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1.
Sensors (Basel) ; 21(6)2021 Mar 10.
Artículo en Inglés | MEDLINE | ID: mdl-33802217

RESUMEN

The progress brought by the deep learning technology over the last decade has inspired many research domains, such as radar signal processing, speech and audio recognition, etc., to apply it to their respective problems. Most of the prominent deep learning models exploit data representations acquired with either Lidar or camera sensors, leaving automotive radars rarely used. This is despite the vital potential of radars in adverse weather conditions, as well as their ability to simultaneously measure an object's range and radial velocity seamlessly. As radar signals have not been exploited very much so far, there is a lack of available benchmark data. However, recently, there has been a lot of interest in applying radar data as input to various deep learning algorithms, as more datasets are being provided. To this end, this paper presents a survey of various deep learning approaches processing radar signals to accomplish some significant tasks in an autonomous driving application, such as detection and classification. We have itemized the review based on different radar signal representations, as it is one of the critical aspects while using radar data with deep learning models. Furthermore, we give an extensive review of the recent deep learning-based multi-sensor fusion models exploiting radar signals and camera images for object detection tasks. We then provide a summary of the available datasets containing radar data. Finally, we discuss the gaps and important innovations in the reviewed papers and highlight some possible future research prospects.

2.
Brief Bioinform ; 21(4): 1182-1195, 2020 07 15.
Artículo en Inglés | MEDLINE | ID: mdl-31190075

RESUMEN

Sepsis is a series of clinical syndromes caused by the immunological response to infection. The clinical evidence for sepsis could typically attribute to bacterial infection or bacterial endotoxins, but infections due to viruses, fungi or parasites could also lead to sepsis. Regardless of the etiology, rapid clinical deterioration, prolonged stay in intensive care units and high risk for mortality correlate with the incidence of sepsis. Despite its prevalence and morbidity, improvement in sepsis outcomes has remained limited. In this comprehensive review, we summarize the current landscape of risk estimation, diagnosis, treatment and prognosis strategies in the setting of sepsis and discuss future challenges. We argue that the advent of modern technologies such as in-depth molecular profiling, biomedical big data and machine intelligence methods will augment the treatment and prevention of sepsis. The volume, variety, veracity and velocity of heterogeneous data generated as part of healthcare delivery and recent advances in biotechnology-driven therapeutics and companion diagnostics may provide a new wave of approaches to identify the most at-risk sepsis patients and reduce the symptom burden in patients within shorter turnaround times. Developing novel therapies by leveraging modern drug discovery strategies including computational drug repositioning, cell and gene-therapy, clustered regularly interspaced short palindromic repeats -based genetic editing systems, immunotherapy, microbiome restoration, nanomaterial-based therapy and phage therapy may help to develop treatments to target sepsis. We also provide empirical evidence for potential new sepsis targets including FER and STARD3NL. Implementing data-driven methods that use real-time collection and analysis of clinical variables to trace, track and treat sepsis-related adverse outcomes will be key. Understanding the root and route of sepsis and its comorbid conditions that complicate treatment outcomes and lead to organ dysfunction may help to facilitate identification of most at-risk patients and prevent further deterioration. To conclude, leveraging the advances in precision medicine, biomedical data science and translational bioinformatics approaches may help to develop better strategies to diagnose and treat sepsis in the next decade.


Asunto(s)
Medicina de Precisión , Sepsis/diagnóstico , Sepsis/terapia , Humanos , Pronóstico , Factores de Riesgo , Sepsis/patología
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