ABSTRACT
Homeopathic ultra-diluted solutions surpass the threshold of matter dispersion and, consequently, their chemical constitution is similar to inert solvent. Nevertheless, randomized clinical trials have shown that the clinical effects of these homeopathic medicines are superior to placebo1. Nuclear magnetic resonance (NMR) is one of the most promising techniques to detect physicochemical alterations induced by homeopathic procedures2,3. Aims: To investigate T2 NMR relaxation times of Zincum metallicumand lactose dynamized samples. Methodology: Zincum metallicumsamples were ground until 6dH using lactose as an excipient. Subsequently, these samples were dynamized with ultrapure water to produce 8dH, 9dH, 10dH,and 11dH. Lactose dynamized samples (6dH-11dH) were used as control. Aliquots of 540µl of each sample were diluted with 60µl of deuterated water (D2O) in 5mm tubes. The analyses were carried out in Bruker Ascend TM 500MHZ spectrometer at 288 K. Results and discussion: The Zincum metallicumand lactose T2 relaxation times were very similar, except for Zincum metallicum8dH, which presented a value of 1.226 in comparison to 1.036 of lactose 8dH. The following T2 values were registered: 1.287 -9dH; 1.413 -10dH; 1.467 -11dH, and 1.303 -9dH; 1.400 10dH; 1.350 -11dH, for Zincum metallicumand lactose, respectively. The differences detected in 8dH samples are probably due to the presence of lactose in the first dilution step, in which 1 part of the 6dH triturated mixture was diluted in 9 parts of water, to prepare 7dH. Following this homeopathic procedure, 8dH solutions remain around 1% of lactose which could be influenced by the T2 values registered.Conclusion: These preliminary results showed the possibility to apply the NMR technique to evaluate the influence of dynamization in the relaxation parameters. Further studies should be carried out with other potencies and/or other homeopathic substances, in addition to the evaluation of T1 and the T1/T2 parameters, as previously described by other groups.
Subject(s)
Preparation Scales , Zincum Metallicum/analysis , Homeopathic Remedy , Proton Magnetic Resonance SpectroscopyABSTRACT
Background: Clinical studies have shown that adverse events in early life are quite stressful and can lead to the development of psychiatric disorders, such as anxiety, in adolescence and adulthood in humans. Experimental models of maternal deprivation (MD) in rats can be a useful tool for the understanding how these events in the early period of development can lead to behavioral changes in adulthood. Aims: The objective of this study was to evaluate the long-term effects of Zincum metallicum (Zinc met) homeopathic treatment in rats subjected to maternal deprivation (MD) in their early days of life. Methods: Newborn female rats were subjected to MD during 10 days, one hour per day, from PND10 to PND21, and treated from the 10th day of lactation (PND10) up to weaning (PND21). On the PND21 the rats were divided in 4 groups (N=8): a) treated with Zinc met 30c; b) treated with Zinc met 6c; c) treated with 10% hydroalcoholic solution (HS); and "blank control", rats without any treatment nor experienced deprivation (ND). The medicines were administered in blind trials, identified by codes. The animals were weighed weekly, from weaning until the end of the experiment, and evaluated in the Open Field (OF) and in the Elevated Plus Maze (EPM) devices, to evaluate mobility, emotionality and anxiety, in 3 moments of life: in PND21 (childhood), during puberty (PND 40) and adulthood (PND75). Data were analyzed statistically by ANOVA, followed by the Bonferroni's Multiple Comparison Test, being p≤0.05. Results: 1) relative to ND group the Zinc met 6c showed reduced body weight while no differences were observed between the other groups; 2) In the OF, the MD group showed increased rearing behavior at PND 40. The Zinc met 6c group reversed this effect showing similar profile as the ND group. Moreover, Zinc met 6c group showed increase in the immobility time at this age; 3) In the EPM, the MD group showed increased time in closed arms and decreased head dips relative to ND group in PND21 period of observation. Treatment with Zinc met 6c but not with Zinc met 30c was effective to reduce this anxiety-like behavior in PND21. Conclusion: According to the proposed model, Zincum metallicum 6c seems to be able to prevent in anxiety-like behavior induced by maternal deprivation in the childhood, mainly in behavioral models related to anxiety. However, other studies still need to be developed to understand the physio-pathological basis of these effects. (AU)
Subject(s)
Animals , Rats , Anxiety Disorders , Zincum Metallicum/therapeutic use , Homeopathy , Maternal DeprivationABSTRACT
Cicatrization can be divided into three phases: inflammation, fibroblastic, maturation and remodeling [1]. The extracellular matrix may be replaced by a stronger and more elastic connective tissue. In a scar collagen is the major component of the mature connective tissue [2]. In homeopathic area, the greater is the investigated segment ultra dilutions [6]. However, little research has been done to explore the effect of dynamized drugs in in vitro cell culture [4]. Using the Zincum metallicum 6CH and Calendula officinalis 6CH applied independently in different concentrations in fibroblast cultures sought to determine the increase in proliferative activity using techniques such as IC50, MTT, flow cytometry and quantification of collagen. As expected from the literature, ie both homeopathic according to the literature are used for treatments that Require skin healing, both showed increased proliferative activity, having Calendula most cellular response, presenting as cell cycle stimulating checked via flow cytometry.(AU)
Subject(s)
Humans , Wound Healing , Zincum Metallicum/therapeutic use , /therapeutic use , High Potencies , FibroblastsABSTRACT
Cicatrization can be divided into three phases: inflammation, fibroblastic, maturation and remodeling [1]. The extracellular matrix may be replaced by a stronger and more elastic connective tissue. In a scar collagen is the major component of the mature connective tissue [2]. In homeopathic area, the greater is the investigated segment ultra dilutions [6]. However, little research has been done to explore the effect of dynamized drugs in in vitro cell culture [4]. Using the Zincum metallicum 6CH and Calendula officinalis 6CH applied independently in different concentrations in fibroblast cultures sought to determine the increase in proliferative activity using techniques such as IC50, MTT, flow cytometry and quantification of collagen. As expected from the literature, ie both homeopathic according to the literature are used for treatments that Require skin healing, both showed increased proliferative activity, having Calendula most cellular response, presenting as cell cycle stimulating checked via flow cytometry.
Subject(s)
Humans , Wound Healing , Zincum Metallicum/therapeutic use , /therapeutic use , High Potencies , FibroblastsABSTRACT
Transtornos da personalidade são um grupo de condições caracterizadas por incapacidade para se relacionar com outras pessoas e aprender da experiência. Sujeitos com transtornos da personalidade podem vir a perceber que as suas crenças e atitudes são diferentes daquelas da maioria das pessoas. Outros descobrem que a sua conduta é inusual, inesperada e mesmo ofensiva. No presente artigo é discutido o caso de um paciente de sexo masculino e 42 anos de idade com transtorno esquizotípico, tendo a alucinação típica de ser sujeito de abuso e perseguição, e posterior sensação de formigamento. Com o medicamento homeopático corretamente selecionado a autoconfiança, sintomas somáticos, estresse e preocupação, ansiedade e alucinações melhoraram, o que sugere que a homeopatia pode ser muito útil no tratamento deste tipo de transtornos da personalidade. (AU)
Personality disorders are a group of conditions characterized by an inability to get on with other people and learn from experience. People with a personality disorder may find that their beliefs and attitudes are different from those of most other people. Others may find their behavior unusual, unexpected or perhaps offensive. In this paper, we discuss a case of a 42- year-old man with schizotypal personality disorder with typical delusions of being abused and persecuted and subsequent formication. With a properly selected homoeopathic medicine the patient experienced symptom improvement in self-confidence, somatic complaints, stress and worry, anxiety, and delusions, suggesting that homoeopathy is quite useful in the treatment of such personality disorders. (AU)
Subject(s)
Humans , Male , Adult , Zincum Metallicum/therapeutic use , Homeopathy , Schizotypal Personality Disorder , Psychotic DisordersABSTRACT
Transtornos da personalidade são um grupo de condições caracterizadas por incapacidade para se relacionar com outras pessoas e aprender da experiência. Sujeitos com transtornos da personalidade podem vir a perceber que as suas crenças e atitudes são diferentes daquelas da maioria das pessoas. Outros descobrem que a sua conduta é inusual, inesperada e mesmo ofensiva. No presente artigo é discutido o caso de um paciente de sexo masculino e 42 anos de idade com transtorno esquizotípico, tendo a alucinação típica de ser sujeito de abuso e perseguição, e posterior sensação de formigamento. Com o medicamento homeopático corretamente selecionado a autoconfiança, sintomas somáticos, estresse e preocupação, ansiedade e alucinações melhoraram, o que sugere que a homeopatia pode ser muito útil no tratamento deste tipo de transtornos da personalidade...
Personality disorders are a group of conditions characterized by an inability to get on with other people and learn from experience. People with a personality disorder may find that their beliefs and attitudes are different from those of most other people. Others may find their behavior unusual, unexpected or perhaps offensive. In this paper, we discuss a case of a 42- year-old man with schizotypal personality disorder with typical delusions of being abused and persecuted and subsequent formication. With a properly selected homoeopathic medicine the patient experienced symptom improvement in self-confidence, somatic complaints, stress and worry, anxiety, and delusions, suggesting that homoeopathy is quite useful in the treatment of such personality disorders...
Subject(s)
Humans , Male , Adult , Homeopathy , Schizotypal Personality Disorder , Zincum Metallicum/therapeutic use , Psychotic DisordersABSTRACT
Introduction: Based on the large amount of patients that seek alternative treatment for clinical complaints compatible with ADHD diagnosis and above all by the high percentage of non adaptation or risk that officially proposed drugs may bring, we developed a laboratorial clinical investigative profile that favors a safe homeopathic treatment.Material: 52 cases with urinary zinc analysis, with ADHD diagnosis.Method: using the diagnosis confirmation questionnaire (SNAP-IV by UFRJ) and Zinc analysis by HPLC method (high performance liquid chromatography) which normal values range from 246 and 846 nmol/liter.Results: in a 52 patients (table 1) sampling with a suggestive ADHD diagnosis, we obtained a quantitative alteration in 31 cases showing high urinary Zinc levels, which allowed therapeutic approach that lead to better clinical result followed by subsequent reduction of urinary Zinc levels, in posterior analysis in eight (8) of these patients.(AU)
Subject(s)
Humans , Attention Deficit Disorder with Hyperactivity , Zincum MetallicumABSTRACT
The objective of this study, stated as Previous Notation, is to demonstrate that Attention Deficit Hyperactivity Disorder Pathology presents a differentiated condition in carriers where a significant percentage, close to 60%, present a higher level of zinc elimination by kidneys. In this study, a direct relation of Zinc Mettalicum pathogenetic symptoms, this disturbance and the elimination of this element which participates in neurotransmission process were identified, and the relation with elements from regular diet, which can act as zinc chelating agents would be involved in the evolution of this disturbance, justifying the issue of individual susceptibility, essential in homeopathic investigation. Keywords: Attention; Impulsivity; Agitation; Zincum Mettalicum; Neurotransmission.(AU)
Subject(s)
Humans , Attention Deficit Disorder with Hyperactivity , Zincum MetallicumABSTRACT
Introduction: Based on the large amount of patients that seek alternative treatment for clinical complaints compatible with ADHD diagnosis and above all by the high percentage of non adaptation or risk that officially proposed drugs may bring, we developed a laboratorial clinical investigative profile that favors a safe homeopathic treatment.Material: 52 cases with urinary zinc analysis, with ADHD diagnosis.Method: using the diagnosis confirmation questionnaire (SNAP-IV by UFRJ) and Zinc analysis by HPLC method (high performance liquid chromatography) which normal values range from 246 and 846 nmol/liter.Results: in a 52 patients (table 1) sampling with a suggestive ADHD diagnosis, we obtained a quantitative alteration in 31 cases showing high urinary Zinc levels, which allowed therapeutic approach that lead to better clinical result followed by subsequent reduction of urinary Zinc levels, in posterior analysis in eight (8) of these patients.
Subject(s)
Humans , Male , Female , Zinc/urine , Zincum Metallicum/therapeutic use , Urinary Sediment AnalysisABSTRACT
Cadmium (Cd) is a major environmental hazard, which usually is detected in its ionic form of Cd2+. It also causes adverse toxic effects on human health and other living organisms. Cd-resistant bacteria were isolated from Cd-contaminated soils. One isolate, TAK1, was highly resistance level to Cd toxicity. TAK1 was isolated from soil contaminated with a high Cd concentration (204.1 mg.kg-1). The result of 16S rDNA sequence analysis found that the TAK1 showed the similarity to Ralstonia sp. Physiological adaptive and cross-protective responses to Cd and Zn killing were investigated in Ralstonia sp.TAK1. Exposure to a low concentration of Cd induced adaptive resistance to higher concentrations of Cd. In addition, pretreatment of Ralstonia sp.TAK1 with an inducing concentration of Cd conferred cross-protective response against subsequent exposure to the lethal concentrations of Zn. The induced adaptive and cross-protective response Ralstonia sp.TAK1 required newly synthesized protein(s). Cd-induced adaptive and cross-protective responses against Cd and Zn toxicity are the important mechanisms used by Ralstonia sp.TAK1 to survive in the heavy metal contaminated environments. These findings might lead to the use of Ralstonia sp.TAK1 for microbial based remediation in Cd and Zn-contaminated soils.
Subject(s)
Cadmium Metallicum/isolation & purification , Cadmium Metallicum/toxicity , In Vitro Techniques , RNA , Sequence Analysis, DNA , Toxicity , Zincum Metallicum/isolation & purification , Zincum Metallicum/toxicity , Environmental Pollution , Environment , Methods , Soil , MethodsABSTRACT
Se realizó un estudio observacional descriptivo con el objetivo de mostrar el resultados del tratamiento conservador en un grupo de pacientes con Insuficiencia Arterial Crónica (IAC) sin criterios de operabilidad, atendidos en el servicio de Angiología del Hospital Provincial"Manuel Ascunce D." y seguidos en la consulta de Homeopatía de la Clínica de la Universidad Médica "Carlos J. Finlay", en el período comprendido entre Noviembro del 2004 a Julio 2005.(AU)
Subject(s)
Middle Aged , Intermittent Claudication , Arterial Occlusive Diseases , Platelet Aggregation Inhibitors , Hypericum , Zincum Metallicum , Homeopathy , Tomography , Diabetes Mellitus , Tobacco Use DisorderABSTRACT
Se realizó un estudio observacional descriptivo con el objetivo de mostrar el resultados del tratamiento conservador en un grupo de pacientes con Insuficiencia Arterial Crónica (IAC) sin criterios de operabilidad, atendidos en el servicio de Angiología del Hospital Provincial"Manuel Ascunce D." y seguidos en la consulta de Homeopatía de la Clínica de la Universidad Médica "Carlos J. Finlay", en el período comprendido entre Noviembro del 2004 a Julio 2005.
Subject(s)
Middle Aged , Arterial Occlusive Diseases , Hypericum , Intermittent Claudication , Platelet Aggregation Inhibitors , Zincum Metallicum , Diabetes Mellitus , Homeopathy , Tobacco Use Disorder , TomographyABSTRACT
Essa dissertacao apresenta, com o apoio de fundamentacao teorico-pratica, o cenario em que se insere a problematica em questao: o efeito antioxidante in vitro dos medicamentos homopaticos Arsenicum album, Cuprum metallicum, Manganum e Zincum metallicum
Subject(s)
Antioxidants , Orthomolecular Therapy , Arsenicum Album , Cuprum , Zincum Metallicum , Manganum Aceticum , Basic Homeopathic ResearchABSTRACT
Essa dissertacao apresenta, com o apoio de fundamentacao teorico-pratica, o cenario em que se insere a problematica em questao: o efeito antioxidante in vitro dos medicamentos homopaticos Arsenicum album, Cuprum metallicum, Manganum e Zincum metallicum
Subject(s)
Antioxidants , Arsenicum Album , Basic Homeopathic Research , Cuprum , Manganum Aceticum , Orthomolecular Therapy , Zincum MetallicumSubject(s)
Case Reports , Humans , Male , Female , Middle Aged , Aged , Zincum Metallicum , Tendinopathy/therapy , Sleep Initiation and Maintenance DisordersSubject(s)
Case Reports , Humans , Male , Medicamentous Diagnosis , Dreams , Illusions , Delirium , Sensation , Symptoms Hierarchy , Alcoholism/therapy , Arsenicum Album/therapeutic use , Tetany/therapy , Silicea Terra/therapeutic use , Anxiety Disorders/therapy , Platinum Metallicum/therapeutic use , Eczema/therapy , Datura stramonium/therapeutic use , Bronchitis/therapy , Natrium Muriaticum/therapeutic use , Depressive Disorder/therapy , Zincum Metallicum/therapeutic use , Neurites/therapy , /therapeutic use , Arthritis/therapy , Sulphur/therapeutic use , Hearing Disorders/therapy , Causticum/therapeutic use , Osteoarthritis, Hip/therapyABSTRACT
Segun Cirlot, en el Zohar, la "cabeza mágica" simboliza luz astral;en el arte medieval simboliza la mente y la vida espiritualEm su Timeo, Platon dice: "la cabeza humana es la imagem del mundo".
Subject(s)
Zincum Metallicum , Materia MedicaABSTRACT
La figura del diablo para los psiquiatras junguianos,representa la parte sombria de nosotros mismos, habita en las zonas oscuras de nuestra psique.El diablo medio hombre y medio bestia, describe el aspecto siniestro y grotesco de nuestro inconsciente, con el que nunca hemos legado a un contacto real.