Comparative Study of Gleason 7 (3+4) and (4+3) Prostatic Adenocarcinomas with Prognostic Criteria and Immunohistochemical Profiles of AMACR, PSA and Ki-67.

BACKGROUND: To compare Gleason 7 (3+4) and (4+3) prostatic adenocarcinoma (PC) with different prognostic criteria through immunohistochemical analysis with anti-PSA, anti-Ki 67 and anti-AMARC antibodies. METHODS: We analyzed 221 surgical specimens from patients between 40 and 86 years-old (mean=63) with PC. The immunohistochemical study was performed with anti-PSA, anti-Ki 67 and anti-AMARC. The microscopic fields were photographed with an Olympus DP70 digital camera coupled to an Olympus BX51 microscope and archived in TIFF. Proportion and intensity criteria were used to quantify the anti-PSA antibody and for the anti-Ki 67 antibody, the quantification by similarity of this antibody in breast carcinomas. Anti-AMACR protein expression was based on four scores: negative, weak, moderate and strong. The statistical analysis was performed with the Graph Pad Prism 5 program. RESULTS: In the Gleason score 7 (3+4) we had 91.72% in pT2 and 8.27% in the pT3 group; 8.27% recurrences, of which 90.90% in the pT2 group. In the Gleason score 7 (4+3) we had 77.27% in the pT2 group and 22.72% in the pT3 group and 10.22% of relapses, of which 66.66% in the pT2 group and 33.33% in the pT3 group. In 6.81% of cases there was an increase in the anti-Ki 67 index and in 2.27% of the cases, there was an increase in the immunoexpression of anti-p53 when comparing Gleason score 7 (3+4) with Gleason score 7 (4+3). CONCLUSION: Our study confirmed differences in the Gleason score 7 (3+4) and Gleason score 7 (4+3) of PC when comparing prognostic criteria. Anti-Ki 67 and anti-PSA antibody immunostaining showed a positive correlation as the Gleason score 7 increased from (3+4) to (4+3).

Cholecystectomy and digestive cancer in Chile: Complementary results from interrupted time series and aggregated data analyses.

Gallbladder cancer (GBC) mortality in Chile is among the highest worldwide. In 2006, the Chilean government launched a programme guaranteeing access to gallbladder surgery (cholecystectomy) for patients aged 35-49 years. We evaluated the impact of this programme on digestive cancer mortality. After conducting an interrupted time series analysis of hospitalisation and mortality data from 2002 to 2018 publicly available from the Chilean Department of Health Statistics and Information, we calculated the change in the proportion of individuals without gallbladder since 10 years. We then estimated age, gender, region, and calendar-year standardised mortality ratios (SMRs) as a function of the change in the proportion of individuals without gallbladder. The cholecystectomy rate increased by 45 operations per 100,000 persons per year (95%CI 19-72) after the introduction of the health programme. Each 1% increase in the proportion of individuals without gallbladder since 10 years was associated with a 0.73% decrease in GBC mortality (95% CI -1.05% to -0.38%), but the negative correlation was limited to women, southern Chile and age over 60. We also found decreasing mortality rates for extrahepatic bile duct, liver, oesophageal and stomach cancer with increasing proportions of individuals without gallbladder. To conclude, 12 years after its inception, the Chilean cholecystectomy programme has markedly and heterogeneously changed cholecystectomy rates. Results based on aggregate data indicate a negative correlation between the proportion of individuals without gallbladder and mortality due to gallbladder and other digestive cancers, which requires validation using individual-level longitudinal data to reduce the potential impact of ecological bias.

Predictors of ischemic stroke in Chagas disease: Insights into mechanisms beyond cardiomyopathy severity.

BACKGROUND: Chagas disease is a risk factor for ischemic stroke, which causes high mortality rates and significant disability. This study aims to determine the incidence and risk factors for ischemic strokes in a large cohort of Chagas cardiomyopathy patients, with a particular focus on the mechanisms involved in the pathophysiology of stroke in this condition. METHODS: The study enrolled 517 patients with Chagas cardiomyopathy who were referred to our institution from March 2000 to December 2021. All patients underwent systematic cardiological and neurological assessments. The primary outcome was the occurrence of ischemic stroke during the follow-up period, classified based on the SSS-TOAST and CCS criteria. Natural cubic splines functions were applied to examine the potential nonlinear association between continuous variables and stroke risk. RESULTS: The mean age of the cohort was 52 ± 13 years, and 299 (58 %) were men. During a mean follow-up period of 4.8 years (interquartile range-IQR 1.1 to 7.1 years), a total of 72 patients (14.8 %) had an ischemic stroke, being fatal in 10. The overall incidence rate of ischemic stroke was 3.0/100 patient-years (95 % confidence interval 2.4 to 3.8). The stroke subtypes were cardioembolic (n = 41), undetermined (n = 11), and other subtypes (n = 20). The predictors of stroke were age, left atrial volume, left ventricular ejection fraction (LVEF), LV thrombus and prior stroke with thrombus. There was a nonlinear relationship between stroke risk, LVEF, and left atrial volume. A bimodal distribution of stroke occurrences was observed according to the severity of LV dysfunction, with a threshold for LVEF of 45 %. The final model for stroke risk prediction showed good discrimination, with a C statistic of 0.775. CONCLUSIONS: In a contemporary cohort of Chagas disease patients with a broad spectrum of disease severity, stroke incidence remains high despite anticoagulation. Stroke risk shows a nonlinear association with ventricular dysfunction and left atrial size, highlighting a distinct bimodal pattern of stroke occurrence in Chagas disease.

Assessing the Relevance of Non-molecular Prognostic Systems for Myelodysplastic Syndrome in the Era of Next-Generation Sequencing.

Background: The Molecular International Prognostic Scoring System (IPSS-M) has improved the prediction of clinical outcomes for myelodysplastic syndromes (MDS). The Artificial Intelligence Prognostic Scoring System for MDS (AIPSS-MDS), based on classical clinical parameters, has outperformed the IPSS, revised version (IPSS-R). For the first time, we validated the IPSS-M and other molecular prognostic models and compared them with the established IPSS-R and AIPSS-MDS models using data from South American patients. Methods: Molecular and clinical data from 145 patients with MDS and 37 patients with MDS/myeloproliferative neoplasms were retrospectively analyzed. Results: Prognostic power evaluation revealed that the IPSS-M (Harrell's concordance [C]-index: 0.75, area under the receiver operating characteristic curve [AUC]: 0.68) predicted overall survival better than the European MDS (EuroMDS; C-index: 0.72, AUC: 0.68) and Munich Leukemia Laboratory (MLL) (C-index: 0.70, AUC: 0.64) models. The IPSS-M prognostic discrimination was similar to that of the AIPSS-MDS model (C-index: 0.74, AUC: 0.66) and outperformed the IPSS-R model (C-index: 0.70, AUC: 0.61). Considering simplified low- and high-risk groups for clinical management, after restratifying from IPSS-R (57% and 32%, respectively, hazard ratio [HR]: 2.8; P=0.002) to IPSS-M, 12.6% of patients were upstaged, and 5% were downstaged (HR: 2.9; P=0.001). The AIPSS-MDS recategorized 51% of the low-risk cohort as high-risk, with no patients being downstaged (HR: 5.6; P<0.001), consistent with most patients requiring disease-modifying therapy. Conclusions: The IPSS-M and AIPSS-MDS models provide more accurate survival prognoses than the IPSS-R, EuroMDS, and MLL models. The AIPSS-MDS model is a valid option for assessing risks for all patients with MDS, especially in resource-limited centers where molecular testing is not currently a standard clinical practice.

Frequency of hepatitis D virus with different hepatitis B virus serological markers and coinfections in hospital patients from Argentina: synchronous testing of anti-HDV antibodies and HDV RNA.

BACKGROUND: Hepatitis D virus (HDV) RNA-positive cases with total anti-HDV antibodies nonreactive were documented. Moreover, HDV infection was observed in subjects with occult hepatitis B virus infection. The prevalence of HDV infection in Argentina is low; however, further research in different populations is needed. OBJECTIVE: This study aimed to perform synchronous HDV detection in reactive hepatitis B virus patients treated in a public hospital in the province of Buenos Aires, Argentina, some of whom were coinfected with hepatitis C virus and/or HIV. A total of 189 hepatitis B virus-reactive serum samples with or without hepatitis C virus and/or HIV coinfection were synchronously analyzed for anti-HDV antibodies and HDV RNA. RESULTS: HDV prevalence was 4.2% with HDV RNA found in 61 samples, most of which were nonreactive to anti-HDV antibodies and hepatitis B surface antigen. Genotype 1 was identified in all HDV sequences. Moreover, triple and quadruple infections were observed, showing a high frequency of HDV infection in hospitalized patients not following the recommended diagnostic algorithm. CONCLUSIONS: This study is evidence that the synchronous testing of anti-HDV antibodies and HDV RNA is necessary for the diagnosis of HDV infection in Argentina. Finally, further research is necessary to identify high-risk populations and improve prevention and control strategies for triple and quadruple infections and their potential consequences.

The burden of pre-operative anaemia and postoperative outcomes in 15 166 surgical patients from a public hospital in Brazil: A retrospective cohort study.

BACKGROUND: Preoperative anaemia is associated with poor postoperative outcomes; however, few studies have reported its prevalence in developing countries and its association with significant postoperative outcomes. OBJECTIVE: We aimed to identify the prevalence of anaemia and its association with postoperative outcomes in a major public hospital in Brazil. DESIGN: Retrospective cohort study. SETTING: Single-centre, 860-bed, quaternary university-affiliated teaching hospital in Southern Brazil. PATIENTS: We included adult patients who had undergone surgery between 2015 and 2019. Main outcome measures: The main outcome was the in-hospital 30-day postoperative mortality. According to the World Health Organisation, we defined anaemia and its sub-classification (mild, moderate, and severe). We developed Poisson regression models to examine the association between preoperative anaemia and outcomes. RESULTS: We included 15 166 patients, of whom 6387 (42.1%) were anaemic. After adjustment for confounding factors, patients with anaemia had an increased risk of in-hospital 30-day postoperative mortality (relative risk (RR) 1.69, 95% confidence interval (CI) 1.44 to 1.99, P  < 0.001). Mild [relative risk (RR) 1.38, 95% CI 1.12 to 1.71, P  = 0.003], moderate (RR 1.73, 95% CI 1.43 to 2.10, P  < 0.001), and severe anaemia (RR 2.43, 95% CI 1.92 to 3.07, P  < 0.001) were associated with the primary outcome. Anaemia increased the transfusion risk (RR 4.44, 95% CI 3.90 to 5.06, P  < 0.001) and postoperative intensive care unit (ICU) admission (RR 1.09, 95% CI 1.04 to 1.16, P  = 0.001). CONCLUSIONS: Four out of 10 patients had anaemia. These patients had an increased risk of adverse postoperative outcomes. Comprehension of the magnitude and impact of anaemia is essential to establish interventions in low-resource scenarios to optimise the patient's journey. STUDY REGISTRATION: Institutional Review Board Registration number 40522820000005327 (Brazilian CEP/CONEP System, available in https://plataformabrasil.saude.gov.br/ ).

Oral cancer screening using cytopathology: An advanced proposal with the Bethesda classification.

BACKGROUND: Oral cancer screening requires analysis capable of detecting changes preceding the clinical manifestation. Oral cytopathology studies as an oral cancer screening have shown promising results. This study aims to evaluate the use of cytopathology in a quali-quantitative analysis using Papanicoloau staining. METHODS: Four experimental groups were evaluated: control (CG), exposed to carcinogens (EG), potentially malignant disorder with and without epithelial dysplasia (D-OPMDG and ND-OPMDG) and oral squamous cell carcinoma (OSCCG). Oral smears were collected using a Cytobrush® and conventional exfoliative cytology. RESULTS: Oral Papanicolaou smears from 143 individuals were analysed in 8100 images. Qualitatively, non-lesional groups exhibited minimal suspected cases (20% in CG and 5% in EG), in the OPMD groups the ability to identify altered cells was low (40% in D-OPMDG and 0% in ND-OPMDG). Conversely, a notable 100% accuracy was achieved in the OSCCG. Quantitatively, a higher percentage of anucleated and a lower percentage of intermediate cells were observed in the OPMDG; a higher proportion of parabasal/suspicious cells was observed in OSCCG. The optimal threshold for improved accuracy in detecting suspected malignancies occurs when the count of parabasal/suspicious cells exceeds 8/100 cells examined. Cytomorphometric analysis revealed a higher nucleus/cytoplasm ratio (N/C) in OSCCG, with a best cutoff point indicating enhanced accuracy in discerning suspected malignancies when exceeding 17% of cells exhibiting this elevated ratio. CONCLUSION: It is possible to suggest updates in cytomorphometric and quantitative analysis in the modified Bethesda system for the oral cavity including objective criteria in the risk classification, therefore improving oral cancer screening.

Two-Year Longitudinal Outcomes of Subjective Cognitive Decline in Hispanics Compared to Non-hispanic Whites.

BACKGROUND: Subjective cognitive decline (SCD), considered a preclinical dementia stage, is less understood in Hispanics, a high-risk group for dementia. We investigated SCD to mild cognitive impairment (MCI) progression risk, as well as baseline and longitudinal features of depressive symptoms, SCD complaints, and objective cognitive performance among Hispanics compared to non-Hispanic Whites (NHW). METHODS: Hispanic (n = 23) and NHW (n = 165) SCD participants were evaluated at baseline and 2-year follow-up. Evaluations assessed function, depressive symptoms, SCD, and objective cognitive performance. RESULTS: Hispanics were at increased risk of progression to MCI (OR: 6.10, 95% CI 1.09-34.20, P = .040). Hispanic participants endorsed more depressive symptoms at baseline (P = .048) that worsened more longitudinally (OR: 3.16, 95% CI 1.18-8.51, P = .023). Hispanic participants had increased SCD complaints on the Brief Cognitive Rating Scale (BCRS) (ß = .40 SE: .17, P = .023), and in specific BCRS domains: concentration (ß = .13, SE: .07, P = .047), past memory (ß = .13, SE: .06, P = .039) and functional abilities (ß = .10, SE: .05, P = .037). In objective cognitive performance, Hispanic ethnicity associated with decline in MMSE (ß = -.27, SE: .13, P = .039), MoCA (ß = -.80 SE: .34, P = .032), Trails A (ß = 2.75, SE: .89, P = .002), Trails B (ß = 9.18, SE: 2.71, P = .001) and Guild Paragraph Recall Delayed (ß = -.80 SE: .28, P = .005). Conclusions: Hispanic ethnicity associated with a significantly increased risk of 2-year progression of SCD to MCI compared to NHW. This increased risk associated with increased depressive symptoms, distinctive SCD features, and elevated amnestic and non-amnestic objective cognitive decline. This supports further research to refine the assessment of preclinical dementia in this high-risk group.

Predictors of lumbar spine trabecular bone score in women with postsurgical hypoparathyroidism.

Hypoparathyroidism is a rare disease that markedly reduces bone remodeling, leading to increased bone mineral density and changes in bone microarchitecture. However, it is currently unclear how these changes affect fracture risk. In this study, we investigated bone mass by dual-energy x-ray absorptiometry, the occurrence of morphometric vertebral fractures, and bone microarchitecture by assessing trabecular bone score in women with postsurgical hypoparathyroidism. We included 67 women with hypoparathyroidism aged 52.9 ± 12.3 years and 63 age- and body mass index-matched controls, which were assessed for femoral and lumbar spine bone mineral density, trabecular bone score, and vertebral fractures by dual-energy x-ray absorptiometry. Women with hypoparathyroidism had significantly higher bone mineral density at the lumbar spine, femoral neck, and total hip compared with controls despite similar trabecular bone score values. Vertebral fracture assessment indicated that two women with hypoparathyroidism presented vertebral fractures, both aged over 65 years. Conversely, no vertebral fractures were detected in control women. In a multivariate linear regression model, we found that older age, diabetes, and lower lumbar spine mineral density were significant predictors of lower trabecular bone score values. Our findings indicate that vertebral fractures are not common among women with postsurgical hypoparathyroidism aged under 65 years. Moreover, trabecular bone score values were similar in women with hypoparathyroidism and age-matched controls and were associated with traditional risk factors for fractures, such as older age, type 2 diabetes, and lower spine bone mineral density. LAY SUMMARY: Chronic parathyroid hormone deficiency decreases bone turnover and modifies skeletal properties, although the impact of these changes on fracture risk remains unclear. We studied 67 women with postsurgical hypoparathyroidism and 63 age and body mass index-matched healthy controls and found that bone mineral density is increased in women with hypoparathyroidism despite similar trabecular bone score values and a low occurrence of morphometric vertebral fractures. This suggests that the low bone turnover in hypoparathyroidism increases bone mass, but this is not accompanied by improved bone microarchitecture, indicating that trabecular bone score may be a valuable tool to complement the assessment of skeletal health and the risk of fractures in this condition.

Prostate cancer focal therapy: surgeon experience influences oncological results.

INTRODUCTION: Characterization of the index lesion of prostate cancer (PCa) has facilitated the development of focal therapy to reduce complications caused by radical treatments. In the present study, we sought to identify factors associated with the oncological results of focal therapy for PCa. METHODS: Between April 2017 and February 2020, 123 PCa patients received focal therapy performed with high-intensity focused ultrasound (HIFU). The patients presented unilateral localized disease, PSA < 20 ng/dl, clinical stage T1-T2, ISUP grade 1-3, and more than 10 years of life expectancy. Five certified surgeons with different levels of experience performed the procedures and were divided into groups #1 and #2 (>30 HIFUs performed) and #3 (10-15 HIFUs performed each). All patients were prospectively followed and underwent surveillance biopsy 1 year post-treatment. The primary endpoint was radical treatment, and secondary endpoints included focal therapy failure and in-field recurrence. Univariate and multivariate logistic regression were used to detect associations between clinical and procedure variables and the endpoints. RESULTS: The median follow-up was 54.3 months, with a mean age of 64.4 years. The mean PSA was 6.6 ng/dl; 59.3% of patients had intermediate-risk disease, and the remaining had low-risk. During follow-up, 29 (23.6%) patients required radical treatment (external beam radiation therapy), 37 (30.1%) experienced treatment failure, and 26 (21.1%) had an in-field recurrence with an ISUP grade of ≥2. Radical treatment in the follow-up was associated with patients treated by surgeons in group #3 and with elevated post-HIFU PSA concentrations. Baseline PSA concentrations, group #3 surgeons, and post-HIFU PSA concentrations were associated with treatment failure. In-field positive biopsies were associated with baseline and post-HIFU PSA concentrations. Furthermore, patients treated by surgeons in group #3 were independently associated with radical treatment and focal therapy failure. CONCLUSION: Focal therapy with HIFU has acceptable oncological outcomes in the medium term, and the surgeon's experience and technique are independently associated with the need for subsequent radical treatment and focal therapy failure.

Effects of sildenafil on gas exchange, ventilatory, and sensory responses to exercise in subjects with mild-to-moderate COPD: A randomized cross-over trial.

Excess exercise ventilation (high ventilation (V̇E)/carbon dioxide output (V̇CO2)) contributes significantly to dyspnea and exercise intolerance since the earlier stages of chronic obstructive pulmonary disease (COPD). A selective pulmonary vasodilator (inhaled nitric oxide) has shown to increase exercise tolerance secondary to lower V̇E/V̇CO2 and dyspnea in this patient population. We aimed to assess whether a clinically more practical option - oral sildenafil - would be associated with similar beneficial effects. In a randomized, placebo-controlled study, twenty-four patients with mild-to-moderate COPD completed, on different days, two incremental cardiopulmonary exercise tests (CPET) one hour after sildenafil or placebo. Eleven healthy participants performed a CPET in a non-interventional visit for comparative purposes with patients when receiving placebo. Patients (FEV1= 69.4 ± 13.5 % predicted) showed higher ventilatory demands (V̇E/V̇CO2), worse pulmonary gas exchange, and higher dyspnea during exercise compared to controls (FEV1= 98.3 ±11.6 % predicted). Contrary to our expectations, however, sildenafil (50 mg; N= 15) did not change exertional V̇E/V̇CO2, dead space/tidal volume ratio, operating lung volumes, dyspnea, or exercise tolerance compared to placebo (P>0.05). Due to the lack of significant beneficial effects, nine additional patients were trialed with a higher dose (100 mg). Similarly, active intervention was not associated with positive physiological or sensory effects. In conclusion, acute oral sildenafil (50 or 100 mg) failed to improve gas exchange efficiency or excess exercise ventilation in patients with predominantly moderate COPD. The current study does not endorse a therapeutic role for sildenafil to mitigate exertional dyspnea in this specific patient subpopulation. Clinical trial registry: https://ensaiosclinicos.gov.br/rg/RBR-4qhkf4 Web of Science Researcher ID: O-7665-2019.

Eighteen-year trends in the rates of intra-operative cardiac arrest and associated mortality at a public university hospital in Brazil.

BACKGROUND: Intra-operative cardiac arrest is a rare but life-threatening event. Over the past two decades, various initiatives have improved the care of patients undergoing surgery at our quaternary teaching hospital in Brazil. We aimed to evaluate the epidemiology of intra-operative cardiac arrest and associated 30-day mortality over an 18-year period. A secondary aim was to identify associated risk factors. METHODS: We conducted a retrospective observational study using data collected from 1 January 2005 to 31 December 2022. Factors associated with cardiac arrest and mortality were identified using multivariable logistic regression analysis. RESULTS: Among the 154,178 cases, the overall rates of intra-operative cardiac arrest (n = 297) and associated 30-day mortality (n = 248) were 19.3 (95%CI (16.6-21.9)) and 16.1 (95% CI 13.9-18.3) per 10,000 anaesthetics, respectively. These decreased over time (2005-2010 vs. 2017-2022) from 26.3 (95%CI 21.0-31.6) to 15.4 (95%CI 12.0-18.7) per 10,000 anaesthetics, and from 23.4 (95%CI 18.8-28.1) to 13.7 (95%CI 10.8-16.7) per 10,000 anaesthetics, respectively. Factors associated with intra-operative cardiac arrest included children aged < 1 year (adjusted OR (95%CI) 3.51 (1.87-6.57)); ASA physical status 3-5 (adjusted OR (95%CI) 13.85 (8.86-21.65)); emergency surgery (adjusted OR (95%CI) 10.06 (7.85-12.89)); general anaesthesia (adjusted OR (95%CI) 8.79 (4.60-19.64)); surgical procedure involving multiple specialities (adjusted OR (95%CI) 9.13 (4.24-19.64)); cardiac surgery (adjusted OR (95%CI) 7.69 (5.05-11.71)); vascular surgery (adjusted OR (95%CI) 6.21 (4.05-9.51)); and gastrointestinal surgery (adjusted OR (95%CI) 2.98 (1.91-4.65)). DISCUSSION: We have shown an important reduction in intra-operative cardiac arrest and associated 30-day mortality over an 18-year period. Identification of relative risk factors associated with intra-operative cardiac arrest can be used to improve the safety and quality of patient care, especially in a resource-limited setting.

Effect of age-related premium readjustment on health insurance cancellation in Brazil: Regression discontinuity approach.

Age is one of the most relevant observable risk attributes in determining the value of health insurance premiums. Empirical evidence indicates that the cost of health insurance is the leading cause of contract switching, which can compromise access to healthcare services and potentially result in treatment discontinuities. Using data from a Health Maintenance Organization in the Southern region of Brazil, we examined the effect of health plan price readjustment resulting from changes in the beneficiary's age group on disenrollment or switches to a more limited coverage plan. The estimates were obtained using the method of regression discontinuity. The main findings indicate that for age group transitions at 59 years old, the price readjustment effect led to an increase in contract cancellations and switching to cheaper plans. These findings highlight that an important consequence of the difference in premium sensitivity among age groups is that the exit of individuals from the health insurance sector is selective in age. The results of this paper can support policymaking to improve access to health insurance.

Yoga como terapia complementaria para el Adulto Mayor / Yoga as a complementary therapy for older adult

Introducción: El yoga es una actividad que trata de un ejercicio el cual contiene una intensidad baja a moderada, la cual no se centra exclusivamente en el entrenamiento físico, sino que también en el desarrollo de la mente y el espíritu de uno mismo. El yoga puede obtener un mayor impacto en el equilibrio y en la ganancia de fuerza de la parte superior del cuerpo, además, demuestra mejora en la aptitud cardiorrespiratoria y flexibilidad. Metodología: El enfoque de desarrollo fue de tipo cuantitativo en donde se realizó una revisión sistemática como metodología de búsqueda de información, relacionada al yoga como una terapia complementaria y los beneficios que éste aportaba al bienestar de las personas mayores. Resultados: En cada uno de los ensayos controlados aleatorizados que fueron recabados para fines de esta revisión sistemática. Se destaca la importancia y los beneficios del yoga en la movilidad, fuerza, flexibilidad y espiritualidad de los usuarios que practican esta terapia. Discusión: Los artículos analizados pertenecen a ensayos clínicos o estudios aleatorizados, los cuales permitieron responder de manera efectiva a nuestra pregunta de investigación, la cual consiste en reconocer si el yoga es efectivo para disminuir el riesgo de dependencia funcional y eliminar hábitos que no son saludables para las personas mayores, además de mejorar la calidad de vida actual. Gracias a ello se pudo evidenciar que esta terapia en adultos mayores genera cambios positivos respecto a estado y condición física, la ejecución de esta práctica mejora la calidad de vida en un 80% Conclusión: La yoga como terapia complementaria si entrega beneficios en la calidad de vida de la población adulta mayor, dado que, que hubo una mejora tanto en la movilidad, calidad de vida y autovalencia de los adultos mayores[AU]

Introduction: Yoga is an activity that deals with a low to moderate intensity exercise, which is not exclusively focused on physical training, but also on the development of the mind and spirit itself. Yoga may have a greater impact on balance and upper body strength gains, and have shown improvements in cardiorespiratory fitness and flexibility. Methodology:the development approach was of a quantitative type where a systematic review was carried out as a methodology for searching for information related to yoga as a complementary therapy and the benefits that it brought to the well-being of the elderly. Results:The importance and benefits of yoga on the mobility, strength, flexibility and spirituality of users who practice this therapy are highlighted in each of the randomized controlled trials that were collected for the purposes of this systematic review. Discussion: The articles analyzed belong to clinical trials or randomized studies, which allowed us to effectively answer our research question. The activity of yoga in older adults generates positive changes regarding state and physical condition, the execution of this practice improves the quality of life by 80% Conclusion: Yoga as a complementary therapy delivers benefits in the quality of life of the adult population elderly, it can be said that there was an improvement in mobility, quality of life and self-valence of the elderly[AU]

Introdução: O Yoga é uma atividade que trata de um exercício de intensidade baixa a moderada, que não se foca exclusivamente no treino físico, mas também no desenvolvimento da mente e do espí-rito. A ioga pode ter um impacto maior no equilíbrio e nos ganhos de força da parte superior do corpo e mostrou melhorias na apti-dão cardiorrespiratória e flexibilidade. Metodologia: a abordagem de desenvolvimento foi do tipo quantitativo onde foi realizada uma revisão sistemática como metodologia de busca de informações re-lacionadas ao yoga como terapia complementar e os benefícios que trouxe para o bem-estar dos idosos. Resultados: A importância e os benefícios do yoga na mobilidade, força, flexibilidade e espiri-tualidade dos usuários que praticam esta terapia são destacados em cada um dos ensaios clínicos randomizados que foram coletados para fins desta revisão sistemática. Discussão: Os artigos analisa-dos pertencem a ensaios clínicos ou estudos randomizados, o que nos permitiu responder de forma eficaz à nossa questão de inves-tigação. A atividade de yoga em idosos gera mudanças positivas quanto ao estado e condição física, a execução desta prática mel-hora a qualidade de vida em 80% Conclusão: o yoga como terapia complementar traz benefícios na qualidade de vida da população adulta idosa, pode-se dizer que houve melhora na mobilidade, qualidade de vida e autovalência dos idosos[AU]

Prevalência de sintomas de doenças musculoesqueléticas na área de abrangência de uma Unidade Básica de Saúde / Prevalence of musculoskeletal disorders in an area covered by a Health Center / Prevalencia de síntomas de enfermedades musculoesqueléticas en el área de cobertura de una unidad básica de salud

Introdução: As doenças musculoesqueléticas (DMSQ) são causas importantes de incapacidade física que tem como consequências a redução da qualidade de vida e o aumento dos custos em saúde. Objetivo: Este estudo teve o objetivo de descrever a prevalência de sintomas de DMSQ e da incapacidade física associada a esses sintomas em uma área de abrangência de uma Unidade Básica de Saúde (UBS) da família em área periurbana, além de analisar a associação da presença desses sintomas com características demográficas e doenças crônicas mais frequentes. Métodos: Estudo transversal realizado na área de cobertura de uma UBS periurbana entre agosto de 2018 e fevereiro de 2019 na qual pessoas com mais de 15 anos, selecionadas ao acaso, foram entrevistadas com o questionário da primeira fase do Community Oriented Program for Control of Rheumatic Diseases (COPOCORD), traduzido e validado para a língua portuguesa. Essas pessoas também foram questionadas quanto à presença de outras doenças diagnosticadas e a medicações em uso. Além disso, foram realizadas medidas de peso, altura e circunferência da cintura de cada participante ­ os dois primeiros foram utilizados para cálculo do índice de massa corporal (IMC). Resultados: Neste estudo foram entrevistadas 372 pessoas com média de idade de 46,5 (±18,3) anos, sendo 212 (57%) do sexo feminino. A prevalência de indivíduos que apresentaram sintomas de DMSQ nos últimos sete dias foi de 66,4% (IC95% 61,6­71,2). Cerca da metade (48,6%) e quase um quarto (24,2%) dos participantes relataram sintomas de intensidade moderada e severa, respectivamente. Os locais mais afetados foram as costas (50,27%), o pescoço (34,9%) e os joelhos (30,64%). A maioria, 209/247 (84,6%), relatou dor em mais de um local e 129/247 (52.2%) relataram limitação física para atividades da vida diária. Das 247 pessoas, 102 (41,3%) procuraram assistência médica, a maioria, 70 (68,6%), na UBS. Indivíduos com sintomas de DMSQ tinham média de idade e de IMC significativamente mais elevada que indivíduos sem esses sintomas, além de apresentarem maior frequência de diabetes e ansiedade e/ou depressão. No entanto, em análise multivariada, nenhuma variável foi preditora independente de sintomas de DMSQ. Conclusões: Sintomas de DMSQ são prevalentes nessa comunidade e a atenção básica deve estar preparada para manejo e reabilitação das pessoas com essas doenças.

Introduction: Musculoskeletal disorders are important causes of physical disability that result in reduced quality of life and increased health costs. Objective: To describe the prevalence of symptoms of musculoskeletal disorders and the physical disability associated with these symptoms in an area covered by a Health Center in a peri-urban area. In addition, we analyzed the association of the presence of these symptoms with demographic characteristics and the most frequent chronic diseases. Methods: This is a cross-sectional study carried out in the area covered by a peri-urban Health Center between August 2018 and February 2019 in which people over 15 years of age, randomly selected, were interviewed using the questionnaire from the first phase of the Community Oriented Program for Control of Rheumatic Diseases (COPOCORD), translated and validated into Brazilian Portuguese. They were also asked about the presence of other chronic diseases and medications in use. In addition, each participant's weight, height, and waist circumference were measured. The first two were used to calculate the body mass index. Results: A total of 372 people were interviewed with a mean age of 46.5 (±18.3) years, 212 (57%) of whom were women. The prevalence of individuals who presented symptoms of musculoskeletal disorders in the last seven days was 66.4% (95%CI: 61.6­71.2). About half (48.6%) and almost a quarter (24.2%) interviewees reported symptoms of moderate and severe intensity, respectively. The most affected sites were the back (50.27%), the neck (34.9%), and the knees (30.64%). The vast majority, 209/247 (84.6%), reported pain in more than one site and 129/247 (52.2%) reported physical impairments in activities of daily living. Of the 247 individuals, 102 (41.3%) sought medical assistance, the majority, 70/102 (68.6%), at the Health Center. Individuals with symptoms of musculoskeletal disorders had a significantly higher mean age and body mass index than individuals without these symptoms. They also had a higher frequency of diabetes and anxiety and/or depression. However, in multivariate analysis, no variable was an independent predictor of symptoms of musculoskeletal disorders. Conclusions: Symptoms of musculoskeletal disorders are prevalent in this community and primary health care must be prepared for the management and rehabilitation of people with these disorders.

Introducción: Las enfermedades musculoesqueléticas son causas importantes de discapacidad física que resultan en una reducción de la calidad de vida y un aumento de los costos de salud. Objetivo: Este estudio tuvo como objetivo describir la prevalencia de síntomas de enfermedades musculoesqueléticas (EME) y la discapacidad física asociada a estos síntomas en un área cubierta por una unidad básica de salud de la familia (UBS) en un área periurbana. También analizamos la asociación de la presencia de estos síntomas con características demográficas y enfermedades crónicas más frecuentes. Métodos: Estudio transversal realizado en el área de cobertura de una UBS periurbana entre agosto de 2018 y febrero de 2019 en el que se entrevistó a personas mayores de 15 años, seleccionadas al azar, mediante la primera fase del cuestionario Community Oriented Program for Control Of Rheumatic Diseases (COPOCORD) traducido y validado al portugués. También se les preguntó sobre la presencia de otras enfermedades diagnosticadas y medicamentos en uso. Además, se tomaron medidas del peso, la altura y la circunferencia de la cintura de cada participante. Los dos primeros se utilizaron para calcular el índice de masa corporal (IMC). Resultados: Fueron entrevistadas 372 personas con una edad media de 46,5 (±18,3) años, de las cuales 212 (57%) eran mujeres. La prevalencia de individuos que presentaron síntomas de enfermedades musculoesqueléticas en los últimos siete días fue del 66,4% (IC 95%: 61,6-71,2). Aproximadamente la mitad (48,6%) y casi una cuarta parte (24,2%) informaron síntomas de intensidad moderada y grave, respectivamente. Las zonas más afectadas fueron la espalda (50,27%), el cuello (34,9%) y las rodillas (30,64%). La gran mayoría, 209/247 (84,6%) refirieron dolor en más de una localización y 129/247 (52,2%) refirieron limitaciones físicas en las actividades de la vida diaria. 102 de los 247 (41,3%) buscaron asistencia médica, la mayoría, 70/102 (68,6%), en la UBS. Las personas con síntomas de DMSQ tenían una edad media y un IMC significativamente más altos que las personas sin estos síntomas. También tenían una mayor frecuencia de diabetes y ansiedad y/o depresión. Sin embargo, en el análisis multivariado, ninguna variable fue un predictor independiente de los síntomas del EMS. Conclusiones: Los síntomas de las enfermedades musculoesqueléticas son prevalentes en esta comunidad y la atención primaria debe estar preparada para el manejo y rehabilitación de las personas con estas enfermedades.

Disfunção sexual em mulheres na atenção primária de Florianópolis: um estudo transversal / Sexual dysfunction in women in primary health care in Florianópolis, Brazil: a cross-sectional study / Disfunción sexual en mujeres en atención primaria en Florianópolis: un estudio transversal

Introdução: A disfunção sexual é mais frequente entre as mulheres, com prevalências entre 25 e 63% naquelas acima de 18 anos. Por meio do questionário Female Sexual Function Index, este estudo busca estimar a frequência de disfunções sexuais em mulheres adultas de duas Equipes de Saúde da Família em Florianópolis, Santa Catarina. Objetivo: O objetivo deste estudo é avaliar a prevalência de disfunção sexual feminina (DSF) nessas populações e investigar a relação entre variáveis sociodemográficas e os domínios representados no escore FSFI. Métodos: Utilizamos o questionário FSFI para avaliar a frequência de disfunções sexuais e realizamos uma análise das variáveis sociodemográficas entre as unidades de saúde. Foram incluídas mulheres adultas atendidas em duas Equipes de Saúde da Família em Florianópolis. Resultados: A prevalência geral de DSF encontrada foi de 67,8%, com uma distribuição homogênea entre as diferentes unidades de saúde e variáveis sociodemográficas. Observamos associações entre anos de estudo e maiores índices de DSF, especialmente nos domínios de desejo, excitação e lubrificação, e entre maior idade e melhor desempenho nos domínios de desejo e excitação. Conclusões: A alta prevalência de distúrbios sexuais femininos em Florianópolis, distribuída de maneira homogênea entre as variáveis sociodemográficas estudadas, destaca a importância da capacitação dos profissionais de saúde na abordagem dessas questões na Atenção Primária

Introduction: Sexual dysfunction is more common among women, with prevalence ranging from 25 to 63% in those over 18 years of age. Through the Female Sexual Function Index (FSFI) questionnaire, in this study we aim to estimate the frequency of sexual dysfunctions in adult women from two Family Health Teams in Florianópolis, state of Santa Catarina, Brazil. Objective: The objective of this study is to evaluate the prevalence of female sexual dysfunction (FSD) in these populations and investigate the relationship between sociodemographic variables and the domains represented in the FSFI score. Methods: The FSFI questionnaire was used to assess the frequency of sexual dysfunctions, and an analysis of sociodemographic variables among the health units was performed. Adult women seen at two Family Health Teams in Florianópolis were included. Results: The overall prevalence of FSD was 67.8%, with a homogeneous distribution among different health units and sociodemographic variables. We observed associations between years of formal education and higher rates of FSD, especially in the domains of desire, arousal, and lubrication, and between older age and better performance in the domains of desire and arousal. Conclusions: The high prevalence of female sexual disorders in Florianópolis, homogeneously distributed among the sociodemographic variables studied, underscores the importance of training healthcare professionals in addressing these issues in Primary Health Care.

Introducción: La disfunción sexual es más común entre las mujeres, con prevalencias que oscilan entre el 25 y el 63% en aquellas mayores de 18 años. A través del cuestionario del Índice de Función Sexual Femenina (FSFI, por sus siglas en inglés), este estudio tiene como objetivo estimar la frecuencia de disfunciones sexuales en mujeres adultas de dos Equipos de Salud Familiar en Florianópolis, Santa Catarina. Objetivo: El objetivo de este estudio es evaluar la prevalencia de la disfunción sexual femenina (DSF) en estas poblaciones e investigar la relación entre variables sociodemográficas y los dominios representados en la puntuación FSFI. Métodos: Utilizamos el cuestionario FSFI para evaluar la frecuencia de disfunciones sexuales y realizamos un análisis de variables sociodemográficas entre las unidades de salud. Se incluyeron mujeres adultas atendidas en dos Equipos de Salud Familiar en Florianópolis. Resultados: La prevalencia general de DSF fue del 67.8%, con una distribución homogénea entre diferentes unidades de salud y variables sociodemográficas. Observamos asociaciones entre años de estudio y mayores índices de DSF, especialmente en los dominios de deseo, excitación y lubricación, y entre mayor edad y mejor desempeño en los dominios de deseo y excitación. Conclusiones: La alta prevalencia de trastornos sexuales femeninos en Florianópolis, distribuida homogéneamente entre las variables sociodemográficas estudiadas, subraya la importancia de capacitar a los profesionales de la salud en abordar estas cuestiones en la Atención Primaria.

Atividade sexual, aptidão física e capacidade funcional em indivíduos acima de 50 anos de idade fisicamente ativos / Sexual activity, physical fitness and functional capacity in physically active individuals over 50 years of age

Contexto e objetivo: No envelhecimento ocorre um declínio na aptidão física e capacidade funcional do indivíduo e a prática da atividade física pode reduzir os riscos causados por este deletério. A atividade sexual é adotada como parte importante do ciclo de vida desse indivíduo, portanto, o objetivo do estudo foi comparar a aptidão física e a capacidade funcional de acordo com a atividade sexual de pessoas > 50 anos. Desenho e local: estudo transversal do Projeto Longitudinal de Envelhecimento e Aptidão Física de São Caetano do Sul. Método: Amostra de 531 mulheres e 62 homens. A aptidão física e a capacidade funcional foram medidas por: força de membros superiores, força de membros inferiores, flexibilidade, endurance cardiovascular, mobilidade, equilíbrio, mobilidade geral e agilidade. A atividade sexual foi medida por uma anamnese. Análise estatística: dados apresentados em média e desvio padrão, comparação feita por teste de Ancova, ajustada por idade, adotado P < 0,05. Resultados: Comparado o grupo sexualmente ativo com o grupo sexualmente inativo, é possível verificar que houve diferenças significativas na aptidão física e na capacidade funcional e força muscular dos membros superiores, equilíbrio e mobilidade geral nas mulheres, e força de membros inferiores e mobilidade geral para homens. Conclusão: Foi observada uma melhor aptidão física e capacidade funcional tanto em mulheres como nos homens no grupo sexualmente ativo.

A perspectiva do consumo de plantas medicinais porpacientes idosos em tratamento quimioterápico / The perspective of the consumption of medicinal plants byelderly patients undergoing chemotherapy treatment

O câncer, frequentemente relacionado ao envelhecimento, impulsiona pacientes a buscarem tratamento hospitalar ou métodos alternativos, como plantas medicinais. Este estudo visou avaliar os perfis sociodemográfico e clínico e o consumo de plantas para fins medicinais entre pacientes idosos em tratamento oncológico no Hospital Araújo Jorge (HAJ). Dados de 55 pacientes foram analisados, abrangendo informações sociodemográficas, tipos de câncer, tratamento, a utilização de plantas medicinais, o objetivo de uso, as fontes de informações sobre plantas e se notaram alguma reação adversa após o consumo. A faixa etária mais encontrada foi 61 a 70 anos (67,27%), a maioria dos pacientes eram homens (63,64%), com ensino fundamental incompleto (32,73%), casados (56,36%) e que moram no interior de Goiás (43,64%). Quanto ao tratamento, a maioria realizava quimioterapia (40,00%) e o câncer gástrico foi mais relatado (14,54%). Sobre o uso de plantas medicinais, a maioria relatou simpatizar com o consumo (58,18%), e acredita em sua segurança devido à origem natural (59,37%). Informações sobre o uso de plantas medicinais eram obtidas com amigos, vizinhos e familiares (21,81%). Ao relatar sobre o consumo de plantas medicinais durante a quimioterapia, a maioria não percebeu nenhum efeito (40,63%). Foram citadas 17 plantas, que eram utilizadas no tratamento anticâncer (29,00%) e preparadas como infusões (18,75%) pelo uso das folhas frescas (60,00%), principalmente para uso interno (46,87%). Diante disso, a atenção farmacêutica se mostra vital para guiar pacientes nas práticas seguras e eficazes de consumo. Isso inclui direcionar sobre doses adequadas, efeitos colaterais e interações, garantindo bem-estar e prevenindo riscos à saúde.

Cancer, which is often related to ageing, drives patients to seek hospital treatment or alternative methods such as medicinal plants. This study aimed to evaluate the sociodemographic and clinical profile and the consumption of plants for medicinal purposes among elderly patients undergoing cancer treatment at the Araújo Jorge Hospital (AJH). Data from 55 patients was analyzed, covering sociodemographic information, types of cancer, treatment, the use of medicinal plants, the purpose of use, the source of information about plants and whether they noticed any adverse reactions after consumption. The most common age group was 61 to 70 years (67.27%), the majority of patients were men (63.64%), had incomplete primary education (32.73%), were married (56.36%) and lived in the interior of Goiás (43.63%). With regard to treatment, the majority were undergoing chemotherapy (40,00%) and gastric cancer was the most frequently reported (14.54%). With regard to the use of medicinal plants, the majority were sympathetic to their consumption (58.18%) and believed them to be safe due to their natural origin (59.37%). Information on the use of medicinal plants was obtained from friends, neighbors and family members (21.81%). When reporting on the consumption of medicinal plants during chemotherapy, the majority did not notice any effect (40.63%). Seventeen plants were mentioned, which were used for anticancer treatment (29,00%) and prepared as infusions (18.75%) with fresh leaves (60,00%), mainly for internal use (46.87%). In view of this, pharmaceutical care is vital to guide patients in safe and effective consumption practices. This includes guidance on appropriate doses, side effects and interactions, ensuring well-being and preventing health risks.

Rastreamento da síndrome metabólica em participantesdo programa Universidade Aberta da Terceira Idade / Metabolic syndrome screening in the participantsat the Open University of the Third Age

Hábitos alimentares inadequados, sedentarismo e a maior expectativa de vida da população contribuem significativamente para a prevalência da síndrome metabólica. Essa doença predispõe uma pessoa a desenvolver diabetes mellitus tipo 2 e doenças cardiovasculares, as quais têm um amplo impacto na saúde pública, induzindo sobrecarga no sistema de saúde e reduzindo a qualidade de vida dos indivíduos afetados. A síndrome metabólica é uma doença multifatorial e está relacionada ao processo de envelhecimento, contudo, ainda há uma lacuna significativa, em termos de estudos, sobre a prevalência da condição em populações idosas. Nesse contexto, o presente estudo objetivou rastrear a prevalência da síndrome metabólica em participantes da Universidade Aberta da Terceira Idade (UNATI), localizada em Francisco Beltrão, Paraná. Os critérios diagnósticos de síndrome metabólica abordados nesta pesquisa incluem: circunferência abdominal ≥ 90 cm para homens e ≥ 80 cm para mulheres, triglicerídeos ≥ 150 mg/dL, HDL ≤ 40 mg/dL para homens e ≤ 50 mg/dL para mulheres, pressão arterial sistólica ≥ 130 mmHg e/ou pressão arterial diastólica ≥ 85 mmHg ou estar em farmacoterapia para hipertensão, além de glicemia de jejum ≥ 100 mg/dL ou estar em tratamento farmacológico para diabetes. Um total de 44 idosos foram avaliados, apresentando uma média de idade de 66,9 ± 7,1 anos, com uma predominância de mulheres (88%). Os resultados revelaram uma prevalência alarmante de síndrome metabólica, atingindo 36,4% da amostra estudada. Além disso, observou-se uma alta prevalência de condições associadas, como hipertensão arterial (67,2%), sobrepeso (58,6%) e obesidade visceral (31%). Esses achados ressaltam a importância da implementação de medidas preventivas direcionadas à promoção da qualidade de vida saudável e ao controle dos fatores de risco metabólicos.

Inadequate dietary habits, sedentary lifestyle, and increased life expectancy significantly contribute to the prevalence of metabolic syndrome. This condition predisposes an individual to develop type 2 diabetes mellitus and cardiovascular diseases, which have a broad impact on public health, inducing a burden on the healthcare system and reducing the quality of life of affected individuals. Metabolic syndrome is a multifactorial disease and is related to the aging process; however, there is still a significant gap in terms of studies on the prevalence of the condition in elderly populations. In this context, this study aimed to screen the prevalence of metabolic syndrome in participants of the Open University for the Third Age (UNATI), located in Francisco Beltrão, Paraná. The diagnostic criteria for metabolic syndrome addressed in this research include: abdominal circumference ≥ 90 cm for men and ≥ 80 cm for women, triglycerides ≥ 150 mg/dL, HDL ≤ 40 mg/dL for men and ≤ 50 mg/dL for women, systolic blood pressure ≥ 130 mmHg and/or diastolic blood pressure ≥ 85 mmHg or being on pharmacotherapy for hypertension, in addition to fasting glucose ≥ 100 mg/dL or being on pharmacological treatment for diabetes. A total of 44 elderly individuals were evaluated, with a mean age of 66.9 ± 7.1 years, predominantly women (88%). The results revealed an alarming prevalence of metabolic syndrome, affecting 36.4% of the studied sample. Furthermore, a high prevalence of associated conditions was observed, such as arterial hypertension (67.2%), overweight (58.6%), and visceral obesity (31%). These findings underscore the importance of implementing preventive measures aimed at promoting healthy lifestyles and controlling metabolic risk factors.

Prevalência de diabetes mellitus autorreferidana população adulta no Brasil / Prevalence of self-reported diabetes mellitusin the adult population in Brazil

Objetivo: verificar a prevalência de diabetes mellitus (DM) autorreferida na população adulta no Brasil. Método: estudo epidemiológico ecológico descritivo realizado no período de 2006 a 2020, com base nos dados do Sistema de Monitoramento de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (Vigitel), para doenças crônicas não transmissíveis. A população foi constituída por adultos (≥ 18 anos de idade) brasileiros de todas as capitais dos 26 estados brasileiros e o Distrito Federal e que participaram do Vigitel. As variáveis de interesse foram: ano, sexo, faixa etária, escolaridade, região e capital. Resultados: observou-se maior prevalência de DM autorreferida nas capitais do Rio de Janeiro (8,1%) e de São Paulo (7,8%), e a menor taxa em Palmas (4,1%). Com relação às grandes regiões, a maior prevalência foi na região Sudeste (7,1%) e a menor na região Norte (5,1%). Verificou-se ainda, maior prevalência no sexo feminino e entre as pessoas com 0 a 8 anos de estudo (11,7%). Conclusão: a prevalência de diabetes mellitus autorreferida na população adulta no Brasil entre os anos de 2006 e 2020 apresentou crescimento em todas as capitais dos estados brasileiros e o Distrito Federal por triênio, destacando-se as capitais do Rio de Janeiro e de São Paulo com os maiores valores e Palmas com o menor valor.

Objective: to verify the prevalence of self-reported diabetes mellitus (DM) in the adult population in Brazil. Method: descriptive ecological epidemiological study conducted in the period of 2006-2020, based on data from the Surveillance Monitoring System of Risk and Protection Factors for Chronic Diseases by Telephone Survey (Vigitel) for chronic non-communicable diseases. The population Abstract consisted of Brazilian adults (≥ 18 years of age) from all the 26 Brazilian state capitals and the Federal District who participated in Vigitel. The variables of interest were data collection year, sex, age, schooling, region, and capital. Results: there was a higher prevalence of self-reported DM in the capitals of Rio de Janeiro (8.1%) and São Paulo (7.8%), and the lowest rate in Palmas (4.1%). Regarding the five- major geographic regions of Brazil, the highest prevalence was in the Southeast (7.1%) and the lowest in the North (5.1%). There was also a higher prevalence in females and among people between 0 to 8 years of schooling (11.7%). Conclusion: the prevalence of self-reported diabetes mellitus in the adult population in Brazil from 2006 to 2020 showed a growth in all capitals of the Brazilian states and the Federal District every triennium. The capitals of Rio de Janeiro and São Paulo showed the highest values and Palmas the lowest one.