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1.
Materials (Basel) ; 16(11)2023 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-37297263

RESUMEN

Over the past few years, alternative power supplies to either supplement or replace batteries for electronic textile and wearable applications have been sought, with the development of wearable solar energy harvesting systems gaining significant interest. In a previous publication the authors reported a novel concept to craft a yarn capable of harvesting solar energy by embedding miniature solar cells within the fibers of a yarn (solar electronic yarns). The aim of this publication is to report the development of a large-area textile solar panel. This study first characterized the solar electronic yarns, and then analyzed the solar electronic yarns once woven into double cloth woven textiles; as part of this study, the effect of different numbers of covering warp yarns on the performance of the embedded solar cells was explored. Finally, a larger woven textile solar panel (510 mm × 270 mm) was constructed and tested under different light intensities. It was observed that a PMAX = 335.3 ± 22.4 mW of energy could be harvested on a sunny day (under 99,000 lux lighting conditions).

2.
Sci Rep ; 10(1): 2767, 2020 02 17.
Artículo en Inglés | MEDLINE | ID: mdl-32066745

RESUMEN

Current therapeutic strategies for Parkinson's disease (PD) aim to delay progression or replace damaged neurons by restoring the original neuronal structures. The poor regenerative capacity of neural tissue highlights the need for the development of cellular environments to model the pathogenesis of PD. In the current work, we have characterised the growth, survival and response to PD mimetics of human SH-SY5Y neuroblastoma and U-87MG glioblastoma cell lines cultured on polyacrylonitrile (PAN) and Jeffamine® doped polyacrylonitrile (PJ) nano-scaffolds. Differentiation induced by a range of agents was evaluated by immunoassays of neural protein biomarkers. PAN and PJ nanofibre scaffolds provided suitable three-dimensional (3D) environment to support the growth, differentiation and network formation of dopaminergic neuron- and astrocyte-like cell populations, respectively. The scaffolds selectively supported the survival and differentiation of both cell populations with prolonged neuronal survival when exposed to PD mimetics in the presence of astrocytes in a co-culture model. Such 3D nanoscaffold-based assays could aid our understanding of the molecular basis of PD mimetic-induced Parkinsonism and the discovery of neuroprotective agents.


Asunto(s)
Resinas Acrílicas/farmacología , Degeneración Nerviosa/tratamiento farmacológico , Fármacos Neuroprotectores/farmacología , Enfermedad de Parkinson/tratamiento farmacológico , Astrocitos/efectos de los fármacos , Muerte Celular/efectos de los fármacos , Diferenciación Celular/efectos de los fármacos , Línea Celular Tumoral , Supervivencia Celular/efectos de los fármacos , Técnicas de Cocultivo , Neuronas Dopaminérgicas/efectos de los fármacos , Neuronas Dopaminérgicas/patología , Humanos , Nanofibras/química , Degeneración Nerviosa/patología , Fármacos Neuroprotectores/química , Oxidopamina/farmacología , Enfermedad de Parkinson/patología , Andamios del Tejido
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