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1.
Multimedia | Recursos Multimedia, MULTIMEDIA-SMS-SP | ID: multimedia-13409

RESUMEN

Boletim informativo sobre a situação do novo coronavírus na capital paulista nos hospitais da rede municipal e de campanha, contratualizados e Atenção Básica.


Asunto(s)
COVID-19
2.
Multimedia | Recursos Multimedia, MULTIMEDIA-SMS-SP | ID: multimedia-13410

RESUMEN

Boletim informativo sobre a situação do novo coronavírus na capital paulista nos hospitais da rede municipal e de campanha, contratualizados e Atenção Básica.


Asunto(s)
COVID-19
3.
Multimedia | Recursos Multimedia, MULTIMEDIA-SMS-SP | ID: multimedia-13411

RESUMEN

Boletim informativo sobre a situação do novo coronavírus na capital paulista nos hospitais da rede municipal e de campanha, contratualizados e Atenção Básica.


Asunto(s)
COVID-19
4.
Multimedia | Recursos Multimedia, MULTIMEDIA-SMS-SP | ID: multimedia-13413

RESUMEN

Boletim informativo sobre a situação do novo coronavírus na capital paulista nos hospitais da rede municipal e de campanha, contratualizados e Atenção Básica.


Asunto(s)
COVID-19
5.
Multimedia | Recursos Multimedia, MULTIMEDIA-SMS-SP | ID: multimedia-13414

RESUMEN

Boletim informativo sobre a situação do novo coronavírus na capital paulista nos hospitais da rede municipal e de campanha, contratualizados e Atenção Básica.


Asunto(s)
COVID-19
6.
Multimedia | Recursos Multimedia, MULTIMEDIA-SMS-SP | ID: multimedia-13415

RESUMEN

Boletim informativo sobre a situação do novo coronavírus na capital paulista nos hospitais da rede municipal e de campanha, contratualizados e Atenção Básica.


Asunto(s)
COVID-19
7.
Afr Health Sci ; 24(1): 76-90, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38962358

RESUMEN

Background: Giving the existing formal education through the internet without a planned transition to distance education negatively affected the learning processes of the students. Objectives: The study aims to identify the midwifery students' changing life conditions and e- learning experiences on the state of their anxiety and hopelessness during the Covid-19 pandemic. Methods: Designed as cross-sectional research, the study was performed with the participation of 1,296 midwifery undergraduate students. The survey form comprised of questions that explored the students' demographic characteristics, life conditions changing during the Covid-19 pandemic and distance education experiences, the Generalized Anxiety Disorder Scale-7, and the Beck Hopelessness Scale were used in the data collection. Findings: It was discerned that, of the participant midwifery students, 55.2% spent the period of the pandemic in the province center, 51.7% used smartphones to have access to the distance education, 50.3% had trouble in following up the courses due to the limited computer and internet access, 63.5% failed to follow up the courses because of the infrastructure problems related to the distance education. It was found that, of the participant midwifery students, 54.6% exhibited anxiety symptoms and 26.3% had hopelessness symptoms. It was identified that having trouble in following up the courses increased anxiety by 1.438 times (CI:1.103-1.875) and hopelessness by 1.980 times (CI:1.459-2.687), having tensions in the family relations increased anxiety by 2.362 times (CI:1.780-3.134) and hopelessness by 1.789 times (CI:1.235-2.594), and having psychological support for anxiety and worry increased anxiety by 2.914 times (CI:2.208-3.8477) and hopelessness by 1.875 times (CI:1.083-3.247). It was ascertained that hopelessness increased anxiety by 2.878 times (CI:2.075-3.991) whilst anxiety increased hopelessness by 2.755 times (CI:1.985-3.823) (p<0.05). Conclusion: As well as the Covid-19 pandemic, health, social life, and economic changes; the digital separation that accompanies distance education also affects the students' mental health. Solving the technical problems experienced in distance education, facilitating the follow-up of the courses, and equipping the midwifery students with problem-solving and coping skills will be useful for reducing the midwifery students' hopelessness and anxiety levels.


Asunto(s)
Ansiedad , COVID-19 , Educación a Distancia , Partería , SARS-CoV-2 , Estudiantes de Enfermería , Humanos , COVID-19/psicología , COVID-19/epidemiología , Femenino , Partería/educación , Estudios Transversales , Ansiedad/epidemiología , Estudiantes de Enfermería/psicología , Adulto , Adulto Joven , Encuestas y Cuestionarios , Pandemias , Esperanza , Masculino
8.
Front Public Health ; 12: 1409214, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38962763

RESUMEN

Background: To explore the relationship between body mass index (BMI), age, sex, and blood pressure (systolic blood pressure, SBP; diastolic blood pressure, DBP) in children during COVID-19, providing reference for the prevention and screening of hypertension in children. Methods: This study adopted a large-scale cross-sectional design to investigate the association between BMI and blood pressure in 7-17-year-old students in City N, China, during COVID-19. Thirty-six primary and secondary schools in City N were sampled using a stratified cluster sampling method. A total of 11,433 students aged 7-17 years in City N, China, were selected for blood pressure (Diastolic blood pressure, DBP, Systolic blood pressure, SBP), height, and weight, Resting heart rate (RHR), chest circumference, measurements, and the study was written using the STROBE checklist. Data analysis was conducted using SPSS 26.0, calculating the mean and standard deviation of BMI and blood pressure for male and female students in different age groups. Regression analysis was employed to explore the impact of BMI, age, and sex on SBP and DBP, and predictive models were established. The model fit was evaluated using the model R2. Results: The study included 11,287 primary and secondary school students, comprising 5,649 boys and 5,638 girls. It was found that with increasing age, BMI and blood pressure of boys and girls generally increased. There were significant differences in blood pressure levels between boys and girls in different age groups. In regression models, LC, Age, BMI, and chest circumference show significant positive linear relationships with SBP and DBP in adolescents, while RHR exhibits a negative linear relationship with SBP. These factors were individually incorporated into a stratified regression model, significantly enhancing the model's explanatory power. After including factors such as Age, Gender, and BMI, the adjusted R2 value showed a significant improvement, with Age and BMI identified as key predictive factors for SBP and DBP. The robustness and predictive accuracy of the model were further examined through K-fold cross-validation and independent sample validation methods. The validation results indicate that the model has a high accuracy and explanatory power in predicting blood pressure in children of different weight levels, especially among obese children, where the prediction accuracy is highest. Conclusion: During COVID-19, age, sex, and BMI significantly influence blood pressure in children aged 7-17 years, and predictive models for SBP and DBP were established. This model helps predict blood pressure in children and reduce the risk of cardiovascular diseases. Confirmation of factors such as sex, age, and BMI provide a basis for personalized health plans for children, especially during large-scale infectious diseases, providing guidance for addressing health challenges and promoting the health and well-being of children.


Asunto(s)
Presión Sanguínea , Índice de Masa Corporal , COVID-19 , Humanos , Adolescente , Niño , Masculino , Femenino , Estudios Transversales , China/epidemiología , Presión Sanguínea/fisiología , Hipertensión , Factores Sexuales , SARS-CoV-2 , Factores de Edad
9.
Front Public Health ; 12: 1372853, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38962769

RESUMEN

Aim: This study seeks to build upon a prior investigation into the impact of the COVID-19 pandemic and to evaluate the prevalence of anxiety among Brazilian children, along with its associated factors, one year after the commencement of the pandemic. Design: A cross-sectional study. Methods: A survey was conducted from April­May 2021 in Brazil. Children aged 6­12 and their guardians from five Brazilian regions were included. The Children's Anxiety Questionnaire (CAQ; scores 4­12) and Numerical Rating Scale (NRS; scores 0­10) were used to measure anxiety. Results: Of the 906 children, 53.3% were girls (average age = 8.79 ± 2.05 years). Mothers responded for 87.1% of the children, and 70.9% were from the Southeast region. Based on a CAQ score of ≥9 and an NRS score of ≥8, the anxiety prevalence was 24.9 and 34.9%, respectively. Using logistic regression, a CAQ ≥9 score was associated with older children and children with chronic disease or disability. An NRS score of ≥8 was associated with reduced family income during the pandemic, the person caring for the children, and with children with chronic disease or disability. Conclusion: These findings suggest the need to implement public health actions aimed at children with chronic diseases and disabilities and their parents to guide them regarding the warning signs and negative emotions. This study contributes to characterizing the evolution of the pandemic in Brazil and provides a basis for comparison with the literature from other countries.


Asunto(s)
Ansiedad , COVID-19 , Humanos , COVID-19/epidemiología , COVID-19/psicología , Brasil/epidemiología , Estudios Transversales , Femenino , Niño , Masculino , Ansiedad/epidemiología , Encuestas y Cuestionarios , Prevalencia , SARS-CoV-2 , Pandemias
10.
Front Public Health ; 12: 1386721, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38962770

RESUMEN

Background: Image and Performance-Enhancing Drugs (IPEDs) can enhance mental and physical capabilities and impact one's overall health. Initially confined in sport environments, IPEDs use has become increasingly widespread in a high-performing society. The present study was aimed at profiling IPEDs use during the COVID-19 lockdown among an international sample of young adults. Methods: A cross-sectional observational study was carried out in eight countries (United Kingdom, Italy, Lithuania, Hungary, Portugal, Spain, Brazil, and Japan) between April and May 2020. The survey questionnaire included validated measurements such as Exercise Addiction Inventory (EAI), Appearance Anxiety Inventory (AAI), and Self-Compassion Scale (SCS) as well as questions about the type of IPEDs, purchasing methods and socio-demographic information. Results: A total of 736 IPEDs users were included in the survey. Their mean age was 33.05 years (±SD = 10.06), and 64.2% were female participants. Overall, 6.8% were found at risk of exercise addiction (EAI >24), 27.6% presented high levels of appearance anxiety, and 24.9% revealed low levels of emotional regulation's self-compassion. Most participants (55.6%) purchased IPEDs through pharmacies/specialized shops, while 41.3% purchased IPEDs on the Internet. Online IPEDs buyers were mainly men who had higher scores on the Exercise Addiction Inventory. One or more IPEDs classifiable as "potentially risky" were used by 66.3% of the sample. Users of "potentially risky IPEDs" were younger and primarily men. They showed higher scores both on the Exercise Addiction Inventory and Appearance Anxiety Inventory. Conclusion: This study profiled users of IPEDs when the most restrictive COVID-19 lockdown policies were implemented in all the participating countries. More targeted post-COVID 19 prevention strategies should be implemented according to the emerged socio-demographic and psychopathological traits and cross-cultural differences emerged. Longitudinal studies will also be needed to determine the long-term effect of the COVID-19 lockdown on IPEDs consumption.


Asunto(s)
COVID-19 , Sustancias para Mejorar el Rendimiento , Humanos , Masculino , COVID-19/epidemiología , Femenino , Adulto , Estudios Transversales , Encuestas y Cuestionarios , Adulto Joven , Ejercicio Físico , Conducta Adictiva/psicología , Trastornos Relacionados con Sustancias/epidemiología , SARS-CoV-2
11.
N Z Med J ; 137(1598): 86-92, 2024 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-38963934

RESUMEN

Despite technological advances and a disproportionate increase in health expenditure at the end-of-life, most New Zealanders die in hospital or in aged residential care. This counters the aspirations espoused by Te Whatu Ora (Health New Zealand) for all New Zealanders "to live well, age well and die well in their homes and communities." Furthermore, despite reported inequities in end-of-life care experienced by ethnic minority communities (EMCs) overseas, and increasing proportions of people identifying with Asian, Middle Eastern, Latin American and African ethnicities in Aotearoa New Zealand, local data, research and policies addressing healthcare needs of EMCs at end-of-life are scant. Acknowledging this invisibility, we reflect on and discuss the current discourses on death and dying, the complex experiences at end-of-life for EMCs, including concepts of a "good death", the impact of recent existential crises (e.g., COVID-19 pandemic, climate change) on death awareness, and the global rise to reclaim dying as an important part of living. We argue for the need: a) to partner with ethnic communities to co-design culturally safe end-of-life health services, and b) to adopt a "compassionate communities" public health approach that can support people of EMCs at the end-of-life to die well.


Asunto(s)
COVID-19 , Cuidado Terminal , Humanos , Nueva Zelanda , COVID-19/etnología , Minorías Étnicas y Raciales , Etnicidad , Actitud Frente a la Muerte/etnología , SARS-CoV-2 , Grupos Minoritarios
13.
Cell ; 2024 Jun 21.
Artículo en Inglés | MEDLINE | ID: mdl-38964326

RESUMEN

The human seasonal coronavirus HKU1-CoV, which causes common colds worldwide, relies on the sequential binding to surface glycans and transmembrane serine protease 2 (TMPRSS2) for entry into target cells. TMPRSS2 is synthesized as a zymogen that undergoes autolytic activation to process its substrates. Several respiratory viruses, in particular coronaviruses, use TMPRSS2 for proteolytic priming of their surface spike protein to drive membrane fusion upon receptor binding. We describe the crystal structure of the HKU1-CoV receptor binding domain in complex with TMPRSS2, showing that it recognizes residues lining the catalytic groove. Combined mutagenesis of interface residues and comparison across species highlight positions 417 and 469 as determinants of HKU1-CoV host tropism. The structure of a receptor-blocking nanobody in complex with zymogen or activated TMPRSS2 further provides the structural basis of TMPRSS2 activating conformational change, which alters loops recognized by HKU1-CoV and dramatically increases binding affinity.

14.
Cell ; 2024 Jun 21.
Artículo en Inglés | MEDLINE | ID: mdl-38964329

RESUMEN

The entry of coronaviruses is initiated by spike recognition of host cellular receptors, involving proteinaceous and/or glycan receptors. Recently, TMPRSS2 was identified as the proteinaceous receptor for HCoV-HKU1 alongside sialoglycan as a glycan receptor. However, the underlying mechanisms for viral entry remain unknown. Here, we investigated the HCoV-HKU1C spike in the inactive, glycan-activated, and functionally anchored states, revealing that sialoglycan binding induces a conformational change of the NTD and promotes the neighboring RBD of the spike to open for TMPRSS2 recognition, exhibiting a synergistic mechanism for the entry of HCoV-HKU1. The RBD of HCoV-HKU1 features an insertion subdomain that recognizes TMPRSS2 through three previously undiscovered interfaces. Furthermore, structural investigation of HCoV-HKU1A in combination with mutagenesis and binding assays confirms a conserved receptor recognition pattern adopted by HCoV-HKU1. These studies advance our understanding of the complex viral-host interactions during entry, laying the groundwork for developing new therapeutics against coronavirus-associated diseases.

15.
BMJ Case Rep ; 17(7)2024 Jul 04.
Artículo en Inglés | MEDLINE | ID: mdl-38964873

RESUMEN

Multisystem inflammatory syndrome in children (MIS-C) is a known complication of COVID-19. There is still limited knowledge about this condition. Here, we report the case of a previously healthy toddler boy, who presented with acute liver failure and duodenal lesions resulting in severe haematemesis and haemorrhagic shock, requiring intensive care unit care. The patient had persistent transaminitis, a deranged coagulation profile, inflammatory markers were elevated, and laboratory tests were negative for common infectious hepatitis aetiologies as well as COVID-19 Reverse transcription polymerase chain reaction. His COVID-19 antibody was reactive. Upper gastrointestinal endoscopy revealed a Forrest grade III duodenal ulcer. Looking into the constellation of symptoms and laboratory findings a confirmed diagnosis of acute viral hepatitis caused by MIS-C was made. Hence, he was given intravenous methylprednisolone along with intravenous immunoglobulins, after which he improved clinically and transaminitis resolved. The patient was discharged on clinical improvement and was doing fine on follow-up up to 6 months.


Asunto(s)
COVID-19 , Hemorragia Gastrointestinal , Fallo Hepático Agudo , Metilprednisolona , Síndrome de Respuesta Inflamatoria Sistémica , Humanos , Masculino , Síndrome de Respuesta Inflamatoria Sistémica/diagnóstico , Síndrome de Respuesta Inflamatoria Sistémica/complicaciones , COVID-19/complicaciones , Fallo Hepático Agudo/diagnóstico , Fallo Hepático Agudo/etiología , Fallo Hepático Agudo/complicaciones , Hemorragia Gastrointestinal/etiología , Hemorragia Gastrointestinal/diagnóstico , Metilprednisolona/uso terapéutico , Metilprednisolona/administración & dosificación , Inmunoglobulinas Intravenosas/uso terapéutico , Hematemesis/etiología , Úlcera Duodenal/complicaciones , Úlcera Duodenal/diagnóstico , SARS-CoV-2 , Preescolar
16.
J Med Virol ; 96(7): e29778, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38965882

RESUMEN

Active and passive immunization is used in high-risk patients to prevent severe courses of COVID-19, but the impact of prophylactic neutralizing antibodies on the immune reaction to the mRNA vaccines has remained enigmatic. Here we show that CD4 T and B cell responses to Spikevax booster immunization are suppressed by the therapeutic antibodies Casirivimab and Imdevimab. B cell and T cell responses were significantly induced in controls but not in antibody-treated patients. The data indicates that humoral immunity, i. e. high levels of antibodies, negatively impacts reactive immunity, resulting in blunted cellular responses upon boosting. This argues for temporal separation of vaccination efforts; with active vaccination preferably applied before prophylactic therapeutic antibody treatment.


Asunto(s)
Anticuerpos Neutralizantes , Anticuerpos Antivirales , Linfocitos B , Vacunas contra la COVID-19 , COVID-19 , SARS-CoV-2 , Glicoproteína de la Espiga del Coronavirus , Humanos , COVID-19/prevención & control , COVID-19/inmunología , Linfocitos B/inmunología , Glicoproteína de la Espiga del Coronavirus/inmunología , Anticuerpos Antivirales/inmunología , Anticuerpos Antivirales/sangre , Anticuerpos Neutralizantes/inmunología , Anticuerpos Neutralizantes/sangre , Vacunas contra la COVID-19/inmunología , SARS-CoV-2/inmunología , Persona de Mediana Edad , Masculino , Femenino , Vacunación , Adulto , Anciano , Linfocitos T CD4-Positivos/inmunología , Linfocitos T/inmunología , Inmunización Secundaria , Inmunidad Humoral , Anticuerpos Monoclonales Humanizados/inmunología , Anticuerpos Monoclonales Humanizados/uso terapéutico
17.
J Med Virol ; 96(7): e29783, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38965890

RESUMEN

Many COVID-19 patients suffer from gastrointestinal symptoms and impaired intestinal barrier function is thought to play a key role in Long COVID. Despite its importance, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on intestinal epithelia is poorly understood. To address this, we established an intestinal barrier model integrating epithelial Caco-2 cells, mucus-secreting HT29 cells and Raji cells. This gut epithelial model allows efficient differentiation of Caco-2 cells into microfold-like cells, faithfully mimics intestinal barrier function, and is highly permissive to SARS-CoV-2 infection. Early strains of SARS-CoV-2 and the Delta variant replicated with high efficiency, severely disrupted barrier function, and depleted tight junction proteins, such as claudin-1, occludin, and ZO-1. In comparison, Omicron subvariants also depleted ZO-1 from tight junctions but had fewer damaging effects on mucosal integrity and barrier function. Remdesivir, the fusion inhibitor EK1 and the transmembrane serine protease 2 inhibitor Camostat inhibited SARS-CoV-2 replication and thus epithelial barrier damage, while the Cathepsin inhibitor E64d was ineffective. Our results support that SARS-CoV-2 disrupts intestinal barrier function but further suggest that circulating Omicron variants are less damaging than earlier viral strains.


Asunto(s)
COVID-19 , Mucosa Intestinal , SARS-CoV-2 , Uniones Estrechas , Replicación Viral , Humanos , SARS-CoV-2/patogenicidad , Células CACO-2 , COVID-19/virología , COVID-19/patología , Mucosa Intestinal/virología , Mucosa Intestinal/patología , Uniones Estrechas/virología , Alanina/análogos & derivados , Proteína de la Zonula Occludens-1/metabolismo , Proteína de la Zonula Occludens-1/genética , Antivirales/farmacología , Células HT29 , Ocludina/metabolismo , Ocludina/genética , Adenosina Monofosfato/análogos & derivados
18.
Artículo en Inglés | MEDLINE | ID: mdl-38965928

RESUMEN

mRNA therapeutics have shown great potential for a broad spectrum of disease treatment. However, the challenges of mRNA's inherent instability and difficulty in cellular entry have hindered its progress in the biomedical field. To address the cellular barriers and deliver mRNA to cells of interest, various delivery systems are designed. Among these, lipid nanoparticles (LNPs) stand out as the most extensively used mRNA delivery systems, particularly following the clinical approvals of corona virus disease 2019 (COVID-19) mRNA vaccines. LNPs are comprised of ionizable cationic lipids, phospholipids, cholesterol, and polyethylene glycol derived lipids (PEG-lipids). In this review, we primarily summarize the recent advancements of the LNP mRNA delivery technology, focusing on the structures of four lipid constituents and their biomedical applications. We delve into structure-activity relationships of the lipids, while also exploring the future prospects and challenges in developing more efficacious mRNA delivery systems. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials > Lipid-Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.


Asunto(s)
Lípidos , Nanopartículas , ARN Mensajero , Humanos , Nanopartículas/química , ARN Mensajero/metabolismo , Lípidos/química , Animales , SARS-CoV-2 , COVID-19 , Sistemas de Liberación de Medicamentos , Vacunas contra la COVID-19/química , Liposomas
19.
Clin Lab ; 70(7)2024 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-38965948

RESUMEN

BACKGROUND: The FilmArray Respiratory Panel RP 2.1 plus (FilmArray RP) is a point-of-care syndromic panel for respiratory pathogens. Although highly valuable in the clinical settings, the co-detection of pathogens in FilmArray RP may confound result interpretation. METHODS: Nasopharyngeal swab specimens collected from patients with respiratory symptoms were analyzed by comparing co-detection results from FilmArray RP with those of Allplex Respiratory Panels (Allplex RP: Power-Chek for SARS-CoV-2). RESULTS: Out of 765 FilmArray RP tests, 143 (18.7%) showed co-detections (two: 122 (85.3%), three: 18 (12.6%), four: 2 (1.4%), and five viruses: 1 (0.7%). The most frequent co-detection was human rhinovirus/enterovirus (HRV/HEV) with respiratory syncytial virus (RSV) (22.3%, 32/143). The overall discordance rate between Film-Array RP and other tests was 32.9%. Notably, discordance in detecting adenovirus (AdV) was significant, with cases detected by FilmArray often not appearing in Allplex RP. CONCLUSIONS: Discordances were varied by virus combination. It is advisable to perform additional confirmatory testing based on clinical relevance.


Asunto(s)
Coinfección , Reacción en Cadena de la Polimerasa Multiplex , Infecciones del Sistema Respiratorio , Humanos , Reacción en Cadena de la Polimerasa Multiplex/métodos , Infecciones del Sistema Respiratorio/virología , Infecciones del Sistema Respiratorio/diagnóstico , Coinfección/virología , Coinfección/diagnóstico , Masculino , Persona de Mediana Edad , Femenino , Adulto , Anciano , Nasofaringe/virología , Niño , COVID-19/diagnóstico , COVID-19/virología , Preescolar , Adolescente , SARS-CoV-2/genética , SARS-CoV-2/aislamiento & purificación , Adulto Joven , Virus/aislamiento & purificación , Virus/genética , Virus/clasificación , Virosis/diagnóstico , Virosis/virología , Lactante
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