Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries.

Objective: Inflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the risk for malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents the archetype of innate immunity deregulation. Therefore, the aim of this study is to investigate the risk for cancer development in FMF. Methods: The risk ratio (RR) for malignancies was separately compared between FMF patients and fibromyalgia subjects, Still's disease patients and Behçet's disease patients. Clinical variables associated with cancer development in FMF patients were searched through binary logistic regression. Results: 580 FMF patients and 102 fibromyalgia subjects, 1012 Behçet's disease patients and 497 Still's disease patients were enrolled. The RR for the occurrence of malignant neoplasms was 0.26 (95% Confidence Interval [CI.] 0.10-0.73, p=0.006) in patients with FMF compared to fibromyalgia subjects; the RR for the occurrence of malignant cancer was 0.51 (95% CI. 0.23-1.16, p=0.10) in FMF compared to Still's disease and 0.60 (95% CI. 0.29-1.28, p=0.18) in FMF compared to Behçet's disease. At logistic regression, the risk of occurrence of malignant neoplasms in FMF patients was associated with the age at disease onset (ß1 = 0.039, 95% CI. 0.001-0.071, p=0.02), the age at the diagnosis (ß1 = 0.048, 95% CI. 0.039-0.085, p=0.006), the age at the enrolment (ß1 = 0.05, 95% CI. 0.007-0.068, p=0.01), the number of attacks per year (ß1 = 0.011, 95% CI. 0.001- 0.019, p=0.008), the use of biotechnological agents (ß1 = 1.77, 95% CI. 0.43-3.19, p=0.009), the use of anti-IL-1 agents (ß1 = 2.089, 95% CI. 0.7-3.5, p=0.002). Conclusions: The risk for cancer is reduced in Caucasic FMF patients; however, when malignant neoplasms occur, this is more frequent in FMF cases suffering from a severe disease phenotype and presenting a colchicine-resistant disease.

Association between rational drug use and health literacy among pregnant women: a cross-sectional study.

Pregnant women should know rational drug use and have enough health literacy both for maternal and fetal health. This study was carried out to examine the rational drug use knowledge and health literacy levels of pregnant women and the relationship between these two variables. A cross-sectional design was used in the study, and it was conducted between July 31 and September 30, 2019 with the participation of 417 pregnant women in Turkey. The cluster sampling method was used for selecting participants. The data collection tools included a Descriptive Information Form, the Rational Drug Use Scale, and the European Health Literacy Survey. The study data were collected by using the face-to-face interview method. In the study, 77.7 percent of the pregnant women knew rational drug use, but 41.2 percent of them had inadequate and 39.8 percent had a problematic-limited level of health literacy. According to the linear regression analysis, it was found that rational drug use was positively affected by the health literacy level and that a one-unit increase in health literacy level of pregnant women increased the level of rational drug use knowledge by 0.190 (ß) units (p < .05). It was found that although more than three quarters of the pregnant women in the study knew rational drug use, their health literacy was inadequate and at a problematic-limited level. This study showed that the health literacy of pregnant women affected their knowledge of rational drug use, and as the level of health literacy increased, the level of rational drug use knowledge increased, as well.

The effect of oxytocin massage and music on breast milk production and anxiety level of the mothers of premature infants who are in the neonatal intensive care unit: A self-controlled trial.

This study was conducted to evaluate the effect of music and oxytocin massage on production and anxiety in mothers of premature infants. The study was designed in the self-controlled trial type and conducted with 73 mothers. The anxiety scores of mothers decreased in the oxytocin massage and the music interventions, and the amount of their breast milk secretion increased (p < 0.05). Music and oxytocin massage has a positive effect on increasing breast milk and decreasing the anxiety of mothers.

Depression in health college students: relationship factors and sleep quality.

This research was conducted to determine depression symptom frequency in health sciences students (n = 445), to investigate sleep quality and some related factors. In this study of the students approximately one fifth of the students showed depressive symptom. Students with poor academic performance, poor economic status, smoking or alcohol use, chronic illness or mental problems are more likely to experience depression. As sleep quality deteriorates, the level of depression also increases. The risk of depressive symptoms in students with poor sleep quality was 3.28 times.

Educational Study to Increase Breast Cancer Knowledge Level and Scanning Participation among Women Working at a University.

OBJECTIVE: The aim of the study is to increase the participation level of women in screening programs by increasing the level of knowledge about early diagnosis and screening methods for breast cancer (BC). MATERIALS AND METHODS: This was a pretest-posttest one group design study held in Eskisehir Osmangazi University, Turkey. The sample consisted of 405 women in all departments of the University. Data were collected using socio-demographic forms and questionnaires. Training about BC was provided for participants. The questionnaire used prior to the training to measure levels of knowledge about BC was re-administered 3 weeks after the training. RESULTS: The women were most commonly aware of the breast self-examination (68.1%). The ratio of women who had had mammography in the previous year was 11.4%. The BC knowledge level significantly increased after the training (p=0.001). CONCLUSION: This study determined that the level of knowledge about BC in terms of early detection and screening was low and that the percentage of participation in screening was also low.