ABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Migraine Disorders/complications , Migraine Disorders/drug therapy , Neurocysticercosis/drug therapy , Neurocysticercosis , Albendazole/therapeutic use , Dexamethasone/therapeutic use , Causality , Neurocysticercosis/complications , Neurocysticercosis/physiopathology , Taenia solium/radiation effects , Tomography, Emission-ComputedABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Neurocysticercosis/complications , Neurocysticercosis/physiopathology , Neurocysticercosis , Cerebrum/injuries , Cerebrum , Taenia solium/pathogenicity , Taenia solium/radiation effects , Calcinosis/pathology , Calcinosis , Headache/complications , Headache/diagnosis , Headache/etiology , Paresthesia/complications , Paresthesia/etiology , Paresthesia , Tomography, Emission-Computed/methods , Tomography, Emission-Computed , Cysts/pathology , CystsABSTRACT
La neurocisticercosis es una parasitosis humana causada por las larvas de la Taenia solium, que es la que con mayor frecuencia afecta el sistema nervioso central. Esta infección es endémica en prácticamente todos los países en vías de desarrollo, pero debido a la globalización y a las migraciones humanas su frecuencia ha aumentado en países desarrollados como los de Europa Occidental. Las manifestaciones clínicas más frecuentes son la epilepsia, signos neurológicos focales e hipertensión intracraneal. Los hallazgos radiológicos dependen del estadio larvario de la Taenia solium, número y localización de los parásitos (parenquimatosa, subaracnoidea e intraventricular), así como de la respuesta inmune del huésped (edema, gliosis, aracnoiditis) y del desarrollo de lesiones secundarias (arteritis, infartos o hidrocefalia). El diagnóstico de esta parasitosis debe establecerse en función de los hallazgos clínicos y radiológicos, especialmente en un contexto epidemiológico adecuado, con apoyo de la serología(AU)
Neurocysticercosis, caused by the larvae of Taenia solium, is the parasitic infection that most commonly involves the central nervous system in humans. Neurocysticercosis is endemic in practically all developing countries, and owing to globalization and immigration it is becoming more common in developed countries like those in western Europe. The most common clinical manifestations are epilepsy, focal neurologic signs, and intracranial hypertension. The imaging findings depend on the larval stage of Taenia solium, on the number and location of the parasites (parenchymal, subarachnoid, or intraventricular), as well as on the host's immune response (edema, gliosis, arachnoiditis) and on the development of secondary lesions (arteritis, infarcts, or hydrocephalus). The diagnosis of this parasitosis must be established on the basis of the clinical and radiological findings, especially in the appropriate epidemiological context, with the help of serological tests(AU)
Subject(s)
Humans , Male , Female , Neurocysticercosis , Taenia solium/radiation effects , /methods , Magnetic Resonance Imaging/instrumentation , Magnetic Resonance Imaging/methods , Encephalitis/complications , Encephalitis , Cysticercosis/classification , Diagnosis, DifferentialABSTRACT
Gamma irradiation of food is considered a possible approach to control food-borne diseases. In cysticercosis, previous studies have shown that irradiating (with 0.3 kGy) pork infected with Taenia solium larvae completely inhibits growth of the parasite. This study was conducted to evaluate the mechanisms that induce the effect of gamma irradiation on metacestodes of T. solium. Metacestodes were obtained from several infected pigs and irradiated with a dose of 0.3 kGy. The viability of the metacestodes was evaluated by their capacity to evaginate in vitro and in vivo development to tapeworms after they were orally infected into prednisolone-treated golden hamsters. Using the typical ladder pattern of fragmented DNA and the TdT-mediated DUTP-nick-end labeling assay, apoptosis was evaluated in metacestodes after irradiation and in the scolices and tapeworms recovered from infected hamsters at 21 days post-infection. Apoptosis was observed in the structure of scolices obtained from hamsters at 21 days post-infection with irradiated metacestodes, This study provides evidence of the existence of apoptosis in the irradiated metacestodes of T. solium and helps elucidate the possible mechanisms that are involved when gamma irradiation inhibits the normal development of the T. solium metacestode into the adult worm.
