Ultrasonic synthesis of green lipid nanocarriers loaded with Scutellaria barbata extract: a sustainable approach for enhanced anticancer and antibacterial therapy.

Ultrasonic manufacturing has emerged as a promising eco-friendly approach to synthesize lipid-based nanocarriers for targeted drug delivery. This study presents the novel ultrasonic preparation of lipid nanocarriers loaded with Scutellaria barbata extract, repurposed for anticancer and antibacterial use. High-frequency ultrasonic waves enabled the precise self-assembly of DSPE-PEG, Span 40, and cholesterol to form nanocarriers encapsulating the therapeutic extract without the use of toxic solvents, exemplifying green nanotechnology. Leveraging the inherent anticancer and antibacterial properties of Scutellaria barbata, the study demonstrates that lipid encapsulation enhances the bioavailability and controlled release of the extract, which is vital for its therapeutic efficacy. Dynamic light scattering and transmission electron microscopy analyses confirmed the increase in size and successful encapsulation post-loading, along with an augmented negative zeta potential indicating enhanced stability. A high encapsulation efficiency of 91.93% was achieved, and in vitro assays revealed the loaded nanocarriers' optimized release kinetics and improved antimicrobial potency against Pseudomonas aeruginosa, compared to the free extract. The combination of ultrasonic synthesis and Scutellaria barbata in an eco-friendly manufacturing process not only advances green nanotechnology but also contributes to sustainable practices in pharmaceutical manufacturing. The data suggest that this innovative nanocarrier system could provide a robust platform for the development of nanotechnology-based therapeutics, enhancing drug delivery efficacy while aligning with environmental sustainability.

Getting to know ovarian cancer: Focusing on the effect of LncRNAs in this cancer and the effective signaling pathways.

This article undertakes a comprehensive investigation of ovarian cancer, examining the complex nature of this challenging disease. The main focus is on understanding the role of long non-coding RNAs (lncRNAs) in the context of ovarian cancer (OC), and their regulatory functions in disease progression. Through extensive research, the article identifies specific lncRNAs that play significant roles in the intricate molecular processes of OC. Furthermore, the study examines the signaling pathways involved in the development of OC, providing a detailed comprehension of the underlying molecular mechanisms. By connecting lncRNA dynamics with signaling pathways, this exploration not only advances our understanding of ovarian cancer but also reveals potential targets for therapeutic interventions. The findings open up opportunities for targeted treatments, highlighting the importance of personalized approaches in addressing this complex disease and driving progress in ovarian cancer research and treatment strategies.

The Moderating Impact of Student Mental Health, Sports Passion, and Athlete Role Model on Students Game Performance: A Survey of Twenty Colleges in Iraq / El impacto moderador de la salud mental de los estudiantes, la pasión por los deportes y el modelo a seguir de los atletas en el rendimiento de los estudiantes en los juegos: una encuesta realizada en veinte universidades de Irak

The objective of this study was to assess the influence of students' mental health, sports passion, and athlete role models on the connection between sports education and their game performance. This research aims to address the inconsistencies identified in the existing body of knowledge through previous studies. Twenty colleges in Iraq collected the data set, which included a total of 184 people. A questionnaire using a Likert scale was chosen to collect data through a simple random sampling method. The research findings were analysed using Statistical Packages for Social Sciences (SPSS) 21. Various statistical tests, including descriptive findings, Pearson's correlation, model summary, Analysis of Variance (ANOVA), and coefficients, were employed to examine the data. The study revealed that students' mental health, passion for sports, and the presence of athlete role models play a crucial role in influencing the relationship between their sports education and game performance. This study aims to address the existing gaps in knowledge that have led to inconsistencies in the literature. Policymakers in Iraq must prioritise the sports education of students, considering their enthusiasm for sports and mental well-being, while also providing them with positive role models.(AU)