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1.
J. Health Biol. Sci. (Online) ; 10(1): 1-9, 01/jan./2022. ilus, tab, graf
Article in English | LILACS | ID: biblio-1378522

ABSTRACT

Objective: the aim of this study was to relate sociodemographic, epidemiological and clinical conditions to the occurrence of severe cases of HZ in reference hospital of Fortaleza. Methods: this is a cross-sectional analytical study, based on medical records of patients admitted from 2009 to 2018. Pearson's x2 test or Fisher's exact test were used when appropriate. Results: we analyzed 196 medical records. The presence of complications occurred in 69.9%, the most affected region was the cranial (68.9%), and 1.5% died. The presence of vesicles (PR=1.37; 95%CI: 1.03-1.82; p=0.01) and the choice of antibiotic associated antiviral therapy (PR=0.58; 95%CI: 0.46-0.73; p=0.00) were significantly associated with the severity. Conclusions: the disease may be more severe at ages over 50. The presence of lesions in vesicles was associated with a higher prevalence of complications and the use of antibiotics and antivirals as a protective factor.


Objetivo: relacionar condições sociodemográficas, epidemiológicas e clínicas à ocorrência de casos graves de HZ em hospital de referência de Fortaleza. Métodos: trata-se de um estudo analítico transversal, baseado em prontuários de pacientes internados de 2009 a 2018. Foram utilizados o teste x2 de Pearson ou o teste exato de Fisher, quando apropriado. Resultados: foram analisados 196 prontuários. A presença de complicações ocorreu em 69,9%, a região mais acometida foi a craniana (68,9%), e 1,5% foi a óbito. A presença de vesículas (RP=1,37; IC95%: 1,03-1,82; p=0,01) e a escolha da terapia antiviral associada a antibióticos (RP=0,58; IC95%: 0,46-0,73; p=0,00) foram significativamente associadas com a gravidade. Conclusões: a doença pode ser mais grave a partir dos 50 anos. A presença de lesões em vesículas foi associada à maior prevalência de complicações e o uso de antibióticos e antivirais como fator de proteção.


Subject(s)
Herpes Zoster , Medical Records , Disease , Epidemiology , Herpesvirus 3, Human , Hospitalization , Inpatients , Methods
2.
Braz. j. oral sci ; 21: e225272, jan.-dez. 2022. tab
Article in English | LILACS, BBO - Dentistry | ID: biblio-1354777

ABSTRACT

Aim: To compare the pre-clinical and clinical students` perceptions about the non-pharmacological behaviour management techniques in paediatric dentistry and to investigate the influence of the dental curriculum on the students` knowledge regarding this issue. Methods: A total of 283 students from the IV-and X-semester completed a questionnaire, consisted of 12 statements, describing the nonpharmacological behaviour management techniques for the treatment of paediatric dental patients. The acceptability rate was evaluated with a Likert scale ranging from 1 to 5. Results: The students from all courses demonstrated high acceptance for Reinforcement and Desensitization techniques and low for the Negative reinforcement and Physical restraint. The comparison between the perceptions of the pre-clinical and clinical students demonstrated a statistically significant increase in the acceptance of the physical restraint, along with Nonverbal communication, Modelling and Parental presence/absence (p<0.05). Conclusion: The results provide information about the students' knowledge and skills in behaviour management techniques together with some insights about how the educational process can modify the students` perceptions and views in dealing with paediatric dental patients


Subject(s)
Humans , Male , Female , Students, Dental , Behavior , Surveys and Questionnaires , Pediatric Dentistry , Methods
3.
J. Health Biol. Sci. (Online) ; 10(1): 1-5, 01/jan./2022. tab
Article in English | LILACS | ID: biblio-1358203

ABSTRACT

Objectives: The present study was designed to examine the efficacy of Cissus quadrangularis paste on fracture healing in artificially induced fractured rabbits. Methods: Fifteen rabbits were separated into three groups namely A, B, and C. Veldt grape paste was applied in groups B and C (Treatment Group) by close reduction and open reduction methods of fracture management; respectively, while group A was kept as control. The blood parameter and fracture healing properties in all animals have been monitored and examined routinely during the study period. Results: Both treated groups revealed lower serum calcium levels (SCL) than the control group after 24 hours of fracture that became within the normal range on the 14th day. Fracture healing in the treated groups has been commenced more rapidly than the control group with complete bridging of discontinuity by a distinct osseous callus in the fracture line on day 7 and complete effacing of fracture line on day 14. Conclusion: We did not find any type of anomalousness, clinical deviations, and alteration of serum calcium level on the 14th day of the fracture in treated animals hence Veldt Grape paste could be readily applicable to the management of the fracture in animals.


Objetivos: avaliar a eficácia da pasta de Cissus quadrangularis na consolidação de fraturas em coelhos fraturados artificialmente. Metodos: quinze coelhos foram separados em três grupos (A, B e C). A pasta foi aplicada nos grupos B e C (Grupo de Tratamento) pelos métodos de redução fechada e redução aberta de gerenciamento de fraturas; respectivamente. O grupo A foi mantido como controle. O parâmetro sanguíneo e as propriedades de cicatrização de fraturas em todos os animais foram monitorados e examinados, rotineiramente, durante o período do estudo. Resultados: ambos os grupos tratados revelaram níveis séricos de cálcio (SCL) mais baixos do que o grupo controle, após 24 horas de fratura que se tornou normal no 14º dia. A cicatrização da fratura nos grupos tratados foi iniciada mais rapidamente do que o grupo controle, com ponte completa de descontinuidade por um calo ósseo distinto na linha de fratura no dia 7 e apagamento completo da linha de fratura no dia 14. Conclusao: não encontramos nenhum tipo de anomalia, desvios clínicos e alteração do nível sérico de cálcio no 14º dia da fratura nos animais tratados, portanto, a pasta Veldt Grape pode ser aplicável ao manejo da fratura em animais.


Subject(s)
Fracture Healing , Cissus , Ointments , Therapeutics , Bony Callus , Fractures, Bone , Goals , Animals, Laboratory , Methods
4.
Lima; Perú. Ministerio de Salud. Instituto Nacional de Salud; Ago. 2022. 44 p. ilus.
Monography in Spanish | MINSAPERÚ | ID: biblio-1382294

ABSTRACT

El documento proporciona al personal de laboratorio los procedimientos estandarizados técnicos de la baciloscopia para el diagnóstico bacteriológico de la TB


Subject(s)
Tuberculosis , Diagnosis , Laboratory Personnel , Methods
5.
RECIIS (Online) ; 16(2): 247-265, abr.-jun. 2022. ilus, tab, graf
Article in Portuguese | LILACS | ID: biblio-1378347

ABSTRACT

Este artigo analisa os saberes e práticas do cuidado em saúde relacionados à covid-19, a partir da observação participante de pessoas que trocam experiências e interagem sobre o tema no grupo da rede social Facebook, no Brasil, 'Eu já tive Covid-19'. A comunidade virtual, com 16,5 mil membros, gerou 397 postagens no período de 8 de março a 18 de abril de 2021. As postagens foram categorizadas e tiveram seus níveis de engajamento calculados com base no número de interações. Experiências em casos de covid-19, dúvidas e questionamentos dos usuários participantes representaram 74% das postagens. Os comentários com mensagens de acolhimento aproximaram as pessoas, fortalecendo seus laços sociais. Foram identificados discursos que contrariavam o saber científico, sendo uma a cada 25 postagens definida como fake news. Temas como automedicação, xarope caseiro, 'kit covid' e tratamento precoce foram destaque dentre os conteúdos e evidenciam o grau de desinformação dos participantes a respeito da covid-19.


This article analyzes the knowledge and practices of health care related to covid-19, based on the participant observation of people who exchange experiences and interact on the topic in the social network Facebook group, in Brazil, 'I already had Covid-19'. The virtual community, with 16,500 members, generated 397 posts, in the period from March 8 to April 18, 2021. They were categorized and had their engagement levels calculated based on the number of interactions. Experiences in cases of covid-19, doubts and questions from participating users represented 74% of posts. The comments with welcoming messages brought these people closer, strengthening their social ties. Speeches that contradicted scientific knowledge were identified, with one in 25 posts classified as fake news. Topics such as self-medication, homemade syrup, 'covid kit' and early treatment were highlighted among these contents and show the degree of disinformation of the participants about covid-19.


Este artículo analiza los conocimientos y prácticas de atención a la salud relacionados con el covid-19, a partir de la observación participante de personas que intercambian experiencias e interactúan sobre el tema en el grupo de la red social Facebook, en Brasil, 'Eu ya tuvo Covid-19'. La comunidad virtual, con 16.500 miembros, generó 397 publicaciones, en el período del 8 de marzo al 18 de abril de 2021. Se categorizaron y se calcularon los niveles de participación en función del número de interacciones. Experiencias en casos de covid-19, dudas y preguntas de los usuarios participantes representaron el 74% de las publicaciones. Los comentarios con mensajes de bienvenida acercaron a estas personas, fortaleciendo sus lazos sociales. Se identificaron discursos que contradecían el conocimiento científico, con una fake news cada 25 publicaciones. En estos contenidos se destacaron temas como la automedicación, el jarabe casero, el 'kit covid' y el tratamiento temprano, evidenciando el grado de desinformación de los participantes sobre el covid-19.


Subject(s)
Humans , Coronavirus , Communication , Delivery of Health Care , Pandemics , Online Social Networking , Brazil , Information Dissemination , Methods
6.
JAMA Netw Open ; 5(7): e2224469, 2022 07 01.
Article in English | MEDLINE | ID: mdl-35819790

Subject(s)
Methods , Humans
7.
Open educational resource in Spanish | CVSP - Regional | ID: oer-4059

ABSTRACT

Conocer y aplicar modelos de acrónimo específicas para definir la pregunta de investigación Tipos de estudios clínicos Funciones de búsqueda y navegación, Localización de descriptores (DeCS/MeSH) Búsqueda


Subject(s)
Libraries, Digital , Nicaragua , Methods , Health Information Exchange
8.
San Salvador; MINSAL; jun. 06, 2022. 69 p. ilus, graf.
Non-conventional in Spanish | LILACS, BISSAL | ID: biblio-1393091

ABSTRACT

El presente manual de procesos y procedimientos, documenta las principales actividades de atención integral en procedimientos quirúrgicos seguros, como parte del proceso de atención en salud integral e integrada a la persona en el curso de vida con enfoque de atención primaria en salud, describe el sistema de operación de los establecimientos de salud, mediante el enfoque por procesos, fomentando el desarrollo organizacional y el mejoramiento continuo para el cumplimiento de la misión institucional. Establece las bases para la ejecución de los procesos y procedimientos, unificando criterios de contenido que permite la sistematización de las actividades y la definición de la metodología para efectuarlas


This manual of processes and procedures documents the main activities of comprehensive care in safe surgical procedures, as part of the process of comprehensive and integrated health care to the person in the course of life with a focus on primary health care, describes the system of operation of health establishments, through a process approach, promoting organizational development and continuous improvement for the fulfillment of the institutional mission. Establishes the bases for the execution of processes and procedures, unifying content criteria that allows the systematization of activities and the definition of the methodology to carry them out


Subject(s)
Surgical Procedures, Operative , Health , Process Assessment, Health Care , Health Facilities , Primary Health Care , El Salvador , Methods
9.
Arq. ciências saúde UNIPAR ; 26(2): 127-133, maio-ago. 2022.
Article in Portuguese, French | LILACS | ID: biblio-1372962

ABSTRACT

Objetivo: caracterizar a prática clínica e identificar as barreiras relacionadas à mobilização precoce em uma Unidade de Terapia Intensiva. Método: estudo observacional analítico e prospectivo que incluiu pacientes em ventilação mecânica por mais de 24 horas. Foram coletados diariamente dados clínicos, critérios de segurança, barreiras e atividades realizadas nos atendimentos de fisioterapia. Posteriormente a amostra foi dividida de acordo com a realização de sedestação à beira do leito. Utilizou-se teste T para comparação entre grupos e para associação teste Qui-quadrado ou Exato de Fischer quando necessário. Resultados: participaram 54 indivíduos com média de idade 51,33±14,85 anos e SAPSIII médio de 63,47±13,37 pontos. A mobilização foi realizada em 1356 sessões, em sua maioria atividades passivas. Nenhuma atividade fora do leito foi realizada com pacientes em ventilação mecânica. As principais barreiras foram sedação, nível de consciência e procedimentos médicos. A não sedestação à beira do leito foi associada à ausência de critérios de segurança, que impediram a mobilização, e ocorrência de óbito. Conclusão: A mobilização foi realizada na maioria das sessões, porém poucas atividades foram realizadas fora do leito. Durante o período de ventilação mecânica nenhuma atividade foi realizada fora do leito. As barreiras mais citadas foram sedação, nível de consciência e procedimentos médicos.


Purpose: characterize the clinical practice and identify barriers related to early mobilization in an Intensive Care Unit. Method: analytical and prospective observational study that included patients on mechanical ventilation for more than 24 hours. Clinical data, safety criteria, barriers and activities performed in physical therapy consultations were collected on a daily basis. Subsequently, the sample was divided according to the performance of the patient sitting at the bedside. The T-test was used for comparison between groups and the Chi-square test or Fisher's exact test were used when necessary. Results: a total of 54 individuals participated, with a mean age of 51.33±14.85 years and mean SAPSIII of 63.47±13.37 points. Mobilization was performed in 1356 sessions, mostly passive activities. No out-of-bed activities were performed with patients on mechanical ventilation. The main barriers were sedation, level of consciousness, and medical procedures. Failure to sit at the bedside was associated with the absence of safety criteria, which prevented mobilization, and the occurrence of death. Conclusion: Mobilization was performed in most sessions, but few activities were performed outside the bed. During the period of mechanical ventilation, no activity was performed outside the bed. The barriers most frequently mentioned were sedation, level of consciousness, and medical procedures.


Subject(s)
Humans , Male , Female , Middle Aged , Health Knowledge, Attitudes, Practice , Early Ambulation , Intensive Care Units , Respiration, Artificial , Physical Therapy Modalities , Consciousness , Death , Mobility Limitation , Deep Sedation , Physical Therapists , Methods
10.
Lima; Perú. Ministerio de Salud; May. 2022. 39 p. ilus, graf.
Monography in Spanish | MINSAPERÚ | ID: biblio-1369415

ABSTRACT

La norma contiene los procesos, procedimientos y condiciones especificas para la atención prehospitalaria y el transporte asistido de pacientes con diagnóstico o sospecha de COVID-19


Subject(s)
Health , Diagnosis , Prehospital Care , COVID-19 , Methods
11.
Lima; Perú. Ministerio de Salud; May. 2022. 37 p. tab.
Monography in Spanish | MINSAPERÚ | ID: biblio-1370463

ABSTRACT

La guía contiene el procedimiento para la determinación de la hemoglobina mediante hemoglobinómetro portátil, que incluye la punción capilar, recojo de la muestra de sangre y materiales que se utilizaran para su correcta aplicación


Subject(s)
Blood , Heme , Methods
12.
Espaç. saúde (Online) ; 23: 1-13, abr.2022. ilus
Article in Portuguese | LILACS | ID: biblio-1367349

ABSTRACT

Diante do cenário pandêmico as instituições de ensino superior necessitaram reinventar os métodos de ensino-aprendizagem, adotando a modalidade remota. Neste cenário, realizou-se um estudo qualitativo por meio do método exploratório-descritivo, realizado com 16 docentes de uma instituição de ensino de Curitiba (PR) que atuam na área de saúde e que adotaram a modalidade de ensino remoto durante o período de pandemia, utilizando a Análise de Conteúdo de Bardin para extração de informações, objetivando descrever a percepção dos docentes quanto à adaptação ao ensino remoto e aos desafios decorrentes da pandemia. Como resultados foram elencadas as categorias: I) Percepção do docente em relação à adaptação ao ensino remoto: II) Percepção do docente em relação ao estudante na modalidade de ensino remoto. Conclui-se que os docentes perceberam o momento como desafiador e de resiliência, despertando a necessidade para novos aprendizados, num processo que envolveu a instituição, seus gestores, docentes e estudantes.


Faced with the pandemic scenario, higher education institutions needed to reinvent teaching-learning methods, adopting the remote modality. In this setting, a qualitative study was carried out using the exploratory-descriptive method, with 16 professors from an educational institution in Curitiba ­ PR, who work in the health area and adopted the remote teaching modality during the pandemic period. Content Analysis proposed by Bardin was used to extract information, aiming to describe the perception of professors regarding the adaptation to remote teaching and the challenges arising from the pandemic. As a result, the following categories were listed: I) Professor's perception regarding adaptation to remote teaching: II) Professor's perception regarding the student in the remote teaching modality. It is concluded that the professors perceived the moment as challenging and of resilience, eliciting the need for new learning, in a process that involved the institution, its managers, professors, and students


Subject(s)
Teaching , Health Human Resource Training , Pandemics , COVID-19 , Methods
13.
Methods Mol Biol ; 2442: 391-411, 2022.
Article in English | MEDLINE | ID: mdl-35320537

ABSTRACT

Galectin-3 is a chimeric galectin involved in diverse intracellular and extracellular functions. Galectin-3 is synthesized in the cytoplasm and then released extracellularly by a poorly understood non-canonical secretion mechanism. As a result, it can play important roles both inside and outside the cell. One important extracellular role of galectin-3 is in modulating clathrin-independent endocytosis (CIE), a form of cellular internalization that is still not well understood. CIE, unlike clathrin-mediated endocytosis, has neither defined signaling sequences nor cytoplasmic machinery. As a result, extracellular interactions like the galectin-glycan interactions are thought to directly drive changes in CIE. This chapter discusses the methods designed to study the role of galectin-glycan interactions in CIE, which have provided us with insight into the functions of galectin-3 and cell surface glycans during CIE cargo internalization. These methods include media supplementation for metabolic glycoengineering, antibody internalization assays, lectin panels to assay changes in glycan patterns, exogenous galectin-3 supplementation, galectin-3 secretion assays, and in vitro assays to monitor the effect of galectins on CIE.


Subject(s)
Clathrin , Endocytosis , Galectin 3 , Cell Membrane/metabolism , Clathrin/metabolism , Endocytosis/physiology , Galectin 3/metabolism , Methods
15.
Fisioter. Bras ; 22(6): 895-903, Fevereiro 7, 2022.
Article in Portuguese | LILACS | ID: biblio-1358380

ABSTRACT

Introdução: A terapia Cuevas Medek Exercises (CME) é um método fisioterapêutico de manuseio sem comandos verbais, pois não busca reações voluntárias e, sim, acessar a via cortical involuntária. As correções dos movimentos acontecem pelo estímulo sensorial da mão do terapeuta. Objetivo: Avaliar o efeito da CME na displasia do desenvolvimento de quadril (DDQ) de uma paciente com paralisia cerebral (PC). Métodos: A pesquisa é caracterizada como estudo de caso, tendo como participante uma menina de seis anos com PC, tetraparesia e displasia bilateral de quadril. As intervenções começaram após avaliação desenvolvida pelo método CME, radiografia de quadril e classificação nos níveis do Sistema de Classificação da Função Motora Grossa (GMFCS). A criança foi submetida a terapia CME para tratar a DDQ durante 10 meses, totalizando 136 sessões (45 minutos cada), composta de quatro a seis exercícios repetidos, seis vezes em média. Foram registrados o tempo e/ou quantas repetições conseguiu realizar. Resultados: Evoluiu de 55 para 61 pontos no score do CME, melhorou sua idade motora e, na radiografia de quadril, o esquerdo passou de subluxado para quadril de risco. Conclusão: A paciente melhorou idade motora, controle de tronco e bipedestação, autonomia e encaixe do quadril em ambos os lados. (AU)


Subject(s)
Child , Cerebral Palsy , Hip , Methods , Developmental Disabilities , Physical Therapy Modalities
16.
Rev. Méd. Inst. Mex. Seguro Soc ; 60(2): 164-170, 24-feb-2022. ilus, tab
Article in Spanish | LILACS | ID: biblio-1367405

ABSTRACT

Introducción: a pesar de que la técnica de papanicolaou es el método más eficaz para la prevención y detección del cáncer cervicouterino, la precisión de esta herramienta sigue siendo controversial; debido a esto, existen esfuerzos médicos y científicos para mejorar la calidad del procedimiento. Objetivo: comparar la calidad en la toma de muestra entre la técnica convencional y la modificada. Material y métodos: estudio observacional descriptivo y comparativo en 150 muestras de citología cervical (75 muestras técnica convencional y 75 en técnica modificada) en mujeres de 25 a 64 años. Se analizaron variables emográficas, características del cérvix y calidad de la muestra. Se realizó estadística descriptiva y medidas de asociación. Estudio con riesgo mayor que el mínimo. Todas las participantes firmaron consentimiento informado. Resultados: la calidad de la muestra fue satisfactoria en el 92% para la técnica convencional frente al 89.3% para la técnica modificada. La causa principal de muestras insatisfactorias fue la celularidad insuficiente, la cual se presentó en el 6.7% de las muestras con técnica convencional frente al 12% de la técnica modificada, sin diferencia significativa entre ambas técnicas p = 0.575 (1.37; 0.45-4.1), hallazgos que rechazan la hipótesis de trabajo. Conclusiones: no hubo diferencia significativa al utilizar ambas pruebas, las muestras con calidad satisfactoria fueron similares entre ambas técnicas.


Background: Despite the fact that the Papanicolaou technique is the most effective method of prevention and detection of cervical cancer, the precision of this tool remains controversial; Because of this, there are medical and scientific efforts to improve the quality of the procedure. Objective: Compare the quality of sampling between the conventional and modified technique. Material and methods: Descriptive and comparative observational study in 150 cervical cytology samples (75 conventional technique samples and 75 in modified technique) in women aged 25 to 64 years. Demographic variables, characteristics of the cervix and quality of the sample were analyzed. Descriptive statistics and association measures were performed. Study with risk greater than the minimum. All participants signed an informed consent. Results: The quality of the sample was satisfactory in 92.0% for the conventional technique vs 89.3% for the modified technique. The main cause of unsatisfactory samples was insufficient cellularity 6.7% in conventional technique vs 12% of the modified technique, with no significant difference between both techniques p = 0.575 (1.37; 0.45-4.1), findings that reject the working hypothesis. Conclusions: There was no significant difference when using both tests, the samples with satisfactory quality were similar between both techniques.


Subject(s)
Humans , Female , Adult , Middle Aged , Uterine Cervical Neoplasms , Papanicolaou Test/instrumentation , Methods , Risk
17.
An. psicol ; 38(1): 93-100, ene. 2022. graf
Article in English | IBECS | ID: ibc-202871

ABSTRACT

Entre el creciente cuerpo de investigación que se ha centrado en el éxito académico, la motivación académica ha captado considerable atención. El objetivo de esta investigación es presentar la primera validación de la Escala de Motivación Académica de los Adolescentes (EMAA). La muestra total estuvo compuesta por 1712 estudiantes de secundaria de dos distritos de la República Dominicana. La medida principal fue la EMAA. Los resultados del AFC fueron satisfactorios: χ2(5) = 57.73, p < .001; CFI = .970; RMSEA = .079, 90% CI [.061, .097], y SRMR = .024. Los análisis de TRI favorecieron al modelo logístico de dos parámetros, indicando que los ítems no fueron igualmente discriminativos. El Modelo de Ecuaciones Estructurales en el que la motivación académica predecía de forma estadísticamente significativa las calificaciones obtuvo un ajuste excelente: χ2(53) = 182.76, p < .001; CFI = .980; RMSEA = .038 [.032, .044], and SRMR = .025. En resumen, este trabajo presenta un exhaustivo análisis psicométrico de la EMAA en una muestra representativa de estudiantes dominicanos de instituto.(AU)


Within the growing body of research that has focused on aca-demic success, academic motivation has gathered considerable attention. The aim of this this research is to present the first validation of the Ado-lescents’ Academic Motivation Scale (AAMS). Total sample was composed by 1712 students of secondary education from two districts in the Domini-can Republic. The main measurement outcome was the AAMS. Results from the CFA were satisfactory: χ2(5) = 57.73, p< .001; CFI = .970; RMSEA = .079 [.061, .097], and SRMR = .024. IRT analyses favored the two-parameter logistic model, indicating that items were not equallydis-criminant. Structural Equation Model with latent variables in which aca-demic motivation was a significant predictor of grades resulted in excellent fit: χ2(53) = 182.76, p< .001; CFI = .980; RMSEA = .038 90% CI [.032, .044], and SRMR = .025. In sum, this work presents an exhaustive psy-chometric analysis of the AAMS in a representative sample of high school Dominican students.(AU)


Subject(s)
Humans , Male , Female , Adolescent , Health Sciences , Motivation , Academic Performance , Psychometrics/methods , Psychometrics/statistics & numerical data , Students , Factor Analysis, Statistical , Methods
18.
Actas esp. psiquiatr ; 50(1): 42-50, enero - febrero 2022. tab, graf
Article in Spanish | IBECS | ID: ibc-203144

ABSTRACT

Introducción. La similitud entre las células retinianas y las neuronas del sistema nervioso central permite que métodos no invasivos de estudio de la función retiniana, como el Electrorretinograma-Patrón (PERG) se postulen como posibles biomarcadores, útiles y seguros en el estudio de patologías psiquiátricas como el Trastorno Bipolar (TB). El objetivo del presente estudio es caracterizar las diferencias en los resultados en el PERG de pacientes con TB y sujetos sanos, así como evaluar una posible correlación entre estos resultados y las descompensaciones afectivas del polo maniaco en el grupo de pacientes bipolares. Material y métodos. Se realizó un estudio transversal en una muestra de 34 pacientes bipolares en diferentes estados clínicos y 36 controles sanos. Se recogieron las variables independientes: sexo, edad, fármacos y estado clínico, medidas mediante escalas validadas y posteriormente se realizó el PERG obteniendo la variable dependiente de interés, la amplitud media de la onda P50. Resultados. Existe una diferencia estadísticamente significativa en los resultados del PERG entre pacientes con TB y controles, y también entre los diversos estados clínicos de los pacientes con TB. Asimismo, encontramos una correlación negativa entre la gravedad de la manía, y la amplitud media de la onda P50. Conclusiones. Las diferencias encontradas, tanto entre sujetos sanos y pacientes bipolares, como entre los estados afectivos dentro del TB, sugieren que las alteraciones en la función retiniana, medidas mediante PERG, pueden ser un prometedor biomarcador de rasgo y de estado en TB.(AU)


Background. The similarity between retinal cells and neurons of the central nervous system allows non-invasive methods to study retinal function, such as the Electroretinogram-Pattern (PERG) to be postulated as possible biomarkers, useful and safe in the study of psychiatric pathologies such as Bipolar Disorder (BD). The objective of the present study is to characterize the differences in the results in the PERG of patients with BD and healthy subjects, as well as to evaluate a possible correlation between these results and the affective decompensations of the manic pole in the group of bipolar patients. Material and methods. A cross-sectional study was carried out in a sample of 34 bipolar patients in different clinical states and 36 healthy controls. The independent variables were collected: sex, age, drugs and clinical status, measured using validated scales and later the PERG was performed, obtaining the dependent variable of interest, the mean amplitude of the P50 wave. Results. There is a statistically significant difference in the PERG results between BD patients and controls, and also between the various clinical states of BD patients. Likewise, we found a negative correlation between the severity of the mania and the mean amplitude of the P50 wave. Conclusions. The differences found, both between healthy subjects and bipolar patients, and between affective states within BD, suggest that alterations in retinal function, measured by PERG, may be a promising biomarker of trait and status in BD.(AU)


Subject(s)
Humans , Health Sciences , Bipolar Disorder , Bipolar and Related Disorders , Retinal Rod Photoreceptor Cells , Biomarkers , Methods
19.
Alerta (San Salvador) ; 5(1): 64-73, ene. 28, 2022. tab
Article in Spanish | LILACS, BISSAL | ID: biblio-1354468

ABSTRACT

Los trastornos hipertensivos asociados al embarazo constituyen uno de los síndromes de mayor interés a escala mundial, cerca de 600 000 mujeres mueren anualmente por causas relacionadas. La Organización Mundial de la Salud considera que la incidencia de preeclampsia es siete veces mayor en los países en vías de desarrollo en comparación a los industrializados (2,8 % y 0,4 %, respectivamente). El estrés oxidativo es una de las principales causas asociadas a la preeclampsia, cuyo diagnóstico y manejo adecuado y oportuno son medidas eficaces para disminuir la tasa de morbimortalidad, por lo que diversos autores se han centrado en la búsqueda de biomarcadores predictores de estrés oxidativo entre los cuales encontramos: especies reactivas del ácido tiobarbitúrico, superóxido, catalasa, superóxido dismutasa y glutatión peroxidasa. El presente trabajo describe los principales biomarcadores de estrés oxidativo estudiados mediante la técnica espectrofotométrica debido a que es económica, rápida y precisa


Hypertensive disorders associated with pregnancy are one of the syndromes of greatest interest worldwide, nearly 600,000 women die annually from related causes. The World Health Organization considers that the incidence of preeclampsia is seven times higher in developing countries compared to industrialized ones (2.8% and 0.4%, respectively). Oxidative stress is one of the main causes associated with preeclampsia, whose proper and timely diagnosis and management are effective measures to reduce the morbidity and mortality rate, which is why various authors have focused on the search for predictive biomarkers of oxidative stress among which we find: reactive species of thiobarbituric acid, superoxide, catalase, superoxide dismutase and glutathione peroxidase. The present work describes the main biomarkers of oxidative stress studied by means of the spectrophotometric technique because it is cheap, fast and precise


Subject(s)
Patients , Pre-Eclampsia , Spectrophotometry , Women , Oxidative Stress , Indicators of Morbidity and Mortality , Morbidity , Methods
20.
Alerta (San Salvador) ; 5(1): 81-87, ene. 28, 2022. ilus
Article in Spanish | LILACS, BISSAL | ID: biblio-1354473

ABSTRACT

El cáncer de cuello uterino es la cuarta causa de mortalidad por cáncer en mujeres; 88 % de los casos provienen de países en vías de desarrollo debido al escaso acceso al tamizaje y tratamiento. Debido a esto, en los países de bajo desarrollo humano estrategias como la autotoma para la detección del virus del papiloma humano han adquirido gran importancia en la actualidad, aumentando hasta en un 45 % el tamizaje en estos países. La presente revisión bibliográfica tiene como objetivo determinar si existen diferencias entre técnica convencional para detección del virus del papiloma humano y la autotoma en países de mediano y bajo desarrollo humano, así como las ventajas y limitantes que esta presenta. Se realizó la búsqueda de la literatura mediante las bases de datos PubMed, Google Scholar y SciELO, empleando artículos originales, ensayos clínicos, de revisión, entre otros. Se demostró que la autotoma para la detección del virus del papiloma humano tiene una especificidad similar a la toma convencional por parte de personal médico y que incrementa el tamizaje, ya que es más aceptada que la muestra tomada por el clínico debido a que facilita el acceso y aborda las limitantes socioculturales percibidas por las usuarias


Cervical cancer is the fourth leading cause of cancer mortality in women; 88% of cases come from developing countries due to poor access to screening and treatment. Due to this, in countries with low human development, strategies such as self-testing for the detection of human papillomavirus have become very important today, increasing screening in these countries by up to 45%. The objective of this bibliographical review is to determine if there are differences between the conventional technique for detecting the human papillomavirus and self-testing in countries with medium and low human development, as well as the advantages and limitations that it presents. The literature search was carried out using the PubMed, Google Scholar and SciELO databases, using original articles, clinical trials, reviews, among others. It was shown that self-sampling for the detection of human papillomavirus has a similar specificity to conventional sampling by medical personnel and that it increases screening, since it is more accepted than the sample taken by the clinician because it facilitates access. and addresses the sociocultural limitations perceived by users


Subject(s)
Women , Uterine Cervical Neoplasms , Mass Screening , Alphapapillomavirus , Self-Testing , Methods , Neoplasms
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