RESUMEN
OBJECTIVE: To estimate the potential monetary reduction induced by the introduction of an ultrasound unit in a major district hospital in a developing country. DESIGN: Propective study. SUBJECTS: Patients referred with abnominal diseases and pregnancy. SETTING: Wad Medani Teaching Hospital, Central Sudan. RESULTS: Local specialists referring the patients stated that an estimated 792 radiologic procedures would have been carried out to obtain the same amount of information as achieved by ultrasound. Such procedures budgeted approximately 8100 US dollars, in terms of equipment, material and personnel by 1987 rates. Such savings have benefited all departments of the hospital. CONCLUSION: The authors consider this as evidence for the fact that despite its initial high investment (15,000 US dollars), availability of ultrasound virtually reduced expenditure on other radiological diagnostic procedures. This is of special benefit for the limited budgets of hospitals in non-industrialised countries.
Asunto(s)
Países en Desarrollo , Hospitales de Distrito/economía , Hospitales de Enseñanza/economía , Ultrasonografía/economía , Gastos de Capital/estadística & datos numéricos , Ahorro de Costo , Femenino , Humanos , Personal de Hospital/economía , Personal de Hospital/provisión & distribución , Embarazo , Estudios Prospectivos , Derivación y Consulta , Sudán , Ultrasonografía/instrumentación , Ultrasonografía/estadística & datos numéricosRESUMEN
Sonographic measurements of the liver, spleen and related blood vessels were performed in 87 healthy controls and in 50 patients with periportal fibrosis (pF) as well as in 52 patients with pF and at least one episode of gastro-oesophageal bleeding due to chronic Schistosoma mansoni infection. There was a progressing shrinkage of the liver paralleled by an increasing rate of patients with a larger left than right liver lobe as involvement of pF due to S. mansoni infection progressed. This was accompanied by an increasing percentage of pathological gallbladder wall enlargement, splenomegaly and an increasing portal vein diameter. It is suggested that organomorphometrical parameters of the liver and spleen can be used for sonographical evaluation of patients with S. mansoni infection as these may be useful for their clinical assessment of the progression of disease.
Asunto(s)
Hepatomegalia/diagnóstico por imagen , Vena Porta/diagnóstico por imagen , Esquistosomiasis mansoni/complicaciones , Esplenomegalia/diagnóstico por imagen , Adulto , Estudios de Casos y Controles , Enfermedad Crónica , Fibrosis , Enfermedades de la Vesícula Biliar/diagnóstico por imagen , Enfermedades de la Vesícula Biliar/epidemiología , Enfermedades de la Vesícula Biliar/parasitología , Enfermedades de la Vesícula Biliar/patología , Hepatomegalia/epidemiología , Hepatomegalia/parasitología , Hepatomegalia/patología , Humanos , Vena Porta/patología , Esplenomegalia/epidemiología , Esplenomegalia/parasitología , Esplenomegalia/patología , UltrasonografíaRESUMEN
In order to compare clinical versus ultrasound based diagnosis of Schistosoma mansoni induced periportal fibrosis (pF) 536 infected Sudanese schoolchildren underwent clinical and sonographical examination. A liver exceeding 3 cm in sternal line and a palpable spleen were considered pathological. Ultrasound criteria for age dependent organometry of a Central European cohort were used as reference. Based on clinical criteria 190 children (35.4%) had hepatomegaly, whereas according to ultrasound results the rate was only 11.4%. Splenomegaly was detected in 77 cases (14.4%) by clinical means, but in 196 by ultrasound (36.6%). The sensitivity of clinical parameters as indication of pF was around 50%. Results for ultrasound detected organomegaly were only slightly better. It was concluded that assessment of liver and spleen sizes was of limited value as an indication for pF and that a considerable discrepancy existed between clinical and ultrasound based assessment of hepato- and splenomegaly.
Asunto(s)
Cirrosis Hepática/diagnóstico por imagen , Esquistosomiasis mansoni/complicaciones , Adolescente , Factores de Edad , Niño , Hepatomegalia , Humanos , Cirrosis Hepática/diagnóstico , Cirrosis Hepática/epidemiología , Morbilidad , Prevalencia , Esplenomegalia , Sudán/epidemiología , UltrasonografíaRESUMEN
Eleven patients with portal hypertension due to infection with Schistosoma mansoni underwent splenectomy and devascularization operations. The patients were examined with ultrasound once preoperatively and twice postoperatively over a period of about 6 months. Following surgery there was significant and sequential reduction in the diameter of the portal vein at the hilum and the splenic vein at the pancreas. The liver lengths and index of liver size did not change significantly. No changes in the degree of periportal fibrosis could be detected.
Asunto(s)
Hipertensión Portal/diagnóstico por imagen , Esquistosomiasis mansoni/diagnóstico por imagen , Esplenectomía , Humanos , Hipertensión Portal/parasitología , Hipertensión Portal/cirugía , Sistema Porta/diagnóstico por imagen , Esquistosomiasis mansoni/complicaciones , Esquistosomiasis mansoni/cirugía , UltrasonografíaRESUMEN
Fifty-nine patients with hepatosplenic schistosomiasis mansoni were investigated by sonography in Northeast Brazil and Central Sudan. The sizes of the organs usually involved in this disease were quantitatively assessed according to a standardized protocol, and measurements were adjusted to the body height of the individual. The results were compared with those of healthy controls matched by sex, age, geographical origin and socio-economic status. Considerable differences were found between patients and controls as well as between residents from the two areas. The liver of both patients and controls from the Sudan was significantly smaller than that of patients and controls from Brazil. Only in Brazil, but not in the Sudan, was the left liver lobe larger in patients than in the controls. The diameter of the portal and the splenic vein, the spleen size and the thickness of the gallbladder wall were significantly increased in patients from both areas. The increase of the portal and splenic vein diameter was significantly correlated with the degree of hepatic periportal fibrosis and the frequency of bleeding from endoscopically proven oesophageal varices in the patients, irrespective of their geographic origin. In contrast, such correlations were not found for the degree of splenomegaly nor for the degree of gallbladder-wall thickening. It is concluded that standardized sonographic organometry permits the assessment of morbidity in hepatosplenic schistosomiasis mansoni under different endemic conditions. Especially the measurement of the portal vein diameter may allow estimation of the risk of gastrointestinal haemorrhage in these patients.
Asunto(s)
Várices Esofágicas y Gástricas/etiología , Hemorragia Gastrointestinal/etiología , Parasitosis Hepáticas/diagnóstico por imagen , Esquistosomiasis mansoni/diagnóstico por imagen , Enfermedades del Bazo/diagnóstico por imagen , Adolescente , Adulto , Anciano , Brasil , Niño , Femenino , Humanos , Parasitosis Hepáticas/complicaciones , Masculino , Persona de Mediana Edad , Factores de Riesgo , Esquistosomiasis mansoni/complicaciones , Enfermedades del Bazo/complicaciones , Sudán , UltrasonografíaRESUMEN
To improve diagnostic capabilities, an ultrasound unit was installed at a major hospital in Wad Medani, Sudan. During the implementation period (October 1986 to March 1987) of ultrasound service, 863 patients were examined cooperatively by Sudanese and German physicians. The service covered internal medicine (47.5%), obstetrics and gynecology (31.6%), surgery (12.5%), and pediatrics (8.4%). Pathologic findings were seen in 75% of the patients. In obstetrics, the rate of pathologic findings was 40%. Five hundred eighty-three pathologic findings were detected in organ systems that constituted the primary indication for ultrasonography (of a total of 1,009 indications). The clinical benefit of ultrasonography was evaluated in 289 randomly selected patients in a standardized questionnaire completed by the attending physicians. The final clinical diagnosis was established or substantially revised in 21.5% of the patients, based on the ultrasonographic report. The previously reported diagnosis was supported in 69.5% of the patients. Medical management was directly influenced in 26% of the patients. We conclude that the clinical benefit of ultrasonography at a district hospital in the tropics is substantial, providing cost-effective, immediate therapeutic benefits in 25% of the patients examined. The technique thereby contributes to better and more rational patient management in institutions with limited resources.
Asunto(s)
Hospitales de Enseñanza/métodos , Medicina Tropical , Ultrasonografía Prenatal , Ultrasonografía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Medicina Interna , Masculino , Persona de Mediana Edad , Servicio de Ginecología y Obstetricia en Hospital , Pediatría , Embarazo , Servicio de Cirugía en Hospital , Clima TropicalRESUMEN
The housemanship performance of the first two classes of the University of Gezira Medical School was assessed on 107 occasions by using a questionnaire administered to the senior doctors (consultants) in the units in which they worked and the data, which covered 32% of all housemanship rotations taken by these graduates, were analysed. On a 5-point scale (poor to excellent) the rating of performance for 26 questions was average and above (S = 3: + S = 4: + S = 5) in 95% of instances. The good and excellent rating (S = 4 + S = 5) for the same questions was about 80%. The grand mean for rating of questions in the cognitive, psychomotor and attitudes domain was 4.1, 3.9 and 4.2 out of 5 respectively. The graduates were found to be better off (45%), comparable to (50%) and less than (5%) when compared to other graduates who worked with the same consultants in the past. Results of three general questions inquiring about graduates' practice safety, overall standing and consultants' preference for Gezira graduates had a 95% positive rating. It is concluded that these results provide significant positive answers for some basic questions concerning credibility which are often raised about Gezira and similar schools with innovative medical curricula.
Asunto(s)
Competencia Clínica , Medicina Comunitaria/normas , Educación de Postgrado en Medicina , Cuerpo Médico de Hospitales/normas , Medicina Comunitaria/educación , Egipto , HumanosRESUMEN
49 Sudanese schoolchildren aged 6-9 years with Schistosoma mansoni infection were ultrasonographically examined by two independent observers in a double-blind fashion. The first observer recorded normal appearance of the liver in 23 cases, whereas the second observer recorded the appearance as normal in 33 cases. There were 23 concordant observations. For Grade I periportal fibrosis (PF), 13 observations were concordant. PF Grade II was rarely observed (2 versus 3 cases), and Grade III was not recorded at all. In total, 38 out of 49 observations were concordant (77.5%). These preliminary data from two ultrasound observers, from observations on a limited number of patients, can be seen as an indication of a potential inter-observer variation of around 20% for the distinction between the absence of PF and a low level of PF.
Asunto(s)
Parasitosis Hepáticas/diagnóstico por imagen , Esquistosomiasis mansoni/diagnóstico por imagen , Niño , Humanos , Variaciones Dependientes del Observador , Proyectos Piloto , Sudán , UltrasonografíaRESUMEN
In February 1987, 322 Sudanese school children were diagnosed for Schistosoma mansoni infection and treated randomly with praziquantel (either 20 mg/kg or 40 mg/kg body weight). A followup of these subjects was carried out in January 1989. This treatment resulted in a substantial reduction of egg output. Patients underwent complete abdominal ultrasonography and periportal fibrosis of the liver was graded into three degrees of severity. The proportion of patients with periportal fibrosis decreased from 36.6% in February 1987 to 21.7% in January 1989. At the time of followup, higher grades of periportal fibrosis (grades II and III) were encountered in only 4.3% and 0.3% of these patients, respectively, compared with 21.1% and 5.9%, respectively, before therapy. This was paralleled by a significant decrease in hepatomegaly from 10.9% to 7% of the patients. In contrast, the rate of splenomegaly showed a slight increase during the period of observation. The different dosage regimens of praziquantel did not result in a significantly different reversibility of periportal fibrosis or a decrease in egg excretion. The reversibility of specific liver lesions 23 months after antischistosomal therapy with praziquantel was substantial. The improvement was greater at 23 months than that obtained seven months after treatment.
Asunto(s)
Vena Porta/diagnóstico por imagen , Praziquantel/uso terapéutico , Esquistosomiasis mansoni/tratamiento farmacológico , Adolescente , Niño , Heces/parasitología , Fibrosis , Estudios de Seguimiento , Humanos , Hígado/diagnóstico por imagen , Morbilidad , Recuento de Huevos de Parásitos , Vena Porta/patología , Distribución Aleatoria , Esquistosomiasis mansoni/complicaciones , Esquistosomiasis mansoni/diagnóstico por imagen , Bazo/diagnóstico por imagen , Esplenomegalia , UltrasonografíaRESUMEN
An analysis of Sudan's health system revealed a lack of sound leadership for village-level providers. The district-based peripheral health system was failing to meet an increased demand for leadership and management support. Some of the principal factors explaining this state of affairs were population growth, increased numbers of health units, long distances and transport difficulties. With a view to solving these problems, the country was divided into smaller health areas around rural hospitals and similar physician-led facilities. A decentralized system based on the principles of primary care was established in these areas under health area management teams. Setbacks encountered in giving effect to the policy have led to proposals for a new implementation strategy.
PIP: Despite Sudan's commitment to primary health care, considerable health system weaknesses still existed in the late 1980s. For example, the health system was still operating under the organizational structure established by the former colonists and most of the allocated funds supported hospitals and salaries. The communities did not participate in primary health care activities and instead depended on official and outside funding. Lack of leadership and management support for health workers in the villages were perhaps the leading factors explaining the weaknesses. Its district-based system collapsed in the late 1970s due to population growth, transport problems in these large districts, creation of urban and rural councils to conduct administrative and decision making functions, separation of preventive and curative services (preventive services under local governments and curative services under the Ministry of Health [MOH]), decline in the national economy and in political commitment to health, increased numbers of physician specialists, and reduced numbers of physicians willing to go to rural areas. The MOH joined with Gezira University in Wad Medani, Sudan to develop a new health care policy. The National Council for Health adopted the new policy in December 1987. It decentralized the health system into 175 health areas around rural hospitals or health centers. Each area had a health area management team. The new policy was based on primary health care, community participation, and sound managerial processes. Since there was no clear national implementation plan, the regional health authorities tried to implement the new policy. Few regions did so successfully. Thus Sudan suggested that each region first implement the policy in 2-3 areas. Health workers would learn some lessons from this phase which they can apply to expand the system.
Asunto(s)
Áreas de Influencia de Salud , Planificación en Salud , Administración de los Servicios de Salud , Centros Comunitarios de Salud , Política de Salud , Hospitales Rurales , Atención Primaria de Salud , SudánRESUMEN
Five hundred thirty six Sudanese schoolchildren with Schistosoma mansoni infection were treated at random with either 20 mg or 40 mg/kg praziquantel. Seven months later 420 children could be reinvestigated by ultrasonography. Reduction of egg excretion and reversibility of sonographically-proven periportal fibrosis (PF) was not significantly different in the two groups. Schistosoma mansoni-induced PF grade II decreased from 22.9% to 6.7% and grade III from 5.2% to 1.6%. An increased prevalence of PF grade I, from 10% to 29.8% of the investigated patients, was observed. This increase was caused partly by a downshifting of patients who had PF II (n = 45) and PF III (n = 8) before therapy, but also by patients who developed PF I in the seven months after therapy (n = 56). The overall percentage of patients with PF before and after treatment was 38.1%. Of 420 children, 17.4% increased in their PF grade, 55% remained at the same level and 27.6% improved. Children younger than 11 years of age had a higher rate of complete reversibility than older ones. The percentage of patients with hepatomegaly decreased significantly (11.6% to 6.9%; p = 0.001). The rate of splenomegaly remained unchanged. It was concluded that within seven months therapy with praziquantel resulted in a considerable qualitative improvement of PF in Sudanese schoolchildren with S. mansoni infection.
Asunto(s)
Cirrosis Hepática/tratamiento farmacológico , Praziquantel/uso terapéutico , Esquistosomiasis mansoni/tratamiento farmacológico , Niño , Hepatomegalia , Humanos , Hígado/diagnóstico por imagen , Cirrosis Hepática/diagnóstico por imagen , Cirrosis Hepática/etiología , Recuento de Huevos de Parásitos , Distribución Aleatoria , Esquistosomiasis mansoni/complicaciones , Esquistosomiasis mansoni/diagnóstico por imagen , Esplenomegalia , Factores de Tiempo , UltrasonografíaRESUMEN
The hepatosplenic form of Schistosoma mansoni infection contributes considerably to morbidity and mortality in endemic areas. The present study investigated serum protein concentrations and serum enzyme activities of 58 Sudanese patients with hepatosplenic schistosomiasis. All of them had a history of infection with S. mansoni and one or several episodes of oesophageal bleeding due to portal hypertension. Diagnosis was based on clinical (n = 24), ultrasonographical (n = 18) and histological (n = 16) grounds. The control group consisted of 40 Sudanese healthy blood donors. Serum albumin was found to be significantly lower in patients with hepatosplenic schistosomiasis (median = 37 g/l) than in controls (median = 47 g/l). Serum enzyme analysis revealed only minimal alterations of cellular enzyme activities, but a marked decrease of cholinesterase activity. Serum albumin concentration correlated significantly with cholinesterase activity. We conclude that liver function in patients with schistosomiasis and portal hypertension is partially disturbed. Low serum albumin and low cholinesterase activity reflected an impaired protein synthesis of the liver. Destruction of parenchymal liver cells was mild or absent.
Asunto(s)
Proteínas Sanguíneas/análisis , Colinesterasas/sangre , Parasitosis Hepáticas/sangre , Esquistosomiasis mansoni/sangre , Enfermedades del Bazo/sangre , Adolescente , Adulto , Alanina Transaminasa/sangre , Aspartato Aminotransferasas/sangre , Femenino , Hepatitis B/complicaciones , Antígenos de Superficie de la Hepatitis B/sangre , Humanos , Parasitosis Hepáticas/enzimología , Masculino , Persona de Mediana Edad , Esquistosomiasis mansoni/complicaciones , Esquistosomiasis mansoni/enzimología , Albúmina Sérica/análisis , Enfermedades del Bazo/enzimología , gammaglobulinas/análisis , gamma-Glutamiltransferasa/sangreRESUMEN
Gallbladder function was studied in 22 patients with portal hypertension due to advanced Schistosoma mansoni infection and in 17 healthy adults. The fasting volume of the gallbladder was significantly less in patients than in controls. The gallbladder wall was grossly thickened in the study group. There was a significant difference between the patients and controls in the reduction of gallbladder volume following a fatty meal. Although the portal vein diameter and the splenic volume were significantly larger in study patients, no significant correlation could be detected between the reduction in volume or wall thickness of the gallbladder and any of the relevant sonographic features of schistosomiasis-induced portal hypertension.
Asunto(s)
Vesícula Biliar/diagnóstico por imagen , Esquistosomiasis mansoni/diagnóstico por imagen , Vesícula Biliar/patología , Vesícula Biliar/fisiopatología , Humanos , Hipertensión Portal/diagnóstico por imagen , Hipertensión Portal/etiología , Hipertensión Portal/fisiopatología , Esquistosomiasis mansoni/complicaciones , Esquistosomiasis mansoni/fisiopatología , UltrasonografíaRESUMEN
Morbidity of Schistosoma mansoni infection was assessed in 536 infected Sudanese schoolchildren using an ultrasonographical staging system for periportal fibrosis of the liver. S. mansoni ova excretion in stools was mild in 28%, moderate in 58%, and severe in 14% of the patients. Grade 1 periportal fibrosis was found in 10.3% grade 2 in 23.1%, and grade 3 in 4.7% of S. mansoni-infected children. Girls and boys were equally affected. The distribution of periportal fibrosis compared to the age of patients was homogenous. There was no significant difference of the rate of periportal fibrosis in the 3 groups of intensity of infection. However, in the 204 patients who showed periportal fibrosis, there was a strong relation between severity of ultrasonographically detectable fibrosis with intensity of egg excretion. In 332 children, of which 73 had a heavy infection, no signs of periportal fibrosis were detected. Sudanese children show a variable susceptibility towards the development of S. mansoni-induced periportal fibrosis. High risk patients can be detected at a childhood stage by measuring the intensity of infection and investigating the liver by ultrasound.
Asunto(s)
Cirrosis Hepática/patología , Hígado/patología , Esquistosomiasis mansoni/patología , Ultrasonografía , Adolescente , Niño , Heces/parasitología , Femenino , Hepatomegalia , Humanos , Cirrosis Hepática/etiología , Masculino , Recuento de Huevos de Parásitos , Esquistosomiasis mansoni/complicaciones , Bazo/patología , EsplenomegaliaRESUMEN
This study reports on the effectiveness, safety and acceptability of captopril in 36 Sudanese patients, who were classified as resistant, moderate to severe and mild according to initial diastolic blood pressure and history of treatment. The patients were titrated against a six-step captopril treatment regime with or without hydrochlorothiazide and reserpine. The median follow up period was 11.6 month. The initial median pre-treatment blood pressure was 159/101, 182/120 and 217/130 and at the end of study 125/77, 120/74 and 165/95 for the mild, severe and resistant groups respectively. Tolerance was good and side effects were mild and similar to others reported in literature. The effective daily treatment was 25-50 mg captopril for mild hypertension, 50 to 100 mg captopril with 50 mg hydrochlorothiazide for severe hypertension while it was 225 mg captopril with 50 to 100 mg hydrochlorothiazide and a need for a third drug in 30% of patients in the resistant group. These results reveal normal responsiveness to captopril among black Sudanese patients with good tolerance and safety.