1.
Psychopharmacologia
; 40(4): 335-40, 1975.
Article
in English
| MEDLINE
| ID: mdl-1096217
ABSTRACT
The appetite stimulating action and the weight gaining potential of one month's treatment with the antihistamine and antiserotonergic compound cyproheptadine (Periactin) 4 mg three times daily was compared to placebo in a double-blind crossover trial in sixteen thin but otherwise normal volunteers who wanted to gain weight. Subjects gained significantly more weight on cyproheptadine than on placebo. There was also a corresponding relative increase in subjective hunger ratings and food intake during the period on active drug. Drowsiness was the most frequent side effect observed. These findings are discussed in relation to a possible serotonergic feeding mechanism.
Subject(s)
Body Weight/drug effects , Cyproheptadine/pharmacology , Hunger/drug effects , Adult , Appetite/drug effects , Clinical Trials as Topic , Cyproheptadine/adverse effects , Diet , Energy Metabolism , Female , Humans , Male , Placebos , Thinness/drug effects
2.
Minerva Med
; 63(89): 4837-41, 1972 Dec 12.
Article
in Italian
| MEDLINE
| ID: mdl-4509436
Subject(s)
Anabolic Agents/therapeutic use , Growth Disorders/drug therapy , Liver Extracts/therapeutic use , Thinness/drug effects , Adolescent , Anorexia Nervosa/etiology , Cachexia/etiology , Endocrine System Diseases/complications , Feeding and Eating Disorders/complications , Female , Gigantism/complications , Humans , Hypogonadism/complications , Male , Obesity/etiology
3.
Folia Endocrinol
; 24(3): 229-34, 1971.
Article
in Italian
| MEDLINE
| ID: mdl-5171724
Subject(s)
Anorexia Nervosa/blood , Growth Hormone/blood , Insulin/pharmacology , Thinness/drug effects , Adolescent , Child , Female , Humans , Male
4.
Minerva Med
; 62(38): 1941-6, 1971 May 12.
Article
in Italian
| MEDLINE
| ID: mdl-5281062
Subject(s)
Anorexia Nervosa/drug therapy , Cyproheptadine/therapeutic use , Feeding and Eating Disorders/drug therapy , Thinness/drug effects , Adolescent , Adult , Aged , Appetite/drug effects , Body Weight/drug effects , Child , Child, Preschool , Female , Humans , Lung Diseases/complications , Male , Middle Aged , Thyroid Diseases/complications
5.
Med Welt
; 37: 2029-30, 1969 Sep 13.
Article
in German
| MEDLINE
| ID: mdl-5352082
6.
Prensa Med Argent
; 55(18): 850-7, 1968 Jun 28.
Article
in Spanish
| MEDLINE
| ID: mdl-5747744
Subject(s)
Cyproheptadine/therapeutic use , Thinness/drug effects , Adolescent , Adult , Appetite/drug effects , Body Weight/drug effects , Child , Female , Humans , Male , Serotonin/adverse effects
7.
Clin Ter
; 41(1): 73-7, 1967 Apr 15.
Article
in Italian
| MEDLINE
| ID: mdl-5614301
8.
Rev Lyon Med
; 15(4): 185-9, 1966 Feb 28.
Article
in French
| MEDLINE
| ID: mdl-5910621