ABSTRACT
Values for the absorption parameters were compared after inhalation or intratracheal instillation of 1.5 microm mass median aerodynamic diameter (MMAD) 233U3O8 particles into the lungs of HMT strain rats. The two sets of parameter values were similar, as were the calculated dose coefficients and predicted biokinetics for workers. Hence the inhalation and instillation techniques can probably both be used to generate values of the absorption parameters for U3O8.
Subject(s)
Lung/metabolism , Models, Biological , Oxides/administration & dosage , Oxides/pharmacokinetics , Radiometry/methods , Uranium Compounds/administration & dosage , Uranium Compounds/pharmacokinetics , Absorption , Administration, Inhalation , Air Pollutants, Radioactive/pharmacokinetics , Air Pollutants, Radioactive/urine , Animals , Computer Simulation , Humans , Inhalation Exposure/analysis , Injections, Intravenous , Metabolic Clearance Rate , Oxides/urine , Radiation Dosage , Rats , Uranium Compounds/urineABSTRACT
This paper provides guidance on the most appropriate monitoring procedures and intervals, the likely uncertainties in the assessment of intake and recommendations on appropriate investigation levels for repeated exposures to uranium trioxide, octoxide and dioxide of natural composition.
Subject(s)
Air Pollutants, Radioactive/pharmacokinetics , Feces/chemistry , Kidney/metabolism , Lung/metabolism , Radiometry/methods , Uranium Compounds/analysis , Uranium Compounds/pharmacokinetics , Absorption , Administration, Inhalation , Air Pollutants, Radioactive/analysis , Animals , Humans , Inhalation Exposure/analysis , Metabolic Clearance Rate , Organ Specificity , Radiation Dosage , Thorax/metabolism , Uranium Compounds/administration & dosage , Uranium Compounds/urineABSTRACT
This study was designed to assess the effect of the initial lung deposit (ILD) on uranium biokinetics in rats after intracheal instillation of biologically soluble uranium compounds. Rats received various doses of either UO4 or UF4 dust. The uranium content was determined in the kidneys, lungs, remaining carcass, urine and faeces at intervals of up to 30 days. The percentages of uranium absorbed into blood, transferred to tissues, and excreted in urine were independent of the uranium lung deposit for the two compounds. The K/K + U ratio 24 h after installation (K is the per cent of uranium retained in the kidneys and U the per cent excreted in urine) which can be used to evaluate kidney function, was essentially constant in the range from 0.02 to 12.5 microg U g(-1) kidneys.