The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis / Efectos del resveratrol sobre el control glucémico y los parámetros cardiometabólicos en pacientes con diabetes mellitus de tipo 2: una revisión sistemática y un metaanálisis

Background:Type 2 diabetes mellitus (T2DM) is a progressive meta-inflammatory disorder, which induce micro and macrovascular complications. Resveratrol is a nutraceutical known to have antioxidant and anti-inflammatory properties. It improves insulin resistance; however, no clear evidence regarding its effects in patients with T2DM.Objectives:We aimed to evaluate the efficacy and the safety of oral resveratrol supplementation in type 2 diabetic patients concerning dose and duration.Methods:We searched PubMed, Cochrane Library, Scopus, WOS, Wiley, and Google Scholar for RCTs evaluating the efficacy and safety of resveratrol on patients with T2DM. We screened the studies for the eligibility criteria, performed the quality assessment, extracted the studies’ characteristics, baseline, and outcome data of interest, and finally conducted the meta-analysis using RevManV5.3.Results:This systematic review and meta-analysis, including 17 RCTs with total 871 patients with T2DM, showed that resveratrol was superior to placebo on fasting blood glucose (FBG) and total cholesterol (TC) with doses ≥500mg {MD=−13.34, 95%CI [−22.73, −3.95], P=0.005}, {MD=−5.64, 95%CI [−6.95, −4.33], P<0.00001} respectively. Moreover, it improved HbA1c at three months {MD=−0.41, 95%CI [−0.65, −0.16], P=0.001 and systolic blood pressure {MD: −7.91, 95%CI [−10.44, −5.37], P<0.00001}.Conclusion:We concluded that resveratrol beneficially modulates glycemic control as well as cardiometabolic parameters in patients with T2DM. (AU)

Fundamento:La diabetes mellitus de tipo 2 (DM2) es un trastorno metainflamatorio progresivo que induce complicaciones micro- y macrovasculares. El resveratrol es un nutracéutico con propiedades antioxidantes y antiinflamatorias que, además, disminuye la resistencia a la insulina; sin embargo, no hay evidencia clara sobre sus efectos en pacientes con DM2.Objetivos:Evaluar la eficacia y la seguridad de la suplementación con resveratrol oral en pacientes con DM2 respecto a la dosis y la duración.Método:Se realizaron búsquedas en PubMed, Cochrane Library, Scopus, WOS, Wiley y Google Scholar en busca de ECA que evaluaran la eficacia y seguridad del resveratrol en pacientes con DM2. Se revisaron los estudios para determinar los criterios de elegibilidad, se hizo la evaluación de la calidad, se extrajeron las características de los estudios, los datos iniciales y los resultados de interés y, finalmente, se realizó el metaanálisis con RevManV5.3.Resultados:Esta revisión sistemática y metaanálisis, que incluyó 17 ECA con un total de 871 pacientes con DM2, mostró que el resveratrol fue superior al placebo en la glucemia en ayunas y el colesterol total con dosis ≥500mg (MD=−13,34; IC 95%: [−22,73; −3,95]; p=0,005 y MD=−5,64; IC 95%: [−6,95; −4,33]; p<0,00001), respectivamente. Además, mejoró la HbA1c a los 3 meses (DM=−0,41; IC 95%: [−0,65; −0,16]; p=0,001) y la presión arterial sistólica (DM: −7,91; IC 95%: [−10,44; −5,37]; p<0,00001).Conclusión:El resveratrol contribuye a mejorar el control glucémico, además de los parámetros cardiometabólicos, en pacientes con DM2. (AU)

The Impact of Bilastine on Symptoms of Allergic Rhinitis and Chronic Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

BACKGROUND: Allergic diseases are immunological exaggerations with symptoms that may interfere with life quality. Bilastine, a novel oral second-generation H-1 antihistamine, is highly selective to H-1 receptors and has anti inflammatory properties. The present evidence regarding the drug efficacy is inconsistent. OBJECTIVES: We aimed to evaluate the efficacy and safety of bilastine compared with the placebo and other active antihistamines in patients who complained either from AR or chronic urticaria. METHODS: We systematically searched the Medline, Scopus, Web of Science, and Cochrane databases for randomized controlled trials (RCTs) evaluating bilastine effects on symptomatic hyper histaminic allergic conditions. We collected data on total symptoms scores (TSS), total nasal symptom scores (TNSS), discomfort associated with these allergic conditions measured by visual analog score (VAS), and quality of life (QOL) for AR and urticaria. Other outcomes such as clinical global impression and safety profiles were reported as well. We pooled the studies in a random effect model using RevMan 5.4 software. RESULTS: We included 9 RCTs comprising 3801 participants. The meta-analysis revealed that bilastine was superior to placebo, improving TSS, TNSS, VAS, and QOL in AR or chronic urticaria participants. Moreover, the bilastine was comparable to active antihistamines such as cetirizine, fexofenadine, and loratadine regarding mentioned outcomes. In addition, the novel drug was safe and tolerable with no difference in the incidence of adverse events with a placebo. CONCLUSIONS: Bilastine safely improved TSS in hyper histaminic allergic conditions involving nasal symptoms in AR. It decreases the discomfort associated with the disease resulting in improving the QOL of the participants.

The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis.

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a progressive meta-inflammatory disorder, which induce micro and macrovascular complications. Resveratrol is a nutraceutical known to have antioxidant and anti-inflammatory properties. It improves insulin resistance; however, no clear evidence regarding its effects in patients with T2DM. OBJECTIVES: We aimed to evaluate the efficacy and the safety of oral resveratrol supplementation in type 2 diabetic patients concerning dose and duration. METHODS: We searched PubMed, Cochrane Library, Scopus, WOS, Wiley, and Google Scholar for RCTs evaluating the efficacy and safety of resveratrol on patients with T2DM. We screened the studies for the eligibility criteria, performed the quality assessment, extracted the studies' characteristics, baseline, and outcome data of interest, and finally conducted the meta-analysis using RevManV5.3. RESULTS: This systematic review and meta-analysis, including 17 RCTs with total 871 patients with T2DM, showed that resveratrol was superior to placebo on fasting blood glucose (FBG) and total cholesterol (TC) with doses ≥500mg {MD=-13.34, 95%CI [-22.73, -3.95], P=0.005}, {MD=-5.64, 95%CI [-6.95, -4.33], P<0.00001} respectively. Moreover, it improved HbA1c at three months {MD=-0.41, 95%CI [-0.65, -0.16], P=0.001 and systolic blood pressure {MD: -7.91, 95%CI [-10.44, -5.37], P<0.00001}. CONCLUSION: We concluded that resveratrol beneficially modulates glycemic control as well as cardiometabolic parameters in patients with T2DM.