ABSTRACT
Two cases of hepatosplenic tuberculosis in patients with acute leukemia during or after chemotherapy following prolonged neutropenia are presented. Tuberculosis should be considered as one cause of hepatosplenic abscesses during prolonged neutropenia, especially in countries where the disease is endemic.
Subject(s)
Candidiasis/diagnosis , Leukemia, Myeloid, Acute/complications , Leukemia/complications , Tuberculosis, Hepatic/diagnosis , Tuberculosis, Splenic/diagnosis , Acute Disease , Adult , Antineoplastic Agents/adverse effects , Antineoplastic Agents/therapeutic use , Candidiasis/microbiology , Diagnosis, Differential , Female , Humans , Leukemia/microbiology , Leukemia/therapy , Leukemia, Myeloid, Acute/microbiology , Leukemia, Myeloid, Acute/therapy , Liver/microbiology , Liver/pathology , Neutropenia/complications , Neutropenia/etiology , Neutropenia/microbiology , Spleen/microbiology , Spleen/pathology , Tuberculosis, Hepatic/chemically induced , Tuberculosis, Hepatic/microbiology , Tuberculosis, Splenic/microbiologyABSTRACT
The time course of hepatic granulomatosis was studied on a CBAxC57B1/6 murine model of a vaccinal process induced by BCG vaccine. It was found that over the natural course of inflammation, there were changes in the spectrum of granulomas from epithelioid cellular to macrophageal and fibrotic ones with stabilization of their sizes, averaged cellular composition and density in the organ. Long-term use of isoniazid caused a considerably (2-fold) reduction in the number of granulomas in the organ and thus a decrease in the level of its fibrotic process. Presumably, in the treated animals, the mechanism responsible for a reduction in the number of granulomas is the "dissociation" of macrophageal cells from them.
Subject(s)
Adjuvants, Immunologic/toxicity , BCG Vaccine/toxicity , Tuberculoma/pathology , Tuberculosis, Hepatic/pathology , Animals , Cell Division , Disease Models, Animal , Fibroblasts/pathology , Follow-Up Studies , Kupffer Cells/pathology , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Tuberculoma/chemically induced , Tuberculosis, Hepatic/chemically inducedABSTRACT
The trend to aggravated running and contribution of air pollution of large industrial centers with polycyclic aromatic hydrocarbons (PAH) to tuberculosis onset and progress dictate the necessity of the search for new treatment methods. The authors made an attempt to treat experimental tuberculosis with sodium glutamate and isoniazide under chronic exposure to PAH dust. Sodium glutamate especially in combination with isoniazide produces a good effect enhancing granulomatous reactions fibroplastic processes in the foci of specific inflammation. Sodium glutamate is thought an effective pathogenetic treatment of tuberculosis.
Subject(s)
Isoniazid/administration & dosage , Polycyclic Compounds/adverse effects , Sodium Glutamate/administration & dosage , Tuberculosis/drug therapy , Tuberculosis/pathology , Xenobiotics/adverse effects , Animals , Drug Therapy, Combination , Guinea Pigs , Tuberculosis/chemically induced , Tuberculosis, Hepatic/chemically induced , Tuberculosis, Hepatic/drug therapy , Tuberculosis, Hepatic/pathology , Tuberculosis, Lymph Node/chemically induced , Tuberculosis, Lymph Node/drug therapy , Tuberculosis, Lymph Node/pathology , Tuberculosis, Pulmonary/chemically induced , Tuberculosis, Pulmonary/drug therapy , Tuberculosis, Pulmonary/pathologyABSTRACT
A 29-year-old Chinese woman presented with a liver mass 2 months after initiation of chemotherapy for disseminated tuberculosis. A percutaneous liver biopsy revealed tuberculous pseudotumour. Although acid-fast bacilli were seen in the biopsy specimen, no organism could be cultured. No changes were made in the antituberculous chemotherapy, and the mass subsequently resolved. The patient was still well 18 months after presentation. To the authors' knowledge, the features of tuberculous pseudotumour seen with ultrasonography and computerized tomography have not previously been described, nor has this condition previously been reported in patients already receiving antituberculous chemotherapy.
