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1.
Rev. cient. cienc. salud ; 3(2): [120-125], 20211200.
Article in Spanish | BDNPAR | ID: biblio-1352360

ABSTRACT

Introducción.La vacuna contra el COVID-19, AstraZeneca, podría dar lugar al desarrollo de anticuerpos contra el factor 4 plaquetario, y desencadenar manifestaciones de trombocitopenia asociados a episodios trombóticos de localización inusual. Se presenta el caso de una paciente con plaquetopenia y trombosis asociada a la vacuna Astrazeneka internada en el Hospital Nacional en agosto 2021. Caso clínico:Mujer de 54 añosde Yaguarón, recibió la vacuna Astrazeneca el 19de junio de 2021, después de 26 días presentó múltiples lesiones equimóticas en miembros inferiores, sin trauma previo, gingivorragias, y epistaxis en moderada cantidad. Por el recuento plaquetario menor a 10.000 se la ingresaal Hospital. No recibió heparina. Los signos vitales normales,IMC 25, recuento de plaquetas <10.000/ mm3, tiempo de protrombina 89%, tiempo parcial de tromboplastina activada 28 segundos, otros parámetros hematológicos normales. Anticuerpo antinuclear (ANA),anti DNA, antiproteinasa 3, anti mieloperoxidasa: negativos;c3 y c4 normal. Serología IgM negativa para toxoplasmosis, citomegalovirus, herpes, rubeola, Chagas, VIH, hepatitisB, C. Ecodopler venoso de miembros inferiores muestra una trombosis de la vena safena parva bilateral. Es tratada con pulsos de metilprednisolona 1g/3 días, seguida de prednisona vía oral 1mg kg/p//día, con recuperación del recuento delas plaquetas. No se realizó prueba anticuerpo anti factor 4 plaquetario. Conclusión:Por la relación temporal entre la administración de la vacuna y la aparición de la plaquetopenia y trombosis,se podría considerar como un efecto adverso de la vacunaAstrazeneka.


ntroduction.The COVID-19 vaccine, AstraZeneca, maylead to the development of antibodies against platelet factor 4, and trigger manifestations of thrombocytopenia associated with thrombotic events of unusual location. Acase of a patient with thrombosis associated with the Astrazeneka vaccine and admittedto the National Hospital in August 2021 is presented. Clinical case:A 54-year-old woman from Yaguaron, received the Astrazeneca vaccine on June 19th, 2021, 26 days later she presentedmultipleecchymotic lesions in lower limbswith nohistory of trauma, gingivorrhagia, epistaxis in moderate quantity. Due to a platelet count lower than10,000/mm3, she was admitted to the Hospital. Shedid not receive heparin. Vital signs were normal, BMI 25,platelet count <10,000 per mm3, prothrombin time 89%, activated partial thromboplastin time 28 seconds, other hematological parameters normal. Antinuclear antibody (ANA), anti DNA, antiproteinase 3, anti myeloperoxidase: negative, c3 and c4 normal. Negative IgM serology for toxoplasmosis, cytomegalovirus, herpes, rubella, Chagas, HIV, hepatitis B, C. Lower limb venous echodpler shows bilateral parva saphenous vein thrombosis. The patient is treated with pulses of methylprednisolone 1g / 3 days, followed by oral prednisone 1mg kg / p / day, with recovery of platelets. An anti-platelet factor 4 antibody test was not performed. Conclusion:due to the temporal relationship between the administration of the vaccine and the appearance of thrombocytopenia and thrombosis, this case may be considered as an adverse effect of the Astrazeneka vaccine.


Subject(s)
Female , Middle Aged , Thrombocytopenia , Thrombosis , Vaccines , Secondary Effect
2.
São Paulo; Propria; 2; 2021. 387 p.
Monography in Portuguese | LILACS, HomeoIndex Homeopathy | ID: biblio-1148202

ABSTRACT

Realizando a ponte entre a farmacologia homeopática (princípio da similitude) e a farmacologia moderna, encontramos uma infinidade de relatos, tanto em compêndios farmacológicos como em experimentos e ensaios clínicos publicados em periódicos científicos, que descrevem uma reação do organismo oposta e secundária a uma ação primária da droga, confirmando a teoria hahnemanniana. Essa ação secundária do organismo, no sentido de manter a homeostase orgânica, é denominada de efeito rebote ou reação paradoxal segundo a racionalidade científica moderna, sendo usada pela homeopatia como resposta terapêutica. (AU)


Building a bridge between homeopathic pharmacology (principle of similitude) and modern pharmacology, one can find countless reports in pharmacological compendia and clinical and experimental trials published in the scientific media describing the secondary reaction of the organism opposed to the primary action of the drug, which confirm Hahnemann's theory. Such secondary action of the organism to preserve organic homeostasis is known in modern science as rebound effect or paradoxical reaction, being used by homeopathy as a therapeutic response.(AU)


Subject(s)
Pharmacology , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Homeopathic Remedy, New , Rebound Effect , Homeopathy
3.
São Paulo; Propria; 2; 2021. 477 p.
Monography in English | LILACS, HomeoIndex Homeopathy | ID: biblio-1148205

ABSTRACT

Building a bridge between homeopathic pharmacology (principle of similitude) and modern pharmacology, one can find countless reports in pharmacological compendia and clinical and experimental trials published in the scientific media describing the secondary reaction of the organism opposed to the primary action of the drug, which confirm Hahnemann's theory. Such secondary action of the organism to preserve organic homeostasis is known in modern science as rebound effect or paradoxical reaction, being used by homeopathy as a therapeutic response. (AU)


Realizando a ponte entre a farmacologia homeopática (princípio da similitude) e a farmacologia moderna, encontramos uma infinidade de relatos, tanto em compêndios farmacológicos como em experimentos e ensaios clínicos publicados em periódicos científicos, que descrevem uma reação do organismo oposta e secundária a uma ação primária da droga, confirmando a teoria hahnemanniana. Essa ação secundária do organismo, no sentido de manter a homeostase orgânica, é denominada de efeito rebote ou reação paradoxal segundo a racionalidade científica moderna, sendo usada pela homeopatia como resposta terapêutica. (AU)


Subject(s)
Pharmacology , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Rebound Effect , Homeopathy , Homeopathic Remedy, New
4.
São Paulo; Propio; 2; 2021. 1310 p.
Monography in Portuguese | LILACS, HomeoIndex Homeopathy | ID: biblio-1148215

ABSTRACT

Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses dinamizadas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos terapêuticos, adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma Matéria Médica Homeopática dos Fármacos Modernos, agrupando os efeitos terapêuticos, adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas tradicionais, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um Repertório Homeopático dos Fármacos Modernos, dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos tradicionais, descrito em outra obra desta coleção. (AU)


Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in another work of this collection. (AU)


Subject(s)
Pharmacology , Materia Medica , Secondary Effect , Law of Similars , Homeopathic Remedy, New , Rebound Effect , Homeopathy
5.
São Paulo; Propria; 2; 2021. 1336 p.
Monography in English | LILACS, HomeoIndex Homeopathy | ID: biblio-1148219

ABSTRACT

Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in another work of this collection. (AU)


Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses dinamizadas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos terapêuticos, adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma Matéria Médica Homeopática dos Fármacos Modernos, agrupando os efeitos terapêuticos, adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas tradicionais, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um Repertório Homeopático dos Fármacos Modernos, dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos tradicionais, descrito em outra obra desta coleção. (AU)


Subject(s)
Materia Medica , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Homeopathic Remedy, New , Rebound Effect , Homeopathy
6.
São Paulo; Propria; 2; 2021. 781 p.
Monography in Portuguese | LILACS, HomeoIndex Homeopathy | ID: biblio-1148263

ABSTRACT

Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses dinamizadas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos terapêuticos, adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma Matéria Médica Homeopática dos Fármacos Modernos, agrupando os efeitos terapêuticos, adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas tradicionais, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um Repertório Homeopático dos Fármacos Modernos, dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos tradicionais, descrito nessa obra. (AU)


Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in this work. (AU)


Subject(s)
Pharmacology , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Homeopathic Repertory , Homeopathic Remedy, New , Rebound Effect , Homeopathy
7.
São Paulo; Proprio; 2021. 808 p.
Monography in English | LILACS, HomeoIndex Homeopathy | ID: biblio-1148266

ABSTRACT

Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in this work. (AU)


Subject(s)
Pharmacology , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Homeopathic Repertory , Homeopathic Remedy, New , Rebound Effect , Homeopathy
8.
Rev. colomb. psiquiatr ; 49(3): 199-201, jul.-set. 2020.
Article in English | LILACS, COLNAL | ID: biblio-1149827

ABSTRACT

ABSTRACT Trazodone is used as an antidepressant in doses between 150 and 600 mg. At lower doses, it is commonly used to treat insomnia. There are few case reports about confusional symptoms as an undesirable side effect of this drug. We report a case of a patient who presented with delirium after prescription of trazodone 100 mg. She required hospitalisation but, shortly after discontinuation of trazodone, the symptoms disappeared without antipsychotic medication. Seven months after the episode, the patient remains asymptomatic.


RESUMEN La trazodona se usa como antidepresivo en dosis de 150-600 mg. En dosis más bajas, se usa comúnmente para tratar el insomnio. Hay pocos reportes de caso sobre síntomas confusionales como un efecto secundario indeseable de este medicamento. Se presenta el caso de una paciente que acudió con delirio después de la prescripción de trazodona 100 mg. La paciente requirió hospitalización pero, poco después de la interrupción de la trazodona, los síntomas desaparecieron sin medicación antipsicótica. A los 7 meses del episodio, la paciente permanecía asintomática.


Subject(s)
Humans , Female , Adult , Trazodone , Delirium , Secondary Effect , Dosage , Prescriptions , Sleep Initiation and Maintenance Disorders , Antidepressive Agents
9.
Bio sci. (En línea) ; 3(5): 1-11, 2020. graf, tab
Article in Spanish | LILACS, LIBOCS | ID: biblio-1141234

ABSTRACT

El objetivo del estudio fue determinar el consumo de psicoestimulantes en estudiante de la Universidad San Francisco Xavier de Chuquisaca. Se recolectaron los datos mediante encuestas aplicadas a 331 estudiantes. El estudio reveló el psicoestimulante de mayor consumo con 31,88% el café y la coca cola con 26,65%, en su mayoría fueron consumidos con fines académicos. En los efectos secundarios, la sed se estableció como el más frecuente en estudiantes con 30,74%, seguido por cefalea con 27,56% y el cansancio en 14,84%. Se concluye que el café se determina como psicoestimulante menor más consumido en épocas de actividad académica y la sed como el efecto secundario más frecuente.


The objective of the study was to determine the consumption of psychostimulants in a student at the San Francisco Xavier de Chuquisaca University. The data were collected through surveys applied to 331 students. The study revealed the psychostimulant with the highest consumption with 31.88%, coffee and coca cola with 26.65%, most of which were consumed for academic purposes. Regarding side effects, thirst was established as the most frequent in students with 30.74%, followed by headache with 27.56% and fatigue in 14.84%. It is concluded that coffee is determined as the minor psychostimulant most consumed in times of academic activity and thirst as the most frequent side effect.


Subject(s)
Coca , Coffee , Fatigue , Population , Secondary Effect , Surveys and Questionnaires
10.
Prensa méd. argent ; 105(5): 309-316, jun 2019. tab, fig
Article in English | LILACS, BINACIS | ID: biblio-1024643

ABSTRACT

Ulcerative colitis is an idiopathic chronic inflammatory disease of the colon for which a lot of treatment modalities are present. However, significant side effects are associated with them, and there is a need for a search for other tretment options. This study was aimed to assess the contribution of niclosamide in experimentally established colitis in rats. Animals were categorized into 5 groups; the control group undergoes no induction of UC, colitis group in which UC was induced, and animals receive no treatment, the niclosamide group that received niclosamide and sulfasalazine group that received sulfasalazine. Each group was composed of 10 animals. After the completion of a one-month period of the experiment animals were sacrificed and the following meausres were done: the weight of the colon, determination of the area of mucosal damage by mm2, histological scoring after hematoxylin and eosin stain together with MAC score and immunohistochemistry of IL-6, TNF-alpha, MPO, MDA, CD62, and ICAM1. The results of the current study revealed that Nicosamide was able to reduce the area of mucosal damage, colon weight, histological and Mac scores and immunohistochemical scores of inflammatory and oxidative markers, significantly when contrasted to a group of colitis (P< 0.05). It has been concluded that Niclosamide was proved to have a significant effect as an adjuvant mode of therapy for colitis through its, anti-inflamatory and anti-oxidant effects (AU)


Subject(s)
Rats , Sulfasalazine/therapeutic use , Colitis, Ulcerative/therapy , Secondary Effect , Evaluation of Results of Therapeutic Interventions , Epidemiology, Experimental , Time-to-Treatment , Animal Culling , Niclosamide/therapeutic use
11.
Rev. colomb. gastroenterol ; 33(4): 473-477, oct.-dic. 2018. graf
Article in Spanish | LILACS | ID: biblio-985503

ABSTRACT

Resumen El albendazol es un medicamento usado para tratar infecciones por helmintos y usualmente presenta pocos o ningún efecto secundario. A pesar de que hay un incremento transitorio de enzimas hepáticas luego de su uso, existe poca evidencia en la literatura en la que se reporte lesión hepática luego de automedicación con albendazol. En este informe, el paciente se presentó con hepatitis aguda luego de automedicarse con albendazol. El paciente cuenta además con una historia de episodios similares después de haber usado el fármaco. Se evaluada la causalidad con el método de evaluación de causalidad de Roussel Uclaf del Concejo para Organizaciones Internacionales de Ciencias Médicas, cuyo resultado fue un puntaje de 10, lo que indicó una alta probabilidad de lesión hepática inducida por albendazol al cabo de realizarse una investigación rigurosa y de excluir otras posibles causas de la condición física del paciente. En conclusión, aunque es ideal agilizar el proceso para combatir a los helmintos, es necesario intensificar la necesidad de monitorizaciones de calidad para evitar reacciones adversas como la hepatitis inducida por medicamentos. Asimismo, la automedicación de cualquier medicamento debe ser siempre evitada.


Abstract Albendazole is used to treat helminth infections and usually has minimal or no side effects. A transient increase in liver enzymes is common following its use, but little evidence of albendazole-induced liver damage has been reported in the literature. This study presents a patient who developed acute hepatitis following self-medication with albendazole. The patient also had a history of similar episodes in the past after using the drug. After a thorough investigation and exclusion of all other causes of the patient's clinical condition, the Roussel Uclaf Causality Assessment Method of the Council for International Organizations of Medical Sciences scale yielded a score of 10 points, indicating a high probability of albendazole-induced liver damage. In conclusion, expediting the process of combating helminths is ideal, but quality monitoring is required to avoid adverse reactions such as drug-induced hepatitis. Moreover, self-medication with any drug should always be discouraged.


Subject(s)
Humans , Female , Adult , Albendazole , Chemical and Drug Induced Liver Injury , Hepatitis , Self Medication , Secondary Effect , Helminths , Liver
12.
INSPILIP ; 2(1): 1-13, ene.-jun. 2018.
Article in English | LILACS | ID: biblio-987247

ABSTRACT

Latent tuberculosis infection is a major health problem worldwide. People with latent tuberculosis infection have a lifetime risk of developing active tuberculosis approximately 5 % to 10%. Patients with latent tuberculosis infection were infected with Mycobacterium tuberculosis. Therefore, early diagnosis and treatment of a latent tuberculosis infection are very important. Patients with latent tuberculosis infection do not have the symptoms, signs, radiographic, and bacteriological evidence of active tuberculosis. Consequently, these patients are not contagious to others. Patients with latent tuberculosis infection usually have a positive tuberculin skin test or interferon-gamma release assays test. Systematic testing is recommended for all patients that are at risk for latent tuberculosis infection. The treatment of latent tuberculosis is recommended for patients that are at increased risk for developing active tuberculosis. The medications recommended to treat latent tuberculosis infection are isoniazid, rifampin, and a combination of isoniazidand rifapentine, and isoniazid and rifampin combination regimens. The most common side effect of these medications is hepatotoxicity. Therefore, patient monitoring during treatment should occur every month to evaluate medications side effects and adherence to medications. Post-treatment patient follow-up is very important, but serial or repeats chest radiography is not recommended.


La infección de tuberculosis latente es un gran problema de salud a nivel mundial. Las personas con infección de tuberculosis latente tienen un riesgo de desarrollar tuberculosis activa en aproximadamente 5 % a 10 % en toda su vida. Pacientes con infección de tuberculosis latente fueron infectados con Mycobacterium tuberculosis, por lo tanto, diagnóstico y tratamiento temprano de la infección de tuberculosis latente es muy importante. Pacientes con infección de tuberculosis latente son asintomáticos, no tienen signos físicos o radiográficos anormales, y no tienen evidencia bacteriológica de tuberculosis activa. Consecuentemente, estos pacientes no son contagiosos a otras personas. Pacientes con infección de tuberculosis latente usualmente son positivos para las pruebas de la tuberculina o Interferon-Gamma Release Assays. Pruebas sistemáticas son recomendadas para todos los pacientes que están en riesgo de presentar infección de tuberculosis latente. El tratamiento de tuberculosis latente es recomendado para los pacientes que tienen un elevado riesgo de desarrollar tuberculosis activa. Los medicamentos recomendados para el tratamiento de la infección de tuberculosis latente son isoniacida, rifampicina, y una combinación de isoniacida y rifapentin, y la combinación de isoniacida y rifampicina. El efecto secundario más común de estos medicamentos es hepatotoxicidad. Por lo tanto, la monitorización de estos pacientes durante el tratamiento debería ser cada mes, para evaluar efectos secundarios de los medicamentos y la adherencia al tratamiento. Es muy importante dar seguimiento después del tratamiento, pero hacer radiografías repetidas de pulmones no es recomendado.


Subject(s)
Humans , Patients , Tuberculin , Health , Risk , Latent Tuberculosis , Secondary Effect , Mass Chest X-Ray
13.
Rev. bras. hematol. hemoter ; 39(1): 4-12, Jan.-Mar. 2017. tab, graf
Article in English | LILACS | ID: biblio-843954

ABSTRACT

Abstract Background: Secondary myeloid neoplasms comprise a group of diseases arising after chemotherapy, radiation, immunosuppressive therapy or from aplastic anemia. Few studies have addressed prognostic factors in these neoplasms. Method: Forty-two patients diagnosed from 1987 to 2008 with secondary myeloid neoplasms were retrospectively evaluated concerning clinical, biochemical, peripheral blood, bone marrow aspirate, biopsy, and immunohistochemistry and cytogenetic features at diagnosis as prognostic factors. The International Prognostic Scoring System was applied. Statistical analysis employed the Kaplan–Meier method, log-rank and Fisher's exact test. Results: Twenty-three patients (54.8%) were male and the median age was 53.5 years (range: 4–88 years) at diagnosis of secondary myeloid neoplasms. Previous diseases included hematologic malignancies, solid tumors, aplastic anemia, autoimmune diseases and conditions requiring solid organ transplantations. One third of patients (33%) were submitted to chemotherapy alone, 2% to radiotherapy, 26% to both modalities and 28% to immunosuppressive agents. Five patients (11.9%) had undergone autologous hematopoietic stem cell transplantation. The median latency between the primary disease and secondary myeloid neoplasms was 85 months (range: 23–221 months). Eight patients were submitted to allogeneic hematopoietic stem cell transplantation to treat secondary myeloid neoplasms. Important changes in bone marrow were detected mainly by biopsy, immunohistochemistry and cytogenetics. The presence of clusters of CD117+ cells and p53+ cells were associated with low survival. p53 was associated to a higher risk according to the International Prognostic Scoring System. High prevalence of clonal abnormalities (84.3%) and thrombocytopenia (78.6%) were independent factors for poor survival. Conclusion: This study demonstrated that cytogenetics, bone marrow biopsy and immunohistochemistry are very important prognostic tools in secondary myeloid neoplasms.


Subject(s)
Humans , Male , Female , Adult , Myelodysplastic Syndromes , Neoplasms, Second Primary , Secondary Effect , Survival Analysis
15.
Rev Panam Salud Publica ; 39(6),jun. 2016
Article in Spanish | PAHO-IRIS | ID: phr-28541

ABSTRACT

Objetivo. Diseñar y validar una encuesta para conocer las causas de tipo administrativo que pueden influir en la baja notificación de reacciones adversas a medicamentos (RAM). Métodos. El cuestionario se diseñó a partir de una revisión bibliográfica y una tormenta de ideas. Las variables que se consideraron que pueden influir en la notificación fueron la carga de trabajo de los profesionales y su percepción del control de la actividad de farmacovigilancia. Para su validación, se encuestó a 60 profesionales de una muestra de conveniencia. La confiabilidad se calculó con la alfa de Cronbach y el coeficiente de Kuder Richardson. La validez de contenido se cuantificó con el coeficiente de Kendall y la de criterio, mediante la concordancia con el criterio establecido. Resultados. El cuestionario tipo encuesta quedó constituido por 15 preguntas y estructurado en dos partes, información general y causas administrativas de la baja notificación de RAM. La alfa de Cronbach fue 0,87, el coeficiente de Kuder Richardson, 0,9033, y la validez total, 1,51, resultante de 70% de concordancia y un coeficiente de correlación por rangos de 0,81. Conclusiones. La confiabilidad de la encuesta validada fue aceptable-elevada y su validez, aceptable.


Objective. Design and validate a survey to determine the administrative causes that can influence low reporting of adverse drug reactions. Methods. The questionnaire design was based on a review of the literature and on brainstorming. The variables considered to influence reporting were professional workload and the professional perception of drug surveillance control activities. To validate the hypothesis, 60 professionals were surveyed in a convenience sample. Reliability was calculated using Cronbach’s alfa and the Kuder-Richardson coefficient. Content validity was measured using the Kendall coefficient, and criterion validity, through concordance with the established criterion. Results. The survey-type questionnaire was composed of 15 questions divided into two parts: general information and administrative causes of low adverse drug reactions reporting. Cronbach’s alfa was 0.87, the Kuder-Richardson coefficient was 0.9033, and overall validity was 1.51, resulting from 70% concordance and a rank correlation coefficient of 0.81. Conclusions. The reliability of the validated survey was acceptable to high and validity was acceptable.


Subject(s)
Secondary Effect , Drug-Related Side Effects and Adverse Reactions , Pharmacovigilance , Cuba , Secondary Effect , Pharmacovigilance , Drug-Related Side Effects and Adverse Reactions
18.
Arch. Soc. Esp. Oftalmol ; 90(12): 588-592, dic. 2015. ilus
Article in Spanish | IBECS | ID: ibc-145848

ABSTRACT

CASO CLÍNICO: Miope magna con cámara anterior estrecha que presentó cierre angular secundario a lorazepam. DISCUSIÓN: El cierre angular generalmente ocurre en pacientes predispuestos desencadenado por factores precipitantes. Muchos fármacos de uso rutinario en la práctica clínica podrían ejercer como factor responsable del cierre angular secundario


CASE REPORT: Myopic magna with narrow anterior chamber that presented with a secondary angle closure due to lorazepam. DISCUSSION: Angle closure usually occurs in predisposed patients and is triggered by precipitating factors. Many drugs routinely used in clinical practice could act as a factor responsible for the secondary angle closure


Subject(s)
Adult , Female , Humans , Myopia/chemically induced , Myopia/complications , Lorazepam/adverse effects , Lorazepam/therapeutic use , Secondary Effect , Vision, Ocular , Vision Disorders/chemically induced , Vision Disorders/complications , Tomography, Optical Coherence/methods , Intraocular Pressure , Acetazolamide/therapeutic use , Ophthalmic Solutions/therapeutic use , Fundus Oculi , Tomography, Optical Coherence/instrumentation , Tomography, Optical Coherence
20.
Lima; s.n; 2015. 53 p. tab, graf.
Thesis in Spanish | LIPECS | ID: biblio-1114124

ABSTRACT

El presente estudio titulado tiene como Objetivo: Determinar los conocimientos sobre la enfermedad, tratamiento y los cuidados ante los efectos secundarios de la quimioterapia en pacientes con cáncer de mama en el Hospital Nacional Edgardo Rebagliati Martins. Material y Método: Estudio de nivel aplicativo, tipo cuantitativo y método descriptivo de corte transversal. La muestra seleccionada fue 69 pacientes. La técnica utilizada fue la entrevista y el instrumento un cuestionario. Resultados: De 69 (100 por ciento) pacientes encuestadas, 85.5 por ciento conocen bastante sobre el cáncer de mama, el 50.7 por ciento no conocen sobre los factores de riesgo y el 43.37 por ciento tampoco conocen sobre los signos y síntomas. Respecto al tratamiento de quimioterapia el 88.4 por ciento conocen bastante sobre la quimioterapia y el cómo actúa, asimismo el 55.7 por ciento conocen bastante sobre los cuidados pre quimioterapia; sin embargo conocen poco sobre sobre los cuidados en caso de náuseas y vómitos (84.06 por ciento) diarrea (78.25 por ciento), anemia (73.91 por ciento) y mucositis (68.12 por ciento). Conclusiones: La mayoría de las pacientes conoce bastante sobre la enfermedad y tratamiento pero poco sobre los cuidados ante los efectos secundarios.


The present study aims entitled. Objective: To determine knowledge about the disease, treatment and care to the side effects of chemotherapy in patients with breast cancer at the National Hospital Edgardo Rebagliati Martins. Methods: Study of application level, quantitative type, descriptive method of cross section. The sample was 69 patients. The technique used was the interview and a questionnaire instrument. Results: Of 69 (100 per cent) patients surveyed, 85.5 per cent know enough about breast cancer, 50.7 per cent did not know about the risk factors and 43.37 per cent either know about the signs and symptoms. Regarding treatment of chemotherapy 88.4 per cent they know enough about chemotherapy and how it works, 55.7 per cent also quite aware about pre chemotherapy treatment; but they know little about care if nausea and vomiting (84.06 per cent), diarrhea (78.25 per cent), anemia (73.91 per cent) and mucositis (68.12 per cent). Conclusions: Most patients know enough about the disease and treatment, but care little about the side effects before.


Subject(s)
Female , Humans , Young Adult , Adult , Middle Aged , Aged , Secondary Effect , Oncology Nursing , Breast Neoplasms , Drug Therapy , Cross-Sectional Studies , Evaluation Studies as Topic
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