Hospitalización por tos ferina en España (1997-2011) / Hospitalization due to whooping cough in Spain (1997-2011)

INTRODUCCIÓN: La tos ferina ha aumentado su incidencia en los últimos años en países con elevadas coberturas de vacunación. El objetivo del estudio ha sido conocer el impacto sanitario de la tos ferina en España en el período 1997-2011 en relación con hospitalizaciones, la mortalidad y los costes asociados. MÉTODOS: Se analizaron de forma retrospectiva las altas hospitalarias incluidas en el Conjunto Mínimo Básico de Datos (CMBD) en España del periodo 1997-2011, con diagnóstico principal o secundarios relacionados con tos ferina. Se calcularon las tasas de incidencia de hospitalización por tos ferina (por 100.000 habitantes) por año, por grupo de edad y por comunidad autónoma, así como las tasas de mortalidad y de letalidad. RESULTADOS: Entre 1997 y 2011 se registraron en España 8.331 altas hospitalarias con diagnóstico de tos ferina. La incidencia global de hospitalizaciones por tos ferina fue de 1,3 casos por 100.000 habitantes. El 92% de las hospitalizaciones correspondieron a niños menores de un año de edad, con una incidencia de 115,2 hospitalizaciones por 100.000 nacidos. Se registraron 47 defunciones, 37 (79%) en el grupo de menores de un año y 6 (13%) en el grupo de mayores de 65 años. El coste estimado de una hospitalización por tos ferina fue de 1.841 euros. CONCLUSIÓN: La epidemiología de los casos graves de tos ferina y su impacto clínico y económico confirman la necesidad de modificar las estrategias de vacunación en España para lograr un control más efectivo en los grupos más vulnerables

INTRODUCTION: Pertussis incidence has increased in recent years in countries with high vaccination coverage. The aim of this study was to determine the health impact of pertussis in Spain in the period 1997-2011 in relation to hospitalizations, mortality, and associated costs. METHODS: We retrospectively analyzed hospital discharges included in the Minimum Data Set (MDS) in Spain for the period 1997-2011, with a primary or secondary diagnosis related to pertussis. We calculated incidence rates of hospitalization for pertussis (per 100,000) per year, by age group and by Autonomous Region, along with the mortality and lethality rates. RESULTS: A total of 8,331 hospital discharges with a diagnosis of pertussis were recorded in Spain between 1997 and 2011. The overall incidence of pertussis hospitalizations was 1.3 cases per 100,000 inhabitants. The large majority (92%) of hospitalizations occurred in children under one year of age, with an incidence of 115.2 hospitalizations per 100,000. There were 47 deaths, 37 (79%) in the group of children under 1 year and 6 (13%) in the group older than 65 years. The estimated cost of hospitalization for pertussis was 1,841 euros. CONCLUSION: The epidemiology of severe cases of pertussis, and its clinical and economic impact, confirms the need to modify the vaccination strategies for Spain to achieve more effective control in the most vulnerable groups

[Hospitalization due to whooping cough in Spain (1997-2011)]. / Hospitalización por tos ferina en España (1997-2011).

INTRODUCTION: Pertussis incidence has increased in recent years in countries with high vaccination coverage. The aim of this study was to determine the health impact of pertussis in Spain in the period 1997-2011 in relation to hospitalizations, mortality, and associated costs. METHODS: We retrospectively analyzed hospital discharges included in the Minimum Data Set (MDS) in Spain for the period 1997-2011, with a primary or secondary diagnosis related to pertussis. We calculated incidence rates of hospitalization for pertussis (per 100,000) per year, by age group and by Autonomous Region, along with the mortality and lethality rates. RESULTS: A total of 8,331 hospital discharges with a diagnosis of pertussis were recorded in Spain between 1997 and 2011. The overall incidence of pertussis hospitalizations was 1.3 cases per 100,000 inhabitants. The large majority (92%) of hospitalizations occurred in children under one year of age, with an incidence of 115.2 hospitalizations per 100,000. There were 47 deaths, 37 (79%) in the group of children under 1 year and 6 (13%) in the group older than 65 years. The estimated cost of hospitalization for pertussis was 1,841 euros. CONCLUSION: The epidemiology of severe cases of pertussis, and its clinical and economic impact, confirms the need to modify the vaccination strategies for Spain to achieve more effective control in the most vulnerable groups.

Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty.

BACKGROUND: The Peptide YY (PYY) secretion pattern was assessed in morbidly obese (MO) patients before and after vertical banded gastroplasty (VBG). METHODS: 12 MO patients (10 women, 2 men) age 29-62 years, BMI 50.7 +/- 9.6 kg/m2, treated with a VBG were studied. Before surgery, blood samples were taken in basal conditions of fasting and 10, 15, 20, 30 and 60 min after the ingestion of a semiliquid test meal. This was repeated in the same patients 6 and 12 months after VBG. Blood samples were also taken from 6 healthy non-obese subjects as controls. PYY plasma concentration was measured by radioimmunoassay with I125. RESULTS: There were statistically significant differences between the preoperative PYY concentration in MO patients compared to controls. After a VBG, PYY concentration varied significantly compared to the preoperative levels. There was no significant difference between the PYY concentrations in the MO patients after VBG and the controls. CONCLUSION: PYY concentration is lower in MO patients compared with non-obese. After VBG, PYY concentration gradually rises to the control levels.