Model for managing scientific research in a public hospital: case study: Chilean National Cancer Institute, from 2015-2022.

Research is an essential element in the practice of healthcare, and hospitals play a fundamental role in its promotion. Research in hospitals can improve the quality of care, knowledge of diseases and the discovery of new therapies. Hospitals can conduct research in various fields, including basic research, clinical research, population-based research and even hospital management research. The findings of hospital research can be directly applied to clinical practice and management, thereby enhancing the quality of patient care, a central paradigm in translational health. This article details the experience of the National Cancer Institute of Chile over the past 8 years in its role as a high-complexity public hospital, specialised institute, healthcare centre, teaching institution, and research facility. It reviews the work of generating and strengthening its institutional research model since its redesign in 2018, the key elements that underpin it, and discusses the challenges the institute faces in its growth amidst the increasing cancer epidemiology in Chile, the recent enactment of a National Cancer Law, the post-pandemic scenario that has left a significant waiting list of oncology patients, and the initiation of the design and construction process for the new institute building.

Sistematización de estudios sobre la utilidad de la lateralidad en los deportes de combate

El proyecto "Estudio de patrones de lateralidad de atletas elites de Cuba" tiene como objetivo el diagnóstico, la caracterización y la valoración de los patrones de lateralidad de atletas activos y retirados con altos resultados deportivos, pero hasta el momento se adolece de una profundización en la utilidad que puede tener la lateralidad en la preparación técnico-táctica en los deportes de combate, por lo que el objetivo de este artículo fue sistematizar las principales investigaciones relacionadas con la utilización de la lateralidad en estos deportes. Para ello, se emplearon los métodos inductivo-deductivo, análisis-síntesis y revisión bibliográfica con el fin de determinar los antecedentes e interpretar las principales investigaciones referentes sobre esta temática. Se concluyó que entre los principales aspectos abordados estuvieron: las ventajas competitivas de los deportistas zurdos, el volumen técnico que se realizó en competiciones, la caracterización del deportista de acuerdo a sus preferencias laterales y cómo estas influyen en el rendimiento deportivo. Sin embargo, no se apreció estudio alguno referido a la utilización de los patrones de la lateralidad en la preparación técnico-táctica en los deportes de combate, lo que devino en carencia, para el estudio de estas disciplinas deportivas.

O projeto "Estudo dos padrões de lateralidade de atletas de elite em Cuba" tem como objetivo diagnosticar, caracterizar e avaliar os padrões de lateralidade de atletas ativos e aposentados com altos resultados esportivos, mas até agora não houve um estudo aprofundado da utilidade que a lateralidade pode ter na preparação técnico-táctica em esportes de combate, portanto o objetivo deste artigo foi sistematizar as principais pesquisas relacionadas com o uso da lateralidade nestes esportes. Para este fim, foram utilizados os métodos indutivo-deducativo, análise-síntese e revisão bibliográfica a fim de determinar os antecedentes e interpretar as principais pesquisas sobre este assunto. Concluiu-se que entre os principais aspectos abordados estavam: as vantagens competitivas dos atletas canhotos, o volume técnico realizado nas competições, a caracterização do atleta de acordo com suas preferências laterais e como estas influenciam o desempenho esportivo. Entretanto, não foi encontrado nenhum estudo sobre o uso de padrões de lateralidade na preparação técnico-táctica em esportes de combate, o que resultou em uma falta de estudo destas disciplinas esportivas.

The project "Study of laterality patterns of elite athletes in Cuba" has as its objective the diagnosis, characterization and assessment of laterality patterns of active and retired athletes with high sports results, but so far it lacks a deepening in the usefulness that laterality can have in the technical-tactical preparation in combat sports, so the objective of this article was to systematize the main researches related to the use of laterality in these sports. For this, the inductive-deductive, analysis-synthesis and bibliographic review methods were used in order to determine the background and interpret the main reference research on this subject. It was concluded that among the main aspects addressed were: the competitive advantages of left-handed athletes, the technical volume that was carried out in competitions, the characterization of the athlete according to their lateral preferences and how they influence sports performance. However, no study was observed regarding the use of laterality patterns in technical-tactical preparation in combat sports, which became a lack, for the study of these sports disciplines.

Room-Temperature C-C σ-Bond Activation of Biphenylene Derivatives on Cu(111).

Activating the strong C-C σ-bond is a central problem in organic synthesis. Directly generating activated C centers by metalation of structures containing strained four-membered rings is one maneuver often employed in multistep syntheses. This usually requires high temperatures and/or precious transition metals. In this paper, we report an unprecedented C-C σ-bond activation at room temperature on Cu(111). By using bond-resolving scanning probe microscopy, we show the breaking of one of the C-C σ-bonds of a biphenylene derivative, followed by insertion of Cu from the substrate. Chemical characterization of the generated species was complemented by X-ray photoemission spectroscopy, and their reactivity was explained by density functional theory calculations. To gain further insight into this unique reactivity on other coinage metals, the reaction pathway on Ag(111) was also investigated and the results were compared with those on Cu(111). This study offers new synthetic routes that may be employed in the in situ generation of activated species for the on-surface synthesis of novel C-based nanostructures.

Short communication: HIV incidence among vulnerable populations in Honduras: results from an integrated behavioral and biological survey among female sex workers, men who have sex with men, and Garifuna in Honduras, 2006.

Honduras has one of the highest HIV prevalence rates in Central America. Data on HIV incidence are needed to identify groups at greatest need of prevention interventions to inform the national HIV response. We applied a test for recent infection to HIV-positive specimens from a biological and behavioral survey to estimate assay-derived incidence among men who have sex with men (MSM), female sex workers (FSW), and the Garifuna population in Honduras. Assay-derived estimates were compared to the mathematically modeled estimates in the same populations to assess plausibility of the assay-based estimates. Assay-derived incidence was 1.1% (95% CI 0.2-2.0) among MSM, 0.4% (95% CI 0.1-0.8) among the Garifuna, and 0% (95% CI 0-0.01) among FSWs. The modeled incidence estimates were similar at 1.03% among MSM, 0.30% among the Garifuna, and 0.23% among FSWs. HIV incidence based on the assay was highest among MSM in Honduras, lowest among FSWs, and similar to modeled incidence in these groups. Targeted programs on HIV prevention, care, and treatment are urgently needed for the MSM population. Continued support for existing prevention programs for FSWs and Garifuna are recommended.

High rates of STD and sexual risk behaviors among Garífunas in Honduras.

BACKGROUND: Honduras has the highest concentration of HIV and AIDS cases in Central America, with an estimated adult HIV prevalence of 1.5%. Prevalence is higher among certain ethnic groups such as the Garífuna with a reported HIV prevalence of 8%. METHODS: A biological and behavioral survey was conducted on a stratified random sample of the Garífuna population in Honduras, using computer-assisted interviews. Blood was tested for HIV, herpes simplex type 2 (HSV-2), and syphilis; urine was tested for Chlamydia trachomatis, Neisseria gonorrhoea, Trichomonas vaginalis, and Mycoplasma genitalum. RESULTS: We enrolled a total of 817 participants, 41% female and 51% male. Estimated prevalences and 95% confidence intervals (CI) were: HIV, 4.5% (95% CI: 3.0 to 6.6), HSV-2, 51.1% (95% CI: 46.7 to 55.6), and syphilis seropositivity, 2.4% (95% CI: 1.4 to 4.0). Sexually transmitted infections in urine were: chlamydia, 6.8% (95% CI: 4.7 to 9.7), gonorrhea, 1.1% (95% CI: 0.4 to 2.9), trichomoniasis, 10.5% (95% CI: 8.1 to 13.6), and Mycoplasma genitalium, 7.1% (95% CI: 5.1 to 9.9). Consistent condom use was low with stable (10.6%) and casual (41.4%) partners. In multivariate analysis, HIV was associated with rural residence. HSV-2 was associated with female sex, older age, and syphilis seropositivity. CONCLUSIONS: We found a moderate prevalence of HIV and a high prevalence of HSV-2 among the Garífunas. HSV-2 may increase the vulnerability of these populations to HIV in the future. Intervention strategies should emphasize sexually transmitted infection control and condom promotion, specifically targeting the Garífuna population.

Encefalitis aguda. estudio de 20 casos / Acute encephalitis: study of 20 cases

Se realiza un estudio de 20 niños con encefalitis aguda que ingresan en la Unidad de Ciudados Intensivos Pediátricos durante los años 1984-1985. En nuestro estudio existe un predominio del 70

del sexo femenino y predomina la causa viral con una relación 4 a 1 sobre la bacteriana. Los principales signos y síntomas al ingreso fueron: fiebre, vómitos, convulsiones, toma de sensorio y cefalia. El manitol al 20

es el único medicamento utilizado en todos los casos, y se aplica tratamiento con hidrocortizona, difenilhidantoina y faustán a más de 60

de estos pacientes; se destaca que en 6 de ellos es necesario la utilización de ventilación mecánica. La complicación más frecuente es el estado convulsivo y la insuficiencia respiratoria aguda, considerándose que en general presentan una estadia hospitalaria alta. En nuestros pacientes sólo hubo un fallecido

Encefalitis aguda: estudio de 20 casos / Acute encephalitis: study of 20 cases

Se realiza un estudio de 20 niños con encefalitis aguda que ingresan en la Unidad de Ciudados Intensivos Pediátricos durante los años 1984-1985. En nuestro estudio existe un predominio del 70 % del sexo femenino y predomina la causa viral con una relación 4 a 1 sobre la bacteriana. Los principales signos y síntomas al ingreso fueron: fiebre, vómitos, convulsiones, toma de sensorio y cefalia. El manitol al 20 % es el único medicamento utilizado en todos los casos, y se aplica tratamiento con hidrocortizona, difenilhidantoina y faustán a más de 60 % de estos pacientes; se destaca que en 6 de ellos es necesario la utilización de ventilación mecánica. La complicación más frecuente es el estado convulsivo y la insuficiencia respiratoria aguda, considerándose que en general presentan una estadia hospitalaria alta. En nuestros pacientes sólo hubo un fallecido