Radiation shielding assessment for interventional radiology personnel: Geant4 dosimetry of lead-free compositions.

The inherent biological hazards associated with ionizing radiation necessitate the implementation of effective shielding measures, particularly in medical applications. Interventional radiology, in particular, poses a unique challenge as it often exposes medical personnel to prolonged periods of high x-ray doses. Historically, lead and lead-based compounds have been the primary materials employed for shielding against photons. However, the drawbacks of lead, including its substantial weight causing personnel's inflexibility and its toxicity, have raised concerns regarding its long-term impact on both human health and the environment. Barium tantalate has emerged as a promising alternative, due to its unique attenuation properties against low-energy x-rays, specifically targeting the weak absorption area of lead. In the present study, we employ the Geant4 Monte Carlo simulation tool to investigate various formulations of barium tantalate doped with rare earth elements. The aim is to identify the optimal composition for shielding x-rays in the context of interventional radiology. To achieve this, we employ a reference x-ray spectrum typical of interventional radiology procedures, with energies extending up to 90 keV, within a carefully designed simulation setup. Our primary performance indicator is the reduction in air kerma transmission. Furthermore, we assess the absorbed doses to critical organs at risk within a standard human body phantom protected by the shield. Our results demonstrate that specific concentrations of the examined rare earth impurities can enhance the shielding performance of barium tantalate. To mitigate x-ray exposure in interventional radiology, our analysis reveals that the most effective shielding performance is achieved when using barium tantalate compositions containing 15% Erbium or 10% Samarium by weight. These findings suggest the possibility of developing lead-free shielding solutions or apron for interventional radiology personnel, offering a remarkable reduction in weight (exceeding 30%) while maintaining shielding performance at levels comparable to traditional lead-based materials.

Effects of spin-orbit coupling on transmission and absorption of electromagnetic waves in strained armchair phosphorene nanoribbons.

We compute the optical conductivity, both the imaginary and real parts of the dielectric constant, and the optical coefficients of armchair phosphorene nanoribbons under application of biaxial and uniaxial strains. The Kane-Mele model Hamiltonian has been applied to obtain the electronic band structure of phosphorene nanoribbons in the presence of a magnetic field. The effects of uniaxial and biaxial in-plane strain on the frequency behavior of the optical dielectric constant, and the frequency behavior of the optical absorption and refractive index of phosphorene nanoribbons have been studied, in terms of magnetic field, spin-orbit coupling and strain effects. Linear response theory and the Green's function approach have been exploited to obtain the frequency behavior of the optical properties of the structure. Moreover, the transmissivity and reflectivity of electromagnetic waves between two media separated by a phosphorene-nanoribbon layer are determined. Our numerical results indicate that the frequency dependence of the optical absorption includes a peak due to applying a magnetic field. Moreover, the effects of both in-plane uniaxial and biaxial strains on the refractive index of single-layer phosphorene have been addressed. Also, the frequency dependence of the transmissivity and reflectivity of electromagnetic waves between two media separated by armchair phosphorene nanoribbons for normal incidence has been investigated in terms of the effects of magnetic field and strain parameters. Both compressive and tensile strain have been considered for the armchair phosphorene nanoribbons in order to study the optical properties of the structure. In particular, the control of the optical properties of phosphorene nanoribbons could lead to extensive applications of phosphorene in the optoelectronics industry. Also, such a study of the optical properties of phosphorene nanoribbons has further applications in light sensors. Meanwhile, the effects of spin-orbit coupling on the optical absorption and transmissivity of electromagnetic waves in phosphorene nanoribbons could be a novel topic in condensed-matter physics.

Strain and magnetic field effects on the electronic and transport properties of γ-graphyne.

In this paper, we apply a tightly binding Hamiltonian model in the presence of a magnetic field for investigating the electronic and transport properties of γ-graphyne layers. We also consider the effects of in-plane biaxial strain on the electronic behavior of γ-graphyne layers. Moreover the impact of strain on magnetic susceptibility and specific heat of the structure is also studied. In particular, the temperature dependence of static thermal conductivity of γ-graphyne layers due to magnetic field and strain effects is studied. We exploit the linear response theory and Green's function approach to obtain the temperature behavior of thermal conductivity, electrical conductivity and the Seebeck coefficient. Our numerical results indicate that thermal conductivity increases upon increasing temperature temperatures. This effect comes from the increasing thermal energy of charge carriers and their excitation to the conduction bands. The temperature dependence of Seebeck coefficient shows that the thermopower of an undoped γ-graphyne layer is positive on the whole range of temperatures in the absence of strain effects. The effects of both electron doping and magnetic field factors on temperature behavior of the electrical conductivity of γ-graphyne are investigated in detail. Moreover the effects of biaxial strain on thermal conductivity of single layer γ-graphyne have been addressed.

The effects of spin-orbit coupling on optical properties of monolayer [Formula: see text] due to mechanical strains.

We have studied the optical conductivity of a quasi two-dimensional [Formula: see text] in the presence of external magnetic field and spin-orbit coupling. Specially, we address the frequency dependence of optical conductivity due to spin-orbit interaction. Using linear response theory the behavior of optical conductivity has been obtained within Green's function method. We have also considered the effects of uniaxial and biaxial in-plane strain on the optical absorption of [Formula: see text] layer. In the absence of external magnetic field with negative uniaxial strain parameter, optical conductivity includes Drude weight at zero frequency limit while Drude weight vanishes for [Formula: see text] layer under positive uniaxial strain. Our results show that the increase of uniaxial positive strain parameter causes to move the position peak to the higher frequencies. In contrast to uniaxial strain case, the Drude weight in optical conductivity appears at positive biaxial strain value 0.15. Also we have studied the effects of magnetic field, electron doping, hole doping in the presence of spin-orbit coupling on frequency dependence of optical conductivity of [Formula: see text] in details. The magnetic field dependence of optical absorption shows a monotonic decreasing behavior for each value of temperature in the absence of strain parameter.

Association between sociodemographic characteristics and knowledge and practice of COVID-19 measures among households in Mombasa and Kilifi County, Kenya.

BACKGROUND: Coronavirus disease 2019 (COVID-19), declared a global pandemic by the World Health Organization (WHO), is a severe acute respiratory disease. The Kenyan Ministry of Health (MoH) put in place measures that included mandatory face masking, hand and cough hygiene and social and physical distancing to reduce disease transmission and increase prevention efforts. The primary objective of this study was to determine how sociodemographic characteristics affect knowledge and practice of the above measures. METHODS: A cross-sectional study was conducted to assess water, sanitation and hygiene practices for the prevention and control of COVID-19 in Kilifi and Mombasa Counties, Kenya. Data collection was accomplished through a mobile data collection tool. Principal component analysis was used to create a wealth index using data on asset ownership and housing characteristics. Bloom cut-off points of 80-100%, 60-79% and ≤59% were used to determine knowledge and practice. RESULTS: Of the 612 households, 339 (55.4%) were from Kilifi County and 273 (44.6%) were from Mombasa County. A total of 431 (70.4%) were female and the mean age of the household members was 38.2±14.8 y.Almost all (99.2%) respondents were aware of COVID-19, with 60% knowing prevention, symptoms and persons at a higher risk of contracting the virus. Females had the highest knowledge of COVID-19 and were likely to practice prevention and control measures, unlike males. Age was significant (p<0.05) with knowledge and practice. CONCLUSIONS: The sociodemographic characteristics of populations play a key role in behavioural aspects as far as prevention and control of COVID-19 are concerned. There is a need for partnerships between the MoH and county governments to put in place a multisectoral community approach to advance feasible behavioural interventions among targeted populations towards combating the spread of COVID-19.

The probiotic properties and potential of vaginal Lactobacillus spp. isolated from healthy women against some vaginal pathogens.

During the last decade, probiotic research has progressed considerably and significant advances have been made in the selection and characterization of specific probiotic strains. The most studied probiotics belong to the genus Lactobacillus. In this study, 80 Lactobacillus spp. isolated from healthy women tolerated low pH and were able to grow in the presence of bile salts. RAPD PCR technique resulted in the identification of 38 different types. These isolates were then evaluated based on adhesion capacity, antibiotic susceptibility and tolerance in simulated gastrointestinal tract. Species-specific PCR and detection of bacteriocin-related genes were also surveyed. Among the isolates, five strains-Lacticaseibacillus rhamnosus NO21, Lacticaseibacillus casei NO1, Lactiplantibacillus plantarum NO4, Lactobacillus acidophilus NO7 and Lactobacillus gasseri NO38-presented acceptable antibiotic susceptibility pattern. Further analysis showed antimicrobial activity of Lacticaseibacillus culture against various bacterial pathogens and real-time PCR showed all five strains were able to prevent the colonization of bacterial pathogens. All five selected strains produced organic acids, hydrogen peroxide and were resistant to the spermicide. In addition, they lacked haemolytic activity with the ability of hydrophobicity, auto-aggregation and co-aggregation with pathogens. These results suggest that the vaginal microbiome could be a good source for the isolation of probiotics and the strains of this study may be considered as good probiotic candidates.

Assessment of water, sanitation and hygiene practices for prevention and control of COVID-19 in Kenya.

BACKGROUND: Safely managed water, sanitation and hygiene (WASH) services are an essential part of preventing and protecting human health during infectious disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Additionally, adherence to COVID-19 measures, including washing hands using soap and proper waste disposal, no doubt can improve containment of the virus. METHODS: A cross-sectional survey was conducted in Kilifi and Mombasa Counties in Kenya. A total of 612 quantitative data were collected using a mobile data collection tool Open Data Kit. Parametric and non-parametric tests were used to examine factors associated with WASH practices and control of COVID-19 in Kenya. RESULTS: More than half of the respondents were from Kilifi, 431 (70.4%) were female and the mean age was 38.2±14.8 y. Households in Kilifi were most likely not to have enough water, while Mombasa households were more likely to pay for water. Sanitation coverage was 47.6%, with more than half sharing sanitation facilities. Sharing of latrines was significantly associated with county and income level. Accessing soap was worse compared with the month prior to the survey, only 3.9% had their garbage collected by formal service providers and only 17% reported wearing any protective gear while handling waste at home. CONCLUSIONS: Water is disproportionately available in the two counties, with low sanitation coverage. There is low knowledge on hand washing and inadequate waste disposal services.

Gamma-irradiation applied to the synthesis of the nanocrystalline Gd2O2S:Pr powders for imaging applications.

Nanocrystalline Gd2O2S:Pr powders were successfully synthesized by the co-participation method. The changes of size, shape and luminescence properties of these nanocrystalline powders were studied under different gamma doses (0-50 kGy) during the synthesizing process. Also, the structural, morphology and luminescence properties of these nanocrystalline powders were characterized using the X-ray diffraction, field emission scanning electron microscopy, energy dispersion of X-ray spectroscopy, photoluminescence, and thermoluminescence. The XRD results confirmed that the nanocrystalline Gd2O2S:Pr powders have a pure hexagonal structure with the high crystallinity at a temperature of 900 °C, and the gamma radiation doses have no effect on the structure. The SEM images showed that the nanocrystalline Gd2O2S:Pr powders have a spherical shape and are agglomerated when the irradiation dose increases. These nanopowders, which were prepared at an irradiation dose of 40 kGy, show the lowest crystallite size and hence the highest intensity of emission peaks at the wavelengths of 506, 515 and 671 nm, which are corresponded to the transitions of the 3P1-3H4, 3P0-3H4 and 3P0-3F2 of Pr ions, respectively. The X-ray radiography image was obtained by the screen of Gd2O2S:Pr nanopowders (prepared at 40 kGy gamma dose), coupled with a radiographic film. The TL glow curves of the sample, prepared at 40 kGy gamma dose, were recorded under the X-ray irradiation in the times of 5 and 10 min. The heating rate and preheat temperature were obtained 2 and 50 °C, respectively. The obtained results were investigated in details.

A combined panel of circulating microRNA as a diagnostic tool for detection of the non-small cell lung cancer.

BACKGROUND: Recently, much attention has been paid to use circulating microRNAs (miRs) as a non-invasive tumor marker. The present study for the first time was designed to evaluate concurrent use of miR-21, miR-638, miR148 and miR-152 as putative diagnostic tool for detection of non-small cell lung carcinoma (NSCLC). METHODS: Forty-three patients diagnosed as primary NSCLC was included in this study. The level of selected miRs was measured in whole blood specimens of patients and controls. The corresponding values were also obtained in stages I-IV. We also assessed possible correlation between selected miRs and the clinicopathological findings of studied individuals. RESULTS: miR-21 was increased in patients compared to controls (P = 0.004). In contrast, circulating miR-638, miR-148 and miR-152 was observed to be down-regulated in NSCLC patients than controls (P = 0.001, 0.003, 0.053, respectively). Rise in miR-21-5p expression and decreased blood level of miR-148a-3p was associated with higher stage of NSCLC. The highest sensitivity (90%) was observed for miR-21 while miR-148 had the highest specificity (71%). The corresponding sensitivity and specificity for combined-miRs-panel was 96.4% and 86.67%, respectively. CONCLUSION: In summary, our data suggested the diagnostic importance of combined-miR-panel including miR-21, miR-638, miR148 and miR-152 for effective discrimination of NSCLC from non-cancerous subjects.

Evaluation of 1,25-dihydroxyvitamin D3 pathway in patients with chronic urticaria.

BACKGROUND: Previous studies showed the role of vitamin D (Vit D) on the progression of chronic urticaria. To the best of our knowledge, there are no other results regarding the contribution of single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes in chronic urticaria (CU). AIM: In the present study, we investigated the Vit pathway and the association between VDR and VDBP gene polymorphisms and CU risk in Iranian population. METHODS: All participating individuals in the present study were evaluated for serum Vit D and VDBP concentration VDR rs1544410 and rs2228570 and VDBP rs7041using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The associations of studied analytes and three SNPs with clinical and laboratory outcomes were investigated in CU patients. RESULTS: Patients with CU showed lower Vit D compared to controls (19.26 ± 1.26 vs. 31.72 ± 7.14 ng/ml, P-value = 0.006). There was a significant correlation between Vit D levels and urticaria activity score. Serum VDBP was significantly higher in CU patients than controls (1317.3 ± 183.71 vs. 395.77 ± 12.96 µg/ml, P-value <0.0001) and had a positive correlation to progression of CU. The A allele of this polymorphism might be a potential risk factor for progression of CU [odds ratio 4.3434, 95% confidence interval (1.7331-10.8852), Z-statistic = 3.133, P-value = 0.0017]. CONCLUSION: In summary, this study demonstrated that change in Vit D pathway in the level of gene or protein may be a risk factor for progression of CU.

Rethinking the Design of Low-Cost Point-of-Care Diagnostic Devices.

Reducing the global diseases burden requires effective diagnosis and treatment. In the developing world, accurate diagnosis can be the most expensive and time-consuming aspect of health care. Healthcare cost can, however, be reduced by use of affordable rapid diagnostic tests (RDTs). In the developed world, low-cost RDTs are being developed in many research laboratories; however, they are not being equally adopted in the developing countries. This disconnect points to a gap in the design philosophy, where parameterization of design variables ignores the most critical component of the system, the point-of-use stakeholders (e.g., doctors, nurses and patients). Herein, we demonstrated that a general focus on reducing cost (i.e., "low-cost"), rather than efficiency and reliability is misguided by the assumption that poverty reduces the value individuals place on their well-being. A case study of clinicians in Kenya showed that "zero-cost" is a low-weight parameter for point-of-use stakeholders, while reliability and standardization are crucial. We therefore argue that a user-driven, value-addition systems-engineering approach is needed for the design of RDTs to enhance adoption and translation into the field.

Inhibitory effect of Lactobacillus plantarum and Lb. fermentum isolated from the faeces of healthy infants against nonfermentative bacteria causing nosocomial infections.

Nosocomial infection constitutes a major public health problem worldwide. Increasing antibiotic resistance of pathogens associated with nosocomial infections has also become a major therapeutic challenge for physicians. Thus, development of alternative treatment protocols, such as the use of probiotics, matters. The aim of this research was to determine the antagonistic properties of Lactobacillus plantarum and Lb. fermentum isolated from the faeces of healthy infants against nonfermentative bacteria causing nosocomial infections. One hundred five samples of nosocomial infections were collected and processed for bacterial isolation and antimicrobial susceptibility testing following standard bacteriologic techniques. The antibiotic susceptibility test was performed by the disk diffusion method, and antagonistic effect of Lactobacillus strains was investigated by well diffusion method. Of 105 samples, a total of 29 bacterial strains were identified as nonfermentative bacteria, including 17 Acinetobacter baumannii and 12 Pseudomonas aeruginosa. A. baumannii showed high resistance to tested antibiotics except ampicillin/sulbactam, and P. aeruginosa showed resistance to ampicillin/sulbactam and gentamicin and sensitive to amikacin and meropenem. Lb. plantarum had antagonistic properties against both A. baumannii and P. aeruginosa strains. Lb. plantarum had considerable effects on preventing the growth of A. baumannii and P. aeruginosa strains. However, further research is needed to better understanding of these effects on P. aeruginosa.

Selective removal of uranium ions from contaminated waters using modified-X nanozeolite.

In order to efficiently remove of uranium anionic species (which are the most dominant species of uranium in natural water at neutral pH) from contaminated waters, nano-NaX zeolite was synthesized and then modified using various divalent cations (Mg2+, Ca2+, Mn2+) and ZnO nanoparticles (from 1.7 to 10.3wt%). Different characterization techniques of XRF, XRD, FE-SEM, TEM, FT-IR, and AAS were used to characterize the final synthesized absorbents. Sorption experiments by batch technique were done to study the effect of solid-liquid ratio, initial uranium concentration, contact time and temperature under neutral condition of pH and presence of all anions and cations which are available in the waters. Results showed that although nano-NaX zeolite due to its negative framework charge had a low sorption capacity for adsorption of uranium anionic species, but modification of parent nano-NaX zeolite with ZnO nanoparticles and various cations effectively improved its uranium adsorption capacity. Also, results showed that under optimum condition of pH=7.56, contact time of 60min at 27°C with solid-liquid ratio of 20g/L a maximum uranium removal efficiency of 99.7% can be obtained in the presence of all anions and cations which are available in the drinking waters by NaX/ZnO nanocomposite.

Dissipative Optomechanical Preparation of Macroscopic Quantum Superposition States.

The transition from quantum to classical physics remains an intensely debated question even though it has been investigated for more than a century. Further clarifications could be obtained by preparing macroscopic objects in spatial quantum superpositions and proposals for generating such states for nanomechanical devices either in a transient or a probabilistic fashion have been put forward. Here, we introduce a method to deterministically obtain spatial superpositions of arbitrary lifetime via dissipative state preparation. In our approach, we engineer a double-well potential for the motion of the mechanical element and drive it towards the ground state, which shows the desired spatial superposition, via optomechanical sideband cooling. We propose a specific implementation based on a superconducting circuit coupled to the mechanical motion of a lithium-decorated monolayer graphene sheet, introduce a method to verify the mechanical state by coupling it to a superconducting qubit, and discuss its prospects for testing collapse models for the quantum to classical transition.

A Lumped Parameter Method to Calculate the Effect of Internal Carotid Artery Occlusion on Anterior Cerebral Artery Pressure Waveform.

BACKGROUND AND OBJECTIVE: Numerical modeling of biological structures would be very helpful tool to analyze hundreds of human body phenomena and also diseases diagnosis. One physiologic phenomenon is blood circulatory system and heart hemodynamic performance that can be simulated by utilizing lumped method. In this study, we can predict hemodynamic behavior of one artery of circulatory system (anterior cerebral artery) when disease such as internal carotid artery occlusion is occurred. METHOD: Pressure-flow simulation is one the leading common approaches for modeling of circulatory system behavior and forecasts of hemodynamic in numerous physiological conditions. In this paper, by using lumped model (electrical analogy), CV system is simulated in MATLAB software (SIMULINK environment). RESULTS: The performance of healthy blood circulation and heart is modeled and the obtained results used for further analyses. The stenosis of internal carotid artery at different rates was, then, induced in the circuit and the effects are studied. In stenosis cases, the effects of internal carotid artery occlusion on  left anterior cerebral artery pressure waveform are investigated. CONCLUSION: The findings of this study may have implications not only for understanding the behavior of human biological system at healthy condition but also for diagnosis of diseases in circulatory and cardiovascular system of human body.

New insight to IL-23/IL-17 axis in Iranian infected adult patients with gastritis: effects of genes polymorphisms on expression of cytokines.

BACKGROUND AND OBJECTIVE: Chronic inflammation is the hallmark of the pathogenesis of H. pylori-induced gastric cancer. IL-17A and IL-17F are inflammatory cytokines expressed by a novel subset of CD4+Th cells and play critical function in inflammation. We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-ß1 mRNAs expression in regard to H. pylori infection with chronic gastritis. MATERIAL AND METHODS: Total RNA and genomic DNA were extracted from gastric biopsies of 58 H. pylori-infected patient with gastritis. Afterward, mucosal IL-6, IL-17, IL-21, IL-23 and TGF-ß1 mRNAs expression and polymorphisms in IL-17A G197A, IL-17F A7488G and IL-23R +2199A/Cin gastric biopsies were determined by real-time PCR and PCR-RFLP. RESULTS: Our results show that IL-17A G197A, IL-17F A7488G andIL23R +2199A/C polymorphisms have no effect on mucosal expression of IL-6, IL-17, IL-21 and TGF-ß1 mRNAs expression in H. pylori-infected patients with chronic gastritis. CONCLUSIONS: These results suggest that IL-17A G197A, IL-17F A7488G and IL23R +2199A/C polymorphisms no alter mucosal cytokine pattern in Iranian patients with H. pylori-associated gastritis diseases.

Antidepressant activities of Feijoa sellowiana fruit.

OBJECTIVE: Many pharmacological activities have been reported for Feijoa sellowiana. The aim of present study was to investigate antidepressant activities of its leaf and fruit extracts. MATERIALS AND METHODS: Antidepressant activities of methanolic extracts were evaluated by modified forced swimming test (FST) and tail suspension tests (TST) in male Swiss albino mice. RESULTS: Extracts showed signicant antidepressant activity in both models. They shortened remarkably the immobility period in both FST and TST and exhibited a dose dependent activity (p < 0.001). Leaf extract showed better activity than fruit extract. At 800 mg kg-1, it showed far better activity than imipramine in FST (p < 0.001). Both extracts showed significantly better activity than imipramine in increasing climbing time (p < 0.001). They showed significant activity in increasing in swimming time as compared to the control group (p < 0.001). CONCLUSIONS: Our studies indicate that Feijoa showed significant antidepressant activity. It produced dose dependent effect on both models. It seems this effect is mainly mediated by inhibition of reuptake of catecholamines. These results introduced these plants as easily accessible source of natural antidepressant.

Do adolescent drug users fare the worst? Onset type, juvenile delinquency, and criminal careers.

Although substance abuse often accompanies delinquency and other forms of antisocial behavior, there is less scholarly agreement about the timing of substance use vis-à-vis an individual's antisocial trajectory. Similarly, although there is extraordinary evidence that onset is inversely related to the severity of the criminal career, there is surprisingly little research on the offense type of onset or the type of antisocial behavior that was displayed when an individual initiated his or her offending career. Drawing on data from a sample of serious adult criminal offenders (N = 500), the current study examined 12 forms of juvenile delinquency (murder, rape, robbery, aggravated assault, burglary, larceny, auto theft, arson, weapons, sexual offense, drug sales, and drug use) in addition to age at arrest onset, age, sex, race to explore their association with chronicity (total arrests), extreme chronicity (1 SD above the mean which was equivalent to 90 career arrests), and lambda (offending per year). The only onset offense type that was significantly associated with all criminal career outcomes was juvenile drug use. Additional research on the offense type of delinquent onset is needed to understand launching points of serious antisocial careers.

Modeling of cerebral aneurysm using equivalent electrical circuit (Lumped Model).

The circle of Willis (CoW) is a key asset in brain performance as it supports adequate blood supply to the brain. The lumped method (electrical equivalent circuits) is a useful model to simulate the process of the human cardiovascular system. In this study, the whole cardiovascular system is modeled, using an equivalent electrical circuit to investigate an aneurysm in an artery. The cerebrovascular system consists of 29 compartments, which includes the CoW. Each vessel is modeled by a resistor, a capacitor and an inductor. Using MATLAB Simulink, the left and right ventricles are modeled by controlled voltage sources and diodes. The effects of the left internal carotid artery aneurysm (Fusiform) on the pressure of the efferent arteries in the circle of Willis are studied. The modeling results are entirely in agreement with the available clinical observations. The results of the present study may have clinical implications for modeling different cardiovascular diseases, such as arterial stiffness and atherosclerosis.

Reversible optical-to-microwave quantum interface.

We describe a reversible quantum interface between an optical and a microwave field using a hybrid device based on their common interaction with a micromechanical resonator in a superconducting circuit. We show that, by employing state-of-the-art optoelectromechanical devices, one can realize an effective source of (bright) two-mode squeezing with an optical idler (signal) and a microwave signal, which can be used for high-fidelity transfer of quantum states between optical and microwave fields by means of continuous variable teleportation.