RESUMEN
GSK249320, a monoclonal antibody directed against myelin-associated glycoprotein (MAG), is being developed for the enhancement of recovery of function poststroke. Potential safety concerns of adverse effects on myelin led to the inclusion of pharmacodynamic measures of peripheral and central neuronal function in this first-time-in-human (FTIH) study. The study also evaluated general safety, pharmacokinetics, and immunogenicity of GSK249320. Single intravenous infusions of GSK249320 (0.04, 0.4, 1.2, 3.5, 10, and 25 mg/kg) or placebo were administered to 47 healthy subjects aged 18-60 years. GSK249320 was well tolerated at all doses. No clinically significant abnormalities were observed in neurological examinations, nerve conduction tests (NCTs), quantitative sensory tests (QSTs), clinical laboratory tests, or electrocardiograms. There were no severe or serious adverse events. GSK249320 had a half-life (HL) of 21 days and a volume of distribution at steady state of 45.8 ml/kg, with AUC showing dose linearity. GSK249320 did not induce antidrug antibodies.
Asunto(s)
Anticuerpos Monoclonales Humanizados/farmacocinética , Anticuerpos Monoclonales/farmacocinética , Glicoproteína Asociada a Mielina/antagonistas & inhibidores , Adolescente , Adulto , Anticuerpos Monoclonales/efectos adversos , Anticuerpos Monoclonales/farmacología , Anticuerpos Monoclonales Humanizados/efectos adversos , Anticuerpos Monoclonales Humanizados/farmacología , Relación Dosis-Respuesta a Droga , Electrocardiografía , Femenino , Semivida , Humanos , Infusiones Intravenosas , Masculino , Persona de Mediana Edad , Glicoproteína Asociada a Mielina/inmunología , Conducción Nerviosa , Umbral Sensorial , Método Simple Ciego , Adulto JovenRESUMEN
This study investigated the effects of single doses of clemastine (2mg orally), mepyramine (2 micrograms intradermally) and placebo on weal and flare caused by intradermal chloroquine 2.5mg and histamine 2 micrograms in 11 healthy black subjects who experienced generalised pruritus with oral chloroquine. Compared with placebo, both antihistamines caused significant reductions in histamine-induced weal and flare. By contrast, chloroquine-induced weal and flare were not significantly altered by clemastine or mepyramine when compared with placebo. It is concluded that histamine is unlikely to be the main mediator of chloroquine-induced weal and flare. These findings are in consonance with the lack of significant effect of antihistamines on chloroquine-induced generalised pruritus.
Asunto(s)
Cloroquina/efectos adversos , Clemastina/uso terapéutico , Histamina/efectos adversos , Prurito/tratamiento farmacológico , Pirilamina/uso terapéutico , Administración Oral , Adolescente , Adulto , Análisis de Varianza , Población Negra , Estudios Cruzados , Histamina/fisiología , Humanos , Inyecciones Intradérmicas , Masculino , Prurito/inducido químicamente , Prurito/fisiopatología , Método Simple CiegoRESUMEN
A water extract of the West African black pepper Piper guineense L. was tested for activity against audiogenic seizures in DBA/2 mice, and against seizures induced in T.O. mice by N-methyl-DL-aspartate (NMDLA), pentylenetetrazole (PTZ) and maximal electroschock. Single intraperitoneal doses of the extract produced significant protection of DBA/2 mice against audiogenic seizures. The highest of three doses tested produced 100% and 58% protection at 6 h and 18 h after treatment, respectively. The extract also protected T.O. mice against convulsions induced by NMDLA and maximal electroshock but it had no significant effect on PTZ-induced convulsions. The doses of the extract tested did not cause significant impairment of performance of T.O. mice on a rotarod test. The results indicate that the extract of P. guineense has prolonged anticonvulsant activity at doses which do not cause significant CNS depression.
Asunto(s)
Anticonvulsivantes/farmacología , Medicinas Tradicionales Africanas , Extractos Vegetales/farmacología , Especias , Estimulación Acústica , Animales , Etanol/química , Masculino , Ratones , Ratones Endogámicos DBA , N-Metilaspartato , Pentilenotetrazol , Convulsiones/tratamiento farmacológico , Convulsiones/etiología , Agua/químicaRESUMEN
The incidence and nature of pruritus induced by chloroquine and halofantrine were studied in 82 patients with acute malaria and in 40 healthy subjects, using a visual analogue scale for quantitating pruritus. Results showed that the proportion of patients with acute malaria manifesting itch to halofantrine was significantly lower than the proportion manifesting itch to chloroquine. Furthermore, the intensity and duration of halofantrine-induced pruritus were significantly lower than those of chloroquine-induced pruritus. The few patients who itched to halofantrine all had a history of itching to chloroquine. The incidence and intensity of chloroquine-induced pruritus were significantly higher in patients with malaria than in healthy subjects. By contrast, there was no significant difference between malaria patients and healthy subjects as regards halofantrine-induced pruritus. These results suggest that itchers to halofantrine may constitute a small group within the population of itchers to chloroquine. Malaria infection appears to enhance chloroquine-induced pruritus but not halofantrine-induced pruritus and this may be of therapeutic importance.
Asunto(s)
Antimaláricos/efectos adversos , Cloroquina/efectos adversos , Erupciones por Medicamentos/etiología , Hipersensibilidad a las Drogas/etiología , Fenantrenos/efectos adversos , Prurito/inducido químicamente , Enfermedad Aguda , Adolescente , Adulto , Erupciones por Medicamentos/epidemiología , Hipersensibilidad a las Drogas/epidemiología , Femenino , Humanos , Cinética , Malaria/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Prurito/epidemiologíaRESUMEN
A review of current knowledge of essential tremor and its treatment is presented. Its prevalence in Africa is not known but it is quite common in those over 40 years in most communities of the world. The condition is characterised by slowly progressive postural tremor of the arms and head without an identifiable organic cause. It is often misdiagnosed as Parkinson's disease. Current treatment is with beta-adrenoceptor blocking drugs, but this treatment is not completely satisfactory. Further studies are required on its pathophysiological mechanisms and new therapeutic directions.
Asunto(s)
Temblor , Diagnóstico Diferencial , Humanos , Propranolol/uso terapéutico , Temblor/clasificación , Temblor/diagnóstico , Temblor/tratamiento farmacológicoRESUMEN
Urine concentrations of methylhistamine were measured in 11 subjects who experienced itching with chloroquine ('itchers') and in 14 who did not itch ('non-itchers'). In each group, urine methylhistamine concentrations were significantly greater at 12, 24 and 36 h after ingestion of 1 g chloroquine phosphate than before. There was no significant difference between itchers and non-itchers as regards urine methylhistamine concentrations at any time-point. Furthermore, there was no correlation between urine methylhistamine concentration and degree of pruritus in itchers. The findings suggest that histamine may be released by chloroquine, but it is unlikely to be the main cause of chloroquine-induced pruritus.
Asunto(s)
Población Negra , Cloroquina/efectos adversos , Metilhistaminas/orina , Prurito/inducido químicamente , Adulto , Análisis de Varianza , Femenino , Humanos , MasculinoRESUMEN
The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale. There was no significant differences between the mean percentage degrees of pruritus recorded with placebo, clemastine and ketotifen. By contrast, the mean percentage degree of pruritus recorded with prednisolone was significantly lower than those with the other three treatments. If these results are confirmed in patients with malaria, it might be more rational to administer a single prophylactic dose of prednisolone in those who experience very disturbing pruritus with chloroquine.
Asunto(s)
Cloroquina/efectos adversos , Clemastina/uso terapéutico , Cetotifen/uso terapéutico , Prednisolona/uso terapéutico , Prurito/tratamiento farmacológico , Pirrolidinas/uso terapéutico , Adulto , Análisis de Varianza , Población Negra , Humanos , Masculino , Prurito/inducido químicamente , Distribución AleatoriaRESUMEN
The effects of intravenous doses of propranolol, sotalol, timolol, atenolol and placebo on exercise-induced tachycardia and exercise-induced increases in hand tremor were assessed in four healthy volunteers. All active drugs produced significant reductions in exercise-induced tachycardia. Exercise caused consistent significant increases in hand tremor which were blocked by the three non-cardioselective drugs but not by atenolol or placebo. The blockade of exercise-induced hand tremor is suggested as a possible test for the assessment of the selectivity of beta-adrenoceptor blockade in man.
Asunto(s)
Antagonistas Adrenérgicos beta/farmacología , Esfuerzo Físico , Receptores Adrenérgicos beta/fisiología , Temblor/fisiopatología , Adulto , Atenolol/farmacología , Mano , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Masculino , Propranolol/farmacología , Sotalol/farmacología , Temblor/etiologíaRESUMEN
Intravenous thymoxamine reduced the power of essential tremor but increased that of physiological and isoprenaline-induced tremor. These findings indicate that essential and physiological tremor have dissimilar pathophysiological mechanisms. They also suggest that central adrenergic mechanisms are involved in the pathophysiology of essential tremor and that isoprenaline-induced tremor is not a good model of essential tremor. Furthermore, alpha-adrenoceptor blockers may be a useful therapy for essential tremor.
Asunto(s)
Sistema Nervioso Central/fisiopatología , Moxisilita , Receptores Adrenérgicos alfa/fisiología , Temblor/fisiopatología , Adulto , Anciano , Presión Sanguínea , Femenino , Frecuencia Cardíaca , Humanos , Isoproterenol , Masculino , Persona de Mediana Edad , Moxisilita/uso terapéutico , Temblor/inducido químicamente , Temblor/tratamiento farmacológicoRESUMEN
The effects of nadolol (or placebo) and carbimazole on thyrotoxic tremor were investigated in 18 thyrotoxic patients. Both nadolol and carbimazole produced significant reductions in tremor power although nadolol did not cause any change in serum free tri-iodothyronine and free thyroxine concentrations. The results are discussed in terms of the pathogenesis of thyrotoxic tremor and the potential usefulness of tremor in the investigation of adrenergic mechanisms in thyrotoxicosis.
Asunto(s)
Antagonistas Adrenérgicos beta/uso terapéutico , Carbimazol/uso terapéutico , Hipertiroidismo/complicaciones , Propanolaminas/uso terapéutico , Temblor/tratamiento farmacológico , Adulto , Ensayos Clínicos como Asunto , Femenino , Humanos , Hipertiroidismo/metabolismo , Masculino , Persona de Mediana Edad , Nadolol , Distribución Aleatoria , Tiroxina/metabolismo , Temblor/complicaciones , Temblor/metabolismo , Triyodotironina/metabolismoRESUMEN
The effects of intravenous propranolol 100 micrograms kg-1, sotalol 500 micrograms kg-1, timolol 7.8 micrograms kg-1, atenolol 125 micrograms kg-1 and placebo on essential, physiological and isoprenaline-induced tremor were studied. These beta-adrenoceptor blocker doses produced equal reduction of standing-induced tachycardia in essential tremor patients. Atenolol produced significantly less reduction of essential and isoprenaline-induced tremor than the non-selective drugs, confirming the importance of beta 2-adrenoceptor blockade in these effects. Propranolol and sotalol produced equal maximal inhibition of isoprenaline-induced tremor but propranolol was significantly more effective in reducing essential tremor. The rate of development of the tremorolytic effect was similar in essential, physiological and isoprenaline-induced tremors but all tremor responses developed significantly more slowly than the heart rate responses. It is proposed that these results indicate that the tremorolytic activity of beta-adrenoceptor blockers in essential, physiological and isoprenaline-induced tremor is exerted via the same beta 2-adrenoceptors located in a deep peripheral compartment which is thought to be in the muscle spindles.