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1.
Gene ; 725: 144191, 2020 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-31654705

RESUMEN

Caloric restriction (CR) has long been known to increase median and maximal lifespans and to decrease mortality and morbidity in short-lived animal models, likely by altering fundamental biological processes that regulate aging and longevity. However, the detailed mechanisms of immunomodulation by CR remain unclear. In this study, we established a mouse model for CR and analyzed the changes of immune cells in these mice. The CR mice fed a calorie-restricted diet for 4 weeks had lower body weight and fat mass compared with control mice. The proportions of CD4+, CD8+, and naïve CD4+ T cells in spleen cells from CR mice were higher than those in of control mice. Additionally, the proportion of CD8+ T cells was significantly decreased and the mRNA expression of proinflammatory cytokines in the colon of CR mice was significantly decreased compared with those of control mice. To determine the effect of CR on microRNA (miRNA) expression, serum and tissues were collected from mice and the expression level of miRNA was analyzed by real-time RT-PCR. As a result, the expressions of miR-16-5p, miR-196b-5p, and miR-218-5p in serum from CR mice were higher than those in control mice. The expression of miR-16-5p increased in the spleen, thymus, colon, and stomach of CR mice compared with expression in control mice. Furthermore, RAW264 cells transfected with a miR-16-5p mimic significantly decreased the mRNA expression of IL-1ß, IL-6, and TNF-α under LPS stimulation. These results suggested that miR-16-5p might be a critical factor involving the anti-inflammatory effects of calorie-restricted feeding.


Asunto(s)
Macrófagos/metabolismo , MicroARNs/genética , MicroARNs/metabolismo , Envejecimiento/metabolismo , Animales , Restricción Calórica/métodos , Citocinas/genética , Citocinas/metabolismo , Dietoterapia , Inflamación/metabolismo , Interleucina-1beta/genética , Masculino , Ratones , Ratones Endogámicos C57BL , Modelos Animales , Células RAW 264.7 , Activación Transcripcional , Factor de Necrosis Tumoral alfa/genética , Regulación hacia Arriba
3.
Hist Cienc Saude Manguinhos ; 26(4): 1299-1315, 2019.
Artículo en Portugués | MEDLINE | ID: mdl-31800843

RESUMEN

The practice of homeopathy developed significantly in Brazil at the turn of the twentieth century. Especially in Rio Grande do Sul, the southernmost state in Brazil, homeopaths were able to introduce their practices by linking them to a scientific perspective that organized a plan for advanced training as well as to a religious movement which disseminated the use of homeopathy through prescriptions received by mediums. These two movements had supporters who worked on several fronts, offering homeopathic medicines for free or spreading their ideas in magazines and other vehicles. The article analyzes these contexts in which homeopaths and Spiritist practices interacted during the first half of the twentieth century in an attempt to understand how these perspectives approached each other and permitted continuity.

4.
Hist Cienc Saude Manguinhos ; 26(4): 1317-1335, 2019.
Artículo en Portugués | MEDLINE | ID: mdl-31800844

RESUMEN

The objective of this text is to analyze how homeopathy was conveyed to the lay public in Brazil during the 1970s, an important period in the process of legitimizing this practice as a medical specialty, which occurred in 1980. The sources analyzed (composed of articles that circulated in the Jornal do Brasil and books intended for the lay public) allow the reader to distinguish different interlocutors with various expectations of homeopathy, revealing a heterogeneous universe of understandings and uses for this medical system. At the same time, the sources establish a universe of representations present in the construction of homeopathy as alternative medicine, which is noticeable in its relationship with the counterculture movements and New Era in forming a "consuming public" for homeopathy.

5.
Hist Cienc Saude Manguinhos ; 26(4): 1337-1354, 2019.
Artículo en Español | MEDLINE | ID: mdl-31800845

RESUMEN

The change in position of homeopathic remedies in the health market produced by the emerging pharmacological paradigm was key to the popularization of homeopathy in Spain. The introduction of specifics and their marketing strategies led to a rise in popular legitimization of homeopathy, and the battles between different professionals created fertile ground for explaining and promoting this doctrine. This article analyzes a contextualized case in Barcelona in the early twentieth century, and explores from different perspectives the new role of pharmacists and medications in spreading homeopathy, centering on strategies for popularizing homeopathic remedies in Spain.

6.
Hist Cienc Saude Manguinhos ; 26(4): 1355-1372, 2019.
Artículo en Español | MEDLINE | ID: mdl-31800846

RESUMEN

This article analyzes the practice and professional status of Colombian homeopaths in the twentieth century, based on applications for licenses in the "Teguas" series in the Archivo General de la Nación. Within the historical context of the practice of medicine in Colombia, it studies homeopathic practice within the framework of the debate between licensed and permitted medicine. In that context, the field of homeopathy was subordinate to university medicine and homeopaths were a group of practitioners who were neither homogeneous nor organized, but characterized by their shared struggle to become "entitled" to practice, and their advocacy of professional status through constant litigation against official reprimands.

7.
Hist Cienc Saude Manguinhos ; 26(4): 1373-1391, 2019.
Artículo en Portugués | MEDLINE | ID: mdl-31800847

RESUMEN

This study is a pre-assessment of homeopathy activities in the municipality of Recife, Pernambuco. Review of official and technical documentation produced a preliminary logical theoretical model for this intervention, based on a matrix of criteria and indicators for evaluation. The model and matrix were submitted to key informants with expertise in the area, and the data were collected from six interviews in 2016. Three major components were seen to be needed for both tools: joint management and coordination; homeopathic care; and education, communication, and social mobilization. We expect the theoretical model and matrix of criteria and indicators which were developed and validated to serve as a reference to establish procedures for monitoring and assessing similar interventions.

8.
Rev. bras. educ. méd ; 43(4): 109-116, Out.-Dec. 2019. tab, graf
Artículo en Inglés | LILACS-Express | ID: biblio-1042091

RESUMEN

ABSTRACT Context Complementary and Alternative Medicine (CAM) are unconventional care practices that, according to the World Health Organization, should be implemented in the Health System, particularly in poor regions of the country. In Brazil, they have been adopted by Care Programs and introduced into undergraduate medical education. In this study we were interested in evaluating the teaching-learning process of Integrative Practices in Brazilian medical schools. Methodology A cross-sectional study was carried out at Brazilian medical schools with a self-administered questionnaire for teachers and a secondary data survey was obtained from medical school websites and government database institutions. For the presentation of the variables, frequency distribution and the Pearson coefficient (X2) -Chi-square tests were used. The proportions were compared using the Chi-square test or the Fisher's Exact Test. When the expected value of a contingency table was equal to or greater than 5, the Chi-square test was used; in all other situations, Fisher's Exact Test was used. The difference between proportions was estimated by the Odds Ratio, calculated through simple logistic regression (95% CI). Results 57 of the 272 medical schools in Brazil address CAM, with it being proportionally higher in the South and Mid-West regions. The medical schools are highly concentrated in state capitals, and the Northeast region presents a significant concentration of medical schools with CAM in the capitals. The number of schools with active and traditional methodologies in CAM is equivalent. Homeopathy, Acupuncture and Integrative Medicine predominate, with a minority using Indigenous Practices, Chronotherapy and Anthroposophic Medicine. The new educational guidelines have not affected the number of schools with CAM. Growth in CAM has been insignificant (p <0.05) in the last ten years. Conclusion There has been no growth in teaching Complementary and Alternative Medicine in undergraduate medical training in Brazil since the introduction of the new curricular guidelines, even in view of the needs of the health system.


RESUMO Contexto Medicinas Complementares e Alternativas (MAC) são práticas de cuidados não convencionais que, segundo a Organização Mundial da Saúde, devem ser implementadas no sistema de saúde, particularmente nas regiões pobres do País. No Brasil, têm sido inseridas na saúde como Práticas Integrativas por meio de programas assistenciais e no ensino de graduação. Objetivou-se avaliar o processo de ensino-aprendizagem em Práticas Integrativas nas escolas médicas brasileiras. Metodologia Um estudo transversal foi realizado em escolas médicas brasileiras com um questionário autoaplicável para professores, e um levantamento de dados secundários foi obtido em websites de escolas médicas e instituições de bancos de dados governamentais. Na apresentação das variáveis utilizou-se a distribuição de frequências e os testes do coeficiente de Pearson (x2) - Qui-Quadrado. As proporções foram comparadas por meio do teste Qui-Quadrado ou do Teste Exato de Fisher. Quando o valor esperado de uma tabela de contingência foi igual ou superior a 5, utilizou-se o teste Qui-Quadrado; em todas as outras situações, utilizou-se o Teste Exato de Fisher. A diferença entre as proporções foi estimada pela Odds Ratio, calculada por meio de regressão logística simples (95% IC). Resultados Das 272 escolas médicas do Brasil, 57 abordam MAC, sendo essa proporção maior nas regiões Sul e Centro-Oeste. Há uma concentração de escolas médicas em capitais, e a Região Nordeste apresenta uma concentração significativa de escolas médicas com MAC nas capitais. O número de escolas com metodologias ativas e tradicionais no ensino de MAC é equivalente. A homeopatia, a acupuntura e a medicina integrativa predominam, com uma minoria usando práticas indígenas, cromoterapia e medicina antroposófica. As novas diretrizes educacionais não causaram impacto no número de escolas com MAC. O crescimento em MAC foi insignificante (p < 0, 5) nos últimos dez anos. Conclusão Não houve crescimento no ensino em Práticas Integrativas e Complementares no Brasil na graduação médica após as novas diretrizes curriculares, mesmo diante das necessidades do sistema de saúde.

9.
J Law Med ; 27(1): 50-54, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31682341

RESUMEN

In R (on the application of British Homeopathic Association) v National Health Service Commissioning Board [2018] EWHC 1359 (Admin) Supperstone J of the High Court of England and Wales delivered an internationally significant judgment on the processes required to be engaged in when guidance is given to medical practitioners about their involvement in homeopathic prescribing. This column explores the bases upon which the challenge by the British Homeopathic Association was lost and the repercussions of the judgment for the practice of non-evidence-based modalities, such as homeopathy.


Asunto(s)
Homeopatía , Legislación Médica , Inglaterra , Programas Nacionales de Salud , Gales
10.
Rev. cient. (Guatem.) ; 29(1)20191126.
Artículo en Español, Inglés | LILACS-Express | ID: biblio-1046011

RESUMEN

El estudio sobre el efecto de los medicamentos en el estado de salud de las personas es amplio y necesario. En salud mental, el estado de salud percibido puede ser determinante para el tratamiento de algunas afecciones. El caso de la depresión es uno de los ejemplos en los que mejorar el estado de salud percibido puede incidir positivamente en el tratamiento. En este artículo se ha realizado un análisis de algunos indicadores relevantes obtenidos en la encuesta española de salud de 2017, con el objetivo de contrastar el efecto sobre el estado de salud percibido de algunas variables que se consideran fundamentales, tales como haber padecido depresión, haberse sometido a un tratamiento con homeopatía o antidepresivos, el nivel de estudios, la edad o la nacionalidad. Es conveniente señalar que los coeficientes de los sujetos que han tomado antidepresivos y homeopatía son próximos entre sí para los estados de salud bueno o muy bueno, algo superior en el caso de los antidepresivos, lo cual se puede interpretar como que ambos tratamientos generan una mejor salud percibida pudiendo optar por cualquiera de ellos pero reduciendo los efectos adversos en el caso de la homeopatía. Por otra parte, cabe destacar que, para el caso de salud percibida muy mala, el uso de homeopatía no empeora ese estado mientras que los antidepresivos sí, lo que confirma esos menores efectos adversos generados por la homeopatía


The study about the effect of medicine on perceived health is wide and necessary. In mental health issues, perceived health could act as a determinant. In case of depression, a better perceived health could help in the medical treatment. In this article, some relevant variables from the Spanish health survey of 2017 have been analyzed, with the aim of contrasting the effect of some essential variables on the perceived health such as the use of homeopathy and antidepressants, nationality, age, or education level. This article shows positive and significant results for using both, homeopathy and antidepressants, in order to get a good or a very good perceived health. Both treatments are useful, but homeopathy has the advantage of having no side effects. Moreover, for the very bad perceived health status, the use of homeopathy does not get a worse perceived health

11.
Medicina (B Aires) ; 79 Suppl 3: 2-5, 2019.
Artículo en Español | MEDLINE | ID: mdl-31603834

RESUMEN

Phenylketonuria, also known as PKU, is the most frequent congenital inborn error of metabolism. The severe form or classic PKU untreated causes intellectual disability, although with the early detection programs in the neonatal period, diagnosis and treatment prevent the appearance of the symptoms. Despite early diagnosis and treatment we have observed some neurotoxicity in treated PKU patients. We analyzed the factors involved apart from the toxicity due to the high cerebral concentrations of phenylalanine (Phe), the defects of synthesis of neurotransmitters, the alteration of cerebral myelination, the effect of the elevation of Phe in the processes of transport and distribution of neutral amino acids with an abnormal synthesis of brain proteins, plasma and cerebral tyrosine deficiency, the neurotoxicity of Phe metabolites, the defect of cholesterol biosynthesis or the increase of oxidative stress. White matter alterations in early treated PKU patients have an important role in neurological manifestations. The treatment of PKU is for life and is based on the reduction of foods containing Phe combined with the administration of a special formula or tetrahydrobiopterin (BH4) treatment. New therapeutic options will be analyzed.


Asunto(s)
Neuronas/patología , Fenilalanina/efectos adversos , Fenilcetonurias/diagnóstico , Fenilcetonurias/terapia , Tirosina/metabolismo , Biopterina/análogos & derivados , Dietoterapia , Diagnóstico Precoz , Humanos , Fenilcetonurias/fisiopatología
14.
Prensa méd. argent ; 105(10): 686-692, oct 2019.
Artículo en Inglés | LILACS, BINACIS | ID: biblio-1025966

RESUMEN

This paper explains the elementary law of homeopathy, the Law of Similars, on the bases of thermodynamic aspects by means of the chemical thermodynamic. Le Chatelier principle was used, to explain the re-establishment of starting biochemical equilibrium compartmentalized in individual human cells of an ill person consuming the remedy, to clarify the Law of Similars. In addition, the application of the Law of mass action during the re-establishment of the initial equilibrium in an ill person when digesting the remedy exposed the law of Similars as the strongest outcome of homeopathy


Asunto(s)
Humanos , Fenómenos Bioquímicos , Acción Farmacodinámica del Medicamento Homeopático , Fundamentos de la Homeopatía/historia , Ley de la Similitud , Homeopatía/historia
15.
Endocrinol. diabetes nutr. (Ed. impr.) ; 66(8): 472-479, oct. 2019.
Artículo en Español | IBECS | ID: ibc-184140

RESUMEN

Antecedentes y objetivo: El tratamiento con antineoplásicos orales tipo inhibidores de tirosina quinasa (ITK) es novedoso, y por ello se conoce poco sobre cómo afectan al estado nutricional (EN), la ingesta dietética, la calidad de vida, y su influencia sobre la supervivencia. Este estudio pretende aportar información sobre estos componentes, para dirigir las recomendaciones nutricionales futuras. Pacientes y método: Estudio prospectivo y observacional en adultos que inician ITK, donde se valoró el EN mediante el cuestionario de valoración subjetiva global generada por el paciente (VSG-GP), medidas antropométricas, parámetros bioquímicos e ingesta dietética (Recuerdo de 24 h). La calidad de vida se estudió con EORTC QLQ-C30. El análisis estadístico empleó pruebas no paramétricas y la supervivencia se analizó mediante curvas de Kaplan-Meier y log-rank. Resultados: El 21,7% de la muestra presentó desnutrición moderada según VSG-GP; el 74,2% mostró pérdida de peso moderada a los 6 meses, aunque ningún paciente tuvo un IMC < 18,5 kg/m2. Los pacientes moderadamente desnutridos presentaron menor supervivencia a los 4 años del diagnóstico (log-rank = 0,015). El 44,4% realizó una ingesta energética inferior a las recomendaciones ESPEN 2017 y ningún paciente cubrió requerimientos proteicos (1,5 g proteína/kg peso) durante el seguimiento. Una peor puntuación en la escala global de salud del EORTC QLQ-C30 se relacionó con peor EN. Conclusiones: El tratamiento con ITK no parece afectar de manera importante el EN y la calidad de vida a los 6 meses de seguimiento. Se debe prevenir la desnutrición, mediante un consejo nutricional individualizado, pues se relaciona con menor supervivencia


Background and objective: Treatment with oral antineoplastic agents known as tyrosine kinase inhibitors (TKIs) is new and, thus, little is known about their impact on nutritional status (NS), dietary intake, quality of life, and survival. The aim of this study was to provide information on these components in order to guide future nutritional recommendations. Patients and method: A prospective, observational study in adults who start treatment with TKIs, in whom NS was assessed using the Patient-Generated Subjective Global Assessment (PG-SGA), anthropometric measures, biochemical parameters, and dietary intake (24-hour dietary recall). The EORTC QLQ-C30 was used to assess quality of life. Nonparametric tests were used in statistical analysis, and survival was analyzed using Kaplan-Meier and log-rank curves. Results: Of the overall sample, 21.7% had moderate malnutrition according to PG-SGA, and 74.2% moderate weight loss at 6 months, but no patient had BMI < 18.5 kg/m2. Patients with moderate malnutrition had lower survival at four years of diagnosis (log-rank = 0.015). Energy intake was lower than recommended by the ESPEN 2017 congress, and no patient covered the protein requirements (1.5 g protein/kg weight) during follow-up. A worse score on the global health scale of the EORTC QLQ-C30 was related to worse NS. Conclusions: Treatment with TKIs does not appear to have a significant impact on NS and quality of life after 6 months of follow-up. Malnutrition should be prevented through individualized nutritional advice because it is related to shorter survival


Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Anciano , Supervivencia , Neoplasias/epidemiología , Estado Nutricional , Proteínas Tirosina Quinasas/antagonistas & inhibidores , Calidad de Vida , Neoplasias/dietoterapia , Estudios Prospectivos , Encuestas y Cuestionarios , Antropometría , Dietoterapia , Dietética
16.
Altern Ther Health Med ; 25(5): 30-38, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31550680

RESUMEN

Context: Small intestinal bacterial overgrowth (SIBO) has gained popularity on the internet in addition to certain clinical and research circles. This interest has expanded awareness of important new dietary, nutraceutical, and pharmaceutical treatments in addition to laboratory evaluation assessment options. Concomitantly, there appears a loss of parsimony regarding how to use these tools resulting in an untenable degree of testing and treatment for this condition. Objectives: A balanced review of the data regarding SIBO testing, treatment, and management with the goal of establishing non-biased best practices. Design: Non-systematic review. Results: The results for the review fall into two categories. Ineffective Action: Treat only SIBO labs; Treat for SIBO if no symptoms are exhibited; Recommending eating or avoiding foods because they might be good or bad for SIBO; Recommending treatments that are non-validated. Effective Action: Use SIBO breath results, in addition to history and current symptoms, to determine the best treatment; Find foods that work for patients based on dietary elimination and reintroduction; Apply validated treatment for SIBO and IBS in a logical 'step-up' like treatment approach. Conclusions: Testing and treating for SIBO can offer patients clinically significant relief. However, these tests and treatments must be applied with circumspection to prevent over-testing, over-treatment, squandering resources, or creating a fear around certain foods.


Asunto(s)
Infecciones Bacterianas/diagnóstico , Enfermedades Intestinales/microbiología , Intestino Delgado/microbiología , Síndrome del Colon Irritable/microbiología , Infecciones Bacterianas/tratamiento farmacológico , Infecciones Bacterianas/microbiología , Pruebas Respiratorias , Dietoterapia , Fármacos Gastrointestinales , Humanos , Enfermedades Intestinales/diagnóstico , Enfermedades Intestinales/terapia
17.
Cochrane Database Syst Rev ; 9: CD009710, 2019 09 04.
Artículo en Inglés | MEDLINE | ID: mdl-31483486

RESUMEN

BACKGROUND: Irritable bowel syndrome (IBS) is a common, chronic disorder that leads to decreased health-related quality of life and work productivity. A previous version of this review was not able to draw firm conclusions about the effectiveness of homeopathic treatment for IBS and recommended that further high quality RCTs were conducted to explore the clinical and cost effectiveness of homeopathic treatment for IBS. Two types of homeopathic treatment were evaluated in this systematic review: 1. Clinical homeopathy where a specific remedy is prescribed for a specific condition; 2. Individualised homeopathic treatment, where a homeopathic remedy based on a person's individual symptoms is prescribed after a detailed consultation. OBJECTIVES: To assess the effectiveness and safety of homeopathic treatment for IBS. SEARCH METHODS: For this update we searched MEDLINE, CENTRAL, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Allied and Complementary Medicine Database (AMED), the Cochrane IBD Group Specialised Register and trials registers from inception to 31 August 2018. SELECTION CRITERIA: Randomised controlled trials (RCTs), cohort and case-control studies that compared homeopathic treatment with placebo, other control treatments, or usual care, in adults with IBS were considered for inclusion. DATA COLLECTION AND ANALYSIS: Two authors independently assessed the risk of bias and extracted data. The primary outcome was global improvement in IBS as measured by an IBS symptom severity score. Secondary outcomes included quality of life, abdominal pain, stool frequency, stool consistency, and adverse events. The overall certainty of the evidence supporting the primary and secondary outcomes was assessed using the GRADE criteria. We used the Cochrane risk of bias tool to assess risk of bias. We calculated the mean difference (MD) and 95% confidence interval (CI) for continuous outcomes and the risk ratio (RR) and 95% CI for dichotomous outcomes. MAIN RESULTS: Four RCTs (307 participants) were included. Two studies compared clinical homeopathy (homeopathic remedy, asafoetida or asafoetida plus nux vomica) to placebo for IBS with constipation (IBS-C). One study compared individualised homeopathic treatment (consultation plus remedy) to usual care for the treatment of IBS in female patients. One study was a three armed RCT comparing individualised homeopathic treatment to supportive listening or usual care. The risk of bias in three studies (the two studies assessing clinical homeopathy and the study comparing individualised homeopathic treatment to usual care) was unclear on most criteria and high for selective reporting in one of the clinical homeopathy studies. The three armed study comparing individualised homeopathic treatment to usual care and supportive listening was at low risk of bias in four of the domains and high risk of bias in two (performance bias and detection bias).A meta-analysis of the studies assessing clinical homeopathy, (171 participants with IBS-C) was conducted. At short-term follow-up of two weeks, global improvement in symptoms was experienced by 73% (46/63) of asafoetida participants compared to 45% (30/66) of placebo participants (RR 1.61, 95% CI 1.18 to 2.18; 2 studies, very low certainty evidence). In the other clinical homeopathy study at two weeks, 68% (13/19) of those in the asafoetida plus nux vomica arm and 52% (12/23) of those in the placebo arm experienced a global improvement in symptoms (RR 1.31, 95% CI 0.80 to 2.15; very low certainty evidence). In the study comparing individualised homeopathic treatment to usual care (N = 20), the mean global improvement score (feeling unwell) at 12 weeks was 1.44 + 4.55 (n = 9) in the individualised homeopathic treatment arm compared to 1.41 + 1.97 (n=11) in the usual care arm (MD 0.03; 95% CI -3.16 to 3.22; very low certainty evidence).In the study comparing individualised homeopathic treatment to usual care, the mean IBS symptom severity score at 6 months was 210.44 + 112.4 (n = 16) in the individualised homeopathic treatment arm compared to 237.3 + 110.22 (n = 60) in the usual care arm (MD -26.86, 95% CI -88.59 to 34.87; low certainty evidence). The mean quality of life score (EQ-5D) at 6 months in homeopathy participants was 69.07 (SD 17.35) compared to 63.41 (SD 23.31) in usual care participants (MD 5.66, 95% CI -4.69 to 16.01; low certainty evidence).For In the study comparing individualised homeopathic treatment to supportive listening, the mean IBS symptom severity score at 6 months was 210.44 + 112.4 (n = 16) in the individualised homeopathic treatment arm compared to 262 + 120.72 (n = 18) in the supportive listening arm (MD -51.56, 95% CI -129.94 to 26.82; very low certainty evidence). The mean quality of life score at 6 months in homeopathy participants was 69.07 (SD 17.35) compared to 63.09 (SD 24.38) in supportive listening participants (MD 5.98, 95% CI -8.13 to 20.09; very low certainty evidence).None of the included studies reported on abdominal pain, stool frequency, stool consistency, or adverse events. AUTHORS' CONCLUSIONS: The results for the outcomes assessed in this review are uncertain. Thus no firm conclusions regarding the effectiveness and safety of homeopathy for the treatment of IBS can be drawn. Further high quality, adequately powered RCTs are required to assess the efficacy and safety of clinical and individualised homeopathy for IBS compared to placebo or usual care.


Asunto(s)
Homeopatía/métodos , Síndrome del Colon Irritable/terapia , Fitoterapia/métodos , Estreñimiento/etiología , Estreñimiento/terapia , Fibras de la Dieta/uso terapéutico , Femenino , Humanos , Masculino , Calidad de Vida , Ensayos Clínicos Controlados Aleatorios como Asunto
18.
Recurso de Internet en Español | LIS - Localizador de Información en Salud | ID: lis-LISBR1.1-46739

RESUMEN

Hablando de Homeopatía nace como UNA RESPUESTA A LA DEMANDA CRECIENTE DE INFORMACIÓN FIABLE, VERAZ Y RIGUROSA SOBRE LA HOMEOPATÍA por parte de profesionales y pacientes.


Asunto(s)
Homeopatía , Terapéutica Homeopática , Clínica Homeopática
19.
Recurso Educacional Abierto en Portugués | ID: oer-3851

RESUMEN

Telessaúde Brasil Redes Mato Grosso do Sul

20.
Phytochemistry ; 167: 112086, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31450092

RESUMEN

The worldwide-cultivated chicory (Cichorium intybus L.) produces food and beneficial compounds, and young pre-flowering inflorescence stems are newly marketed vegetables. These sink-organs undergo growth by metabolizing sugars of leaf origin; the carbohydrate content and sweetness are crucial aspects for consumers' nutrition and acceptance. NMR profiling of 31 hydrosoluble phytochemicals showed that stem contents varied as influenced by genotype, environment and interaction, and that higher sucrose levels were associated with the sweeter of two landraces. Integrative analyses of metabolic and transcriptomic profile variations allowed the dissection of sucrose pathway. Overall, 427 and 23 unigenes respectively fell into the categories of sucrose metabolism and sugar carriers. Among 10 differentially expressed genes, the 11474/sucrose synthase, 53458/fructokinase, 9306 and 17035/hexokinases, and 20171/SWEET-type genes significantly associated to sugar content variation, and deduced proteins were characterised in silico. Correlation analyses encompassing sugar level variation, expressions of the former genes and of computationally assigned transcription factors (10938/NAC, 14712/bHLH, 40133/TALE and 17846/MIKC) revealed a gene network. The latter was minimally affected by the environment and accomplished with markers, representing a resource for biological studies and breeding.


Asunto(s)
Achicoria/genética , Achicoria/metabolismo , Perfilación de la Expresión Génica , Metabolómica , Tallos de la Planta/metabolismo , Sacarosa/metabolismo , Redes Reguladoras de Genes/genética , Genes de Plantas/genética
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