Tratamento da úlcera plantar devido à hanseníase / Treatment of leprosy-induced plantar ulcers

Introdução: A úlcera plantar por hanseníase é uma lesão no pé resultante da falta de sensibilidade plantar. O objetivo é descrever o tratamento realizado em portadores de úlceras plantares por hanseníase. Métodos: Estudo de prontuários de portadores de úlcera plantar atendidos no Hospital Sarah em Brasília, de 2006 a 2016, quanto ao sexo, idade, etiologia, localização e tratamento. Resultados: Foram atendidos 27 pacientes, 17(62,96%) homens e 10 (37,04%) mulheres, procedentes de Goiás e DF, na faixa etária de 41 a 60 anos (40,74%). Todos necessitaram de um ou mais procedimentos cirúrgicos. Conclusão: Observou-se maior frequência no sexo masculino, grau avançado, localizadas no primeiro artelho. Todos necessitaram de procedimentos cirúrgicos e não cirúrgicos, evoluindo com cicatrização completa da ferida, amputação transtibial em um caso e de artelhos em sete casos, e 90% dos casos apresentaram recorrência da úlcera após um ano.

Introduction: Leprosy-induced plantar ulcers result from a lack of plantar sensitivity. Objective: This study aimed to describe the treatment provided to patients with leprosy-induced plantar ulcers. Methods: We retrospectively reviewed the medical records of patients with plantar ulcers treated at Sarah Hospital in Brasilia from 2006 to 2016 and collected information about sex, age, etiology, location, and treatment. Results: A total of 27 patients (17 [62.96%] men, 10 [37.04%] women; 40.74% were aged 41­60 years) were treated from Goiás and the Federal District. All required ≥1 surgical procedure. Conclusion: A higher frequency of advanced grade was observed in men, primarily on the first toe. All needed surgical and non-surgical procedures and achieved complete wound healing. Transtibial amputation was required in 1 case and toe amputation in 7 cases; 90% patients developed ulcer recurrence after 1 year.

Medication reconciliation errors in a tertiary care hospital in Saudi Arabia: admission discrepancies and risk factors

Background: Medication reconciliation is a major component of safe patient care. One of the main problems in the implementation of a medication reconciliation process is the lack of human resources. With limited resources, it is better to target medication reconciliation resources to patients who will derive the most benefit from it. Objective: The primary objective of this study was to determine the frequency and types of medication reconciliation errors identified by pharmacists performing medication reconciliation at admission. Each medication error was rated for its potential to cause patient harm during hospitalization. A secondary objective was to determine risk factors associated with medication reconciliation errors. Methods: This was a prospective, single-center pilot study conducted in the internal medicine and surgical wards of a tertiary care teaching hospital in the Eastern province of Saudi Arabia. A clinical pharmacist took the best possible medication history of patients admitted to medical and surgical services and compared with the medication orders at hospital admission; any identified discrepancies were noted and analyzed for reconciliation errors. Multivariate logistic regression was performed to determine the risk factors related to reconciliation errors. Results: A total of 328 patients (138 in surgical and 198 in medical) were included in the study. For the 1419 medications recorded, 1091 discrepancies were discovered out of which 491 (41.6%) were reconciliation errors. The errors affected 177 patients (54%). The incidence of reconciliation errors in the medical patient group was 25.1% and 32.0% in the surgical group (p<0.001). In both groups, the most frequent reconciliation error was the omission (43.5% and 51.2%). Lipid-lowering (12.4%) and antihypertensive agents were most commonly involved. If undetected, 43.6% of order errors were rated as potentially requiring increased monitoring or intervention to preclude harm; 17.7% were rated as potentially harmful. A multivariate logistic regression model showed that patients aged ≥65 years, polypharmacy, and prescriptions for hypoglycemic drugs and warfarin were more likely associated with reconciliation errors. Conclusion: There is a high failure rate in medication reconciliation process in patients admitted to the medical and surgical department. The reconciliation process proves to be a useful tool since nearly half of avoided reconciliation errors were unintentional and had the potential for harm. This strategy, based on our results and the difficulty of applying the process to all patients should be directed primarily to the patients at increased risk of error (AU)

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Choque séptico por infecção odontogênica em paciente com diabetes melito tipo I / Odontogenic septic shock in patient with type 1 diabetes mellitus

O objetivo deste estudo é apresentar um caso de paciente com diabetes melito tipo I descompensado e infecção odontogênica severa que, apesar do tratamento, progrediu para choque séptico e óbito. Os achados clínicos e laboratoriais, diagnóstico e tratamento são apresentados e discutidos. A sepse é uma condição potencialmente fatal que ocorre quando mediadores químicos da inflamação são liberados na corrente sanguínea para combater a infecção e iniciam respostas inflamatórias sistêmicas. A sepse pode progredir para sepse severa e, finalmente, choque séptico, uma condição com altas taxas de mortalidade e pode estar associada às infecções dentárias. Infecções odontogênicas podem se disseminar para os espaços profundos do pescoço, resultando em complicações graves, especialmente em pacientes com doenças crônicas imunodepressoras. Cirurgiões-Dentistas e médicos devem ter conhecimento dos sinais e sintomas associados à condição e devem considerar o diagnóstico de sepse em pacientes com infecções odontogênicas, uma vez que o reconhecimento precoce e tratamento efetivo podem prevenir a morte.

The aim of this study is to present a case of a patient with poorly controlled type I diabetes mellitus and severe odontogenic infection that progressed to septic shock and succumbed despite therapy. Clinical and laboratory findings, diagnosis and treatment are presented and discussed. Sepsis is a potentially life-threatening condition that occurs when chemicals mediators of inflammation are released into the bloodstream to combat the infection and trigger inflammatory multi-system responses. Sepsis can progress to severe sepsis and finally septic shock, a condition with high mortality rates and may be associated with dental infections. Odontogenic infections can spread to deep neck spaces leading to severe complications, especially in patients with chronic systemic immunocompromised diseases. Dentists and physicians must be aware of the signals and symptoms associated with the disease and should consider the diagnosis of sepsis in patients with odontogenic infection once early recognition and effective management could prevent death.