1.
Bioorg Med Chem Lett
; 9(6): 895-900, 1999 Mar 22.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10206557
RESUMEN
A novel scaffold for P4-P2 dipeptide mimics containing a rigid pyridone spacer was designed based on a virtual library strategy. Several selected nonpeptidic 4-aralkyl or 4-alkylpyridones incorporating a P1-argininal sequence were prepared. The modeling studies, synthesis and biological activities of these unique pyridone derivatives are reported herein.