RESUMEN
The aim of this work is to analytically study the thermo-mechanical response of two-dimensional skin tissues when subjected to instantaneous heating. A complete understanding of the heat transfer process and the associated thermal and mechanical effects on the patient's skin tissues is critical to ensuring the effective applications of thermal therapy techniques and procedures. The surface boundary of the half-space undergoes a heat flux characterized by an exponentially decaying pulse, while maintaining a condition of zero traction. The utilization of Laplace and Fourier transformations is employed, and the resulting formulations are then applied to human tissues undergoing regional hyperthermia treatment for cancer therapy. To perform the inversion process for Laplace and Fourier transforms, a numerical programming method based on Stehfest numerical inverse method is employed. The findings demonstrate that blood perfusion rate and thermal relaxation time significantly influence all the analyzed distributions. Numerical findings suggest that thermo-mechanical waves propagate through skin tissue over finite distances, which helps mitigate the unrealistic predictions made by the Pennes' model.
Asunto(s)
Hipertermia Inducida , Modelos Biológicos , Humanos , Conductividad Térmica , Piel , Hipertermia Inducida/métodos , Temperatura Cutánea , CalorRESUMEN
Continuous release of image databases with fully or partially identical inner categories dramatically deteriorates the production of autonomous Computer-Aided Diagnostics (CAD) systems for true comprehensive medical diagnostics. The first challenge is the frequent massive bulk release of medical image databases, which often suffer from two common drawbacks: image duplication and corruption. The many subsequent releases of the same data with the same classes or categories come with no clear evidence of success in the concatenation of those identical classes among image databases. This issue stands as a stumbling block in the path of hypothesis-based experiments for the production of a single learning model that can successfully classify all of them correctly. Removing redundant data, enhancing performance, and optimizing energy resources are among the most challenging aspects. In this article, we propose a global data aggregation scale model that incorporates six image databases selected from specific global resources. The proposed valid learner is based on training all the unique patterns within any given data release, thereby creating a unique dataset hypothetically. The Hash MD5 algorithm (MD5) generates a unique hash value for each image, making it suitable for duplication removal. The T-Distributed Stochastic Neighbor Embedding (t-SNE), with a tunable perplexity parameter, can represent data dimensions. Both the Hash MD5 and t-SNE algorithms are applied recursively, producing a balanced and uniform database containing equal samples per category: normal, pneumonia, and Coronavirus Disease of 2019 (COVID-19). We evaluated the performance of all proposed data and the new automated version using the Inception V3 pre-trained model with various evaluation metrics. The performance outcome of the proposed scale model showed more respectable results than traditional data aggregation, achieving a high accuracy of 98.48%, along with high precision, recall, and F1-score. The results have been proved through a statistical t-test, yielding t-values and p-values. It's important to emphasize that all t-values are undeniably significant, and the p-values provide irrefutable evidence against the null hypothesis. Furthermore, it's noteworthy that the Final dataset outperformed all other datasets across all metric values when diagnosing various lung infections with the same factors.
Asunto(s)
COVID-19 , Neumonía , Humanos , COVID-19/diagnóstico por imagen , Rayos X , Neumonía/diagnóstico por imagen , Algoritmos , Pulmón/diagnóstico por imagenRESUMEN
This paper presents an analytical approach associated with Laplace transformation, experimental temperature data, and a sequential concept over time to obtain the thermal damage and the temperature in a living tissue due to laser irradiation. The analytical solutions in the Laplace domain are appreciably obtainable. The thermal damage to the tissue is completely assessed by the denatured protein range using the formulation of Arrhenius. Numerical outcomes for temperatures and the thermal damages are graphically introduced. Besides, the comparison between the numerical computations and the existing experimental study shows that a current mathematical model is an effective tool for evaluating the biological heat transfer in biological tissues.
Asunto(s)
Calor , Rayos Láser , Modelos Biológicos , Fenómenos Fisiológicos de la Piel , Desnaturalización Proteica , Conductividad TérmicaRESUMEN
In the present paper, the bioheat equation under fractional derivatives is used to study the thermal damage within the skin tissue during the thermal therapy. Basically, the analytical solutions in the Laplace domain are easily obtainable. The influences of the fractional derivative and moving heat source velocity on the temperature of skin tissues and the thermal injuries are precisely investigated. The outcomes show that the fractional bioheat model are reduced to the hyperbolic and parabolic bioheat models when the fractional order parameter is equal to one and the relaxation time is close to zero respectively. The thermal injuries to the tissue are assessed by the denatured protein range using the formulation of Arrhenius. The numerical outcomes of thermal injuries and temperatures are graphically introduced. In conclusion, a parametric analysis is devoted to the identification of an appropriate procedure for selecting important design variables to reach effective heating in hyperthermia treatment.