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1.
Med J Malaysia ; 76(6): 870-875, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34806675

RESUMEN

INTRODUCTION: Intravenous (IV) thrombolysis with recombinant tissue plasminogen activator (rt-PA) is effective in treating acute ischaemic stroke. Our primary objective is to assess the outcome of these acute ischaemic stroke (AIS) patients after IV alteplase with the modified Rankin scale (mRS). METHODS: This is a cross-sectional study in which patients receiving IV alteplase in Hospital Universiti Sains Malaysia, from January 2017 to April 2020 were recruited. Demographical data, National Institutes of Health Stroke Scale (NIHSS) scores, door-to-needle time were recorded. Modified Rankin scale (mRS) scores were evaluated at 90 days after initial therapy. Good and poor functional outcomes were defined as 0-2 and 3-6, respectively. RESULTS: A total of 30 patients were included in the study with a mean age of 59±11.47 years old. 76.7% of them were male and the rest were female. From the study, onset-toneedle time was 197.47±51.74 minutes, whereas door-toneedle time was 120.93±53.63 minutes. Seventeen (56.3%) patients achieved a favourable score of 0-2 on the mRS at 90 days after treatment. Haemorrhagic transformation occurred in eight (26.7%) of the patients with a mortality rate of 13.3%. CONCLUSION: 56.7% of our patients showed improvement in the mRS at 90 days post thrombolysis for AIS. Higher baseline NIHSS scores and diabetes mellitus were associated with poorer functional outcomes after thrombolysis.


Asunto(s)
Isquemia Encefálica , Accidente Cerebrovascular Isquémico , Activador de Tejido Plasminógeno , Anciano , Isquemia Encefálica/complicaciones , Isquemia Encefálica/tratamiento farmacológico , Estudios Transversales , Femenino , Hospitales , Humanos , Accidente Cerebrovascular Isquémico/tratamiento farmacológico , Malasia , Masculino , Persona de Mediana Edad , Terapia Trombolítica , Activador de Tejido Plasminógeno/uso terapéutico , Resultado del Tratamiento
3.
Med J Malaysia ; 71(2): 77-8, 2016 04.
Artículo en Inglés | MEDLINE | ID: mdl-27326948

RESUMEN

Damage Control Resuscitation and Surgery is the concept of controlled hypotension, haemostatic resuscitation and abbreviated surgical procedures following severe trauma; the practice of which has resulted in improved mortality and morbidity. We describe a rare case of thoraco-abdominal impalement successfully managed based on the concept of Damage Control Resuscitation.


Asunto(s)
Traumatismos Abdominales , Resucitación , Humanos , Heridas Penetrantes
4.
Artículo en Inglés | WPRIM (Pacífico Occidental) | ID: wpr-630735

RESUMEN

Damage Control Resuscitation and Surgery is the concept of controlled hypotension, haemostatic resuscitation and abbreviated surgical procedures following severe trauma; the practice of which has resulted in improved mortality and morbidity. We describe a rare case of thoraco-abdominal impalement successfully managed based on the concept of Damage Control Resuscitation.


Asunto(s)
Hipotensión
5.
Acta Crystallogr Sect E Struct Rep Online ; 68(Pt 8): o2545, 2012 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-22904977

RESUMEN

The four six-membered fused rings in the title compound, C(10)H(20)N(6)·2H(2)O, adopt chair conformations; the H atoms of the four secondary N atoms occupy axial positions. Hydrogen bonds of the types N-H⋯N, N-H⋯O and O-H⋯N link the organic and water mol-ecules into a three-dimensional network.

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