RESUMEN
In the present study, a new hydrazone ligand (2-((2-phthalazin-1-yl)hydrazono)methyl)phenol) prepared by condensation of hydralazine (1-Hydralazinophthalazine) with salicylaldehyde (SAH). The synthesized SAH-hydrazone and its metal complexes have been characterized by elemental analyses, IR, (1)H NMR, solid reflectance, magnetic moment, molar conductance, mass spectra, UV-vis and thermal analysis (TGA). The analytical data of the complexes show the formation of 1:1 [M:L] ratio, where M represents Ni(II), Co(II) and Cu(II) ions, while L represents the deprotonated hydrazone ligand. IR spectra show that SAH is coordinated to the metal ions in a tridentate manner through phthalazine-N, azomethine-N and phenolic-oxygen groups. The ligand and their metal chelates have been screened for their antimicrobial activities using the disc diffusion method against the selected bacteria and fungi. Proton-ligand association constants of (SAH) and the stepwise stability constants of its metal complexes are determined potentiometrically in 0.1 M NaNO(3) at different temperatures and the corresponding thermodynamic parameters were derived and discussed. The order of -ΔG° and -ΔH° were found to obey Mn(2+)Asunto(s)
Antiinfecciosos/química
, Antiinfecciosos/farmacología
, Complejos de Coordinación/química
, Complejos de Coordinación/farmacología
, Hidrazonas/química
, Hidrazonas/farmacología
, Antiinfecciosos/síntesis química
, Bacterias/efectos de los fármacos
, Infecciones Bacterianas/tratamiento farmacológico
, Complejos de Coordinación/síntesis química
, Hongos/efectos de los fármacos
, Humanos
, Hidralazina/síntesis química
, Hidralazina/química
, Hidrazonas/síntesis química
, Micosis/tratamiento farmacológico
, Termodinámica