland Neoplasms/complications , Skin Diseases/pathology , Skin Diseases/etiology , Calcinosis Cutis , KeratosisSubject(s)
Sweat Gland Neoplasms , Syringoma , Humans , Syringoma/pathology , Syringoma/diagnosis , Sweat Gland Neoplasms/pathology , Sweat Gland Neoplasms/diagnosis , Female , Male , AdultABSTRACT
ABSTRACT: A 43-year-old woman presented with a palpable, pruritic, minimally painful right vulvar lesion. Physical examination revealed approximately 2.0-cm tender nodule at 70' clock in the right labia majora. Histological sections of the excision specimen showed an unremarkable epidermis with large, well-circumscribed dermal proliferation with extension to the reticular dermis. Within this proliferation are small solid and ductal structures relatively evenly distributed in the sclerotic stroma. The epithelial elements consisted of monomorphous cuboidal cells and assumed round, oval, curvilinear, or have other peculiar geometric shapes, including "comma-like" or "tadpole"-like configurations. The tumor cells were positive for CEA, EMA, and estrogen receptor and negative for progesterone receptor. The clinical presentation and the deep extension of the tumor were similar to the microcystic adnexal carcinoma. Although a syringoma generally presents with multiple lesions and usually involves the superficial dermis, a syringoma with deep extension was favored based on the lack of follicular differentiation, atypia, mitoses, and perineural invasion. Microcystic adnexal carcinoma and syringoma have a morphologic overlap and are misdiagnosed in 30% of the cases. Thus, it is exceptionally important for pathologists to be aware of and be able to distinguish these entities. To the best of our knowledge, this is the first case of a solitary, painful vulvar syringoma with deep extension.
Subject(s)
Skin Neoplasms , Sweat Gland Neoplasms , Syringoma , Vulvar Neoplasms , Female , Humans , Adult , Syringoma/diagnosis , Syringoma/pathology , Skin Neoplasms/pathology , Vulvar Neoplasms/diagnosis , Vulvar Neoplasms/surgery , Vulvar Neoplasms/pathology , Diagnostic Errors , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/surgery , Sweat Gland Neoplasms/pathologyABSTRACT
Syringoma is rare disease that in classical variant occurs mainly on lower eyelids. In previously published researches, there is increasing evidence that eruptive syringomas must be discussed as an inflammatory dermal reaction pattern. And there was a proposal to change a name from eruptive syringoma to reactive syringomatous proliferation in appropriate cases. We conduct retrospective study on histopathological archived material to study the histopathological findings in cases of eruptive syringomas and correlate it with hypothesis that eruptive syringomas is not true adnexal neoplasms "de novo" but a hyperplastic response of the acrosyringium to an inflammatory process.According to obtained data and literature correlation, we can conclude that there is apparent diversity in eruptive syringomas. Part of cases can be calculated as neoplastic lesions arising "de novo," and another part as reactive syringomatous proliferation due to preceding cutaneous inflammatory process. Thus, term "eruptive syringoma" may be changed in appropriate cases to a "reactive syringomatous proliferation."Clinical variants of eruptive syringoma with evidence of underlying inflammatory process may be more responsive on types of treatments used for inflammatory disorders. Thus, more global clinicopathological correlative researches should be conducted and classification with terminology should be appropriately changed.
Subject(s)
Dermatitis , Sweat Gland Neoplasms , Syringoma , Humans , Syringoma/diagnosis , Syringoma/pathology , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/pathology , Retrospective Studies , Skin/pathology , InflammationABSTRACT
The authors describe the clinical and histologic findings of the clear cell variant of syringoma. Three adult female patients (age range 39-76 years old) were found to have multiple, flesh-colored lower eyelid papules, clinically consistent with syringomas, but histologically displaying abundant clear cell change. Two patients had known diagnoses of uncontrolled diabetes.
Subject(s)
Diabetes Mellitus , Sweat Gland Neoplasms , Syringoma , Adult , Humans , Female , Middle Aged , Aged , Syringoma/diagnosis , Syringoma/pathology , Sweat Gland Neoplasms/pathology , Eyelids/pathologyABSTRACT
BACKGROUND: Eruptive syringomas is a rare variant of syringoma, which is a benign adenoma differentiated from the terminal ducts of the eccrine glands. Nowadays, it's widely valued because of obvious skin lesions, large scope of influence, and high misdiagnosis rate. OBJECTIVES: We aim to explore the clinical features of eruptive syringomas and the current research progress. MATERIALS AND METHODS: We firstly summarized the clinical features of 90 cases of eruptive syringomas. Then, the chi-square test was used to analyze the relationship between the onset site of eruptive syringomas and age, as well as gender. Finally, we briefly reviewed the previous literature. RESULTS: During 12 years, 90 cases of eruptive syringomas were diagnosed in our hospital, including 28 males (31.1%) and 62 females (68.9%). The average diagnosed age was 28.8. Patients from 20 to 40 years old is 63 (70%), which is the most. 60 (66.7%) patients had the course for more than 1 year. Among onset sites, the neck, chest, and abdomen were in the top three. The chi-square test showed that there were no significant differences in the onset sites of patients aged ≤ 20 and >20 years old (p-value = 0.181), as well as male and female (p-value = 0.363). CONCLUSION: We found that more female than male was affected, and the most common onset sites were the neck, chest, and abdomen. Neither age nor gender was significantly associated with onset site distribution. Our study provides some data support for the research of eruptive syringomas.
Subject(s)
Sweat Gland Neoplasms , Syringoma , Adult , Female , Humans , Male , Young Adult , Diagnosis, Differential , Neck/pathology , Syringoma/diagnosis , Syringoma/etiology , Syringoma/pathology , Thorax/pathologyABSTRACT
Syringomatous adenoma of the nipple is a rare benign infiltrative neoplasm that was first described in 1983. At the time of this writing, a literature search revealed no cases of syringomatous adenoma of the nipple in association with invasive carcinoma of the breast. We report a case of syringomatous adenoma of the nipple in a 40-year old female who also had bilateral invasive ductal carcinoma and ductal carcinoma in situ of the breasts. Syringomatous adenomas of the nipple have been postulated to originate from eccrine structures of the nipple due to their microscopic similarity to other tumors of eccrine origin, such as syringomatous carcinoma. However, their exact origin is uncertain. Despite their benign behavior, they usually demonstrate an infiltrative and expansile proliferation into adjacent nipple and breast tissue. They have been confused with tubular carcinoma and low-grade adenosquamous carcinoma of the breast, both clinically and histologically. Complete excision is the therapy of choice, and only incompletely excised lesions have shown recurrence. We present this case to raise awareness that syringomatous adenoma of the nipple may present in patients with a simultaneous invasive carcinoma of the breast.
Subject(s)
Adenocarcinoma , Adenoma , Breast Neoplasms , Sweat Gland Neoplasms , Syringoma , Female , Humans , Adult , Nipples/pathology , Syringoma/diagnosis , Syringoma/surgery , Syringoma/pathology , Adenoma/diagnosis , Adenoma/surgery , Adenocarcinoma/pathology , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/surgery , Sweat Gland Neoplasms/pathology , Breast Neoplasms/diagnosis , Breast Neoplasms/surgery , Breast Neoplasms/pathologySubject(s)
Neoplasms , Sweat Gland Neoplasms , Syringoma , Humans , Nipples/pathology , Syringoma/pathology , Genomics , Neoplasms/pathology , Sweat Gland Neoplasms/pathologySubject(s)
Sweat Gland Neoplasms/pathology , Syringoma/pathology , Vulvar Neoplasms/pathology , Adult , Female , HumansABSTRACT
We report a 43-year-old woman with asymptomatic vulvar papules. Histopathology showed ducts with luminal differentiation and eosinophil debris with a tadpole shape. Based on these findings, the diagnosis vulvar syringoma was made. Syringoma are benign eccrine sweat gland tumour mostly located on lower eyelids and cheeks. Vulvar syringoma are rare.
Subject(s)
Sweat Gland Neoplasms/diagnosis , Syringoma/diagnosis , Vulvar Neoplasms/diagnosis , Adult , Diagnosis, Differential , Female , Humans , Sweat Gland Neoplasms/pathology , Syringoma/pathology , Vulva/pathology , Vulvar Neoplasms/pathologyABSTRACT
Infiltrating syringomatous adenoma of the nipple (SAN) is a rare benign neoplasm of the breast that is often misdiagnosed. SAN may present with a subareolar lesion and clinical, mammographic, and ultrasonographic findings associated with malignancy. We present the case of a 60-year-old woman with a painful, firm, solid tumor in her left breast and deformation of the left nipple-areolar complex (NAC). Histopathological test results were conflicting. The tumor, including the NAC were locally excised. Postsurgical immuno-histochemical tests revealed squamous histology, whereas myoepithelial cells were present in the resected specimen, a feature consistent with SAN. The pathologist noted microscopically positive surgical margins. Three months after surgery, tumor recurrence occurred. The patient underwent revision surgery with wide excision of the skin and gland around the lesion, followed by immediate breast reconstruction, using a pedicled myocutaneous latissimus dorsi (pLD) flap. Extreme care should be taken when diagnosing SAN to ensure proper treatment and prevent recurrence.
Subject(s)
Adenoma/surgery , Diagnostic Errors/adverse effects , Neoplasm Recurrence, Local/surgery , Nipples/surgery , Syringoma/surgery , Adenoma/pathology , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Female , Humans , Mammaplasty , Mammography , Middle Aged , Neoplasm Recurrence, Local/pathology , Nipples/pathology , Papilloma/pathology , Papilloma/surgery , Syringoma/diagnosis , Syringoma/pathology , Treatment OutcomeABSTRACT
BACKGROUND: Eccrine duct dilatation (EDD) has been noted to occur significantly more often in primary lymphocytic scarring alopecias compared with non-scarring alopecias, thus serving as a possible histopathologic marker for primary scarring alopecias with a lymphocytic infiltrate. This study aims to determine the presence and role of EDD in primary neutrophilic scarring alopecias. METHODS: We performed a retrospective review comparing primary scarring alopecia (neutrophilic, n = 90; lymphocytic, n = 100) and non-scarring alopecia (n = 123) for presence of EDD, seen in Boston University School of Medicine between 2013 and 2017. RESULTS: EDD was more commonly seen in primary neutrophilic scarring (62.2%, 56/90) and primary lymphocytic scarring alopecias (54.0%, 54/100) than in non-scarring alopecias (25.2%, 31/123) (P < 0.001). Albeit uncommon, non-scarring alopecias exhibited the biggest ratio of dilated eccrine duct lumen to background duct lumen (14.33), followed by lymphocytic (10.99) and neutrophilic scarring alopecias (6.66). CONCLUSION: EDD is seen more frequently in primary scarring alopecias compared with non-scarring alopecias and usually found in sections containing inflammation and dermal fibrosis, serving as a possible histopathologic clue for a scarring process. Non-scarring alopecias have significantly fewer but considerably larger EDD which, may imply a different pathologic cause.
Subject(s)
Alopecia/pathology , Dilatation/statistics & numerical data , Sweat Glands/pathology , Syringoma/pathology , Adult , Aged , Cicatrix/pathology , Dermis/pathology , Female , Fibrosis/pathology , Humans , Inflammation/pathology , Lymphocytes/pathology , Male , Middle Aged , Neutrophils/pathology , Retrospective StudiesABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Hyperpigmentation/pathology , Hyperpigmentation/diagnostic imaging , Syringoma/diagnosis , Skin Pigmentation , Torso/pathology , Ultrasonography , Biopsy , Syringoma/pathology , Diagnosis, DifferentialABSTRACT
He had a history of multiple asymptomatic flesh-colored papules, which had slowly increased in number and coalesced into plaques, on both upper and lower eyelids. Some of the plaques were giant and mostly coalescent in nature. We excised surgically the giant plaques which were approximately 1.5-2 cm in diameter symmetrically from upper and lower eylids and the remaining plaques were left to be treated with cauterization. Histopathological examination revealed syringoma. Both of the eyelids were observed to have a cosmetically adequate appearence after the surgical intervention.